{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004235974239232.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1128/iai.00881-18"}},{"identifier":{"@type":"URI","@value":"https://journals.asm.org/doi/pdf/10.1128/IAI.00881-18"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"<i>Salmonella</i>Fimbrial Protein FimH Is Involved in Expression of Proinflammatory Cytokines in a Toll-Like Receptor 4-Dependent Manner"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Type 1 fimbriae are proteinaceous filamentous structures present on bacterial surfaces and are mainly composed of the major fimbrial protein subunit FimA and the adhesive protein FimH, which is located at the tip of the fimbrial shaft. Here, we investigated the involvement of type 1 fimbriae in the expression of proinflammatory cytokines in macrophages infected with<jats:named-content content-type=\"genus-species\">Salmonella enterica</jats:named-content>serovar Typhimurium.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004235974239106","@type":"Researcher","foaf:name":[{"@value":"Kei-ichi Uchiya"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology, Faculty of Pharmacy, Meijo University, Nagoya, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235974239369","@type":"Researcher","foaf:name":[{"@value":"Yurie Kamimura"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology, Faculty of Pharmacy, Meijo University, Nagoya, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235974239371","@type":"Researcher","foaf:name":[{"@value":"Ayumi Jusakon"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology, Faculty of Pharmacy, Meijo University, Nagoya, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235974239241","@type":"Researcher","foaf:name":[{"@value":"Toshiaki Nikai"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology, Faculty of Pharmacy, Meijo University, Nagoya, Japan"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1380004235974239248","@type":"Researcher","foaf:name":[{"@value":"Manuela Raffatellu"}],"role":"editor"}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00199567"},{"@type":"EISSN","@value":"10985522"}],"prism:publicationName":[{"@value":"Infection and Immunity"}],"dc:publisher":[{"@value":"American Society for Microbiology"}],"prism:publicationDate":"2019-03","prism:volume":"87","prism:number":"3"},"reviewed":"false","dc:rights":["https://journals.asm.org/non-commercial-tdm-license"],"url":[{"@id":"https://journals.asm.org/doi/pdf/10.1128/IAI.00881-18"}],"createdAt":"2019-01-03","modifiedAt":"2023-09-12","project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256825427328","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K08049"},{"@type":"JGN","@value":"JP15K08049"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08049/"}],"notation":[{"@language":"ja","@value":"非結核性抗酸菌症の病態および増加要因の解明とその臨床応用"},{"@language":"en","@value":"Analysis of clinical manifestations or increased factor of nontuberculous mycobacteria disease and its clinical application"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360001114115008256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Carbohydrate-binding sites of the mannose-specific fimbrial lectins of enterobacteria"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144654227584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"LPS induction of gene expression in human monocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145779922560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Type 1 fimbriae are important factors limiting the dissemination and colonization of mice by Salmonella Enteritidis and contribute to the induction of intestinal inflammation during Salmonella invasion"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013199865892608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pathogenicity Islands and the Evolution of<i>Salmonella</i>Virulence"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016870028408320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Involvement of mitogen-activated protein kinase pathways in the nuclear responses and cytokine production induced by Salmonella typhimurium in cultured intestinal epithelial cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618863833600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fimbriae and infectivity in Salmonella typhimurium (Plate XXIX)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619515620096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Signal transduction through NF-κB"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620208497024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cutting Edge: FimH Adhesin of Type 1 Fimbriae Is a Novel TLR4 Ligand"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095164422784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fimbriae and adhesive properties in salmonellae"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095350379904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>Salmonella enterica</i>Serovar Typhimurium Infection Induces Cyclooxygenase 2 Expression in Macrophages: Involvement of<i>Salmonella</i>Pathogenicity Island 2"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095606924672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096056367360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Analysis of the Type 1 Pilin Gene Cluster\n            <i>fim</i>\n            in\n            <i>Salmonella</i>\n            : Its Distinct Evolutionary Histories in the 5′ and 3′ Regions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576216045699840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the\n                    <i>Lps</i>\n                    Gene Product"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232151013504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Salmonella fimbrial protein StcD induces cyclooxygenase-2 expression via Toll-like receptor 4"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043645078528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prolonged Impact of Antibiotics on Intestinal Microbial Ecology and Susceptibility to Enteric\n                    <i>Salmonella</i>\n                    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Enteropathogenic\n                    <i>Salmonella</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044876120192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>Salmonella</i>: strategies for survival"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044897939968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045289503104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The<i>Salmonella enterica</i>Serotype Typhimurium Effector Proteins SipA, SopA, SopB, SopD, and SopE2 Act in Concert To Induce Diarrhea in Calves"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045453024512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>Salmonella</i>Interactions with Host Cells: Type III Secretion at Work"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045857103744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium."}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519552607744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cytokine Profiling of Macrophages Exposed to<i>Porphyromonas gingivalis</i>, Its Lipopolysaccharide, or Its FimA Protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519576293888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in\n            <i>Tlr4</i>\n            Gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520191338240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Cell Biology of Macrophage Activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520891707776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential interactions of fimbriae and lipopolysaccharide from Porphyromonas gingivalis with the Toll-like receptor 2-centred pattern recognition apparatus"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520927805440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521254583040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Shared Principles in NF-κB Signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993808164352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Type 1 Fimbriated<i>Escherichia coli–</i>Mast Cell Interactions in Cystitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995079485440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fimbria-dependent activation of pro-inflammatory molecules in Porphyromonas gingivalis infected human aortic endothelial cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943527694848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bacterial Fimbriae Stimulate Proinflammatory Activation in the Endothelium through Distinct TLRs"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943916235776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"FimH adhesin of type 1 pili is assembled into a fibrillar tip structure in the Enterobacteriaceae."}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944831774848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"CsgA is a pathogen‐associated molecular pattern of <i>Salmonella enterica</i> serotype Typhimurium that is recognized by Toll‐like receptor 2"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945767598336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"FimH Adhesin of Type 1 Fimbriae Is a Potent Inducer of Innate Antimicrobial Responses Which Requires TLR4 and Type 1 Interferon Signalling"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419359065600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Flagellin, a Novel Mediator of\n                    <i>Salmonella</i>\n                    -Induced Epithelial Activation and Systemic Inflammation: IκBα Degradation, Induction of Nitric Oxide Synthase, Induction of Proinflammatory Mediators, and Cardiovascular Dysfunction"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419548032512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"In Macrophages, Caspase-1 Activation by SopE and the Type III Secretion System-1 of S. Typhimurium Can Proceed in the Absence of Flagellin"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893805417088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Salmonella enterica Serovar Typhimurium Exploits Inflammation to Compete with the Intestinal Microbiota"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894979925120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of a pathogenicity island required for Salmonella survival in host cells."}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368408037888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bacterial Fimbriae and Their Peptides Activate Human Gingival Epithelial Cells through Toll-Like Receptor 2"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369421419392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Type 1 Pili Enhance the Invasion of <i>Salmonella braenderup</i> and 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virulence and proliferation in macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268519540992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Polymyxin-B inhibition of LPS-induced interleukin-1 secretion by human monocytes is dependent upon the LPS origin"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268642149504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Allosteric Catch Bond Properties of the FimH Adhesin from Salmonella enterica Serovar Typhimurium"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269758286080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"X-ray Structure of the FimC-FimH Chaperone-Adhesin Complex from Uropathogenic\n            <i>Escherichia coli</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270131373056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"FimH-mediated Escherichia coli K1 invasion of human brain 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article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1128/iai.00881-18"},{"@type":"KAKEN","@value":"PRODUCT-22003684"},{"@type":"OPENAIRE","@value":"doi_dedup___::7328a701e1d21247836313f5a13fcfaa"},{"@type":"CROSSREF","@value":"10.1248/yakushi.20-00193_references_DOI_Va6ccpUPtnsiORzkpXDlW3EOF4K"},{"@type":"CROSSREF","@value":"10.1016/j.jmii.2021.11.001_references_DOI_Va6ccpUPtnsiORzkpXDlW3EOF4K"}]}