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The incorporation of clinically relevant target sequences into NGS‐based gene panel tests has generated practical diagnostic tools that enable individualized cancer‐patient care. The clinical utility of gene panel testing includes investigation of the genetic basis for an individual's response to therapy, such as signaling pathways associated with a response to specific therapies, microsatellite instability and a hypermutated phenotype, and deficiency in the DNA double‐strand break repair pathway. In this review, we describe the concept of precision cancer medicine using target sequences in gene panel tests as well as the importance of the control of sample quality in routine NGS‐based genomic testing. We describe geographic and ethnic differences in cancer genomes, and discuss issues that need to be addressed in the future based on our experiences in Japan.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004235490456961","@type":"Researcher","foaf:name":[{"@value":"Masayuki Nagahashi"}],"jpcoar:affiliationName":[{"@value":"Division of Digestive and General Surgery Graduate School of Medical and Dental Sciences Niigata University Niigata Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235490456717","@type":"Researcher","foaf:name":[{"@value":"Yoshifumi Shimada"}],"jpcoar:affiliationName":[{"@value":"Division of Digestive and General Surgery Graduate School of Medical and Dental Sciences Niigata University Niigata Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235490456837","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Ichikawa"}],"jpcoar:affiliationName":[{"@value":"Division of Digestive and General Surgery Graduate School of Medical and Dental 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