{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004235490612352.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/cas.13933"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcas.13933"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/am-pdf/10.1111%2Fcas.13933"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cas.13933"}},{"identifier":{"@type":"PMID","@value":"30629318"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2020221127"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Dendritic cells (<jats:styled-content style=\"fixed-case\">DC</jats:styled-content>) play a key role in the initiation of both antitumor immunity and immunological tolerance. It has been demonstrated that exposure to soluble factors produced by tumor cells modulates <jats:styled-content style=\"fixed-case\">DC</jats:styled-content> functions and induces tolerogenic <jats:styled-content style=\"fixed-case\">DC</jats:styled-content> differentiation. In this study, we investigated the effects of neuroblastoma cell line‐derived soluble factors on <jats:styled-content style=\"fixed-case\">DC</jats:styled-content> differentiation. Monocytes isolated from healthy volunteers were incubated with interleukin (<jats:styled-content style=\"fixed-case\">IL</jats:styled-content>)‐4 and granulocyte‐macrophage colony‐stimulating factor in the presence of culture supernatants from neuroblastoma cell lines. The culture supernatants from neuroblastoma cell lines, such as <jats:styled-content style=\"fixed-case\">NLF</jats:styled-content> and <jats:styled-content style=\"fixed-case\">GOTO</jats:styled-content>, partially blocked both downregulation of <jats:styled-content style=\"fixed-case\">CD</jats:styled-content>14 and upregulation of <jats:styled-content style=\"fixed-case\">CD</jats:styled-content>1a, and dramatically decreased <jats:styled-content style=\"fixed-case\">IL</jats:styled-content>‐12 and tumor necrosis factor (<jats:styled-content style=\"fixed-case\">TNF</jats:styled-content>)‐α production from mature <jats:styled-content style=\"fixed-case\">DC</jats:styled-content>, while no effect of <jats:styled-content style=\"fixed-case\">SH</jats:styled-content>‐<jats:styled-content style=\"fixed-case\">SY</jats:styled-content>5Y cell supernatant was noted. In addition, <jats:styled-content style=\"fixed-case\">IL</jats:styled-content>‐6 and <jats:styled-content style=\"fixed-case\">IL</jats:styled-content>‐10 production from monocytes was increased by the supernatants of <jats:styled-content style=\"fixed-case\">NLF</jats:styled-content> and <jats:styled-content style=\"fixed-case\">GOTO</jats:styled-content> cells at 24 hours after incubation. Furthermore, we evaluated <jats:styled-content style=\"fixed-case\">DC</jats:styled-content> functions through stimulation of invariant natural killer T (<jats:styled-content style=\"fixed-case\">iNKT</jats:styled-content>) cells. α‐Galactosylceramide‐pulsed <jats:styled-content style=\"fixed-case\">DC</jats:styled-content> co‐cultured with supernatants of <jats:styled-content style=\"fixed-case\">NLF</jats:styled-content> cells were unable to sufficiently stimulate <jats:styled-content style=\"fixed-case\">iNKT</jats:styled-content> cells. The decreased ability of <jats:styled-content style=\"fixed-case\">iNKT</jats:styled-content> cells to produce interferon (<jats:styled-content style=\"fixed-case\">IFN</jats:styled-content>)‐γ after stimulation with neuroblastoma cell line supernatant‐cultured <jats:styled-content style=\"fixed-case\">DC</jats:styled-content> was reversed by addition of <jats:styled-content style=\"fixed-case\">IL</jats:styled-content>‐12. <jats:styled-content style=\"fixed-case\">CD</jats:styled-content>40 expression and <jats:styled-content style=\"fixed-case\">IL</jats:styled-content>‐12 production in <jats:styled-content style=\"fixed-case\">NLF</jats:styled-content>‐sup‐treated <jats:styled-content style=\"fixed-case\">DC</jats:styled-content> were increased by addition of exogenous <jats:styled-content style=\"fixed-case\">IFN</jats:styled-content>‐γ. These results indicate that tolerogenic <jats:styled-content style=\"fixed-case\">DC</jats:styled-content> are induced in the neuroblastoma tumor microenvironment and attenuate the antitumor effects of <jats:styled-content style=\"fixed-case\">iNKT</jats:styled-content> cells. Interactions between <jats:styled-content style=\"fixed-case\">iNKT</jats:styled-content> cells and αGalCer‐pulsed <jats:styled-content style=\"fixed-case\">DC</jats:styled-content> have the potential to restore the immunosuppression of tolerogenic <jats:styled-content style=\"fixed-case\">DC</jats:styled-content> through <jats:styled-content style=\"fixed-case\">IFN</jats:styled-content>‐γ production.