{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004236339518976.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1155/2011/407031"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/journals/bmri/2011/407031.pdf"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/journals/bmri/2011/407031.xml"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1155/2011/407031"}},{"identifier":{"@type":"PMID","@value":"21660135"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Dysfunction of Lacrimal and Salivary   Glands in Sjögren′s Syndrome: Nonimmunologic Injury in   Preinflammatory Phase and Mouse Model"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Sjögren′s syndrome (SjS) is a chronic autoimmune disorder characterized by dry eyes and dry mouth due to dacryoadenitis and sialoadenitis with SS‐A/Ro and/or SS‐B/La autoantibodies in genetically predisposed individuals. Destruction of lacrimal and salivary glands by autoimmune reactions may lead to clinical manifestation. However, the mechanisms behind the decreased volume of secretions in tears and saliva are complex and are not fully understood. Exocrine gland dysfunction may precede autoimmunity (acquired immunity) or represent a process independent from inflammation in the pathogenesis of SjS. The preceded functional and morphologic changes of those tissues by nonimmunologic injury before the development of inflammation at the sites of target organs have been implicated. This paper focuses on the several factors and components relating to glandular dysfunction and morphologic changes by nonimmunologic injury during the preinflammatory phase in mouse model, including the factors which link between innate immunity and adaptive immunity.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004236339519104","@type":"Researcher","foaf:name":[{"@value":"Toshiharu Hayashi"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1380582632943341448","@type":"Researcher","foaf:name":[{"@value":"Oreste Gualillo"}],"role":"editor"}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"23146133"},{"@type":"EISSN","@value":"23146141"}],"prism:publicationName":[{"@value":"BioMed Research International"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2011-01","prism:volume":"2011","prism:number":"1"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by/3.0/"],"url":[{"@id":"http://downloads.hindawi.com/journals/bmri/2011/407031.pdf"},{"@id":"http://downloads.hindawi.com/journals/bmri/2011/407031.xml"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1155/2011/407031"}],"createdAt":"2011-06-01","modifiedAt":"2024-07-04","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Lacrimal%20Apparatus","dc:title":"Lacrimal Apparatus"},{"@id":"https://cir.nii.ac.jp/all?q=Autoimmunity","dc:title":"Autoimmunity"},{"@id":"https://cir.nii.ac.jp/all?q=Review%20Article","dc:title":"Review Article"},{"@id":"https://cir.nii.ac.jp/all?q=Adaptive%20Immunity","dc:title":"Adaptive Immunity"},{"@id":"https://cir.nii.ac.jp/all?q=Salivary%20Glands","dc:title":"Salivary Glands"},{"@id":"https://cir.nii.ac.jp/all?q=Sialadenitis","dc:title":"Sialadenitis"},{"@id":"https://cir.nii.ac.jp/all?q=Dacryocystitis","dc:title":"Dacryocystitis"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Sjogren's%20Syndrome","dc:title":"Sjogren's Syndrome"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257059878528","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21580362"},{"@type":"JGN","@value":"JP21580362"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21580362/"}],"notation":[{"@language":"ja","@value":"自己免疫疾患の効果相における効果細胞・分子によるNicheと標的細胞の破壊"},{"@language":"en","@value":"Destruction of niche and target-cells in autoimmune diseases by effector cells and molecules"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144155034368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Viruses induce high expression of BAFF by salivary gland epithelial cells through TLR‐ and type‐I IFN‐dependent and ‐independent pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144667527168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of the type I interferon system in primary Sjögren's syndrome: A possible etiopathogenic mechanism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145726142080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cytokine messenger rna expression in the labial salivary glands of patients with Sjögren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146610348544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fatigue in primary Sjögren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146628170624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjögren’s syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016870028061184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A new animal model for primary Sjögren's syndrome in NFS/\n                    <i>sld</i>\n                    mutant mice."}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710689916032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Chitinase expression in parotid glands of non‐obese diabetic mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618656480512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Systemic and Local Interleukin-17 and Linked Cytokines Associated with Sjögren’s Syndrome Immunopathogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618811927424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin 1β and tumour necrosis factor α secreting cells are increased in the peripheral blood of patients with primary Sjögren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618904992128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction, exacerbation and inhibition of allergic and autoimmune diseases by infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619404438144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Modified aquaporin 5 expression and distribution in submandibular glands from NOD mice displaying autoimmune exocrinopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620083618304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neuropeptides of the autonomic nervous system in Sjögren’s syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620303786496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"P<scp>rogress in</scp> U<scp>nderstanding</scp> A<scp>utoimmune</scp> E<scp>xocrinopathy</scp> U<scp>sing the</scp> N<scp>on-obese</scp> D<scp>iabetic</scp> M<scp>ouse</scp>: A<scp>n</scp> U<scp>pdate</scp>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298345516791296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cytokine mRNA expression in salivary gland biopsies of Sjögren's syndrome."