{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004235673179264.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/j.1523-5378.2011.00833.x"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1523-5378.2011.00833.x"}},{"identifier":{"@type":"URI","@value":"http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1523-5378.2011.00833.x/fullpdf"}},{"identifier":{"@type":"PMID","@value":"21585606"}},{"identifier":{"@type":"NAID","@value":"10030297992"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Clinicopathological Analysis of Early-Stage Gastric Cancers Detected After Successful Eradication of Helicobacter pylori"}],"dcterms:alternative":[{"@value":"Gastric cancer after H. pylori eradication"}],"description":[{"notation":[{"@value":"The results of a randomized controlled study and meta-analysis study have recently proved that Helicobacter pylori eradication has a preventive effect against the development of metachronous and primary gastric cancer. However, gastric cancer is sometimes detected after successful eradication. There is a lack of study about gastric cancers in eradicated patients. To clarify the characteristics of gastric cancers detected after H. pylori eradication, we analyzed the clinicopathological features of these cancers.The subjects were 18 early-stage gastric cancer specimens resected from 17 patients who had received successful eradication of H. pylori from February 1995 to March 2009. The control group consisted of 36 specimens from noneradicated patients with persistent H. pylori infection who were matched with the subjects in age, sex, and depth of invasion. Clinicopathological features and mucin phenotypes of gastric cancer were clinically and immunohistologically evaluated.The average diameter of gastric cancer was smaller and Ki-67 index was lower in the eradication group. The morphological distribution of depression types was significantly lower in the control group. Immunohistochemical phenotyping revealed that 72.2% of the lesions in the eradicated group were complete gastric type or gastric predominant mixed type, whereas the percentages of gastric type and intestinal type in the control group were similar.Our findings indicate that the clinicopathological characteristics of gastric cancers detected after H. pylori eradication are different from those of gastric cancers in patients with persistent H. pylori infection. H. pylori eradication may suppress intestinalization during the development of gastric cancer."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004235673179394","@type":"Researcher","foaf:name":[{"@value":"Keiko Yamamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235673179142","@type":"Researcher","foaf:name":[{"@value":"Mototsugu Kato"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235673179398","@type":"Researcher","foaf:name":[{"@value":"Masakazu Takahashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235673179274","@type":"Researcher","foaf:name":[{"@value":"Masahira Haneda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235673179264","@type":"Researcher","foaf:name":[{"@value":"Keisuke Shinada"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235673179143","@type":"Researcher","foaf:name":[{"@value":"Urara Nishida"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235673179399","@type":"Researcher","foaf:name":[{"@value":"Takeshi Yoshida"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235673179137","@type":"Researcher","foaf:name":[{"@value":"Norikazu Sonoda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235673179393","@type":"Researcher","foaf:name":[{"@value":"Shoko Ono"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235673179278","@type":"Researcher","foaf:name":[{"@value":"Manabu Nakagawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235673179402","@type":"Researcher","foaf:name":[{"@value":"Yasuaki Mori"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235673179140","@type":"Researcher","foaf:name":[{"@value":"Soichi Nakagawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235673179280","@type":"Researcher","foaf:name":[{"@value":"Katsuhiro Mabe"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235673179136","@type":"Researcher","foaf:name":[{"@value":"Yuichi Shimizu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235673179144","@type":"Researcher","foaf:name":[{"@value":"Jun Moriya"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235673179403","@type":"Researcher","foaf:name":[{"@value":"Kanako Kubota"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235673179401","@type":"Researcher","foaf:name":[{"@value":"Yoshihiro Matsuno"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235673179275","@type":"Researcher","foaf:name":[{"@value":"Tadakazu Shimoda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235673179276","@type":"Researcher","foaf:name":[{"@value":"Hidenobu Watanabe"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235673179400","@type":"Researcher","foaf:name":[{"@value":"Masahiro Asaka"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10834389"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/10834389"}],"prism:publicationName":[{"@value":"Helicobacter"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2011-05-18","prism:volume":"16","prism:number":"3","prism:startingPage":"210","prism:endingPage":"216"},"reviewed":"false","dc:rights":["http://doi.wiley.com/10.1002/tdm_license_1.1"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1523-5378.2011.00833.x"},{"@id":"http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1523-5378.2011.00833.x/fullpdf"}],"createdAt":"2011-05-18","modifiedAt":"2021-07-05","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Helicobacter%20pylori","dc:title":"Helicobacter pylori"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Helicobacter%20Infections","dc:title":"Helicobacter Infections"},{"@id":"https://cir.nii.ac.jp/all?q=Stomach%20Neoplasms","dc:title":"Stomach Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Case-Control%20Studies","dc:title":"Case-Control Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Early%20Detection%20of%20Cancer","dc:title":"Early Detection of Cancer"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Follow-Up%20Studies","dc:title":"Follow-Up Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasm%20Staging","dc:title":"Neoplasm Staging"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257043371904","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21249065"},{"@type":"JGN","@value":"JP21249065"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21249065/"}],"notation":[{"@language":"ja","@value":"動体追跡医科学研究"},{"@language":"en","@value":"Research for Real-time Tracking Medical Science"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004231260255744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Magnifying narrow-band imaging of surface maturation in early differentiated-type gastric cancers after Helicobacter pylori eradication"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239633416832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Characteristics and predictors of gastric cancer after 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