{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004235498899840.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/cpr.12045"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcpr.12045"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cpr.12045"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cpr.12045"}},{"identifier":{"@type":"PMID","@value":"23869758"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Interleukin‐6‐induced satellite cell proliferation is regulated by induction of the<scp>JAK</scp>2/<scp>STAT</scp>3 signalling pathway through cyclin D1 targeting"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Objectives</jats:title><jats:p>To determine whether interleukin‐6 (<jats:styled-content style=\"fixed-case\">IL</jats:styled-content>‐6) stimulates rat muscle satellite cell proliferation in culture, and if so, to clarify the signalling mechanisms.</jats:p></jats:sec><jats:sec><jats:title>Materials and methods</jats:title><jats:p>Primary satellite cells were isolated from thirty male F344 rats, 11 weeks of age.<jats:styled-content style=\"fixed-case\">IL</jats:styled-content>‐6 at concentrations of 0.01, 0.1, 1, 10 or 100 ng/ml was added to culture media.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>IL‐6 at 0.01–1 ng/ml induced dose‐dependent increase in cell proliferation. After treatment with 1 ng/ml IL‐6, cell proliferation increased by 31%, and p‐STAT3<jats:sup>+</jats:sup>/MyoD<jats:sup>+</jats:sup>cells increased in number compared to those in control media (<jats:italic>P</jats:italic> < 0.05). Inhibitors of JAK2 (AG 490) and STAT3 (STAT3 peptide) blocked the increase in BrdUrd<jats:sup>+</jats:sup>cell numbers at 6 h post stimulation with 1 ng/ml IL‐6 (<jats:italic>P</jats:italic> < 0.05). Furthermore, cyclin D1<jats:styled-content style=\"fixed-case\">mRNA</jats:styled-content>expression and cyclin D1<jats:sup>+</jats:sup>/MyoD<jats:sup>+</jats:sup>cell numbers significantly increased in cultures treated with 1 ng/ml IL‐6 compared to those in control media (<jats:italic>P</jats:italic> < 0.05). In contrast, treatment with 10 and 100 ng/ml IL‐6 did not stimulate cell proliferation. Treatment with 10 ng/ml IL‐6 induced greater SOCS3<jats:styled-content style=\"fixed-case\">mRNA</jats:styled-content>expression than with 1 ng/ml IL‐6 and control media. Moreover, co‐localization of SOCS3 and myogenin was observed after treatment with 10 ng/ml IL‐6.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p><jats:styled-content style=\"fixed-case\">IL</jats:styled-content>‐6 induced dose‐dependent increase in satellite cell proliferation by activating the<jats:styled-content style=\"fixed-case\">JAK</jats:styled-content>2/<jats:styled-content style=\"fixed-case\">STAT</jats:styled-content>3/cyclin D1 pathway.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004235498899840","@type":"Researcher","foaf:name":[{"@value":"M. Kurosaka"}],"jpcoar:affiliationName":[{"@value":"School of Physical Education Tokai University Kanagawa 259‐1292 Japan"},{"@value":"Department of Physiology St. Marianna University School of Medicine Kanagawa 216‐8511 Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235498899712","@type":"Researcher","foaf:name":[{"@value":"S. Machida"}],"jpcoar:affiliationName":[{"@value":"School of Physical Education Tokai University Kanagawa 259‐1292 Japan"},{"@value":"Graduate School of Health and Sports Science Juntendo University Chiba 270‐1695 Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09607722"},{"@type":"EISSN","@value":"13652184"}],"prism:publicationName":[{"@value":"Cell Proliferation"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2013-07-21","prism:volume":"46","prism:number":"4","prism:startingPage":"365","prism:endingPage":"373"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcpr.12045"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/cpr.12045"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cpr.12045"}],"createdAt":"2013-07-22","modifiedAt":"2024-05-15","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Nucleus","dc:title":"Cell Nucleus"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=STAT3%20Transcription%20Factor","dc:title":"STAT3 Transcription 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