{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004234283265152.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1080/15548627.2017.1387342"}},{"identifier":{"@type":"URI","@value":"https://www.tandfonline.com/doi/pdf/10.1080/15548627.2017.1387342"}},{"identifier":{"@type":"DOI","@value":"10.6084/m9.figshare.6011045"}},{"identifier":{"@type":"DOI","@value":"10.6084/m9.figshare.6011045.v1"}},{"identifier":{"@type":"PMID","@value":"29173006"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Systematic analysis of ATG13 domain requirements for autophagy induction"}],"description":[{"notation":[{"@value":"Macroautophagy/autophagy is an evolutionarily conserved cellular process whose induction is regulated by the ULK1 protein kinase complex. The subunit ATG13 functions as an adaptor protein by recruiting ULK1, RB1CC1 and ATG101 to a core ULK1 complex. Furthermore, ATG13 directly binds both phospholipids and members of the Atg8 family. The central involvement of ATG13 in complex formation makes it an attractive target for autophagy regulation. Here, we analyzed known interactions of ATG13 with proteins and lipids for their potential modulation of ULK1 complex formation and autophagy induction. Targeting the ATG101-ATG13 interaction showed the strongest autophagy-inhibitory effect, whereas the inhibition of binding to ULK1 or RB1CC1 had only minor effects, emphasizing that mutations interfering with ULK1 complex assembly do not necessarily result in a blockade of autophagy. Furthermore, inhibition of ATG13 binding to phospholipids or Atg8 proteins had only mild effects on autophagy. Generally, the observed phenotypes were more severe when autophagy was induced by MTORC1/2 inhibition compared to amino acid starvation. Collectively, these data establish the interaction between ATG13 and ATG101 as a promising target in disease-settings where the inhibition of autophagy is desired."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004234283265282","@type":"Researcher","foaf:name":[{"@value":"Nora Wallot-Hieke"}],"jpcoar:affiliationName":[{"@value":"Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283265153","@type":"Researcher","foaf:name":[{"@value":"Neha Verma"}],"jpcoar:affiliationName":[{"@value":"Institute for Pharmaceutical and Medicinal Chemistry, Faculty of Mathematics and Natural Sciences, Heinrich Heine University Düsseldorf, Düsseldorf, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283265280","@type":"Researcher","foaf:name":[{"@value":"David Schlütermann"}],"jpcoar:affiliationName":[{"@value":"Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283265025","@type":"Researcher","foaf:name":[{"@value":"Niklas Berleth"}],"jpcoar:affiliationName":[{"@value":"Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283265154","@type":"Researcher","foaf:name":[{"@value":"Jana Deitersen"}],"jpcoar:affiliationName":[{"@value":"Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283265281","@type":"Researcher","foaf:name":[{"@value":"Philip Böhler"}],"jpcoar:affiliationName":[{"@value":"Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283265024","@type":"Researcher","foaf:name":[{"@value":"Fabian Stuhldreier"}],"jpcoar:affiliationName":[{"@value":"Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283265283","@type":"Researcher","foaf:name":[{"@value":"Wenxian Wu"}],"jpcoar:affiliationName":[{"@value":"Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283265152","@type":"Researcher","foaf:name":[{"@value":"Sabine Seggewiß"}],"jpcoar:affiliationName":[{"@value":"Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283265155","@type":"Researcher","foaf:name":[{"@value":"Christoph Peter"}],"jpcoar:affiliationName":[{"@value":"Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283265156","@type":"Researcher","foaf:name":[{"@value":"Holger Gohlke"}],"jpcoar:affiliationName":[{"@value":"Institute for Pharmaceutical and Medicinal Chemistry, Faculty of Mathematics and Natural Sciences, Heinrich Heine University Düsseldorf, Düsseldorf, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326228232576","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10353434"},{"@type":"NRID","@value":"1000010353434"},{"@type":"ORCID","@value":"0000-0002-6258-6444"},{"@type":"CINII_AUTHOR_ID","@value":"DA17383593"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA17383593#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA17383593"},{"@type":"NRID","@value":"9000000608727"},{"@type":"NRID","@value":"9000392059639"},{"@type":"NRID","@value":"9000015193213"},{"@type":"NRID","@value":"9000356537034"},{"@type":"NRID","@value":"9000399551752"},{"@type":"NRID","@value":"9000255959181"},{"@type":"NRID","@value":"9000002741867"},{"@type":"NRID","@value":"9000256816144"},{"@type":"NRID","@value":"9000256840239"},{"@type":"NRID","@value":"9000301720562"},{"@type":"NRID","@value":"9000018238521"},{"@type":"NRID","@value":"9000253557254"},{"@type":"NRID","@value":"9000392060467"},{"@type":"NRID","@value":"9000255679601"},{"@type":"NRID","@value":"9000256667099"},{"@type":"NRID","@value":"9000017134924"},{"@type":"NRID","@value":"9000017743920"},{"@type":"NRID","@value":"9000315682124"},{"@type":"NRID","@value":"9000254459852"},{"@type":"NRID","@value":"9000015203063"},{"@type":"NRID","@value":"9000241626951"},{"@type":"NRID","@value":"9000257690798"},{"@type":"NRID","@value":"9000344117