{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004235800580480.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/mmi.13886"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmmi.13886"}},{"identifier":{"@type":"URI","@value":"http://api.wiley.com/onlinelibrary/chorus/v1/articles/10.1111%2Fmmi.13886"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/mmi.13886"}},{"identifier":{"@type":"PMID","@value":"29215176"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Protective role of the HOG pathway against the growth defect caused by impaired biosynthesis of complex sphingolipids in yeast <i>Saccharomyces cerevisiae</i>"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Summary</jats:title><jats:p>Complex sphingolipids play critical roles in various cellular events in the yeast <jats:italic>Saccharomyces cerevisiae</jats:italic>. To identify genes that are related to the growth defect caused by disruption of complex sphingolipid biosynthesis, we screened for suppressor mutations and multicopy suppressor genes that confer resistance against repression of <jats:italic>AUR1</jats:italic> encoding inositol phosphorylceramide synthase. From the results of this screening, we found that the activation of high‐osmolarity glycerol (HOG) pathway is involved in suppression of growth defect caused by impaired biosynthesis of complex sphingolipids. Furthermore, it was found that transcriptional regulation via Msn2, Msn4 and Sko1 is involved in the suppressive effect of the HOG pathway. Lack of the HOG pathway did not enhance the reductions in complex sphingolipid levels or the increase in ceramide level caused by the <jats:italic>AUR1</jats:italic> repression, implying that the suppressive effect of the HOG pathway on the growth defect is not attributed to restoration of impaired biosynthesis of complex sphingolipids. On the contrary, the HOG pathway and Msn2/4‐mediated transcriptional activation was involved in suppression of aberrant reactive oxygen species accumulation caused by the <jats:italic>AUR1</jats:italic> repression. These results indicated that the HOG pathway plays pivotal roles in maintaining cell growth under impaired biosynthesis of complex sphingolipids.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004235800579969","@type":"Researcher","foaf:name":[{"@value":"Yutaro Yamaguchi"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, Faculty of Sciences Kyushu University, 744, Motooka Nishi‐ku Fukuoka 819‐3905 Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235800580362","@type":"Researcher","foaf:name":[{"@value":"Yuka Katsuki"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, Faculty of Sciences Kyushu University, 744, Motooka Nishi‐ku Fukuoka 819‐3905 Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235800580232","@type":"Researcher","foaf:name":[{"@value":"Seiya Tanaka"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, Faculty of Sciences Kyushu University, 744, Motooka Nishi‐ku Fukuoka 819‐3905 Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235800580483","@type":"Researcher","foaf:name":[{"@value":"Ryotaro Kawaguchi"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, Faculty of Sciences Kyushu University, 744, Motooka Nishi‐ku Fukuoka 819‐3905 Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235800580097","@type":"Researcher","foaf:name":[{"@value":"Hiroto Denda"}],"jpcoar:affiliationName":[{"@value":"Department of Biofunctional Science and Technology, Graduate School of Biosphere Science Hiroshima University, Kagamiyama 1‐4‐4  Higashi‐Hiroshima 739‐8528 Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235800580488","@type":"Researcher","foaf:name":[{"@value":"Takuma Ikeda"}],"jpcoar:affiliationName":[{"@value":"Department of Biofunctional Science and Technology, Graduate School of Biosphere Science Hiroshima University, Kagamiyama 1‐4‐4  Higashi‐Hiroshima 739‐8528 Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276161729536","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30379854"},{"@type":"NRID","@value":"1000030379854"},{"@type":"NRID","@value":"9000014586664"},{"@type":"NRID","@value":"9000318135517"},{"@type":"NRID","@value":"9000242678554"},{"@type":"NRID","@value":"9000000729225"},{"@type":"NRID","@value":"9000406380385"},{"@type":"NRID","@value":"9000010419860"},{"@type":"NRID","@value":"9000242707730"},{"@type":"NRID","@value":"9000252832100"},{"@type":"NRID","@value":"9000283270891"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0117551"}],"foaf:name":[{"@value":"Kouichi Funato"}],"jpcoar:affiliationName":[{"@value":"Department