Neutrophil‐to‐lymphocyte ratio predicts recurrence after radiofrequency ablation in hepatitis B virus infection
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- Kazuto Tajiri
- The Third Department of Internal Medicine Toyama University Hospital Toyama Japan
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- Hayato Baba
- The Third Department of Internal Medicine Toyama University Hospital Toyama Japan
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- Kengo Kawai
- The Third Department of Internal Medicine Toyama University Hospital Toyama Japan
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- Masami Minemura
- The Third Department of Internal Medicine Toyama University Hospital Toyama Japan
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- Satoshi Yasumura
- The Third Department of Internal Medicine Toyama University Hospital Toyama Japan
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- Terumi Takahara
- The Third Department of Internal Medicine Toyama University Hospital Toyama Japan
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- Toshiro Sugiyama
- The Third Department of Internal Medicine Toyama University Hospital Toyama Japan
書誌事項
- 公開日
- 2016-07
- 資源種別
- journal article
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/jgh.13287
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background and Aim:</jats:title><jats:p>Radiofrequency ablation (RFA) is an established treatment for small hepatocellular carcinoma (HCC) wherein non‐recurrence is essential for long‐term survival. Recently, neutrophil‐to‐lymphocyte ratio (NLR), a marker of systemic inflammation that is associated with tumor‐associated macrophages (TAMs), was suggested to be a prognostic marker of HCC treated with RFA. Therefore, we evaluated predictive factors, including NLR, associated with recurrence after curative RFA.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>A total of 163 patients initially diagnosed with HCC and treated with RFA were enrolled. We retrospectively analyzed factors associated with recurrence and survival after RFA. Furthermore, TAMs were evaluated using surgically resected specimens.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>Hepatitis C virus (HCV) infection was the most frequent cause of HCC in this population (111 cases, 68.1%), whereas hepatitis B virus (HBV) infection accounted for 26 cases (16.0%). Recurrence, mostly intrahepatic distant recurrence, was found in 101 cases (61.9%). Recurrence and posttreatment NLR were independent prognostic factors related to survival, and male sex, HCV infection, serum des‐<jats:italic>γ</jats:italic>‐carboxy prothrombin > 40 AU/L, and posttreatment NLR were associated with recurrence. Pretreatment NLR showed no association with recurrence, whereas posttreatment NLR showed prognostic value. Interestingly, pretreatment NLR > 2.5 was significantly associated with recurrence in HBV‐HCC patients (odds ratio 3.439, <jats:italic>P</jats:italic> = 0.037) not but HCV‐HCC (odds ratio 1.430, <jats:italic>P</jats:italic> = 0.17). Furthermore, TAMs were increased in the peripheral area of HCCs with HBV infection compared with those with HCV.</jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p>Recurrence of HCC after RFA was strongly associated with survival. NLR is useful as a predictive marker of recurrence, especially in HBV‐HCC patients.</jats:p></jats:sec>
収録刊行物
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- Journal of Gastroenterology and Hepatology
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Journal of Gastroenterology and Hepatology 31 (7), 1291-1299, 2016-07
Wiley