882"},{"@type":"NRID","@value":"9000000714795"},{"@type":"NRID","@value":"9000001999617"},{"@type":"NRID","@value":"9000000423538"},{"@type":"NRID","@value":"9000402476919"},{"@type":"NRID","@value":"9000261695189"},{"@type":"NRID","@value":"9000015265641"},{"@type":"NRID","@value":"9000002738166"},{"@type":"NRID","@value":"9000391780487"},{"@type":"NRID","@value":"9000321409657"},{"@type":"NRID","@value":"9000256840011"},{"@type":"NRID","@value":"9000309989220"},{"@type":"NRID","@value":"9000341533626"},{"@type":"NRID","@value":"9000406047884"},{"@type":"NRID","@value":"9000253522482"},{"@type":"NRID","@value":"9000405763579"},{"@type":"NRID","@value":"9000255901872"},{"@type":"NRID","@value":"9000318153402"},{"@type":"NRID","@value":"9000362192881"},{"@type":"NRID","@value":"9000392061863"},{"@type":"NRID","@value":"9000005933526"},{"@type":"NRID","@value":"9000006518404"},{"@type":"NRID","@value":"9000020542214"},{"@type":"NRID","@value":"9000255945015"},{"@type":"NRID","@value":"9000256840713"},{"@type":"NRID","@value":"9000340457279"},{"@type":"NRID","@value":"9000254458511"},{"@type":"NRID","@value":"9000015479901"},{"@type":"NRID","@value":"9000021330336"},{"@type":"NRID","@value":"9000253522446"},{"@type":"NRID","@value":"9000018391967"},{"@type":"NRID","@value":"9000364552104"},{"@type":"NRID","@value":"9000255959316"},{"@type":"NRID","@value":"9000256814456"},{"@type":"NRID","@value":"9000004633014"},{"@type":"NRID","@value":"9000253522437"},{"@type":"NRID","@value":"9000015341423"},{"@type":"NRID","@value":"9000344117633"},{"@type":"NRID","@value":"9000256840472"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0079761"}],"foaf:name":[{"@value":"Noboru Mizushima"}],"jpcoar:affiliationName":[{"@value":"Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of Tokyo, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234283265157","@type":"Researcher","foaf:name":[{"@value":"Björn Stork"}],"jpcoar:affiliationName":[{"@value":"Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"15548627"},{"@type":"EISSN","@value":"15548635"}],"prism:publicationName":[{"@value":"Autophagy"}],"dc:publisher":[{"@value":"Informa UK Limited"}],"prism:publicationDate":"2018-03-21","prism:volume":"14","prism:number":"5","prism:startingPage":"743","prism:endingPage":"763"},"reviewed":"false","url":[{"@id":"https://www.tandfonline.com/doi/pdf/10.1080/15548627.2017.1387342"}],"createdAt":"2017-11-26","modifiedAt":"2020-09-06","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Knockout","dc:title":"Mice, Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=Amino%20Acid%20Motifs","dc:title":"Amino Acid Motifs"},{"@id":"https://cir.nii.ac.jp/all?q=Autophagosomes","dc:title":"Autophagosomes"},{"@id":"https://cir.nii.ac.jp/all?q=Autophagy-Related%20Proteins","dc:title":"Autophagy-Related Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Mechanistic%20Target%20of%20Rapamycin%20Complex%202","dc:title":"Mechanistic Target of Rapamycin Complex 2"},{"@id":"https://cir.nii.ac.jp/all?q=Fibroblasts","dc:title":"Fibroblasts"},{"@id":"https://cir.nii.ac.jp/all?q=Mechanistic%20Target%20of%20Rapamycin%20Complex%201","dc:title":"Mechanistic Target of Rapamycin Complex 1"},{"@id":"https://cir.nii.ac.jp/all?q=Structure-Activity%20Relationship","dc:title":"Structure-Activity Relationship"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Domains","dc:title":"Protein Domains"},{"@id":"https://cir.nii.ac.jp/all?q=Mutation","dc:title":"Mutation"},{"@id":"https://cir.nii.ac.jp/all?q=Autophagy","dc:title":"Autophagy"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Autophagy-Related%20Protein-1%20Homolog","dc:title":"Autophagy-Related Protein-1 Homolog"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Amino%20Acid%20Sequence","dc:title":"Amino Acid Sequence"},{"@id":"https://cir.nii.ac.jp/all?q=Amino%20Acids","dc:title":"Amino Acids"},{"@id":"https://cir.nii.ac.jp/all?q=Apoptosis%20Regulatory%20Proteins","dc:title":"Apoptosis Regulatory Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Brief%20Report%20-%20Basic%20Science","dc:title":"Brief Report - Basic Science"},{"@id":"https://cir.nii.ac.jp/all?q=Adaptor%20Proteins,%20Signal%20Transducing","dc:title":"Adaptor Proteins, Signal Transducing"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Binding","dc:title":"Protein Binding"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256843848704","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K21749"},{"@type":"JGN","@value":"JP15K21749"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-INTERNATIONAL-15K21749/"}],"notation":[{"@language":"ja","@value":"オートファジー研究の国際活動支援"},{"@language":"en","@value":"International Activities Support for Autophagy Research"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257211675776","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25111005"},{"@type":"JGN","@value":"JP25111005"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-25111005/"}],"notation":[{"@language":"ja","@value":"オートファジーの生理・病態生理学的意義とその分子基盤"},{"@language":"en","@value":"Physiological and pathophysiological roles for autophagy and its molecular basis"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002218469946496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Atg13 Is Essential for Autophagy and Cardiac Development in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002219092343552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dynamic