{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004236357610112.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1155/2018/5450768"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/journals/sci/2018/5450768.pdf"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/journals/sci/2018/5450768.xml"}},{"identifier":{"@type":"PMID","@value":"30224921"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Detection, Characterization, and Clinical Application of Mesenchymal Stem Cells in Periodontal Ligament Tissue"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Mesenchymal stem cells (MSCs) are a kind of somatic stem cells that exert a potential to differentiate into multiple cell types and undergo robust clonal self-renewal; therefore, they are considered as a highly promising stem cell population for tissue engineering. MSCs are identified in various adult organs including dental tissues. Periodontal ligament (PDL) is a highly specialized connective tissue that surrounds the tooth root. PDL also contains MSC population, and many researchers have isolated them and performed their detailed characterization. Here, we review the current understanding of the features and functions of MSC population in PDL tissues and discuss their possibility for the application of PDL regeneration.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751159749888","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20507777"},{"@type":"NRID","@value":"1000020507777"},{"@type":"ORCID","@value":"0000-0002-1638-4008"},{"@type":"NRID","@value":"9000406390472"},{"@type":"NRID","@value":"9000237786850"},{"@type":"NRID","@value":"9000380969197"},{"@type":"NRID","@value":"9000409360005"},{"@type":"NRID","@value":"9000365539763"},{"@type":"NRID","@value":"9000410606520"},{"@type":"NRID","@value":"9000378124573"},{"@type":"NRID","@value":"9000399346020"},{"@type":"NRID","@value":"9000399346002"},{"@type":"NRID","@value":"9000415434631"},{"@type":"NRID","@value":"9000403952297"},{"@type":"NRID","@value":"9000414073318"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/tomoki4"}],"foaf:name":[{"@value":"Atsushi Tomokiyo"}],"jpcoar:affiliationName":[{"@value":"Division of Endodontics, Kyushu University Hospital, Fukuoka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236357610496","@type":"Researcher","foaf:name":[{"@value":"Shinichiro Yoshida"}],"jpcoar:affiliationName":[{"@value":"Division of Endodontics, Kyushu University Hospital, Fukuoka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236357610240","@type":"Researcher","foaf:name":[{"@value":"Sayuri Hamano"}],"jpcoar:affiliationName":[{"@value":"Department of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan"},{"@value":"OBT Research Center, Kyushu University, Fukuoka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236357610113","@type":"Researcher","foaf:name":[{"@value":"Daigaku Hasegawa"}],"jpcoar:affiliationName":[{"@value":"Division of Endodontics, Kyushu University Hospital, Fukuoka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236357610112","@type":"Researcher","foaf:name":[{"@value":"Hideki Sugii"}],"jpcoar:affiliationName":[{"@value":"Division of Endodontics, Kyushu 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Maeda"}],"jpcoar:affiliationName":[{"@value":"Division of Endodontics, Kyushu University Hospital, Fukuoka, Japan"},{"@value":"Department of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"1687966X"},{"@type":"EISSN","@value":"16879678"}],"prism:publicationName":[{"@value":"Stem Cells International"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2018-08-26","prism:volume":"2018","prism:startingPage":"1","prism:endingPage":"9"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"http://downloads.hindawi.com/journals/sci/2018/5450768.pdf"},{"@id":"http://downloads.hindawi.com/journals/sci/2018/5450768.xml"}],"createdAt":"2018-08-26","modifiedAt":"2018-08-26","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Review%20Article","dc:title":"Review Article"},{"@id":"https://cir.nii.ac.jp/all?q=Internal%20medicine","dc:title":"Internal medicine"},{"@id":"https://cir.nii.ac.jp/all?q=RC31-1245","dc:title":"RC31-1245"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781957808512","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17H04385"},{"@type":"JGN","@value":"JP17H04385"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04385/"}],"notation":[{"@language":"ja","@value":"iPS由来神経堤細胞によるバイオミメティクスに基づいた新規歯周組織再生療法の開発"},{"@language":"en","@value":"Development of the new periodontal ligament regeneration method based on iPS-derived neural crest cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782006279424","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K19651"},{"@type":"JGN","@value":"JP18K19651"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K19651/"}],"notation":[{"@language":"ja","@value":"iPS創薬とゲノム創薬の融合による歯根膜幹細胞賦活化物質の創出と再生医療への応用"},{"@language":"en","@value":"Generation of a compound that has the potential to induce the formation of PDLSCs using iPS- and genome-based drug discovery technology."}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256931296000","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17H01598"},{"@type":"JGN","@value":"JP17H01598"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H01598/"}],"notation":[{"@language":"ja","@value":"iPS細胞を用いた3次元的歯根膜作製法の確立と人工歯根開発への応用"},{"@language":"en","@value":"Establishment of the the method to develop 3D-periodontal ligament from iPS cells, and its application for artificial tooth root"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050306506459193344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Vascular Cell-Like Potential of Undifferentiated Ligament Fibroblasts to Construct Vascular Cell-Specific Marker-Positive Blood Vessel Structures in a PI3K Activation-Dependent Manner"}]},{"@id":"https://cir.nii.ac.jp/crid/1050564289002450304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Enhanced bone-forming activity of side population cells in the periodontal ligament."