}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093958782848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Systemic increase in type I interferon activity in Sjögren's syndrome: A putative role for plasmacytoid dendritic cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094031725824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Increased Expression of Cathepsins and Obesity-Induced Proinflammatory Cytokines in Lacrimal Glands of Male NOD Mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094217487104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pathogenesis and treatment of Sj??gren??s syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094560916992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autoantibodies in Primary Sjögren's Syndrome: New Insights into Mechanisms of Autoantibody Diversification and Disease Pathogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094576251904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immunohistopathology of Sjögren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094670424576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjögren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094724441344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mild autonomic dysfunction in primary Sjögren's syndrome: a controlled study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095400392448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sjögrens syndrome—the non-apoptotic model of glandular hypofunction"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095447586688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sialoadenitis progression in nonobese diabetic mice and its correlation with expression of apoptosis-associated proteins in salivary glands and serum IgG levels"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096120099968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Impaired vascular responses to parasympathetic nerve stimulation and muscarinic receptor activation in the submandibular gland in nonobese diabetic mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096328694272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Low salivary dehydroepiandrosterone and androgen‐regulated cysteine‐rich secretory protein 3 levels in Sjögren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096575933952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Influence of androgens and pituitary hormones on the structural profile and secretory activity of the lacrimal gland"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096582028032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"T and B Lymphocytes in Peripheral Blood and Tissue Lesions in Sjögren's Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568713214720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Androgen Deficiency, Meibomian Gland Dysfunction, and Evaporative Dry Eye"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568790185216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sicca Complex and Infection With Human Immunodeficiency Virus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569478663808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Characterization of the Changing Lymphocyte Populations and Cytokine Expression in the Exocrine Tissues of Autoimmune Nod Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569838800384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Subcellular distribution of aquaporin 5 in salivary glands in primary Sjögren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571440318336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The distribution of the endogenous retroviruses HERV-K113 and HERV-K115 in health and disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043609538560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Health-related quality of life in patients with primary Sjögren's syndrome: relationship with serum levels of proinflammatory cytokines"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043822739456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autonomic nervous symptoms in primary Sjogren's; syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044811667968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"PATHOGENESIS OF SJÖGREN’S SYNDROME"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045813829376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046515736576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of innate immune responses through Toll‐like receptor 3 causes a rapid loss of salivary gland function"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518824826880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of tear lipocalin as a novel autoantigen target in Sjögren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519499267712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epstein–Barr virus in autoimmune diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519506434176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pathogenetic mechanisms in the initiation and perpetuation of Sjögren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519714169856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Usefulness of mouse models to study the pathogenesis of Sjögren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519777709952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tear Secretion by Lacrimal Glands in Transgenic Mice Lacking Water Channels AQP1, AQP3, AQP4 and AQP5"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520143336704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Critical role of IL‐2 and TGF‐β in generation, function and stabilization of Foxp3<sup>+</sup>CD4<sup>+</sup> Treg"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520146939520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IMMUNOREACTIVE CIRCULATING ALPHA-INTERFERON IS LOW IN SJÖGREN'S SYNDROME"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520182043264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Serum type I interferon activity is dependent on maternal diagnosis in anti‐SSA/Ro–positive mothers of children with neonatal lupus"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520750766976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Th1/Th2 cytokine balance changes with the progress of the immunopathological lesion of Sjogren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521028550400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Basal lamina disorganisation of the acini and ducts of labial salivary glands from patients with Sjögren's syndrome: association with mononuclear cell infiltration"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994447502208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The CGGGG insertion/deletion polymorphism of the <i>IRF5</i> promoter is a strong risk factor for primary Sjögren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994493995392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression of B7 costimulatory molecules by salivary gland epithelial cells in patients with Sj�gren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994506023424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of Autoantibodies to a Pancreatic Antigen in Patients with Idiopathic Chronic Pancreatitis and Sjögrenʼs Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995224806016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Distribution of salivary aquaporin-5 in Sjögren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995403154176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immunogenetics of primary Sj�gren?s syndrome in Colombians"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995648528768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cryptic T-cell epitopes and their role in the pathogenesis of autoimmune diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996012896512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Salivary gland tissue expression of interleukin‐23 and interleukin‐17 in Sjögren's syndrome: Findings in humans and mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468343861632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Difference of Aquaporin 5 Distribution in Acinar and Ductal Cells in Lacrimal and Parotid Glands"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468519335808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetics of systemic lupus erythematosus and Sjögren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468929955072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cytokines in Sjögren’s syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469288434944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Impaired salivary gland function in NOD mice: Association with changes in cytokine profile but not with histopathologic changes in the salivary gland"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469470368640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epstein‐Barr virus (types 1 and 2) in the tear film in Sjogren's syndrome and HIV infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469825488384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"SJÖGRENʼS SYNDROME"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469971497344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An etiopathogenic role for the type I IFN system in SLE"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470444753792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association of copy number variation in the FCGR3B gene with risk of autoimmune diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470524473728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sjögren's syndrome: why autoimmune epithelitis?"