{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004236366960384.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1158/0008-5472.can-12-0088"}},{"identifier":{"@type":"URI","@value":"https://aacrjournals.org/cancerres/article-pdf/73/1/364/2682736/364.pdf"}},{"identifier":{"@type":"PMID","@value":"23066037"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"NF-κB Activity Regulates Mesenchymal Stem Cell Accumulation at Tumor Sites"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>Mesenchymal stem cells (MSC) accumulate at tumor sites when injected into tumor-bearing mice, perhaps offering cellular vectors for cancer-targeted gene therapy. However, the molecular mechanisms involved in MSC targeting the tumors are presently little understood. We focused on MSC–endothelial cell (EC) adhesion following TNF-α stimulation in an attempt to elucidate these mechanisms. Interestingly, stimulation of MSCs with TNF-α enhanced the adhesion of MSCs to endothelial cells in vitro. This adhesion was partially inhibited by blocking antibodies against vascular cell adhesion molecule-1 (VCAM-1) and very late antigen-4 (VLA-4). It is well known that TNF-α induces VCAM-1 expression via the NF-κB signaling pathway. Parthenolide has an anti-inflammatory activity and suppressed NF-κB activity by inhibition of IκBα phosphorylation after TNF-α stimulation and strongly inhibited TNF-α–induced VCAM-1 expression on MSCs. In vivo imaging using luciferase-expressing MSCs revealed that the bioluminescent signal gradually increased at tumor sites in mice injected with untreated MSCs. In contrast, we observed very weak signals at tumor sites in mice injected with parthenolide-treated MSCs. Our results suggest that NF-κB activity regulates MSC accumulation at tumors, by inducing VCAM-1 and thereby its interaction with tumor vessel endothelial cells. These findings have implications for the ongoing development of efficient MSC-based gene therapies for cancer treatment. Cancer Res; 73(1); 364–72. ©2012 AACR.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004236366960387","@type":"Researcher","foaf:name":[{"@value":"Ryosuke Uchibori"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Division of Genetic Therapeutics, Center for Molecular Medicine; 2Department of Obstetrics and Gynecology; 3Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi; and 4Department of Biochemistry and Molecular Biology, Osaka University, Osaka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420292707120551040","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10362120"},{"@type":"NRID","@value":"1000010362120"},{"@type":"NRID","@value":"9000016989492"},{"@type":"NRID","@value":"9000243720852"},{"@type":"NRID","@value":"9000412637222"},{"@type":"NRID","@value":"9000383703451"},{"@type":"NRID","@value":"9000003762351"},{"@type":"NRID","@value":"9000014207101"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0116201"}],"foaf:name":[{"@value":"Tomonori Tsukahara"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Division of Genetic Therapeutics, Center for Molecular Medicine; 2Department of Obstetrics and Gynecology; 3Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi; and 4Department of Biochemistry and Molecular Biology, Osaka University, Osaka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236366960259","@type":"Researcher","foaf:name":[{"@value":"Hiroyuki Mizuguchi"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Division of Genetic Therapeutics, Center for Molecular Medicine; 2Department of Obstetrics and Gynecology; 3Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi; and 4Department of Biochemistry and Molecular Biology, Osaka University, Osaka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236366960386","@type":"Researcher","foaf:name":[{"@value":"Yasushi Saga"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Division of Genetic Therapeutics, Center for Molecular Medicine; 2Department of Obstetrics and Gynecology; 3Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi; and 4Department of Biochemistry and Molecular Biology, Osaka University, Osaka, 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2Department of Obstetrics and Gynecology; 3Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi; and 4Department of Biochemistry and Molecular Biology, Osaka University, Osaka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236366960258","@type":"Researcher","foaf:name":[{"@value":"Akihiro Kume"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Division of Genetic Therapeutics, Center for Molecular Medicine; 2Department of Obstetrics and Gynecology; 3Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi; and 4Department of Biochemistry and Molecular Biology, Osaka University, Osaka, 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Ozawa"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Division of Genetic Therapeutics, Center for Molecular Medicine; 2Department of Obstetrics and Gynecology; 3Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi; and 4Department of Biochemistry and Molecular Biology, Osaka University, Osaka, Japan"},{"@value":"Authors' Affiliations: 1Division of Genetic Therapeutics, Center for Molecular Medicine; 2Department of Obstetrics and Gynecology; 3Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi; and 4Department of Biochemistry and Molecular Biology, Osaka University, Osaka, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00085472"},{"@type":"EISSN","@value":"15387445"}],"prism:publicationName":[{"@value":"Cancer Research"}],"dc:publisher":[{"@value":"American Association for Cancer Research (AACR)"}],"prism:publicationDate":"2013-01-01","prism:volume":"73","prism:number":"1","prism:startingPage":"364","prism:endingPage":"372"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://aacrjournals.org/cancerres/article-pdf/73/1/364/2682736/364.pdf"}],"createdAt":"2012-10-12","modifiedAt":"2022-06-17","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20BALB%20C","dc:title":"Mice, Inbred BALB C"},{"@id":"https://cir.nii.ac.jp/all?q=Blotting,%20Western","dc:title":"Blotting, Western"},{"@id":"https://cir.nii.ac.jp/all?q=NF-kappa%20B","dc:title":"NF-kappa B"},{"@id":"https://cir.nii.ac.jp/all?q=Endothelial%20Cells","dc:title":"Endothelial Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Vascular%20Cell%20Adhesion%20Molecule-1","dc:title":"Vascular Cell Adhesion Molecule-1"},{"@id":"https://cir.nii.ac.jp/all?q=Mesenchymal%20Stem%20Cells","dc:title":"Mesenchymal Stem Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasms,%20Experimental","dc:title":"Neoplasms, Experimental"},{"@id":"https://cir.nii.ac.jp/all?q=Flow%20Cytometry","dc:title":"Flow Cytometry"},{"@id":"https://cir.nii.ac.jp/all?q=Immunohistochemistry","dc:title":"Immunohistochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line,%20Tumor","dc:title":"Cell Line, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Adhesion","dc:title":"Cell Adhesion"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782167782016","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23591548"},{"@type":"JGN","@value":"JP23591548"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591548/"}],"notation":[{"@language":"ja","@value":"ＥＶＩ１癌遺伝子活性化によるゲノム不安定化の分子機構"},{"@language":"en","@value":"Genome instability caused by EVI1 oncogene activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782176889856","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23659493"},{"@type":"JGN","@value":"JP23659493"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659493/"}],"notation":[{"@language":"ja","@value":"再生医療のための部位特異的遺伝子組込み法の開発: 発生工学的手法を用いた基盤研究"},{"@language":"en","@value":"Development of a site-specific gene insertion technology for  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