{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004235779440128.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/jgh.13242"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjgh.13242"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jgh.13242"}},{"identifier":{"@type":"PMID","@value":"26590105"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"MAIT cells are activated and accumulated in the inflamed mucosa of ulcerative colitis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Background and Aim:</jats:title><jats:p>Ulcerative colitis (UC) is a chronic, relapsing and remitting, inflammatory disorder of the large intestine. Mucosal associated invariant T (MAIT) cells are a member of innate‐like lymphocytes found abundantly in the mucosal tissue. The contribution of MAIT cells in the pathogenesis of UC is still unclear; therefore, this study aimed at investigating the role of these cells in patients with UC.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>The frequency of MAIT cells, as well as the production of cytokines and expression levels of activation markers by these cells in the peripheral blood of UC patients and healthy controls, was analyzed by flow cytometry. MAIT cells were also quantified in colon biopsies of UC patients using a confocal microscope.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>There was a significant reduction in MAIT cell frequency in the peripheral blood of UC patients compared with healthy controls (<jats:italic>P</jats:italic> < 0.0001). MAIT cells from UC patients secreted more interleukin (IL)‐17 than healthy controls (<jats:italic>P</jats:italic> < 0.05). The expression levels of CD69 on these cells were correlated with disease activity and endoscopic scores and plasma levels of IL‐18. Furthermore, MAIT cells increased in the inflamed mucosa, and their frequency was correlated with clinical and endoscopic disease activity in UC patients.</jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p>The findings from this study indicate that MAIT cells could be associated with UC and may serve as potential biomarkers or therapeutic targets in UC.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004235779440395","@type":"Researcher","foaf:name":[{"@value":"Keiichi Haga"}],"jpcoar:affiliationName":[{"@value":"Departments of Immunology Juntendo University School of Medicine  Tokyo Japan"},{"@value":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235779440261","@type":"Researcher","foaf:name":[{"@value":"Asako Chiba"}],"jpcoar:affiliationName":[{"@value":"Departments of Immunology Juntendo University School of Medicine  Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276164976640","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60365616"},{"@type":"NRID","@value":"1000060365616"},{"@type":"NRID","@value":"9000022055255"},{"@type":"NRID","@value":"9000402944744"},{"@type":"NRID","@value":"9000002371336"},{"@type":"NRID","@value":"9000326658333"},{"@type":"NRID","@value":"9000283422301"},{"@type":"NRID","@value":"9000021860267"},{"@type":"NRID","@value":"9000020796658"},{"@type":"NRID","@value":"9000378087347"},{"@type":"NRID","@value":"9000261027762"},{"@type":"NRID","@value":"9000296665186"},{"@type":"NRID","@value":"9000022189246"},{"@type":"NRID","@value":"9000258626508"},{"@type":"NRID","@value":"9000412599493"},{"@type":"NRID","@value":"9000391594101"},{"@type":"NRID","@value":"9000399230538"},{"@type":"NRID","@value":"9000405884686"},{"@type":"NRID","@value":"9000283666270"},{"@type":"NRID","@value":"9000258625409"},{"@type":"NRID","@value":"9000326658482"},{"@type":"NRID","@value":"9000273021891"},{"@type":"NRID","@value":"9000258626799"},{"@type":"NRID","@value":"9000415314819"},{"@type":"NRID","@value":"9000361240734"},{"@type":"NRID","@value":"9000414937436"},{"@type":"NRID","@value":"9000258622889"},{"@type":"NRID","@value":"9000408770529"},{"@type":"NRID","@value":"9000021384883"},{"@type":"NRID","@value":"9000413751315"},{"@type":"NRID","@value":"9000414094056"},{"@type":"NRID","@value":"9000402944718"},{"@type":"NRID","@value":"9000409523371"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/428t"}],"foaf:name":[{"@value":"Tomoyoshi Shibuya"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235779440263","@type":"Researcher","foaf:name":[{"@value":"Taro Osada"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235779440396","@type":"Researcher","foaf:name":[{"@value":"Dai Ishikawa"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235779440257","@type":"Researcher","foaf:name":[{"@value":"Tomohiro Kodani"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235779440264","@type":"Researcher","foaf:name":[{"@value":"Osamu Nomura"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235779440513","@type":"Researcher","foaf:name":[{"@value":"Sumio