{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004235489812992.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/cas.13460"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcas.13460"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cas.13460"}},{"identifier":{"@type":"PMID","@value":"29193587"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Phlebotomy as a preventive measure for crocidolite‐induced mesothelioma in male rats"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Malignant mesothelioma (MM) is a rare but socially important neoplasm due to its association with asbestos exposure. Malignant mesothelioma is difficult to diagnose at an early stage, yet there are no particularly effective treatments available at the advanced stage, thus necessitating efficient strategies to prevent MM in individuals already exposed to asbestos. We previously showed that persistent oxidative damage caused by foreign body reaction and affinity of asbestos both to hemoglobin and histones is one of the major pathogeneses. Accordingly, as an effective strategy to prevent asbestos‐induced MM, we undertook the use of an iron chelator, deferasirox, which decreased the epithelial–mesenchymal transition in a crocidolite‐induced rat MM model. However, this agent may show adverse effects. Here, we studied the effects of iron removal by phlebotomy as a realistic measure on the same rat model. We injected a total of 5 mg crocidolite i.p. to F1 hybrid rats between the Fischer‐344 and Brown‐Norway strains at the age of 6 weeks. We repeated weekly or biweekly phlebotomy of 6‐8 mL/kg/time from 10 to 60 weeks of age. The animals were observed until 120 weeks. In male rats, phlebotomy significantly decreased the weight and nuclear grade of MM, and modestly reduced the associated ascites and the fraction of more malignant sarcomatoid subtype. Weekly phlebotomy prolonged long‐term survival. Our results indicate that appropriate phlebotomy may be a practical preventive measure to attenuate the initiation and promotion capacity of asbestos towards MM by reducing iron in individuals exposed to asbestos.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004235489812998","@type":"Researcher","foaf:name":[{"@value":"Yuuki Ohara"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380579811663751424","@type":"Researcher","foaf:name":[{"@value":"Shan‐Hwu Chew"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235489813135","@type":"Researcher","foaf:name":[{"@value":"Takahiro Shibata"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751149598080","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30403489"},{"@type":"NRID","@value":"1000030403489"},{"@type":"NRID","@value":"9000283422851"},{"@type":"NRID","@value":"9000366128602"},{"@type":"NRID","@value":"9000398801595"},{"@type":"NRID","@value":"9000398801722"},{"@type":"NRID","@value":"9000378128259"},{"@type":"NRID","@value":"9000391552593"},{"@type":"NRID","@value":"9000009908699"},{"@type":"NRID","@value":"9000006780564"},{"@type":"NRID","@value":"9000261654699"},{"@type":"NRID","@value":"9000018762743"},{"@type":"NRID","@value":"9000019061581"},{"@type":"NRID","@value":"9000369748163"},{"@type":"NRID","@value":"9000366128597"},{"@type":"NRID","@value":"9000272994209"},{"@type":"NRID","@value":"9000242545028"},{"@type":"NRID","@value":"9000283422428"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0149073"}],"foaf:name":[{"@value":"Yasumasa Okazaki"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235489813252","@type":"Researcher","foaf:name":[{"@value":"Kyoko Yamashita"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya 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Toyokuni"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan"},{"@value":"Sydney Medical School The University of Sydney Sydney NSW Australia"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13479032"},{"@type":"EISSN","@value":"13497006"}],"prism:publicationName":[{"@value":"Cancer Science"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2018-01-04","prism:volume":"109","prism:number":"2","prism:startingPage":"330","prism:endingPage":"339"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by-nc/4.0/"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcas.13460"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cas.13460"}],"createdAt":"2017-11-29","modifiedAt":"2023-09-06","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Mesothelioma","dc:title":"Mesothelioma"},{"@id":"https://cir.nii.ac.jp/all?q=Lung%20Neoplasms","dc:title":"Lung Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Iron","dc:title":"Iron"},{"@id":"https://cir.nii.ac.jp/all?q=Asbestos,%20Crocidolite","dc:title":"Asbestos, Crocidolite"},{"@id":"https://cir.nii.ac.jp/all?q=Mesothelioma,%20Malignant","dc:title":"Mesothelioma, Malignant"},{"@id":"https://cir.nii.ac.jp/all?q=Original%20Articles","dc:title":"Original Articles"},{"@id":"https://cir.nii.ac.jp/all?q=Survival%20Analysis","dc:title":"Survival Analysis"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Tumor%20Burden","dc:title":"Tumor Burden"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Treatment%20Outcome","dc:title":"Treatment Outcome"},{"@id":"https://cir.nii.ac.jp/all?q=Phlebotomy","dc:title":"Phlebotomy"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781849245568","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K08398"},{"@type":"JGN","@value":"JP15K08398"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08398/"}],"notation":[{"@language":"ja","@value":"細胞増殖・鉄代謝に関連するDAP分子の機能解析"},{"@language":"en","@value":"An analyses of DMT1 Associated Protein that is related to celllular proliferation and iron metabolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000781957409536","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17H04064"},{"@type":"JGN","@value":"JP17H04064"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04064/"}],"notation":[{"@language":"ja","@value":"鉄ダイナミクスと多層オミクス解析による酸化ストレス発がん克服のための基盤形成"},{"@language":"en","@value":"Analyses based on iron dynamics and multiomics to overcome oxidative stress-induced carcinogenesis"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282813782579200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Iron and thiol redox signaling in cancer: An exquisite balance to escape ferroptosis"},{"@value":"Iron and thiol redox signaling in cancer: An exquisite balance ot escape ferroptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236376805760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Deferasirox Induces Mesenchymal–Epithelial Transition in Crocidolite-Induced Mesothelial Carcinogenesis in Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005517253948416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Carbonic anhydrase 9 confers resistance to ferroptosis/apoptosis in malignant mesothelioma under hypoxia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142886257792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142906713984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate Bioengineering"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144334541312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Retrospective nationwide survey of Japanese patients with transfusion‐dependent MDS and aplastic anemia highlights the negative impact of iron overload on morbidity/mortality"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146297661696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168860975744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Ferroptosis-dependent extracellular vesicles from macrophage contribute to asbestos-induced mesothelial carcinogenesis through loading ferritin"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013335402740480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"BRCA1 haploinsufficiency promotes chromosomal amplification under Fenton reaction-based carcinogenesis through 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mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185442114688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dual preventive benefits of iron elimination by desferal in asbestos‐induced mesothelial carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095235405184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evaluation of the neutrophil-lymphocyte ratio as a measure of distress in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095581698304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Solid Tumors: A Systematic Review and Meta-Analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580229830305152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Three-Dimensional Regulation of Ferroptosis at the Intersection of Iron, Sulfur, and Oxygen Executing Scrap and Build Toward Evolution"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848655179001472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Iron overload signature in chrysotile‐induced malignant mesothelioma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659152855808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Superiority of rat over murine model for studies on the evolution of cancer genome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660482633216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Asbestos surface provides a niche for oxidative modification"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848663203046272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Connective tissue growth factor-specific monoclonal antibody inhibits growth of malignant mesothelioma in an orthotopic mouse model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567517855872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Ferroptosis at the crossroads of infection, aging and cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568878782208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of iron in carcinogenesis: Cancer as a ferrotoxic disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568949567488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Polycythemia vera and essential thrombocythemia: 2017 update on diagnosis, risk‐stratification, and 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