{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004234674583936.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/ndt/gfr750"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/ndt/article-pdf/27/8/3186/7634909/gfr750.pdf"}},{"identifier":{"@type":"PMID","@value":"22645322"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Renal biopsy criterion in children with asymptomatic constant isolated proteinuria"}],"description":[{"notation":[{"@value":"The criterion of a renal biopsy in children with asymptomatic persistent isolated proteinuria is controversial.To determine an adequate renal biopsy criterion in children with asymptomatic constant isolated proteinuria, the optimal cutoff maximum urinary protein/creatinine ratio (uP/Cr) to separate minor glomerular abnormalities (MGA) and other significant glomerular changes was obtained by receiver operating characteristic analysis in 44 children with asymptomatic constant isolated proteinuria (uP/Cr ≥ 0.2 g/g) screened from 1167 patients who underwent a renal biopsy between September 2000 and April 2010. Patients were divided into two groups according to the cutoff value to verify its validity.The optimal uP/Cr was 0.5 g/g. In Group 1 (uP/Cr0.5 g/g, n = 15), only one patient (6.7%) showed focal segmental glomerulosclerosis (FSGS) and the other 14 patients (93.3%) had MGA. In Group 2 (uP/Cr ≥ 0.5 g/g at least once before biopsy, n = 29), 5 patients showed FSGS and 7 patients had nephritis such as IgA nephropathy (41.4%, n = 12) and the other 17 patients (58.6%) showed MGA. These findings indicated that the ratio of non-MGA/MGA was significantly higher in Group 2 than that in Group 1 (P = 0.016) and that if renal biopsies were performed with a criterion of a maximum uP/Cr ≥ 0.5 g/g (criterion for Group 2), renal biopsies could be avoided in 45.2% of patients with MGA. One patient with FSGS in Group 1 showed proteinuria with uP/Cr ≥ 0.5 g/g in the clinical course.An adequate renal biopsy criterion in children with asymptomatic constant isolated proteinuria is uP/Cr ≥ 0.5 g/g."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004234674584074","@type":"Researcher","foaf:name":[{"@value":"T. Hama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234674583941","@type":"Researcher","foaf:name":[{"@value":"K. Nakanishi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234674584066","@type":"Researcher","foaf:name":[{"@value":"Y. Shima"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234674583942","@type":"Researcher","foaf:name":[{"@value":"H. Mukaiyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234674584071","@type":"Researcher","foaf:name":[{"@value":"H. Togawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234674584067","@type":"Researcher","foaf:name":[{"@value":"R. Tanaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234674583937","@type":"Researcher","foaf:name":[{"@value":"K. Hamahira"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234674584068","@type":"Researcher","foaf:name":[{"@value":"H. Kaito"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234674584075","@type":"Researcher","foaf:name":[{"@value":"K. Iijima"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234674584077","@type":"Researcher","foaf:name":[{"@value":"N. Yoshikawa"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09310509"},{"@type":"EISSN","@value":"14602385"}],"prism:publicationName":[{"@value":"Nephrology Dialysis Transplantation"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2012-01-09","prism:volume":"27","prism:number":"8","prism:startingPage":"3186","prism:endingPage":"3190"},"reviewed":"false","url":[{"@id":"http://academic.oup.com/ndt/article-pdf/27/8/3186/7634909/gfr750.pdf"}],"createdAt":"2012-01-10","modifiedAt":"2021-12-25","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Adolescent","dc:title":"Adolescent"},{"@id":"https://cir.nii.ac.jp/all?q=Glomerulosclerosis,%20Focal%20Segmental","dc:title":"Glomerulosclerosis, Focal Segmental"},{"@id":"https://cir.nii.ac.jp/all?q=Biopsy","dc:title":"Biopsy"},{"@id":"https://cir.nii.ac.jp/all?q=Kidney%20Glomerulus","dc:title":"Kidney Glomerulus"},{"@id":"https://cir.nii.ac.jp/all?q=Glomerulonephritis,%20IGA","dc:title":"Glomerulonephritis, IGA"},{"@id":"https://cir.nii.ac.jp/all?q=Kidney","dc:title":"Kidney"},{"@id":"https://cir.nii.ac.jp/all?q=Amidohydrolases","dc:title":"Amidohydrolases"},{"@id":"https://cir.nii.ac.jp/all?q=Proteinuria","dc:title":"Proteinuria"},{"@id":"https://cir.nii.ac.jp/all?q=Child,%20Preschool","dc:title":"Child, Preschool"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Child","dc:title":"Child"},{"@id":"https://cir.nii.ac.jp/all?q=Follow-Up%20Studies","dc:title":"Follow-Up 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