Watanabe"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751140454784","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50266045"},{"@type":"NRID","@value":"1000050266045"},{"@type":"NRID","@value":"9000242075361"},{"@type":"NRID","@value":"9000412351893"},{"@type":"NRID","@value":"9000024032248"},{"@type":"NRID","@value":"9000001031531"},{"@type":"NRID","@value":"9000347038783"},{"@type":"NRID","@value":"9000001669832"},{"@type":"NRID","@value":"9000350631069"},{"@type":"NRID","@value":"9000316210489"},{"@type":"NRID","@value":"9000262366997"},{"@type":"NRID","@value":"9000001904876"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/miyakesachiko"}],"foaf:name":[{"@value":"Sachiko Miyake"}],"jpcoar:affiliationName":[{"@value":"Departments of Immunology Juntendo University School of Medicine  Tokyo Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08159319"},{"@type":"EISSN","@value":"14401746"}],"prism:publicationName":[{"@value":"Journal of Gastroenterology and Hepatology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2016-04-28","prism:volume":"31","prism:number":"5","prism:startingPage":"965","prism:endingPage":"972"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjgh.13242"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jgh.13242"}],"createdAt":"2015-11-21","modifiedAt":"2023-10-02","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Antigens,%20Differentiation,%20T-Lymphocyte","dc:title":"Antigens, Differentiation, T-Lymphocyte"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Colon","dc:title":"Colon"},{"@id":"https://cir.nii.ac.jp/all?q=Lymphocyte%20Activation","dc:title":"Lymphocyte Activation"},{"@id":"https://cir.nii.ac.jp/all?q=Severity%20of%20Illness%20Index","dc:title":"Severity of Illness Index"},{"@id":"https://cir.nii.ac.jp/all?q=Mucosal-Associated%20Invariant%20T%20Cells","dc:title":"Mucosal-Associated Invariant T Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Antigens,%20CD","dc:title":"Antigens, CD"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Lectins,%20C-Type","dc:title":"Lectins, C-Type"},{"@id":"https://cir.nii.ac.jp/all?q=Intestinal%20Mucosa","dc:title":"Intestinal Mucosa"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Death","dc:title":"Cell Death"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Immunity,%20Innate","dc:title":"Immunity, Innate"},{"@id":"https://cir.nii.ac.jp/all?q=Chemotaxis,%20Leukocyte","dc:title":"Chemotaxis, Leukocyte"},{"@id":"https://cir.nii.ac.jp/all?q=Case-Control%20Studies","dc:title":"Case-Control Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Cytokines","dc:title":"Cytokines"},{"@id":"https://cir.nii.ac.jp/all?q=Colitis,%20Ulcerative","dc:title":"Colitis, Ulcerative"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Inflammation%20Mediators","dc:title":"Inflammation Mediators"},{"@id":"https://cir.nii.ac.jp/all?q=Biomarkers","dc:title":"Biomarkers"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257266085120","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26293234"},{"@type":"JGN","@value":"JP26293234"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293234/"}],"notation":[{"@language":"ja","@value":"腸管免疫による自己免疫制御法の開発"},{"@language":"en","@value":"Gut immunity in the regulation of autoimmune diseases"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002219005526784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Activation status of mucosal-associated invariant T cells reflects disease activity and pathology of systemic lupus erythematosus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004234900582144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reduced Numbers and Proapoptotic Features of Mucosal-associated Invariant T Cells as a Characteristic Finding in Patients with Inflammatory Bowel Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239437894784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mucosal-Associated Invariant T Cells in Autoimmune Diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144092652800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Toll-Like Receptor 8 Agonist and Bacteria Trigger Potent Activation of Innate Immune Cells in Human Liver"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168824534784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Characteristics of mucosal-associated invariant T cells and their roles in immune diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360286991724622720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Gut dysbiosis and multiple sclerosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360287144193079808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A Critical Role for Mucosal-Associated Invariant T Cells as Regulators and Therapeutic Targets in Systemic Lupus Erythematosus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618862431744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619944443008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mucosal-associated invariant T cells: unconventional development and function"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620262303232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mucosal-Associated