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004235490612359","@type":"Researcher","foaf:name":[{"@value":"Kazuaki Harada"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Immunology Graduate School of Medicine Chiba University  Chiba Japan"},{"@value":"Department of Pediatric Surgery Graduate School of Medicine Chiba University  Chiba Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1030285133630402944","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40779906"},{"@type":"NRID","@value":"1000040779906"},{"@type":"NRID","@value":"9000283515598"},{"@type":"NRID","@value":"9000258216939"},{"@type":"NRID","@value":"9000356552814"},{"@type":"NRID","@value":"9000403279618"},{"@type":"NRID","@value":"9000337085090"},{"@type":"NRID","@value":"9000261043203"},{"@type":"NRID","@value":"9000403279777"},{"@type":"NRID","@value":"9000243895021"},{"@type":"NRID","@value":"9000368929419"},{"@type":"NRID","@value":"9000408489044"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/meneki-chiba"}],"foaf:name":[{"@value":"Fumie Ihara"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Immunology Graduate School of Medicine Chiba University  Chiba Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801199912960","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60770906"},{"@type":"NRID","@value":"1000060770906"},{"@type":"NRID","@value":"9000399005329"},{"@type":"NRID","@value":"9000001356767"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/takami"}],"foaf:name":[{"@value":"Mariko Takami"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Immunology Graduate School of Medicine Chiba University  Chiba Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235490612488","@type":"Researcher","foaf:name":[{"@value":"Toshiko Kamata"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Immunology Graduate School of Medicine Chiba University  Chiba Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235490612493","@type":"Researcher","foaf:name":[{"@value":"Naoko Mise"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Immunology Graduate School of Medicine Chiba University  Chiba Japan"},{"@value":"Department of Pediatric Surgery Graduate School of Medicine Chiba University  Chiba Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235490612497","@type":"Researcher","personIdentifier":[{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/0607"}],"foaf:name":[{"@value":"Hiroko Yoshizawa"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Immunology Graduate School of Medicine Chiba University  Chiba Japan"},{"@value":"Department of Pediatric Surgery Graduate School of Medicine Chiba University  Chiba Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276180620032","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00375776"},{"@type":"NRID","@value":"1000000375776"},{"@type":"NRID","@value":"9000258071816"},{"@type":"NRID","@value":"9000388507477"},{"@type":"NRID","@value":"9000003514845"},{"@type":"NRID","@value":"9000364866908"},{"@type":"NRID","@value":"9000364847937"},{"@type":"NRID","@value":"9000364849054"},{"@type":"NRID","@value":"9000364901350"},{"@type":"NRID","@value":"9000045428748"},{"@type":"NRID","@value":"9000309182795"},{"@type":"NRID","@value":"9000364910268"},{"@type":"NRID","@value":"9000404114560"},{"@type":"NRID","@value":"9000409323792"},{"@type":"NRID","@value":"9000397842797"},{"@type":"NRID","@value":"9000257949521"},{"@type":"NRID","@value":"9000364906250"},{"@type":"NRID","@value":"9000364874893"},{"@type":"NRID","@value":"9000256302918"},{"@type":"NRID","@value":"9000259859439"},{"@type":"NRID","@value":"9000364907868"},{"@type":"NRID","@value":"9000364869243"},{"@type":"NRID","@value":"9000312254186"},{"@type":"NRID","@value":"9000003514749"},{"@type":"NRID","@value":"9000413510961"},{"@type":"NRID","@value":"9000364847406"},{"@type":"NRID","@value":"9000364874356"},{"@type":"NRID","@value":"9000364878317"},{"@type":"NRID","@value":"9000370754510"},{"@type":"NRID","@value":"9000402933281"},{"@type":"NRID","@value":"9000363212985"},{"@type":"NRID","@value":"9000403308315"},{"@type":"NRID","@value":"9000364872207"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/sapporoken"}],"foaf:name":[{"@value":"Tomoro Hishiki"}],"jpcoar:affiliationName":[{"@value":"Division of Surgical Oncology Children's Cancer Center National Center for Child Health and Development  Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801183992064","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20406044"},{"@type":"NRID","@value":"1000020406044"},{"@type":"NRID","@value":"9000345254687"},{"@type":"NRID","@value":"9000312725700"},{"@type":"NRID","@value":"9000347127346"},{"@type":"NRID","@value":"9000411525193"},{"@type":"NRID","@value":"9000259859440"},{"@type":"NRID","@value":"9000368938367"},{"@type":"NRID","@value":"9000405677496"},{"@type":"NRID","@value":"9000412133931"}],"foaf:name":[{"@value":"Takeshi Saito"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatric Surgery Graduate School of Medicine Chiba University  Chiba Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235490612614","@type":"Researcher","foaf:name":[{"@value":"Keita Terui"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatric Surgery Graduate School of Medicine Chiba University  Chiba Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235490612613","@type":"Researcher","foaf:name":[{"@value":"Mitsuyuki Nakata"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatric Surgery Graduate School of Medicine Chiba University  Chiba Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235490612365","@type":"Researcher","foaf:name":[{"@value":"Shugo Komatsu"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatric Surgery Graduate School of Medicine Chiba University  