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470563604224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Elimination of CD4<sup>+</sup>CD25<sup>+</sup> T cell accelerates the development of glomerulonephritis during the preactive phase in autoimmune‐prone female NZB × NZW F<sub>1</sub> mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944993907200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The geoepidemiology of Sjögren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945106939520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pathogenesis of Sjögren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945223980544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Apoptosis and Sjögren syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945260720384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cytokine Expression in Labial Salivary Glands from Patients with Primary Sjöugren's Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946091824768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human primary Sjögren's syndrome autoantibodies as mediators of nitric oxide release coupled to lacrimal gland muscarinic acetylcholine receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418504971904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Circulating antibodies against rat parotid gland M3 muscarinic receptors in primary Sjögren’s syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418567230592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Androgens and Integrins in Salivary Glands in Sjögren’s Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418960203136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Infection in systemic lupus erythematosus: friend or foe?"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419059327104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420063657856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Circulating Cytokines in Primary Sjögren's Syndrome Determined by a Multiplex Cytokine Array System"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420130579328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Alpha 6.beta 1 integrin (laminin receptor) is down-regulated by tumor necrosis factor alpha and interleukin-1 beta in human endothelial cells."}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420538156928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Distribution and roles of aquaporins in salivary glands"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420702357376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lacrimal gland fluid secretion and lymphocytic infiltration in the NZB/W mouse model of Sjögren’s syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893435312896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Selective Down-Regulation of Aquaporin-1 in Salivary Glands in Primary Sjögren's Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893770694016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjögren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893874032256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of IL-18 and Th17 Cells in Salivary Glands of Patients with Sjögren’s Syndrome, and Amplification of IL-17-Mediated Secretion of Inflammatory Cytokines from Salivary Gland Cells by IL-18"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894207422336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Androgen Deficiency and Defective Intracrine Processing of Dehydroepiandrosterone in Salivary Glands in Sjögren’s Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894270495360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetically Programmed Development of Salivary Gland Abnormalities in the NOD (Nonobese Diabetic)-scidMouse in the Absence of Detectable Lymphocytic Infiltration: A Potential Trigger for Sialoadenitis of NOD Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894678173952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association of an <i>IRF5</i> gene functional polymorphism with Sjögren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894859100672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ultrastructure of myoepithelial cells as a target cell in sialoadenitis of submandibular glands of lupus-prone female NZBxNZWF1 mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895164084864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Influence of Sex Steroids on Sjögren's Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895972545280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Proinflammatory cytokines tumor necrosis factor-α and interferon-γ alter tight junction structure and function in the rat parotid gland Par-C10 cell line"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369248784128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neuroendocrine Dysfunction in Sjögren’s Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369309252480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A weak signal for strong responses: interferon-alpha/beta revisited"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370313545344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Relationship between Sialoadenitis and Periductal Laminin Expression in the Submandibular Salivary Gland of NZBxNZWF1Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371048281472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fas-Induced Apoptosis Is a Rare Event in Sjögren's Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371093758080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Age-related Alterations in IL-1β, TNF-α, and IL-6 Concentrations in Parotid Acinar Cells from BALB/c and Non-obese Diabetic Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371317856512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Monoclonal Antibody Detection of Laminin in Minor Salivary Glands of Patients with Sjögren's Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843956634496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammatory stimuli accelerate Sjögren's syndrome–like disease in (NZB × NZW)F<sub>1</sub> mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844039819520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Primary Sjögren's Syndrome Associated Neuropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844505062016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular mechanisms mediated by human endogenous retroviruses (HERVs) in autoimmunity"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846084987136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression of HLA-DR and Cytokine Genes on Interferon-&gamma;-Stimulated Human Salivary Gland Cell