{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004235488359552.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/cas.12731"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcas.12731"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cas.12731"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cas.12731"}},{"identifier":{"@type":"PMID","@value":"26132605"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Potential clinical application of interleukin‐27 as an antitumor agent"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Cancer immunotherapies such as sipuleucel‐T and ipilimumab are promising new treatments that harness the power of the immune system to fight cancer and achieve long‐lasting remission. Interleukin (<jats:styled-content style=\"fixed-case\">IL</jats:styled-content>)‐27, a member of the <jats:styled-content style=\"fixed-case\">IL</jats:styled-content>‐12 heterodimeric cytokine family, has pleiotropic functions in the regulation of immune responses with both pro‐inflammatory and anti‐inflammatory properties. Evidence obtained using a variety of preclinical mouse models indicates that <jats:styled-content style=\"fixed-case\">IL</jats:styled-content>‐27 possesses potent antitumor activity against various types of tumors through multiple mechanisms without apparent adverse effects. These mechanisms include those mediated not only by <jats:styled-content style=\"fixed-case\">CD</jats:styled-content>8<jats:sup>+</jats:sup> T cells, natural killer cells and macrophages, but also by antibody‐dependent cell‐mediated cytotoxicity, antiangiogenesis, direct antiproliferative effects, inhibition of expression of cyclooxygenase‐2 and prostaglandin E<jats:sub>2</jats:sub>, and suppression of epithelial–mesenchymal transition, depending on the characteristics of individual tumors. However, the endogenous role of <jats:styled-content style=\"fixed-case\">IL</jats:styled-content>‐27 subunits and one of its receptor subunits, <jats:styled-content style=\"fixed-case\">WSX</jats:styled-content>‐1, in the susceptibility to tumor development after transplantation of tumor cell lines or endogenously arising tumors seems to be more complicated. <jats:styled-content style=\"fixed-case\">IL</jats:styled-content>‐27 functions as a double‐edged sword: <jats:styled-content style=\"fixed-case\">IL</jats:styled-content>‐27 increases <jats:styled-content style=\"fixed-case\">IL</jats:styled-content>‐10 production and the expression of programmed death ligand 1 and T‐cell immunoglobulin and mucin domain‐3, and promotes the generation of regulatory T cells, and <jats:styled-content style=\"fixed-case\">IL</jats:styled-content>‐27 receptor α singling enhances transformation; <jats:styled-content style=\"fixed-case\">IL</jats:styled-content>‐27 may augment protumor effects as well. Here, we review both facets of <jats:styled-content style=\"fixed-case\">IL</jats:styled-content>‐27, antitumor effects and protumor effects, and discuss the potential clinical application of <jats:styled-content style=\"fixed-case\">IL</jats:styled-content>‐27 as an antitumor agent.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004235488359298","@type":"Researcher","foaf:name":[{"@value":"Yukino Chiba"}],"jpcoar:affiliationName":[{"@value":"Department of Immunoregulation Institute of Medical Science Tokyo Medical University Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235488359296","@type":"Researcher","foaf:name":[{"@value":"Ren Tsunoda"}],"jpcoar:affiliationName":[{"@value":"Department of Immunoregulation Institute of Medical Science Tokyo Medical University Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235488359553","@type":"Researcher","foaf:name":[{"@value":"Kaname Higuchi"}],"jpcoar:affiliationName":[{"@value":"Department of Immunoregulation Institute of Medical Science Tokyo Medical University Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235488359299","@type":"Researcher","foaf:name":[{"@value":"Jun‐Ichi Furusawa"}],"jpcoar:affiliationName":[{"@value":"Department of Immunoregulation Institute of Medical Science Tokyo Medical University Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276169698432","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00569527"},{"@type":"NRID","@value":"1000000569527"},{"@type":"NRID","@value":"9000240170826"},{"@type":"NRID","@value":"9000248233571"}],"foaf:name":[{"@value":"Izuru Mizoguchi"}],"jpcoar:affiliationName":[{"@value":"Department of Immunoregulation Institute of Medical Science Tokyo Medical University Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801213053696","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80597964"},{"@type":"NRID","@value":"1000080597964"},{"@type":"NRID","@value":"9000240170824"},{"@type":"NRID","@value":"9000248233570"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/80597964Xu"}],"foaf:name":[{"@value":"Mingli Xu"}],"jpcoar:affiliationName":[{"@value":"Department of Immunoregulation Institute of Medical Science Tokyo Medical University Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235488359552","@type":"Researcher","foaf:name":[{"@value":"Takayuki Yoshimoto"}],"jpcoar:affiliationName":[{"@value":"Department of Immunoregulation Institute of Medical Science Tokyo Medical University Tokyo Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13479032"},{"@type":"EISSN","@value":"13497006"}],"prism:publicationName":[{"@value":"Cancer Science"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2015-08-06","prism:volume":"106","prism:number":"9","prism:startingPage":"1103","prism:endingPage":"1110"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by-nc-nd/4.0/"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcas.12731"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cas.12731"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cas.12731"}],"createdAt":"2015-07-01","modifiedAt":"2023-10-02","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-27","dc:title":"Interleukin-27"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasms","dc:title":"Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Antineoplastic%20Agents","dc:title":"Antineoplastic 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