Chiba Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235490612609","@type":"Researcher","foaf:name":[{"@value":"Takayuki Ikeuchi"}],"jpcoar:affiliationName":[{"@value":"Center for Advanced Medicine Chiba University Hospital  Chiba Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235490612481","@type":"Researcher","foaf:name":[{"@value":"Toshinori Nakayama"}],"jpcoar:affiliationName":[{"@value":"Department of Immunology Graduate School of Medicine Chiba University  Chiba Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235490612480","@type":"Researcher","foaf:name":[{"@value":"Hideo Yoshida"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatric Surgery Graduate School of Medicine Chiba University  Chiba Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801188244352","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60345022"},{"@type":"NRID","@value":"1000060345022"},{"@type":"NRID","@value":"9000006078153"},{"@type":"NRID","@value":"9000410152550"},{"@type":"NRID","@value":"9000363353541"},{"@type":"NRID","@value":"9000399005331"},{"@type":"NRID","@value":"9000014161060"},{"@type":"NRID","@value":"9000363355506"},{"@type":"NRID","@value":"9000254178927"},{"@type":"NRID","@value":"9000242794733"},{"@type":"NRID","@value":"9000412096607"},{"@type":"NRID","@value":"9000309180996"},{"@type":"NRID","@value":"9000404852002"},{"@type":"NRID","@value":"9000356552815"},{"@type":"NRID","@value":"9000337085091"},{"@type":"NRID","@value":"9000376554843"},{"@type":"NRID","@value":"9000391775995"},{"@type":"NRID","@value":"9000241432935"},{"@type":"NRID","@value":"9000307248611"},{"@type":"NRID","@value":"9000021936102"},{"@type":"NRID","@value":"9000413758544"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/motohashi-shinichiro"}],"foaf:name":[{"@value":"Shinichiro Motohashi"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Immunology Graduate School of Medicine Chiba University  Chiba Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13479032"},{"@type":"EISSN","@value":"13497006"}],"prism:publicationName":[{"@value":"Cancer Science"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2019-02","prism:volume":"110","prism:number":"3","prism:startingPage":"888","prism:endingPage":"902"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by-nc-nd/4.0/"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcas.13933"},{"@id":"https://onlinelibrary.wiley.com/doi/am-pdf/10.1111%2Fcas.13933"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cas.13933"},{"@id":"https://search.jamas.or.jp/link/ui/2020221127"}],"createdAt":"2019-01-10","modifiedAt":"2023-09-11","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Lipopolysaccharide%20Receptors","dc:title":"Lipopolysaccharide Receptors"},{"@id":"https://cir.nii.ac.jp/all?q=Granulocyte-Macrophage%20Colony-Stimulating%20Factor","dc:title":"Granulocyte-Macrophage Colony-Stimulating Factor"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Differentiation","dc:title":"Cell Differentiation"},{"@id":"https://cir.nii.ac.jp/all?q=Original%20Articles","dc:title":"Original Articles"},{"@id":"https://cir.nii.ac.jp/all?q=Dendritic%20Cells","dc:title":"Dendritic Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Lymphocyte%20Activation","dc:title":"Lymphocyte Activation"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-12","dc:title":"Interleukin-12"},{"@id":"https://cir.nii.ac.jp/all?q=Monocytes","dc:title":"Monocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line","dc:title":"Cell Line"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-10","dc:title":"Interleukin-10"},{"@id":"https://cir.nii.ac.jp/all?q=Antigens,%20CD1","dc:title":"Antigens, CD1"},{"@id":"https://cir.nii.ac.jp/all?q=Interferon-gamma","dc:title":"Interferon-gamma"},{"@id":"https://cir.nii.ac.jp/all?q=Neuroblastoma","dc:title":"Neuroblastoma"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line,%20Tumor","dc:title":"Cell Line, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-4","dc:title":"Interleukin-4"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781973536384","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17K16892"},{"@type":"JGN","@value":"JP17K16892"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K16892/"}],"notation":[{"@language":"ja","@value":"腫瘍微小環境における免疫抑制細胞の作用と機序の解明と新規治療法への発展"},{"@language":"en","@value":"Development of novel treatment to target immune suppressive cells in tumor microenvironment"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256873393792","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16H02778"},{"@type":"JGN","@value":"JP16H02778"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H02778/"}],"notation":[{"@language":"ja","@value":"小児がん研究グループによる小児肝がんの海外診療状況調査と国際共同臨床研究基盤整備"},{"@language":"en","@value":"Study of clinical states and infrastructure development of International co-operative clinical trial for childhood liver tumors by children's cancer study group"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256931299072","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17H01592"},{"@type":"JGN","@value":"JP17H01592"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H01592/"}],"notation":[{"@language":"ja","@value":"小児悪性固形腫瘍の新規病理分子学的リスク分類の開発とゲノム診療に向けた基盤構築"},{"@language":"en","@value":"Development