{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004236327207808.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1152/ajpregu.00310.2017"}},{"identifier":{"@type":"URI","@value":"https://www.physiology.org/doi/pdf/10.1152/ajpregu.00310.2017"}},{"identifier":{"@type":"PMID","@value":"29513560"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Roles of IL-1α/β in regeneration of cardiotoxin-injured muscle and satellite cell function"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Skeletal muscle regeneration after injury is a complex process involving interactions between inflammatory microenvironments and satellite cells. Interleukin (IL)-1 is a key mediator of inflammatory responses and exerts pleiotropic impacts on various cell types. Thus, we aimed to investigate the role of IL-1 during skeletal muscle regeneration. We herein show that IL-1α/β-double knockout (IL-1KO) mice exhibit delayed muscle regeneration after cardiotoxin (CTX) injection, characterized by delayed infiltrations of immune cells accompanied by suppressed local production of proinflammatory factors including IL-6 and delayed increase of paired box 7 (PAX7)-positive satellite cells postinjury compared with those of wild-type (WT) mice. A series of in vitro experiments using satellite cells obtained from the IL-1KO mice unexpectedly revealed that IL-1KO myoblasts have impairments in terms of both proliferation and differentiation, both of which were reversed by exogenous IL-1β administration in culture. Intriguingly, the delay in myogenesis was not attributable to the myogenic transcriptional program since MyoD and myogenin were highly upregulated in IL-1KO cells, instead appearing, at least in part, to be due to dysregulation of cellular fusion events, possibly resulting from aberrant actin regulatory systems. We conclude that IL-1 plays a positive role in muscle regeneration by coordinating the initial interactions among inflammatory microenvironments and satellite cells. Our findings also provide compelling evidence that IL-1 is intimately engaged in regulating the fundamental function of myocytes.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004236327207941","@type":"Researcher","foaf:name":[{"@value":"Chayanit Chaweewannakorn"}],"jpcoar:affiliationName":[{"@value":"Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan"},{"@value":"Tohoku University Graduate School of Biomedical Engineering, Sendai, 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Hagiwara"}],"jpcoar:affiliationName":[{"@value":"Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236327207937","@type":"Researcher","foaf:name":[{"@value":"Keiichi Sasaki"}],"jpcoar:affiliationName":[{"@value":"Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, Sendai, 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Skeletal"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Proliferation","dc:title":"Cell Proliferation"},{"@id":"https://cir.nii.ac.jp/all?q=MyoD%20Protein","dc:title":"MyoD Protein"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"},{"@id":"https://cir.nii.ac.jp/all?q=Toxins,%20Biological","dc:title":"Toxins, Biological"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256894307968","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16K11580"},{"@type":"JGN","@value":"JP16K11580"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K11580/"}],"notation":[{"@language":"ja","@value":"Fusion Errorによる筋痛の慢性化"},{"@language":"en","@value":"Chronic muscle pain due to the impairment of myoblast 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