{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004235487644416.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/cas.12298"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcas.12298"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cas.12298"}},{"identifier":{"@type":"PMID","@value":"24118411"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Genome‐wide analysis of <scp>DNA</scp> methylation changes induced by gestational arsenic exposure in liver tumors"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Inorganic arsenic is known to be a human carcinogen. Previous studies have reported that DNA methylation changes are involved in arsenic‐induced carcinogenesis, therefore, DNA methylation changes that are specific to arsenic‐induced tumors would be useful to distinguish tumors induced by arsenic from tumors caused by other factors and to dissect arsenic carcinogenesis. Previous studies have shown that gestational arsenic exposure of C3H mice, which tend to spontaneously develop liver tumors, increases the incidence of tumors in male offspring. In this study we used the same experimental protocol as in those previous studies and searched for DNA regions where methylation status was specifically altered in the liver tumors of arsenic‐exposed offspring by using methylated DNA immunoprecipitation–CpG island microarrays. The methylation levels of the DNA regions selected were measured by quantitative methylation‐specific PCR and bisulfite sequencing. The results of this study clarified a number of regions where DNA methylation status was altered in the liver tumors in the C3H mice compared to normal liver tissues. Among such regions, we showed that a gene body region of the oncogene <jats:italic>Fosb</jats:italic> underwent alteration in DNA methylation by gestational arsenic exposure. We also showed that <jats:italic>Fosb</jats:italic> expression significantly increased corresponding to the DNA methylation level of the gene body in the arsenic‐exposed group. These findings suggest that the DNA methylation status can be used to identify tumors increased by gestational arsenic exposure.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751141878400","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60425494"},{"@type":"NRID","@value":"1000060425494"},{"@type":"NRID","@value":"9000305636727"},{"@type":"NRID","@value":"9000258089436"}],"foaf:name":[{"@value":"Takehiro Suzuki"}],"jpcoar:affiliationName":[{"@value":"Center for Environmental Health Sciences National Institute for Environmental Studies Tsukuba Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235487644163","@type":"Researcher","foaf:name":[{"@value":"Satoshi Yamashita"}],"jpcoar:affiliationName":[{"@value":"Division of Epigenomics National Cancer Center Research Institute Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235487644418","@type":"Researcher","foaf:name":[{"@value":"Toshikazu Ushijima"}],"jpcoar:affiliationName":[{"@value":"Division of Epigenomics National Cancer Center Research Institute Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801201927680","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80570770"},{"@type":"NRID","@value":"1000080570770"},{"@type":"NRID","@value":"9000006775773"},{"@type":"NRID","@value":"9000018986327"},{"@type":"NRID","@value":"9000240184753"},{"@type":"NRID","@value":"9000392000051"},{"@type":"NRID","@value":"9000391991929"},{"@type":"NRID","@value":"9000398439393"},{"@type":"NRID","@value":"9000398439399"},{"@type":"NRID","@value":"9000380433373"},{"@type":"NRID","@value":"9000017047814"},{"@type":"NRID","@value":"9000258089437"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/stakumi"}],"foaf:name":[{"@value":"Shota Takumi"}],"jpcoar:affiliationName":[{"@value":"Center for Environmental Health Sciences National Institute for Environmental Studies Tsukuba Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658770862212","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10178808"},{"@type":"NRID","@value":"1000010178808"},{"@type":"NRID","@value":"9000254701023"},{"@type":"NRID","@value":"9000005386760"},{"@type":"NRID","@value":"9000254693209"},{"@type":"NRID","@value":"9000005180189"},{"@type":"NRID","@value":"9000240184755"},{"@type":"NRID","@value":"9000254225506"},{"@type":"NRID","@value":"9000254697534"},{"@type":"NRID","@value":"9000370282513"},{"@type":"NRID","@value":"9000010011600"},{"@type":"NRID","@value":"9000254693765"},{"@type":"NRID","@value":"9000383840209"},{"@type":"NRID","@value":"9000254225520"},{"@type":"NRID","@value":"9000254791028"}],"foaf:name":[{"@value":"Tomoharu Sano"}],"jpcoar:affiliationName":[{"@value":"Center for Environmental Measurement and Analysis National Institute for Environmental Studies Tsukuba Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235487644416","@type":"Researcher","foaf:name":[{"@value":"Takehiro Michikawa"}],"jpcoar:affiliationName":[{"@value":"Center for Environmental Health Sciences National Institute for Environmental Studies Tsukuba Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235487644429","@type":"Researcher","foaf:name":[{"@value":"Keiko Nohara"}],"jpcoar:affiliationName":[{"@value":"Center for Environmental Health Sciences National Institute for Environmental Studies Tsukuba Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13479032"},{"@type":"EISSN","@value":"13497006"}],"prism:publicationName":[{"@value":"Cancer Science"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2013-11-08","prism:volume":"104","prism:number":"12","prism:startingPage":"1575","prism:endingPage":"1585"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcas.12298"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cas.12298"}],"createdAt":"2013-10-12","modifiedAt":"2023-10-03","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C3H","dc:title":"Mice, Inbred C3H"},{"@id":"https://cir.nii.ac.jp/all?q=Base%20Sequence","dc:title":"Base