{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004235802684928.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/nep.12863"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fnep.12863"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/nep.12863"}},{"identifier":{"@type":"PMID","@value":"27461874"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Clinical and histological features of lupus nephritis in Japan: A cross‐sectional analysis of the Japan Renal Biopsy Registry (J‐RBR)"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Aim</jats:title><jats:p>The clinical and histological features of lupus nephritis (LN) are highly variable, depending on race and ethnicity. The Japan Renal Biopsy Registry (J‐RBR) is a nationwide registry of renal biopsies. Here, we report a cross‐sectional analysis of Japanese LN using the J‐RBR database.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Out of 18 463 patients registered in the J‐RBR, 331 LN patients, who received renal biopsy for the first time, were extracted and their clinical features were analyzed according to the ISN/RPS 2003 classification.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The median age of the 331 LN patients was 37 years (women, 81.3%). The frequencies of each of the ISN/RPS Classes were as follows: I, 1.2%; II, 7.9%; III (±V), 25.1%; IV‐S (±V), 13.0%; IV‐G (±V), 31.1%; V, 20.8%; and VI, 0.9%. The level of proteinuria and the prevalence of nephrotic syndrome were highest for Class IV‐G (±V). When Classes I, II, and VI were excluded from the analysis, Class IV‐G (±V) was significantly associated with a lower eGFR and severer haematuria than the other classes.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>This nationwide study revealed that Class IV‐G (±V) was the most prevalent form of LN in Japan and was associated with a severe clinical renal presentation.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004235802684935","@type":"Researcher","foaf:name":[{"@value":"Keiju Hiromura"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine and Clinical Science Gunma University Graduate School of Medicine  Maebashi Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235802684938","@type":"Researcher","foaf:name":[{"@value":"Hidekazu Ikeuchi"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine and Clinical Science Gunma University Graduate School of Medicine  Maebashi Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235802684809","@type":"Researcher","foaf:name":[{"@value":"Ken Kayakabe"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine and Clinical Science Gunma University Graduate School of Medicine  Maebashi Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235802684813","@type":"Researcher","foaf:name":[{"@value":"Hitoshi Sugiyama"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine and Clinical Science Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences  Okayama Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235802684675","@type":"Researcher","foaf:name":[{"@value":"Michio Nagata"}],"jpcoar:affiliationName":[{"@value":"Department of Kidney and Vascular Pathology, Faculty of Medicine University of Tsukuba  Tsukuba Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235802684934","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Sato"}],"jpcoar:affiliationName":[{"@value":"Clinical Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences Tohoku University  Sendai Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235802684816","@type":"Researcher","foaf:name":[{"@value":"Hitoshi Yokoyama"}],"jpcoar:affiliationName":[{"@value":"Division of Nephrology Kanazawa Medical University School of Medicine  Uchinada Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235802684930","@type":"Researcher","foaf:name":[{"@value":"Yoshihisa Nojima"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine and Clinical Science Gunma University Graduate School of Medicine  Maebashi Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13205358"},{"@type":"EISSN","@value":"14401797"}],"prism:publicationName":[{"@value":"Nephrology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2017-10-17","prism:volume":"22","prism:number":"11","prism:startingPage":"885","prism:endingPage":"891"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fnep.12863"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/nep.12863"}],"createdAt":"2016-07-27","modifiedAt":"2023-09-29","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Biopsy","dc:title":"Biopsy"},{"@id":"https://cir.nii.ac.jp/all?q=Kidney","dc:title":"Kidney"},{"@id":"https://cir.nii.ac.jp/all?q=Lupus%20Nephritis","dc:title":"Lupus Nephritis"},{"@id":"https://cir.nii.ac.jp/all?q=Cross-Sectional%20Studies","dc:title":"Cross-Sectional Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Registries","dc:title":"Registries"},{"@id":"https://cir.nii.ac.jp/all?q=Glomerular%20Filtration%20Rate","dc:title":"Glomerular Filtration Rate"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781915324672","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16K09616"},{"@type":"JGN","@value":"JP16K09616"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K09616/"}],"notation":[{"@language":"ja","@value":"尿細管特異的保護機構発現による腎疾患の新規治療法開発"},{"@language":"en","@value":"Development of novel therapeutic approaches for kidney diseases by protection specific for tubular 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