{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004234622390784.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/jb/mvw074"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/jb/article-pdf/161/3/237/13153187/mvw074.pdf"}},{"identifier":{"@type":"PMID","@value":"28003431"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Targeting the Hippo signalling pathway for cancer treatment"}],"description":[{"notation":[{"@value":"The Hippo signalling pathway monitors cell-cell contact and external factors that shape tissue structure. In mice, tumourigenesis and developmental abnormalities are common consequences of dysregulated Hippo signalling. Expression of Hippo pathway components is also frequently altered in human tumours and correlates with poor prognosis and reduced patient survival. Thus, the Hippo pathway is an attractive anti-cancer target. Here, we provide an overview of the function and regulation of Hippo signalling components and summarize progress to date on the development of agents able to regulate Hippo signalling for cancer therapy."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004234622390790","@type":"Researcher","foaf:name":[{"@value":"Keisuke Nakatani"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751139427840","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40322755"},{"@type":"NRID","@value":"1000040322755"},{"@type":"NRID","@value":"9000403272966"},{"@type":"NRID","@value":"9000253172225"},{"@type":"NRID","@value":"9000005267808"},{"@type":"NRID","@value":"9000253167793"},{"@type":"NRID","@value":"9000252814252"},{"@type":"NRID","@value":"9000356605602"},{"@type":"NRID","@value":"9000000331218"},{"@type":"NRID","@value":"9000409867741"},{"@type":"NRID","@value":"9000410510158"},{"@type":"NRID","@value":"9000411205082"},{"@type":"NRID","@value":"9000391606664"},{"@type":"NRID","@value":"9000413945368"},{"@type":"NRID","@value":"9000408632272"},{"@type":"NRID","@value":"9000413853180"},{"@type":"NRID","@value":"9000391605602"},{"@type":"NRID","@value":"9000006502860"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0166101"}],"foaf:name":[{"@value":"Tomohiko Maehama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234622390912","@type":"Researcher","foaf:name":[{"@value":"Miki Nishio"}]},{"@id":"https://cir.nii.ac.jp/crid/1420292030012626176","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20734495"},{"@type":"NRID","@value":"1000020734495"}],"foaf:name":[{"@value":"Hiroki Goto"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234622390785","@type":"Researcher","foaf:name":[{"@value":"Wakako Kato"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234622390918","@type":"Researcher","foaf:name":[{"@value":"Hirofumi Omori"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234622390914","@type":"Researcher","foaf:name":[{"@value":"Yosuke Miyachi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234622390917","@type":"Researcher","foaf:name":[{"@value":"Hideru Togashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751145386752","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90594630"},{"@type":"NRID","@value":"1000090594630"},{"@type":"NRID","@value":"9000000699153"},{"@type":"NRID","@value":"9000409206072"},{"@type":"NRID","@value":"9000378104729"},{"@type":"NRID","@value":"9000011131123"},{"@type":"NRID","@value":"9000010100358"},{"@type":"NRID","@value":"9000356605609"},{"@type":"NRID","@value":"9000378105296"},{"@type":"NRID","@value":"9000314791677"},{"@type":"NRID","@value":"9000399009050"},{"@type":"NRID","@value":"9000004440177"},{"@type":"NRID","@value":"9000336038146"},{"@type":"NRID","@value":"9000336757386"},{"@type":"NRID","@value":"9000258205402"},{"@type":"NRID","@value":"9000413848531"},{"@type":"NRID","@value":"9000251861162"},{"@type":"NRID","@value":"9000018837054"},{"@type":"NRID","@value":"9000290814089"},{"@type":"NRID","@value":"9000265559653"},{"@type":"NRID","@value":"9000324642559"},{"@type":"NRID","@value":"9000409848488"},{"@type":"NRID","@value":"9000391518652"},{"@type":"NRID","@value":"9000402941764"},{"@type":"NRID","@value":"9000301734367"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/ys138090807"}],"foaf:name":[{"@value":"Yohei Shimono"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234622390916","@type":"Researcher","foaf:name":[{"@value":"Akira Suzuki"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0021924X"},{"@type":"EISSN","@value":"17562651"}],"prism:publicationName":[{"@value":"Journal of Biochemistry"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2016-12-21","prism:startingPage":"mvw074"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://academic.oup.com/jb/article-pdf/161/3/237/13153187/mvw074.pdf"}],"createdAt":"2016-11-16","modifiedAt":"2019-09-15","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Neoplasms","dc:title":"Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Hippo%20Signaling%20Pathway","dc:title":"Hippo Signaling Pathway"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Serine-Threonine%20Kinases","dc:title":"Protein Serine-Threonine Kinases"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781847356288","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K07020"},{"@type":"JGN","@value":"JP15K07020"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K07020/"}],"notation":[{"@language":"ja","@value":"核小体におけるストレス感知：PICT1を起点としたその仕組みの解明"},{"@language":"en","@value":"Nucleolar stress sensing in the nucleolus"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000781858481536","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K14381"},{"@type":"JGN","@value":"JP15K14381"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K14381/"}],"notation":[{"@language":"ja","@value":"細胞順応による初期転移巣成立機構解析の基盤構築"},{"@language":"en","@value":"Molecular basis for the establishment of early metastatic lesion through cell adaptation"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256840846080","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K19026"},{"@type":"JGN","@value":"JP15K19026"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K19026/"}],"notation":[{"@language":"ja","@value":"Hippo経路による骨・軟骨制御機構の解明"},{"@language":"en","@value":"Elucidation of regulation of osteogenesis and chondrogenesis by Hippo pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257274070656","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26400205"},{"@type":"JGN","@value":"JP26400205"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26400205/"}],"notation":[{"@language":"ja","@value":"細胞接着の数理：実験、モデリング、解析"},{"@language":"en","@value":"Mathematics of cell adhesion: experiments, modeling and analysis"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002219091574272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hippo pathway regulation by cell morphology and stress fibers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235521828992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hippo vs. Crab: tissue‐specific functions of the mammalian Hippo pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145331658496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145518996352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Arhgef7 promotes activation of the Hippo pathway core kinase 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kinase"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570342840320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Yorkie Promotes Transcription by Recruiting a Histone Methyltransferase Complex"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571234597120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"AMPK modulates Hippo pathway activity to regulate energy homeostasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045700425216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tao-1 Phosphorylates Hippo/MST Kinases to Regulate the Hippo-Salvador-Warts Tumor Suppressor Pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045912478976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptional Co-repressor Function of the Hippo Pathway Transducers YAP and 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ligases"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269752275840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetic and pharmacological disruption of the TEAD–YAP complex suppresses the oncogenic activity of YAP"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271128409984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1093/jb/mvw074"},{"@type":"KAKEN","@value":"PRODUCT-21174881"},{"@type":"KAKEN","@value":"PRODUCT-21101320"},{"@type":"KAKEN","@value":"PRODUCT-21121009"},{"@type":"KAKEN","@value":"PRODUCT-21067135"},{"@type":"OPENAIRE","@value":"doi_dedup___::3777f6e8ad66bddabb55718f865baada"},{"@type":"CROSSREF","@value":"10.1111/gtc.12461_references_DOI_aEXe1QUU6WpLhbm8u3sQ51sOCnK"}]}