for a new histobiological risk stratification and establishing of genomic medicine for pediatric malignant solid tumors"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256970191872","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18H02892"},{"@type":"JGN","@value":"JP18H02892"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02892/"}],"notation":[{"@language":"ja","@value":"肺癌腫瘍局所の免疫応答理解に基づくNKT細胞標的免疫療法の開発"},{"@language":"en","@value":"NKT cell-targeted cancer immunotherapy based on the comprehension of anti-tumor immune response in the lung cancer microenvironment"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256977454720","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K08535"},{"@type":"JGN","@value":"JP18K08535"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K08535/"}],"notation":[{"@language":"ja","@value":"胆道閉鎖症の細胞性免疫環境構築に果たすオートファジーの役割"},{"@language":"en","@value":"Role of Autophagy in the Cellular Immunity of Biliary Atresia"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256981405824","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K16274"},{"@type":"JGN","@value":"JP18K16274"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K16274/"}],"notation":[{"@language":"ja","@value":"神経芽腫のがん微小環境における免疫抑制解除を目指したNKT細胞免疫療法の開発研究"},{"@language":"en","@value":"Development of iNKT cell-based immunotherapy targeting neuroblastoma by canceling the immunosuppression in the tumor microenvironment"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256981475712","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K16409"},{"@type":"JGN","@value":"JP18K16409"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K16409/"}],"notation":[{"@language":"ja","@value":"肺癌治療に向けたNKT細胞免疫療法におけるAhRシグナルの作用機構の解明"},{"@language":"en","@value":"A role of AhR signaling in NKT cell based immunotherapy for lung cancer"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011143589414528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A cytokine-mediated link between innate immunity, inflammation, and cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143910369792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Natural killer T cell anergy, co-stimulatory molecules and immunotherapeutic interventions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144430300416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Loss of IFN-γ Production by Invariant NK T Cells in Advanced Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144553812992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inhibition of the Differentiation of Dendritic Cells From CD34+ Progenitors by Tumor Cells: Role of Interleukin-6 and Macrophage Colony-Stimulating Factor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144858510336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tumor-derived factors modulating dendritic cell function"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145059372288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TNF-<i>α</i>Promotes IFN-<i>γ</i>-Induced CD40 Expression and Antigen Process in Myb-Transformed Hematological Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618859133056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Costimulatory Molecules on Immunogenic Versus Tolerogenic Human Dendritic Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621414221056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human tolerogenic DC-10: perspectives for clinical applications"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093658309120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dendritic Cells in Immunity and Tolerance—Do They Display Opposite Functions?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093700543488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gangliosides from Human Melanoma Tumors Impair Dendritic Cell Differentiation from Monocytes and Induce Their Apoptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095231558400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immunology and immunotherapy of neuroblastoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360579816409613312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TGF-β1 Prevents the Noncognate Maturation of Human Dendritic Langerhans Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846645579174272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NKT Cells as an Ideal Anti-Tumor Immunotherapeutic"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568603159680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction of suppressive phenotype in monocyte-derived dendritic cells by leukemic cell products and IL-1β"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568617269504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Exploiting Gene Expression Profiling to Identify Novel Minimal Residual Disease Markers of Neuroblastoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569410404224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Reversible Defect in Natural Killer T Cell Function Characterizes the Progression of Premalignant to Malignant Multiple Myeloma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570584645376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tolerogenic