{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004236376755456.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1158/1940-6207.capr-10-0010"}},{"identifier":{"@type":"URI","@value":"https://aacrjournals.org/cancerpreventionresearch/article-pdf/3/8/940/2248651/940.pdf"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Dual Inhibition of Both the Epidermal Growth Factor Receptor and erbB2 Effectively Inhibits the Promotion of Skin Tumors during Two-Stage Carcinogenesis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:p>The erbB family of receptor tyrosine kinases are known to play important roles in normal epithelial development and epithelial neoplasia. Considerable evidence also suggests that signaling through the epidermal growth factor receptor (EGFR) plays an important role in multistage skin carcinogenesis in mice; however, less is known about the role of erbB2. In this study, to further examine the role of both erbB2 and EGFR in epithelial carcinogenesis, we examined the effect of a dual erbB2/EGFR tyrosine kinase inhibitor, GW2974, given in the diet on skin tumor promotion during two-stage carcinogenesis in wild-type and BK5.erbB2 mice. In BK5.erbB2 mice, erbB2 is overexpressed in the basal layer of epidermis and leads to heightened sensitivity to skin tumor development. GW2974 effectively inhibited skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in wild-type and BK5.erbB2 mice, although a more marked effect was seen in BK5.erbB2 mice. In addition, this inhibitory effect was reversible when GW2974 treatment was withdrawn. GW2974 inhibited 12-O-tetradecanoylphorbol-13-acetate–induced epidermal hyperproliferation, which correlated with reduced activation of both the EGFR and erbB2. These results support the hypothesis that both the EGFR and erbB2 play an important role in the development of skin tumors during two-stage skin carcinogenesis, especially during the tumor promotion stage. Furthermore, the marked sensitivity of BK5.erbB2 mice to the inhibitory effects of GW2974 during tumor promotion suggest greater efficacy for this compound when erbB2 is overexpressed or amplified as an early event in the carcinogenic process. Cancer Prev Res; 3(8); 940–52. ©2010 AACR.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381694371260459267","@type":"Researcher","foaf:name":[{"@value":"Kaoru Kiguchi"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas and 2Division of Pharmacology & Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas"}]},{"@id":"https://cir.nii.ac.jp/crid/1030285133807379584","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60404878"},{"@type":"NRID","@value":"1000060404878"}],"foaf:name":[{"@value":"Takuya Kitamura"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas and 2Division of Pharmacology & Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694371260459392","@type":"Researcher","foaf:name":[{"@value":"Tricia Moore"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas and 2Division of Pharmacology & Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694371260459265","@type":"Researcher","foaf:name":[{"@value":"Mohammad Rumi"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas and 2Division of Pharmacology & Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694371260459396","@type":"Researcher","foaf:name":[{"@value":"Hsiang-Chun Chang"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas and 2Division of Pharmacology & Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694371260459273","@type":"Researcher","foaf:name":[{"@value":"Devon Treece"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas and 2Division of Pharmacology & Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694371260459141","@type":"Researcher","foaf:name":[{"@value":"Lynnsie Ruffino"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas and 2Division of Pharmacology & Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694371260459395","@type":"Researcher","foaf:name":[{"@value":"Kevin Connolly"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas and 2Division of Pharmacology & Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas"}]},{"@id":"https://cir.nii.ac.jp/crid/1381694371260459269","@type":"Researcher","foaf:name":[{"@value":"John DiGiovanni"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas and 2Division of Pharmacology & Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas"},{"@value":"Authors' Affiliations: 1Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas and 2Division of Pharmacology & Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"19406207"},{"@type":"EISSN","@value":"19406215"}],"prism:publicationName":[{"@value":"Cancer Prevention Research"}],"dc:publisher":[{"@value":"American Association for Cancer Research (AACR)"}],"prism:publicationDate":"2010-08-01","prism:volume":"3","prism:number":"8","prism:startingPage":"940","prism:endingPage":"952"},"reviewed":"false","url":[{"@id":"https://aacrjournals.org/cancerpreventionresearch/article-pdf/3/8/940/2248651/940.pdf"}],"createdAt":"2010-08-04","modifiedAt":"2022-06-08","project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257114061952","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22791294"},{"@type":"JGN","@value":"JP22791294"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791294/"}],"notation":[{"@language":"ja","@value":"胆汁誘発性食道癌発生におけるerbB2の役割"},{"@language":"en","@value":"The role of erbB2 during bile-promotedesophageal carcinogenesis"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144358758272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comparative analysis of the expression of ERBIN and Erb-B2 in normal human skin and cutaneous carcinomas."}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618575353600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Altered expression of the epidermal growth factor receptor and transforming growth factor‐α during multistage skin carcinogenesis in SENCAR mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618905084032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Analysis of the Ability of 12-O-Tetradecanoylphorbol-13-Acetate to Induce Epidermal Hyperplasia, Transforming Growth Factor-α, and Skin Tumor Promotion in wa-1 Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619402391808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Growth Factors and Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619901340544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epidermal Growth Factor-related Peptides Activate Distinct Subsets of ErbB Receptors and Differ in Their Biological Activities"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620580194176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3."