{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004236343207808.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1155/2013/170316"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/archive/2013/170316.pdf"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/archive/2013/170316.xml"}},{"identifier":{"@type":"PMID","@value":"24967302"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Traveled Distance Is a Sensitive and Accurate Marker of Motor Dysfunction in a Mouse Model of Multiple Sclerosis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Multiple sclerosis (MS) is a common central nervous system disease associated with progressive physical impairment. To study the mechanisms of the disease, we used experimental autoimmune encephalomyelitis (EAE), an animal model of MS. EAE is induced by myelin oligodendrocyte <mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mrow><mml:mtext>glycoprotein</mml:mtext></mml:mrow><mml:mrow><mml:mn mathvariant=\"normal\">3</mml:mn><mml:mn mathvariant=\"normal\">5</mml:mn><mml:mtext>–</mml:mtext><mml:mn mathvariant=\"normal\">5</mml:mn><mml:mn mathvariant=\"normal\">5</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math> peptide, and the severity of paralysis in the disease is generally measured using the EAE score. Here, we compared EAE scores and traveled distance using the open-field test for an assessment of EAE progression. EAE scores were obtained with a 6-step observational scoring system for paralysis, and the traveled distance was obtained by automatic trajectory analysis of natural exploratory behaviors detected by a computer. The traveled distance of the EAE mice started to decrease significantly at day 7 of the EAE process, when the EAE score still did not reflect a change. Moreover, in the relationship between the traveled distance and paralysis as measured by the EAE score after day 14, there was a high coefficient of determination between the distance and the score. The results suggest that traveled distance is a sensitive marker of motor dysfunction in the early phases of EAE progression and that it reflects the degree of motor dysfunction after the onset of paralysis in EAE.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326234769792","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70297547"},{"@type":"NRID","@value":"1000070297547"},{"@type":"NRID","@value":"9000397860742"},{"@type":"NRID","@value":"9000006498532"},{"@type":"NRID","@value":"9000011100972"},{"@type":"NRID","@value":"9000258112243"},{"@type":"NRID","@value":"9000253621885"},{"@type":"NRID","@value":"9000410015981"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0190910"}],"foaf:name":[{"@value":"Takako Takemiya"}],"jpcoar:affiliationName":[{"@value":"Medical Research Institute, Tokyo Women’s Medical University, Tokyo 162-8666, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236343207808","@type":"Researcher","foaf:name":[{"@value":"Chisen Takeuchi"}],"jpcoar:affiliationName":[{"@value":"Kita Medical and Rehabilitation Center for Disabled, Tokyo 114-0033, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"23144661"}],"prism:publicationName":[{"@value":"ISRN Neuroscience"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2013-12-10","prism:volume":"2013","prism:startingPage":"1","prism:endingPage":"4"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by/3.0/"],"url":[{"@id":"http://downloads.hindawi.com/archive/2013/170316.pdf"},{"@id":"http://downloads.hindawi.com/archive/2013/170316.xml"}],"createdAt":"2013-12-10","modifiedAt":"2020-12-10","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Research%20Article","dc:title":"Research Article"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782260175232","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25461563"},{"@type":"JGN","@value":"JP25461563"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461563/"}],"notation":[{"@language":"ja","@value":"神経可塑性における細胞接着分子Arcadlinの役割"},{"@language":"en","@value":"Role of Arcadlin on synaptic plasticity"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360567182344556032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Microsomal prostaglandin E synthase-1 aggravates inflammation and demyelination in a mouse model of multiple sclerosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093978929152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H‐2<sup>b</sup> mice: Fine specificity and T cell receptor Vβ expression of encephalitogenic T cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095551360512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Active induction of experimental allergic encephalomyelitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658886186624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570343466496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The immunopathology of adoptively transferred experimental allergic encephalomyelitis (EAE) in Lewis rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044205676032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Multiple Sclerosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993369259904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471363601664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cytosolic Phospholipase A2 Plays a Key Role in the Pathogenesis of Multiple Sclerosis-like Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945420783616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Enhancement of Experimental Allergic Encephalomyelitis (EAE) by DNA Immunization with Myelin Proteolipid Protein (PLP) Plasmid DNA"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419779921664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Passive induction of experimental allergic 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Modulation by anti-inflammatory treatments"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843694460928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Acute Experimental Allergic Encephalomyelitis in SJL/J Mice Induced by a Synthetic Peptide of Myelin Proteolipid Protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845061413248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Behavioral aspects of experimental autoimmune encephalomyelitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318220649728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"[37] Experimental allergic encephalomyelitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321087704704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"T‐ and B‐cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1155/2013/170316"},{"@type":"KAKEN","@value":"PRODUCT-15083987"},{"@type":"OPENAIRE","@value":"doi_dedup___::08aa3eca82f6a155646322697a84d215"}]}