Line"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320565151744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthetic CpG oligodeoxynucleotides accelerate the development of lupus                 nephritis during preactive phase in NZB ×NZWF1 mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320617283072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Type I Interferon in Systemic Lupus Erythematosus and Other Autoimmune Diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320845041152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An Alternative Perspective to the Immune Response in Autoimmune Exocrinopathy: Induction of Functional Quiescence Rather Than Destructive Autoaggression"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793242692864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pathogenesis of Sjögren's syndrome and therapeutic consequences"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793346253312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Innervation pattern and Ca<sup>2+</sup> signalling in labial salivary glands of healthy individuals and patients with primary Sjögren’s syndrome (pSS)"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793904860672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Systemic treatment of anti‐CD4<sup>+</sup>CD25<sup>+</sup> T cell monoclonal antibody exacerbates sialoadenitis in submandibular glands during the early life in lupus‐prone female NZB × NZWF<sub>1</sub> mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793940787584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lipopolysaccharide‐induced elevation and secretion of interleukin‐1β in the submandibular gland of male mice*"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794922328960","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Two Different Types of Sialoadenitis in the NOD- and MRL/lpr Mouse Models for Sjögren's Syndrome: A Differential Role for Dendritic Cells in the Initiation of Sialoadenitis?"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795750438016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Abnormal Distribution of Aquaporin-5 Water Channel Protein in Salivary Glands from Sjögren's Syndrome Patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268192598784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Disruption of tight junction structure in salivary glands from Sjögren's syndrome patients is linked to proinflammatory cytokine exposure"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268328858624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Serum antibodies to carbonic anhydrase I and II in patients with idiopathic chronic pancreatitis and Sjogren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268399248896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammatory Mediators in Autoimmune Lacrimal Gland Disease in MRL/Mpj Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268586209024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Salivary Acinar Cells from Aquaporin 5-deficient Mice Have Decreased Membrane Water Permeability and Altered Cell Volume Regulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269484743936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Impaired microvascular response to cholinergic stimuli in primary Sjögren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269778113280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lack of efficacy of etanercept in Sjögren syndrome correlates with failed suppression of tumour necrosis factor α and systemic immune activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270216914176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271214642176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Development of Sjögren’s Syndrome in Nonobese Diabetic-Derived Autoimmune-Prone C57BL/6.NOD-\n                    <i>Aec1Aec2</i>\n                    Mice Is Dependent on Complement Component-3"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271231118848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Acetylcholine-evoked calcium mobilization and ion channel activation in human labial gland acinar cells from patients with primary Sjögren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1370582632943341440","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inappropriate apoptosis of salivary and lacrimal gland epithelium of immunodeficient NOD-scid mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1370582632943341441","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autonomic nervous system dysfunction involving the gastrointestinal and the urinary tracts in primary Sjögren′s syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1370582632943341442","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Impaired neurotransmitter release from lacrimal and salivary gland nerves of a murine model of Sjögren′s syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1370582632943341445","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of infectious agents in systemic rheumatic diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1370582632943341446","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Abnormal distribution of aquaporin-5 in salivary glands in the NOD mouse model for Sjögren′s syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1370582632943341447","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Viruses in the etiopathogenesis of Sjögren′s syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1370582632943341448","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role, of proinflammatory cytokines in the impaired lacrimation associated with autoimmune xerophthalmia"}]},{"@id":"https://cir.nii.ac.jp/crid/1370582632943341569","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic leucocytoclastic vasculitis in NZBxNZWF1 mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1370582632943341570","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sjogren′s syndrome in relation to other autoimmune diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1370582632943341571","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Salivary gland changes in the NOD mouse model for Sjögren′s syndrome: is there a non-immune genetic trigger?"}]},{"@id":"https://cir.nii.ac.jp/crid/1370582632943341573","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autonomic cardiovascular neuropathy in Sjögren′s syndrome. A controlled study"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681321985664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of Cevimeline on the Immunolocalization of Aquaporin-5 and the Ultrastructure of Salivary Glands in Sjoegren's Syndrome Model Mice"},{"@value":"Effects of Cevimeline on the Immunolocalization of Aquaporin-5 and the Ultrastructure of Salivary Glands in Sjögren’s Syndrome Model Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854174679765376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Aquaporins in health and disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075402117120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The spectrum of benign to malignant lymphoproliferation in Sjogren's syndrome"},{"@value":"The spectrum of benign to malignant lymphoproliferation in Sjögren′s syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231874818135168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pro-and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1155/2011/407031"},{"@type":"KAKEN","@value":"PRODUCT-12882280"},{"@type":"KAKEN","@value":"PRODUCT-12882290"},{"@type":"OPENAIRE","@value":"doi_dedup___::baaa98f9dd12b3e2e8279d6328de37e6"},{"@type":"CROSSREF","@value":"10.1111/j.1601-0825.2012.01904.x_references_DOI_WI6vAuh00imYldxLSdUmiLhvxHl"}]}