Invariant T Cell Deficiency in Systemic Lupus Erythematosus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621180288640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Early Mucosal Healing With Infliximab Is Associated With Improved Long-term Clinical Outcomes in Ulcerative Colitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643753751680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Activated Mucosal-associated Invariant T Cells Have a Pathogenic Role in a Murine Model of Inflammatory Bowel Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757449699456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mucosal-associated invariant T cells are activated in an interleukin-18-dependent manner in Epstein–Barr virus-associated T/natural killer cell lymphoproliferative diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565164390639360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mucosal‐associated invariant T cells promote inflammation and exacerbate disease in murine models of arthritis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567189656597376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Involvement of Mucosal-associated Invariant T cells in Ankylosing Spondylitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092458268544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"iPSC-derived mucosal-associated invariant T cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093961459712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Early and nonreversible decrease of CD161++/MAIT cells in HIV infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096567347328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Accumulation of V 7.2-J 33 invariant T cells in human autoimmune inflammatory lesions in the nervous system"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846642500874240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mucosal-associated invariant T cells regulate Th1 response in multiple sclerosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360850169179845888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mucosal-Associated Invariant T Cells in Regenerative Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593781930752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mucosal‐Associated Invariant T Cells Are Involved in Acute Ischemic Stroke by Regulating Neuroinflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707145545984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet–Fed Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519399189760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stepwise Development of MAIT Cells in Mouse and Human"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520735022592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520938374144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521389993984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MR1-Restricted Vα19\n                    <i>i</i>\n                    Mucosal-Associated Invariant T Cells Are Innate T Cells in the Gut Lamina Propria That Provide a Rapid and Diverse Cytokine Response"}]},{"@id":"https://cir.nii.ac.jp/crid/1361694368236097024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Activation of mucosal-associated invariant T cells in the lungs of sarcoidosis patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1361694369558791168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Association of mucosal-associated invariant T cells with different disease phases of polymyalgia rheumatica"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993885771776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<scp>CD</scp>8<sup>+</sup><scp>MAIT</scp> cells infiltrate into the <scp>CNS</scp> and alterations in their blood frequencies correlate with <scp>IL</scp>‐18 serum levels in multiple sclerosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994443583616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immunopathology of inflammatory bowel disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975841878868992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Gut environmental factors and multiple sclerosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471037091200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Correlations among total colonoscopic findings, clinical symptoms, and laboratory markers in ulcerative colitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419017739392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893437252224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17–secreting T cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895652239232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896284500352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Invariant Vα19i T cells regulate autoimmune inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843604004992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Polyclonal