Sequence"},{"@id":"https://cir.nii.ac.jp/all?q=Carcinogenesis","dc:title":"Carcinogenesis"},{"@id":"https://cir.nii.ac.jp/all?q=Sequence%20Analysis,%20DNA","dc:title":"Sequence Analysis, DNA"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20Methylation","dc:title":"DNA Methylation"},{"@id":"https://cir.nii.ac.jp/all?q=Arsenic","dc:title":"Arsenic"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Liver%20Neoplasms,%20Experimental","dc:title":"Liver Neoplasms, Experimental"},{"@id":"https://cir.nii.ac.jp/all?q=Liver","dc:title":"Liver"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=CpG%20Islands","dc:title":"CpG Islands"},{"@id":"https://cir.nii.ac.jp/all?q=Proto-Oncogene%20Proteins%20c-fos","dc:title":"Proto-Oncogene Proteins c-fos"},{"@id":"https://cir.nii.ac.jp/all?q=Genome-Wide%20Association%20Study","dc:title":"Genome-Wide Association Study"},{"@id":"https://cir.nii.ac.jp/all?q=Oligonucleotide%20Array%20Sequence%20Analysis","dc:title":"Oligonucleotide Array Sequence Analysis"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782152506368","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23390166"},{"@type":"JGN","@value":"JP23390166"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390166/"}],"notation":[{"@language":"ja","@value":"環境化学物質が酸化ストレスを介してエピジェネティック変化を誘導する機序の解明"},{"@language":"en","@value":"Involvement of oxidative stress in the epigenetic changes induced by environmental chemicals"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257206947200","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24790600"},{"@type":"JGN","@value":"JP24790600"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790600/"}],"notation":[{"@language":"ja","@value":"酸化ストレスによるＤＮＡ脱メチル化酵素の発現誘導メカニズムの解明"},{"@language":"en","@value":"Analysis of the effects of oxidative stress on DNA methylation and the expression of active DNA demethylation related genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257235619712","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25460831"},{"@type":"JGN","@value":"JP25460831"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460831/"}],"notation":[{"@language":"ja","@value":"ヒ素による後発的発癌増加に関するFosファミリー遺伝子発現調節メカニズムの解析"},{"@language":"en","@value":"Studies on the regulation of Fos family gene expression involved in late-onset increases of tumor induced by arsenic"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004237926403840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"DNA methylation inhibitor attenuates polyglutamine‐induced neurodegeneration by regulating Hes5"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011142937057280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human DNA methylomes at base resolution show widespread epigenomic differences"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144185092096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Aberrant DNA methylation in contrast with mutations"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144635523072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DNA methylation landscapes: provocative insights from epigenomics"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390769611904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"DNA Methylation Aberrations in Dimethylarsinic Acid-Induced Bladder Carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692643986688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Late-onset Increases in Oxidative Stress and Other Tumorigenic Activities and Tumors With a Ha-ras Mutation in the Liver of Adult Male C3H Mice Gestationally Exposed to Arsenic"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285705132190464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Augmenting effects of gestational arsenite exposure of C3H mice on the hepatic tumors of the F<sub>2</sub> male offspring via the F<sub>1</sub> male offspring"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711796155008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618828361600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Global DNA methylation in the mouse liver is affected by methyl deficiency and arsenic in a sex-dependent manner"}]},{"@id":"https://cir.nii.ac.jp/crid/1360564063960931072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Understanding diagnostic tests 3: receiver operating characteristic curves"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567180108739456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Long‐term arsenic exposure induces histone H3 Lys9 dimethylation without altering DNA methylation in the promoter region of p16<sup>INK4a</sup> and down‐regulates its expression in the liver of mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567189464023296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Maternal Protein Restriction Alters the Renal Ptger1 DNA Methylation State in SHRSP Offspring"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094696988288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A human B cell methylome at 100−base pair resolution"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095688538368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gene Body-Specific Methylation on the Active X Chromosome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096076447232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum."}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567764804352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Gestational arsenic exposure and paternal intergenerational epigenetic inheritance"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571503984896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects Of Arsenic Exposure On Dna Methylation And Epigenetic Gene Regulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044397327360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The history of cancer epigenetics"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518768824704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comparison of the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced CYP1A1 gene expression profile in lymphocytes from mice, rats, and humans: Most potent induction in humans"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519372319232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The power and the promise of DNA methylation markers"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519791348352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mortality in Young Adults following\n                    <i>in Utero</i>\n                    and Childhood Exposure to Arsenic in Drinking Water"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995195175424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Arsenic Exposure and Toxicology: A Historical Perspective"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995608803584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Development of a Novel Output Value for Quantitative Assessment in Methylated DNA Immunoprecipitation-CpG Island Microarray Analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469298554624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Arsenic: toxicity, oxidative stress and human disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943634726784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Estrogen Signaling in Livers of Male Mice With Hepatocellular Carcinoma Induced by Exposure to Arsenic In Utero"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944608106368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Promotion of hepatocarcinogenesis in humans and animal models"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945804307200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanism of arsenic carcinogenesis: an integrated approach"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420213701248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chronic Oral Exposure to Inorganic Arsenate Interferes with Methylation Status of p16INK4a and RASSF1A and Induces Lung Cancer in A/J Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420315636864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895835140224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An Emerging Role for Epigenetic Dysregulation in Arsenic Toxicity and Carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843378022016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Fos family of transcription factors and their role in tumourigenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844733777920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Constitutively Active Aryl Hydrocarbon Receptor Expressed Specifically in T-Lineage Cells Causes Thymus Involution and Suppresses the Immunization-Induced Increase in Splenocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319069155968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"RAS oncogenes: weaving a tumorigenic web"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319082823936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794078742528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Kidney Cancer Mortality"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794492302592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chromosomal Instability and Tumors Promoted by DNA Hypomethylation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795717766784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transplacental carcinogenicity of inorganic arsenic in the drinking water: induction of hepatic, ovarian, pulmonary, and adrenal tumors in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206362026624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"無機ヒ素によるマウス肝がん増加に関連したエピジェネティック変化とDNAメチル化マーカーの探索"},{"@language":"en","@value":"Exploration of Epigenetic Changes and DNA Methylation Markers Associated with Liver Tumors Induced by Inorganic Arsenite Exposure in Mice"},{"@language":"ja-Kana","@value":"ムキ ヒソ ニ ヨル マウス カンガン ゾウカ ニ カンレン シタ エピジェネティック ヘンカ ト DNA メチルカ マーカー ノ タンサク"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681339444608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Increase in Incidence of Hepatic Tumors Caused by Oncogenic Somatic Mutation in Mice Maternally Exposed to Inorganic Arsenic and the Multigenerational and Transgenerational Effects of Inorganic Arsenic"},{"@language":"ja","@value":"妊娠期無機ヒ素曝露による子での癌遺伝子体細胞突然変異を介した
発癌増加と多世代・継世代影響"},{"@language":"ja-Kana","@value":"ニンシンキ ムキ ヒソ バクロ ニ ヨル コ デ ノ ガン イデンシ タイサイボウ トツゼン ヘンイ オ カイシタ ハツガン ゾウカ ト タセダイ ・ ケイセダイ エイキョウ"}]},{"@id":"https://cir.nii.ac.jp/crid/2050307416984345984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tumor-augmenting effects of gestational arsenic exposure on F1 and F2 in mice"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/cas.12298"},{"@type":"KAKEN","@value":"PRODUCT-13945637"},{"@type":"KAKEN","@value":"PRODUCT-14875270"},{"@type":"KAKEN","@value":"PRODUCT-15076616"},{"@type":"OPENAIRE","@value":"doi_dedup___::8aa39d48a7d04eaee1fa8972747d1211"},{"@type":"CROSSREF","@value":"10.15252/emmm.201708547_references_DOI_VbRAQcTnq5LZaI97rlMvmJAwtJz"},{"@type":"CROSSREF","@value":"10.3390/cancers15215274_references_DOI_VbRAQcTnq5LZaI97rlMvmJAwtJz"},{"@type":"CROSSREF","@value":"10.1002/jat.3149_references_DOI_VbRAQcTnq5LZaI97rlMvmJAwtJz"},{"@type":"CROSSREF","@value":"10.1186/s12885-018-4221-0_references_DOI_VbRAQcTnq5LZaI97rlMvmJAwtJz"},{"@type":"CROSSREF","@value":"10.1186/s41021-016-0069-1_references_DOI_VbRAQcTnq5LZaI97rlMvmJAwtJz"},{"@type":"CROSSREF","@value":"10.3390/nu10101436_references_DOI_VbRAQcTnq5LZaI97rlMvmJAwtJz"},{"@type":"CROSSREF","@value":"10.1016/j.taap.2020.115319_references_DOI_VbRAQcTnq5LZaI97rlMvmJAwtJz"},{"@type":"CROSSREF","@value":"10.1265/jjh.70.181_references_DOI_VbRAQcTnq5LZaI97rlMvmJAwtJz"},{"@type":"CROSSREF","@value":"10.1265/jjh.69.92_references_DOI_VbRAQcTnq5LZaI97rlMvmJAwtJz"}]}