association of the ULK1 complex with omegasomes during autophagy induction"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143925411200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146514569344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025430657439872","@type":"Article","resourceType":"preprint","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691145957760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structural Basis of the Autophagy-Related LC3/Atg13 LIR Complex: Recognition and Interaction Mechanism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708938157568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Atg13 HORMA domain recruits Atg9 vesicles during autophagosome formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708951334528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Autophagy-related Protein Kinase Atg1 Interacts with the Ubiquitin-like Protein Atg8 via the Atg8 Family Interacting Motif to Facilitate Autophagosome Formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617865518336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618817445504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of RB1CC1, a novel human gene that can induce RB1 in various human cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618839836032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619659190144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620847812736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621419685120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of Autophagy By Signaling Through the Atg1/ULK1 Complex"}]},{"@id":"https://cir.nii.ac.jp/crid/1360564064114109952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ammonia-induced autophagy is independent of ULK1/ULK2 kinases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165841866368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574092892962688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fiji: an open-source platform for biological-image analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094600706176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095082711680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ULK2 Ser 1027 Phosphorylation by PKA Regulates Its Nuclear Localization Occurring through Karyopherin Beta 2 Recognition of a PY-NLS Motif"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095228082432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DrugScorePPI webserver: fast and accurate in silico alanine scanning for scoring protein–protein interactions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095725069952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095850060928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The ULK1 complex"}]},{"@id":"https://cir.nii.ac.jp/crid/1360845539086525952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autophagy signal transduction by ATG proteins: from hierarchies to networks"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658382694528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structural basis of starvation-induced assembly of the autophagy initiation complex"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658382763520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structure of the Atg101–Atg13 complex reveals essential roles of Atg101 in autophagy initiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569717289984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570574612992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hot spots—A review of the protein–protein interface determinant amino‐acid residues"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571357646720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861711227776256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"SIRT1 enhances hepatitis virus B transcription independent of hepatic autophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519214180992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Metabolic-Stress-Induced Rearrangement of the 14-3-3ζ Interactome Promotes Autophagy via a ULK1- and AMPK-Regulated 14-3-3ζ Interaction with Phosphorylated Atg9"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519408310144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Atg1-Atg13 Complex Regulates Atg9 and Atg23 Retrieval Transport from the Pre-Autophagosomal Structure"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521394926080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993588502272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994920308096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nuclear ULK1 promotes cell death in response to oxidative stress through PARP1"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995085377792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Resolving Hot Spots in the C-Terminal Dimerization Domain that Determine the Stability of the Molecular Chaperone Hsp90"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995676587904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995736836608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Free Energy Calculations by the Molecular Mechanics Poisson−Boltzmann Surface Area