The role of iNOS‐mediated DNA damage in infection‐ and asbestos‐induced carcinogenesis
書誌事項
- 公開日
- 2010-08
- 資源種別
- journal article
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/j.1749-6632.2010.05602.x
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>Chronic inflammation contributes to a substantial part of environmental carcinogenesis. Various infectious diseases and physical, chemical, and immunological factors participate in inflammation‐related carcinogenesis. Under inflammatory conditions, reactive oxygen and nitrogen species are generated from inflammatory and epithelial cells, and resulting DNA damage may participate in carcinogenesis. 8‐Nitroguanine is a mutagenic DNA lesion formed during chronic inflammation. We performed immunohistochemical analysis, and demonstrated that 8‐nitroguanine was formed at the sites of carcinogenesis in animal models and patients with various cancer‐prone infectious and inflammatory diseases, caused by parasites, viruses, and asbestos exposure. In asbestos‐exposed mice, 8‐nitroguanine was formed in bronchial epithelial cells, and it is noteworthy that crocidolite induced significantly more intense 8‐nitroguanine formation than chrysotile, inconsistent with their carcinogenic potentials. On the basis of these findings, we have proposed that 8‐nitroguanine could be a potential biomarker to evaluate the risk of inflammation‐related carcinogenesis.</jats:p>
収録刊行物
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- Annals of the New York Academy of Sciences
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Annals of the New York Academy of Sciences 1203 (1), 15-22, 2010-08
Wiley
