{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004235992919680.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1128/mcb.00136-16"}},{"identifier":{"@type":"URI","@value":"https://journals.asm.org/doi/pdf/10.1128/MCB.00136-16"}},{"identifier":{"@type":"URI","@value":"https://www.tandfonline.com/doi/pdf/10.1128/MCB.00136-16"}},{"identifier":{"@type":"PMID","@value":"27457617"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"AJUBA LIM Proteins Limit Hippo Activity in Proliferating Cells by Sequestering the Hippo Core Kinase Complex in the Cytosol"}],"description":[{"notation":[{"@value":"The Hippo pathway controls organ growth and is implicated in cancer development. Whether and how Hippo pathway activity is limited to sustain or initiate cell growth when needed is not understood. The members of the AJUBA family of LIM proteins are negative regulators of the Hippo pathway. In mammalian epithelial cells, we found that AJUBA LIM proteins limit Hippo regulation of YAP, in proliferating cells only, by sequestering a cytosolic Hippo kinase complex in which LATS kinase is inhibited. At the plasma membranes of growth-arrested cells, AJUBA LIM proteins do not inhibit or associate with the Hippo kinase complex. The ability of AJUBA LIM proteins to inhibit YAP regulation by Hippo and to associate with the kinase complex directly correlate with their capacity to limit Hippo signaling during Drosophila wing development. AJUBA LIM proteins did not influence YAP activity in response to cell-extrinsic or cell-intrinsic mechanical signals. Thus, AJUBA LIM proteins limit Hippo pathway activity in contexts where cell proliferation is needed."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004235992919552","@type":"Researcher","foaf:name":[{"@value":"Radhika Jagannathan"}],"jpcoar:affiliationName":[{"@value":"The ICCE Institute, Washington University, St. Louis, Missouri, USA"},{"@value":"Department of Cell Biology and Physiology, Washington University, St. Louis, Missouri, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235992919680","@type":"Researcher","foaf:name":[{"@value":"Gregory V. Schimizzi"}],"jpcoar:affiliationName":[{"@value":"The ICCE Institute, Washington University, St. Louis, Missouri, USA"},{"@value":"Department of Cell Biology and Physiology, Washington University, St. Louis, Missouri, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235992919808","@type":"Researcher","foaf:name":[{"@value":"Kun Zhang"}],"jpcoar:affiliationName":[{"@value":"The ICCE Institute, Washington University, St. Louis, Missouri, USA"},{"@value":"Department of Medicine (Oncology), Washington University, St. Louis, Missouri, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235992919681","@type":"Researcher","foaf:name":[{"@value":"Andrew J. Loza"}],"jpcoar:affiliationName":[{"@value":"The ICCE Institute, Washington University, St. Louis, Missouri, USA"},{"@value":"Department of Biochemistry and Biophysics, Washington University, St. Louis, Missouri, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326205993344","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10343245"},{"@type":"NRID","@value":"1000010343245"},{"@type":"NRID","@value":"9000000187564"},{"@type":"NRID","@value":"9000007054242"},{"@type":"NRID","@value":"9000411520320"},{"@type":"NRID","@value":"9000238936636"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0092303"}],"foaf:name":[{"@value":"Norikazu Yabuta"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Genetics, Research Institute for Microbial Disease, Osaka University, Osaka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235992919809","@type":"Researcher","foaf:name":[{"@value":"Hitoshi Nojima"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Genetics, Research Institute for Microbial Disease, Osaka University, Osaka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004235992919810","@type":"Researcher","foaf:name":[{"@value":"Gregory D. Longmore"}],"jpcoar:affiliationName":[{"@value":"The ICCE Institute, Washington University, St. Louis, Missouri, USA"},{"@value":"Department of Medicine (Oncology), Washington University, St. Louis, Missouri, USA"},{"@value":"Department of Cell Biology and Physiology, Washington University, St. Louis, Missouri, USA"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"10985549"}],"prism:publicationName":[{"@value":"Molecular and Cellular Biology"}],"dc:publisher":[{"@value":"Informa UK Limited"}],"prism:publicationDate":"2016-10-01","prism:volume":"36","prism:number":"20","prism:startingPage":"2526","prism:endingPage":"2542"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://journals.asm.org/doi/pdf/10.1128/MCB.00136-16"},{"@id":"https://www.tandfonline.com/doi/pdf/10.1128/MCB.00136-16"}],"createdAt":"2016-07-26","modifiedAt":"2023-03-17","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Intracellular%20Signaling%20Peptides%20and%20Proteins","dc:title":"Intracellular Signaling Peptides and Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Epithelial%20Cells","dc:title":"Epithelial Cells"},{"@id":"https://cir.nii.ac.jp/all?q=YAP-Signaling%20Proteins","dc:title":"YAP-Signaling Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Articles","dc:title":"Articles"},{"@id":"https://cir.nii.ac.jp/all?q=LIM%20Domain%20Proteins","dc:title":"LIM Domain Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Serine-Threonine%20Kinases","dc:title":"Protein Serine-Threonine Kinases"},{"@id":"https://cir.nii.ac.jp/all?q=Phosphoproteins","dc:title":"Phosphoproteins"},{"@id":"https://cir.nii.ac.jp/all?q=Cytosol","dc:title":"Cytosol"},{"@id":"https://cir.nii.ac.jp/all?q=Drosophila%20melanogaster","dc:title":"Drosophila melanogaster"},{"@id":"https://cir.nii.ac.jp/all?q=HEK293%20Cells","dc:title":"HEK293 Cells"},{"@id":"https://cir.nii.ac.jp/all?q=MCF-7%20Cells","dc:title":"MCF-7 Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Drosophila%20Proteins","dc:title":"Drosophila Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Wings,%20Animal","dc:title":"Wings, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Hippo%20Signaling%20Pathway","dc:title":"Hippo Signaling 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Acts Downstream of α-Catenin to Control Epidermal Proliferation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996362026496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation."}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996459484672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ajuba, a Novel LIM Protein, Interacts with Grb2, Augments Mitogen-Activated Protein Kinase Activity in Fibroblasts, and Promotes Meiotic Maturation of\n                    <i>Xenopus</i>\n                    Oocytes in a Grb2- and Ras-Dependent Manner"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469610307840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ajuba 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Oncogene"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795646142976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795725614080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ajuba Family Proteins Link JNK to Hippo Signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795895869824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The LIM Protein, LIMD1, Regulates AP-1 Activation through an Interaction with TRAF6 to Influence Osteoclast Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269199518208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Fat and Warts signaling pathways: new insights into their regulation,mechanism and 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