Mucosa-Associated Invariant T Cells Have Unique Innate Functions in Bacterial Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318456249984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<scp>CD</scp>161<sup>++</sup><scp>CD</scp>8<sup>+</sup><scp>T</scp> cells, including the <scp>MAIT</scp> cell subset, are specifically activated by <scp>IL</scp>‐12+<scp>IL</scp>‐18 in a <scp>TCR</scp>‐independent manner"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794431197568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Blood-based Biomarkers Used to Predict Disease Activity in Crohnʼs Disease and Ulcerative Colitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795046307200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mucosal Healing Predicts Sustained Clinical Remission in Patients With Early-Stage Crohn's Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268506019712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An Invariant T Cell Receptor α Chain Defines a Novel TAP-independent Major Histocompatibility Complex Class Ib–restricted α/β T Cell Subpopulation in Mammals"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268586944896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammatory Bowel Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269253459968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269829925888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expansion of Functional Human Mucosal-Associated Invariant T Cells via Reprogramming to Pluripotency and Redifferentiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270770176512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antimicrobial activity of mucosal-associated invariant T cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1370004235779440266","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Characterization of serum cytokine profile in predominantly colonic inflammatory bowel disease to delineate ulcerative and Crohn's colitides"}]},{"@id":"https://cir.nii.ac.jp/crid/1370004235779440386","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Jα33+ MAIT cells play a protective role in TNBS induced intestinal inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204631199488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Circulating activated innate lymphoid cells and mucosal-associated invariant T cells are associated with airflow limitation in patients with asthma"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204902765696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"<b>Possible involvement of mucosal-associated invariant T cells in the progression of inflammatory bowel </b><b>diseases </b>"},{"@value":"Possible involvement of mucosal-associated invariant T cells in the progression of inflammatory bowel diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1390017455877760256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Potential of MAIT cells to modulate asthma"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/jgh.13242"},{"@type":"KAKEN","@value":"PRODUCT-21031414"},{"@type":"OPENAIRE","@value":"doi_dedup___::d6b40fbb09793b708131ba67c6f6000e"},{"@type":"CROSSREF","@value":"10.1186/s13075-017-1257-5_references_DOI_RzIIaNEeNk4tCxADEPc4gaPTJtK"},{"@type":"CROSSREF","@value":"10.3389/fimmu.2018.01333_references_DOI_RzIIaNEeNk4tCxADEPc4gaPTJtK"},{"@type":"CROSSREF","@value":"10.1093/intimm/dxab070_references_DOI_RzIIaNEeNk4tCxADEPc4gaPTJtK"},{"@type":"CROSSREF","@value":"10.2220/biomedres.38.111_references_DOI_RzIIaNEeNk4tCxADEPc4gaPTJtK"},{"@type":"CROSSREF","@value":"10.1016/j.clim.2020.108380_references_DOI_RzIIaNEeNk4tCxADEPc4gaPTJtK"},{"@type":"CROSSREF","@value":"10.3389/fimmu.2019.02681_references_DOI_RzIIaNEeNk4tCxADEPc4gaPTJtK"},{"@type":"CROSSREF","@value":"10.1016/j.jcmgh.2021.08.018_references_DOI_RzIIaNEeNk4tCxADEPc4gaPTJtK"},{"@type":"CROSSREF","@value":"10.1093/cei/uxab004_references_DOI_RzIIaNEeNk4tCxADEPc4gaPTJtK"},{"@type":"CROSSREF","@value":"10.1016/j.alit.2023.07.006_references_DOI_RzIIaNEeNk4tCxADEPc4gaPTJtK"},{"@type":"CROSSREF","@value":"10.3899/jrheum.151133_references_DOI_RzIIaNEeNk4tCxADEPc4gaPTJtK"},{"@type":"CROSSREF","@value":"10.1016/b978-0-12-822230-0.00012-0_references_DOI_RzIIaNEeNk4tCxADEPc4gaPTJtK"},{"@type":"CROSSREF","@value":"10.3389/fimmu.2017.01711_references_DOI_RzIIaNEeNk4tCxADEPc4gaPTJtK"},{"@type":"CROSSREF","@value":"10.1161/jaha.120.018803_references_DOI_RzIIaNEeNk4tCxADEPc4gaPTJtK"},{"@type":"CROSSREF","@value":"10.3390/ijms232315309_references_DOI_RzIIaNEeNk4tCxADEPc4gaPTJtK"},{"@type":"CROSSREF","@value":"10.1038/s41598-019-49903-6_references_DOI_RzIIaNEeNk4tCxADEPc4gaPTJtK"},{"@type":"CROSSREF","@value":"10.1093/rheumatology/keaa054_references_DOI_RzIIaNEeNk4tCxADEPc4gaPTJtK"},{"@type":"CROSSREF","@value":"10.1016/j.jneuroim.2018.07.015_references_DOI_RzIIaNEeNk4tCxADEPc4gaPTJtK"},{"@type":"CROSSREF","@value":"10.1016/j.alit.2016.07.005_references_DOI_RzIIaNEeNk4tCxADEPc4gaPTJtK"}]}