Method"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468894340864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469377634176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470516400384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470607586432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK Complex"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945471383168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946403846528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420764737024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Insights into Protein–Protein Binding by Binding Free Energy Calculation and Free Energy Decomposition for the Ras–Raf and Ras–RalGDS Complexes"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421331601024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Macromolecular assembly of the adaptor SLP-65 at intracellular vesicles in resting B cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893576762368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Early Steps in Autophagy Depend on Direct Phosphorylation of Atg9 by the Atg1 Kinase"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896148434048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The mammalian autophagy initiator complex contains 2 HORMA domain proteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368406122496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autophagy in cancer metastasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368902195968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A HORMA domain in Atg13 mediates PI 3-kinase recruitment in autophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369059891328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autophagy fights disease through cellular self-digestion"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369116311552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Proteomic Mapping of the Human Mitochondrial Intermembrane Space in Live Cells via Ratiometric APEX Tagging"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370327291520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autophagy in the Pathogenesis of Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371134017024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843551788544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of FIP200 in cardiac and liver development and its regulation of TNFα and TSC–mTOR signaling pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844677154688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844885267712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Intrinsically disordered regions in autophagy proteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845545577472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846005704704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Atg1–kinase complex tethers Atg9-vesicles to initiate autophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319349368320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321307868032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793238514688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular interactions of the<i>Saccharomyces cerevisiae</i>Atg1 complex provide insights into assembly and regulatory mechanisms"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793414005632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Atg17 recruits Atg9 to organize the pre‐autophagosomal structure"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793431693696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793638728320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Binding of the Atg1/ULK1 kinase to the ubiquitin‐like protein Atg8 regulates autophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794001735168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795198069760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796090656896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Directed evolution of APEX2 for electron microscopy and proximity labeling"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268282049152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268401819776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268461403008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270367736576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271120262784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Selective Autophagy in Cancer Development and Therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271262828672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Atg101, a novel mammalian autophagy protein interacting with Atg13"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204696174976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Atg101: Not Just an Accessory Subunit in the Autophagy-initiation Complex"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1080/15548627.2017.1387342"},{"@type":"KAKEN","@value":"PRODUCT-21926162"},{"@type":"KAKEN","@value":"PRODUCT-21641594"},{"@type":"OPENAIRE","@value":"doi_dedup___::0211c2afd97d0e7c544c22c2cd46725e"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2020.04.031_references_DOI_MvJK7sjdlA2WhbX1aXU4V37Yk1i"},{"@type":"CROSSREF","@value":"10.7554/elife.101531.1_references_DOI_MvJK7sjdlA2WhbX1aXU4V37Yk1i"},{"@type":"CROSSREF","@value":"10.1038/s41467-020-20309-7_references_DOI_MvJK7sjdlA2WhbX1aXU4V37Yk1i"}]}