}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232006608896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comparison of different tissue-derived stem cell sheets for periodontal regeneration in a canine 1-wall defect 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Bone"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567184436733440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differentiation of Induced Pluripotent Stem Cells Into Dental Mesenchymal Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186812709632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Promise of periodontal ligament stem cells in regeneration of periodontium"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092563330304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mass acquisition of human periodontal ligament stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093833938688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immortalized cementoblasts and periodontal ligament cells in 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cells to IFN-γ and TLR-agonists"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570000250624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Erk1/2 signalling is involved in the differentiation of periodontal ligament stem cells to Schwann cells in dog"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570370390016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The efficacy of mesenchymal stem cells to regenerate and repair dental structures"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046230076672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lipopolysaccharide can modify differentiation and immunomodulatory potential of periodontal ligament stem cells via ERK1,2 signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046371067648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Isolation of multipotent stem cells from adult rat periodontal ligament by neurosphere-forming culture system"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520037870080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"On the Repair Potential of Periodontal Tissues"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993428243584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Embryonic Stem Cell Lines Derived from Human Blastocysts"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994245845120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differentiation of Neural-Crest-Derived Intermediate Pluripotent Progenitors into Committed Periodontal Populations Involves Unique Molecular Signature Changes, Cohort Shifts, and Epigenetic Modifications"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994573001600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transdifferentiation of human periodontal ligament stem cells into pancreatic cell 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<sup>+</sup>\n                    PDL Mesenchymal Progenitor Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943883392000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immortalization of human dental papilla, dental pulp, periodontal ligament cells and gingival fibroblasts by telomerase reverse transcriptase"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945766764544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mesenchymal progenitor cells in human umbilical cord blood"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418785810816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanisms that Regulate Stem Cell Aging and Life Span"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420749253504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cells With Osteoblastic Phenotypes Can Be Explanted From Human Gingiva and Periodontal Ligament"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420769216256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894606487552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Multilineage Potential of Adult Human Mesenchymal Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895639857792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cardiomyogenesis of periodontal ligament-derived stem cells by dynamic tensile strain"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895781823104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Allogeneic Periodontal Ligament Stem Cell Therapy for Periodontitis in Swine"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896168543616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Priming integrin alpha 5 promotes the osteogenic differentiation of human periodontal ligament stem cells due to cytoskeleton and cell cycle changes"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896399790976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immunomodulatory properties of human periodontal ligament stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368507451648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Periodontal Ligament Stem Cells in the Periodontitis Microenvironment Are Sensitive to Static Mechanical Strain"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368612826496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sonic Hedgehog Stimulates Proliferation of Human Periodontal Ligament Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369223992704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression profile of the embryonic markers nanog, OCT‐4, SSEA‐1, SSEA‐4, and frizzled‐9 receptor in human periodontal ligament mesenchymal stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369849873152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Establishing and characterizing human periodontal ligament fibroblasts immortalized by SV40T-antigen and hTERT gene transfer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370651157760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Multipotency of clonal cells derived from swine periodontal ligament and differential regulation by fibroblast growth factor and bone morphogenetic 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