{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004234898166016.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1097/md.0000000000000519"}},{"identifier":{"@type":"URI","@value":"https://journals.lww.com/10.1097/MD.0000000000000519"}},{"identifier":{"@type":"PMID","@value":"25674750"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Diurnal Variations in Blood Flow at Optic Nerve Head and Choroid in Healthy Eyes"}],"dcterms:alternative":[{"@value":"Diurnal Variations in Blood Flow"}],"description":[{"notation":[{"@value":"To investigate the diurnal variations of the ocular blood flow in healthy eyes using laser speckle flowgraphy (LSFG), and to determine the relationship of the diurnal variations between the ocular blood flow and other ocular parameters.This prospective cross-sectional study was conducted at Nagoya University Hospital. We studied 13 healthy volunteers whose mean age was 33.5 ± 7.6 years. The mean blur rate (MBR), expressing the relative blood flow, on the optic nerve head (ONH) and choroidal blood flow was determined by LSFG (LSFG-NAVI) every 3 hours from 6:00 to 24:00 hours. The intraocular pressure (IOP), choroidal thickness measured by enhanced depth imaging optical coherence tomography, systolic (SBP) and diastolic (DBP) blood pressure, and heart rate (HR) in the brachial artery were also recorded. We evaluated the diurnal variations of the parameters and compared the MBR to the other parameters using a linear mixed model.The diurnal variations of the MBR on the ONH varied significantly with a trough at 9:00 hours and a peak at 24:00 hours (P  0.001, linear mixed model). The MBR of choroid also had significant diurnal variations with a trough at 15:00 hours and a peak at 18:00 hours (P = 0.001). The IOP (P  0.001), choroidal thickness (P  0.001), SBP (P = 0.005), DBP (P = 0.001), and HR (P  0.001) also had significant diurnal variations. Although the diurnal variation of the MBR on the ONH was different from the other parameters, that on the choroid was significantly and positively correlated with the DBP (P = 0.002), mean arterial pressure (P = 0.023), and mean ocular perfusion pressure (P = 0.047).We found significant diurnal variations in the ONH and choroidal blood flow. Although the ONH blood flow had its own diurnal variation because of strong autoregulation, the choroidal blood flow was more likely affected by systemic circulatory factors because of poor autoregulation."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004234898165765","@type":"Researcher","foaf:name":[{"@value":"Takeshi Iwase"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234898165775","@type":"Researcher","foaf:name":[{"@value":"Kentaro Yamamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234898165772","@type":"Researcher","foaf:name":[{"@value":"Eimei Ra"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234898165776","@type":"Researcher","foaf:name":[{"@value":"Kenta Murotani"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234898165893","@type":"Researcher","foaf:name":[{"@value":"Shigeyuki Matsui"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004234898165506","@type":"Researcher","foaf:name":[{"@value":"Hiroko Terasaki"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00257974"}],"prism:publicationName":[{"@value":"Medicine"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2015-02","prism:volume":"94","prism:number":"6","prism:startingPage":"e519"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://journals.lww.com/10.1097/MD.0000000000000519"}],"createdAt":"2015-02-12","modifiedAt":"2021-05-14","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Choroid","dc:title":"Choroid"},{"@id":"https://cir.nii.ac.jp/all?q=5800","dc:title":"5800"},{"@id":"https://cir.nii.ac.jp/all?q=Optic%20Disk","dc:title":"Optic Disk"},{"@id":"https://cir.nii.ac.jp/all?q=Blood%20Pressure","dc:title":"Blood Pressure"},{"@id":"https://cir.nii.ac.jp/all?q=Circadian%20Rhythm","dc:title":"Circadian Rhythm"},{"@id":"https://cir.nii.ac.jp/all?q=Cross-Sectional%20Studies","dc:title":"Cross-Sectional Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Heart%20Rate","dc:title":"Heart Rate"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Prospective%20Studies","dc:title":"Prospective Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Intraocular%20Pressure","dc:title":"Intraocular Pressure"},{"@id":"https://cir.nii.ac.jp/all?q=Tomography,%20Optical%20Coherence","dc:title":"Tomography, Optical Coherence"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782305917184","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26462635"},{"@type":"JGN","@value":"JP26462635"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462635/"}],"notation":[{"@language":"ja","@value":"網膜疾患では網脈絡膜循の変化はいつ，どのようにして起こるか？"},{"@language":"en","@value":"When and how are changes of chorioretinal blood flow caused in retinal disease?"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050304183897647488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Correlation between optic nerve head circulation and visual function before and after anti-VEGF therapy for central retinal vein occlusion : prospective, interventional case series"}]},{"@id":"https://cir.nii.ac.jp/crid/1050571704623137536","@type":"Article","resourceType":"学術雑誌論文(journal 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