{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004234482393984.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1089/neu.2017.5008"}},{"identifier":{"@type":"URI","@value":"http://www.liebertpub.com/doi/full-xml/10.1089/neu.2017.5008"}},{"identifier":{"@type":"URI","@value":"http://www.liebertpub.com/doi/pdf/10.1089/neu.2017.5008"}},{"identifier":{"@type":"PMID","@value":"28683586"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Vitronectin Regulates the Fibrinolytic System during the Repair of Cerebral Cortex in Stab-Wounded Mice"}],"description":[{"notation":[{"@value":"Vitronectin (VN), one of the serum proteins, is known to be involved in the regulation of blood coagulation, fibrinolysis, and cell migration. It has been proposed that the regulation of fibrinolysis by VN promotes the blood-brain barrier (BBB) recovery from brain injuries such as traumatic injury and subarachnoid hemorrhage. The effects of VN on fibrinolysis in the injured brain remain unclear, however. We examined the effects of VN on the fibrinolytic system in the stab-wounded cerebral cortex of VN-knockout (KO) mice. First, hemorrhage and recovery from BBB breakdown in the wounded regions were assessed by serum immunoglobulin G (IgG) extravasation. The level of IgG extravasation increased 3-7 days after the stab wound (D3-7) in the cortex of VN-KO mice, compared with that in wild type mice, indicating that VN deficiency inhibited the recovery from BBB breakdown. The VN deficiency decreased fibrin fiber deposition at D1-3, suggesting that VN deficiency tilts the balance between fibrinogenesis and fibrinolysis toward fibrinolysis. Next, the effects of VN deficiency on the fibrinolytic factors were analyzed in the stab-wounded cortex. The VN deficiency impaired the activity of plasminogen activator inhibitor-1, an inhibitor of the fibrinolytic system, at D3-5. Further, VN deficiency up-regulated the mRNA and protein expression levels of tissue-type plasminogen activator, and urokinase-type plasminogen activator. These results demonstrate that VN contributes to the regulation of the fibrinolytic system and recovery from BBB breakdown in the wounded brain."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420564276164544256","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50835733"},{"@type":"NRID","@value":"1000050835733"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/keihashimoto"}],"foaf:name":[{"@value":"Kei Hashimoto"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Humanities and Sciences, Ochanomizu University, Otsuka, Bunkyo-ku, Tokyo, Japan."},{"@value":"Institute for Human Life Innovation, Ochanomizu University, Otsuka, Bunkyo-ku, Tokyo, Japan."},{"@value":"Program for Leading Graduate Schools, Ochanomizu University, Otsuka, Bunkyo-ku, Tokyo, Japan."},{"@value":"Research Fellow of Japan Society for the Promotion of Science, Kojimachi, Chiyoda-ku, Tokyo, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234482393987","@type":"Researcher","foaf:name":[{"@value":"Natsumi Ikeda"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Humanities and Sciences, Ochanomizu University, Otsuka, Bunkyo-ku, Tokyo, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234482393986","@type":"Researcher","foaf:name":[{"@value":"Mari Nakashima"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Humanities and Sciences, Ochanomizu University, Otsuka, Bunkyo-ku, Tokyo, Japan."},{"@value":"Institute for Human Life Innovation, Ochanomizu University, Otsuka, Bunkyo-ku, Tokyo, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234482394112","@type":"Researcher","foaf:name":[{"@value":"Hiroko Ikeshima-Kataoka"}],"jpcoar:affiliationName":[{"@value":"Faculty of Science and Engineering, Waseda University, Okubo, Shinjuku-ku, Tokyo, Japan."},{"@value":"Department of Pharmacology and Neuroscience, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801198094848","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50272737"},{"@type":"NRID","@value":"1000050272737"},{"@type":"NRID","@value":"9000255959249"},{"@type":"NRID","@value":"9000011112049"},{"@type":"NRID","@value":"9000253106943"},{"@type":"NRID","@value":"9000408838808"},{"@type":"NRID","@value":"9000253108412"},{"@type":"NRID","@value":"9000253108310"},{"@type":"NRID","@value":"9000253682250"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/Yasunori_Miyamoto"}],"foaf:name":[{"@value":"Yasunori Miyamoto"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Humanities and Sciences, Ochanomizu University, Otsuka, Bunkyo-ku, Tokyo, Japan."},{"@value":"Institute for Human Life Innovation, Ochanomizu University, Otsuka, Bunkyo-ku, Tokyo, Japan."},{"@value":"Program for Leading Graduate Schools, Ochanomizu University, Otsuka, Bunkyo-ku, Tokyo, Japan."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08977151"},{"@type":"EISSN","@value":"15579042"}],"prism:publicationName":[{"@value":"Journal of Neurotrauma"}],"dc:publisher":[{"@value":"SAGE Publications"}],"prism:publicationDate":"2017-11-15","prism:volume":"34","prism:number":"22","prism:startingPage":"3183","prism:endingPage":"3191"},"reviewed":"false","dc:rights":["http://www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/"],"url":[{"@id":"http://www.liebertpub.com/doi/full-xml/10.1089/neu.2017.5008"},{"@id":"http://www.liebertpub.com/doi/pdf/10.1089/neu.2017.5008"}],"createdAt":"2017-07-06","modifiedAt":"2026-02-09","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Cerebral%20Cortex","dc:title":"Cerebral Cortex"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Knockout","dc:title":"Mice, Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=Fibrin","dc:title":"Fibrin"},{"@id":"https://cir.nii.ac.jp/all?q=Time%20Factors","dc:title":"Time Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Fibrinolysis","dc:title":"Fibrinolysis"},{"@id":"https://cir.nii.ac.jp/all?q=Urokinase-Type%20Plasminogen%20Activator","dc:title":"Urokinase-Type Plasminogen Activator"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Blood-Brain%20Barrier","dc:title":"Blood-Brain Barrier"},{"@id":"https://cir.nii.ac.jp/all?q=Brain%20Injuries","dc:title":"Brain Injuries"},{"@id":"https://cir.nii.ac.jp/all?q=Tissue%20Plasminogen%20Activator","dc:title":"Tissue Plasminogen Activator"},{"@id":"https://cir.nii.ac.jp/all?q=Plasminogen%20Activator%20Inhibitor%201","dc:title":"Plasminogen Activator Inhibitor 1"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Head%20Injuries,%20Penetrating","dc:title":"Head Injuries, Penetrating"},{"@id":"https://cir.nii.ac.jp/all?q=RNA,%20Messenger","dc:title":"RNA, Messenger"},{"@id":"https://cir.nii.ac.jp/all?q=Vitronectin","dc:title":"Vitronectin"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781966766976","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17K07105"},{"@type":"JGN","@value":"JP17K07105"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K07105/"}],"notation":[{"@language":"ja","@value":"細胞外マトリックス分子ビトロネクチンによる小脳顆粒前駆細胞の軸索決定制御"},{"@language":"en","@value":"Regulation of axon specification by a extracellular matrix protein, vitronectin in cerebellar granule cell 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