of Biofunctional Science and Technology, Graduate School of Biosphere Science Hiroshima University, Kagamiyama 1‐4‐4  Higashi‐Hiroshima 739‐8528 Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326218395136","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20452740"},{"@type":"NRID","@value":"1000020452740"},{"@type":"ORCID","@value":"0000-0003-4316-8260"},{"@type":"NRID","@value":"9000001294141"},{"@type":"NRID","@value":"9000410606914"},{"@type":"NRID","@value":"9000018562264"},{"@type":"NRID","@value":"9000345302182"},{"@type":"NRID","@value":"9000356684006"},{"@type":"NRID","@value":"9000000366212"},{"@type":"NRID","@value":"9000414939820"},{"@type":"NRID","@value":"9000014204172"},{"@type":"NRID","@value":"9000263035607"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0134181"}],"foaf:name":[{"@value":"Motohiro Tani"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, Faculty of Sciences Kyushu University, 744, Motooka Nishi‐ku Fukuoka 819‐3905 Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0950382X"},{"@type":"EISSN","@value":"13652958"}],"prism:publicationName":[{"@value":"Molecular Microbiology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2017-12-22","prism:volume":"107","prism:number":"3","prism:startingPage":"363","prism:endingPage":"386"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fmmi.13886"},{"@id":"http://api.wiley.com/onlinelibrary/chorus/v1/articles/10.1111%2Fmmi.13886"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/mmi.13886"}],"createdAt":"2017-12-07","modifiedAt":"2023-09-28","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Glycerol","dc:title":"Glycerol"},{"@id":"https://cir.nii.ac.jp/all?q=Sphingolipids","dc:title":"Sphingolipids"},{"@id":"https://cir.nii.ac.jp/all?q=Saccharomyces%20cerevisiae%20Proteins","dc:title":"Saccharomyces cerevisiae Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Osmolar%20Concentration","dc:title":"Osmolar Concentration"},{"@id":"https://cir.nii.ac.jp/all?q=Saccharomyces%20cerevisiae","dc:title":"Saccharomyces cerevisiae"},{"@id":"https://cir.nii.ac.jp/all?q=Ceramides","dc:title":"Ceramides"},{"@id":"https://cir.nii.ac.jp/all?q=Glycosphingolipids","dc:title":"Glycosphingolipids"},{"@id":"https://cir.nii.ac.jp/all?q=DNA-Binding%20Proteins","dc:title":"DNA-Binding Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Repressor%20Proteins","dc:title":"Repressor Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Basic-Leucine%20Zipper%20Transcription%20Factors","dc:title":"Basic-Leucine Zipper Transcription Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Hexosyltransferases","dc:title":"Hexosyltransferases"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Deletion","dc:title":"Gene Deletion"},{"@id":"https://cir.nii.ac.jp/all?q=Transcription%20Factors","dc:title":"Transcription Factors"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781913336064","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16K07693"},{"@type":"JGN","@value":"JP16K07693"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K07693/"}],"notation":[{"@language":"ja","@value":"スフィンゴ脂質によるTORキナーゼ複合体1の新規制御機構の解明"},{"@language":"en","@value":"Sphingolipid-dependent mechanisms of TOR kinase complex I regulation"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011142933416320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Designer deletion strains derived fromSaccharomyces cerevisiae S288C: A useful set of strains and plasmids for PCR-mediated gene disruption and other applications"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146072466048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Roles for Sphingolipids in Saccharomyces 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yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619036821376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Requirement of STE50 for Osmostress-Induced Activation of the STE11 Mitogen-Activated Protein Kinase Kinase Kinase in the High-Osmolarity Glycerol Response Pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620186020096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Turning genes off by Ssn6–Tup1: a conserved system of transcriptional repression in eukaryotes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621257282048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sphingolipid Synthesis as a Target for Antifungal Drugs"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298336559190912","@type":"Article","resourceType":"学術雑誌論文(journal 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