{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004235487079552.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/cas.12042"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcas.12042"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cas.12042"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Genetic factors related to gastric cancer susceptibility identified using a genome‐wide association study"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Gastric cancer (<jats:styled-content style=\"fixed-case\">GC</jats:styled-content>) is one of the major malignant diseases worldwide, especially in <jats:styled-content style=\"fixed-case\">A</jats:styled-content>sia, where <jats:styled-content style=\"fixed-case\">J</jats:styled-content>apan and <jats:styled-content style=\"fixed-case\">K</jats:styled-content>orea have the highest incidence in the world. Gastric cancer is classified into intestinal and diffuse types. While the former is almost absolutely caused by <jats:italic><jats:styled-content style=\"fixed-case\">H</jats:styled-content>elicobacter pylori</jats:italic> infection as the initial insult, the latter seems to include cases in which the role of infection is limited, if any, and a contribution of genetic factors is anticipated. Previously, we performed a genome‐wide association study (<jats:styled-content style=\"fixed-case\">GWAS</jats:styled-content>) on diffuse‐type <jats:styled-content style=\"fixed-case\">GC</jats:styled-content> by using single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP</jats:styled-content>) catalogued for Japanese population (<jats:styled-content style=\"fixed-case\">JSNP</jats:styled-content>), and identified a prostate stem cell antigen (<jats:italic><jats:styled-content style=\"fixed-case\">PSCA</jats:styled-content></jats:italic>) gene encoding a glycosylphosphatidylinositol‐anchored cell surface antigen as a <jats:styled-content style=\"fixed-case\">GC</jats:styled-content> susceptibility gene. From the second candidate locus identified using the <jats:styled-content style=\"fixed-case\">GWAS</jats:styled-content>, 1q22, we found the Mucin 1 (<jats:italic><jats:styled-content style=\"fixed-case\">MUC</jats:styled-content>1</jats:italic>) gene encoding a cell membrane‐bound mucin protein as another gene related to diffuse‐type <jats:styled-content style=\"fixed-case\">GC</jats:styled-content>. A two‐allele analysis based on risk genotypes of the two genes revealed approximately 95% of Japanese population have at least one of the two risk genotypes, and approximately 56% of the population have both risk genotypes. The two‐<jats:styled-content style=\"fixed-case\">SNP</jats:styled-content> genotype might offer ample room to further stratify a high <jats:styled-content style=\"fixed-case\">GC</jats:styled-content> risk subpopulation in Japan and Asia by adding another genetic and/or non‐genetic factor. Recently, a <jats:styled-content style=\"fixed-case\">GWAS</jats:styled-content> on the Chinese population disclosed an additional three <jats:styled-content style=\"fixed-case\">GC</jats:styled-content> susceptibility loci: 3q13.31, 5p13.1 and 10q23. (<jats:italic>Cancer Sci</jats:italic> 2013; 104: 1–8)</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326236206848","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80466200"},{"@type":"NRID","@value":"1000080466200"},{"@type":"NRID","@value":"9000005729678"},{"@type":"NRID","@value":"9000399218946"},{"@type":"NRID","@value":"9000017479093"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/gsdm2000psca2008"}],"foaf:name":[{"@value":"Norihisa Saeki"}],"jpcoar:affiliationName":[{"@value":"Division of Genetics National Cancer Center Research Institute Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235487079571","@type":"Researcher","foaf:name":[{"@value":"Hiroe Ono"}],"jpcoar:affiliationName":[{"@value":"Division of Genetics National Cancer Center Research Institute Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235487079563","@type":"Researcher","foaf:name":[{"@value":"Hiromi Sakamoto"}],"jpcoar:affiliationName":[{"@value":"Division of Genetics National Cancer Center Research Institute Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235487079440","@type":"Researcher","foaf:name":[{"@value":"Teruhiko Yoshida"}],"jpcoar:affiliationName":[{"@value":"Division of Genetics National Cancer Center Research Institute Tokyo Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13479032"},{"@type":"EISSN","@value":"13497006"}],"prism:publicationName":[{"@value":"Cancer Science"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2012-11-24","prism:volume":"104","prism:number":"1","prism:startingPage":"1","prism:endingPage":"8"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcas.12042"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cas.12042"}],"createdAt":"2012-10-12","modifiedAt":"2023-10-30","project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782156570240","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23501327"},{"@type":"JGN","@value":"JP23501327"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23501327/"}],"notation":[{"@language":"ja","@value":"ゲノム網羅的関連解析により導かれた胃がん発生抑制分子経路の解明とその創薬への応用"},{"@language":"en","@value":"Study of PSCA, a gastric cancer susceptibility 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