dendritic cells and the quest for transplant tolerance"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570949226880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tolerogenic Dendritic Cells Generated with Different Immunosuppressive Cytokines Induce Antigen-Specific Anergy and Regulatory Properties in Memory CD4+ T Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857671383027584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cutting Edge: Inhibition of Experimental Tumor Metastasis by Dendritic Cells Pulsed with α-Galactosylceramide"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044804654336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Elevated Interleukin-6 and G-CSF in Human Pancreatic Cancer Cell Conditioned Medium Suppress Dendritic Cell Differentiation and Activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518443952896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antitumor Responses of Invariant Natural Killer T Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995872206592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Janus-like role of regulatory iNKT cells in autoimmune disease and tumour immunity"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468656801536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Leukemic cell products down-regulate human dendritic cell differentiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421078077440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical applications of natural killer T cell–based immunotherapy for cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421273087488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Natural Killer T Cells Infiltrate Neuroblastomas Expressing the Chemokine CCL2"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369870116096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Generation of mature dendritic cells from human blood An improved method with special regard to clinical applicability"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370533877760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Natural Killer T (NKT) Cell Ligand α-Galactosylceramide Demonstrates Its Immunopotentiating Effect by Inducing Interleukin (IL)-12 Production by Dendritic Cells and IL-12 Receptor Expression on NKT Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845395296384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Functional characterization of a STAT3-dependent dendritic cell-derived CD14<sup>+</sup>cell population arising upon IL-10-driven maturation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846253883520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The NKT cell system: bridging innate and acquired immunity"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320164189696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Generation of Tolerogenic Dendritic Cells and Their Therapeutic Applications"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320222116864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immune-based therapies for childhood cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320849324544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inhibition of the Differentiation of Monocyte-Derived Dendritic Cells by Human Gingival Fibroblasts"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795117574528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Development of treatment strategies for advanced neuroblastoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268277869824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-6 Regulates In Vivo Dendritic Cell Differentiation through STAT3 Activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1370004235490612614","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Coordinate morphological and biochemical interconversion of human neuroblastoma cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572699702859264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Establishment and characterization of a human neuroblastoma cell line in tissue culture"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572700306439040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Multiple defects of the nerve growth factor receptor in human neuroblastomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417125099329024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Drug resistance patterns of human neuroblastoma cell lines derived from patients at different phases of therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543024922383872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Neuroblastoma-derived gangliosides inhibit dendritic cell generation and function"},{"@value":"Neuroblastoma‐derived gangliosides inhibit dendritic cell generation and function"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/cas.13933"},{"@type":"KAKEN","@value":"PRODUCT-22500868"},{"@type":"KAKEN","@value":"PRODUCT-22690687"},{"@type":"KAKEN","@value":"PRODUCT-23643027"},{"@type":"KAKEN","@value":"PRODUCT-23101997"},{"@type":"KAKEN","@value":"PRODUCT-22265417"},{"@type":"KAKEN","@value":"PRODUCT-22174421"},{"@type":"KAKEN","@value":"PRODUCT-23127203"},{"@type":"OPENAIRE","@value":"doi_dedup___::f9a4e20c1468c916710f1fbffe0a60c1"}]}