}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620790460672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Proliferation?differentiation relationships in the expression of heparin-binding epidermal growth factor-related factors and erbB receptors by normal and psoriatic human keratinocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565164539693824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Genomic and transcriptional alterations of cholangiocarcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095630111616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chemopreventive and Therapeutic Efficacy of Orally Active Tyrosine Kinase Inhibitors in a Transgenic Mouse Model of Gallbladder Carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096280555648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Increased level of c-erbB-2/neu/HER-2 protein in cutaneous squamous cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570867423872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Severe follicular hyperplasia and spontaneous papilloma formation in transgenic mice expressing theneu oncogene under the control of the bovine keratin 5 promoter"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043623599104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The deaf and the dumb: the biology of ErbB-2 and ErbB-3"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044743354752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structural analysis of p185c-neu and epidermal growth factor receptor tyrosine kinases: oligomerization of kinase domains."}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045649342592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin."}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046014673280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Constitutive expression of erbB2 in epidermis of transgenic mice results in epidermal hyperproliferation and spontaneous skin tumor development"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046138387584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Distribution of neu (c-erbB-2) Protein in Human Skin"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046317813888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Signal transduction by receptors with tyrosine kinase activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519927746688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Measurement of chemically induced cell proliferation in rodent liver and kidney: a comparison of 5-bromo-2′-deoxyuridine and[<sup>3</sup>H]thymidine administered by injection or osmotic pump"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521239770496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Coexpression patterns of EGFR, HER2, HER3 and HER4 in non-melanoma skin cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993780931072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chemoprevention of UV Light-Induced Skin Tumorigenesis by Inhibition of the Epidermal Growth Factor Receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993899956224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of erbB2 and c-src in phorbol ester-treated mouse epidermis: possible role in mouse skin tumor promotion"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994066250624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Altered expression of epidermal growth factor receptor ligands in tumor promoter–treated mouse epidermis and in primary mouse skin tumors induced by an initiation-promotion protocol"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994156546304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994532525440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comparison of Epidermal Growth Factor Binding and Receptor Distribution in Normal Human Epidermis and Epidermal Appendages"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995024366464","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFα expression in transgenic mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996214378368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comparison of the histological changes in the skin of DBA/2 and C57BL/6 mice following exposure to various promoting agents"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996293686656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression of EGF receptor, involucrin, and cytokeratins in basal cell carcinomas and squamous cell, carcinomas of the skin"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468454817152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470272918272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Heterodimerization of epidermal growth factor receptorand wild-type or kinase-deficient Neu: a mechanism of interreceptor kinaseactivation and transphosphorylation."}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943435950464","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family."}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944700543744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epidermal Growth Factor Receptors in Different Skin Tumors"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945163762304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419181993856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immunohistochemical detection of the epidermal growth factor receptor in paraffin‐embedded human tissues"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893509156608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Erbb2 Regulates Inflammation and Proliferation in the Skin after Ultraviolet Irradiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895432254720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368325379328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Growth factor signaling by receptor tyrosine kinases"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368627520640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential gene expression in epidermis of mice sensitive and resistant to phorbol ester skin tumor promotion"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368639792512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Erbb2 Suppresses DNA Damage-Induced Checkpoint Activation and UV-Induced Mouse Skin Tumorigenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369005997184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer."}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371056878720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The UV (Ribotoxic) Stress Response of Human Keratinocytes Involves the Unexpected Uncoupling of the Ras-Extracellular Signal-Regulated Kinase Signaling Cascade from the Activated Epidermal Growth Factor Receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845045127040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845114983936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation."}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845420645120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epidermal expression of transforming growth factor‐α in transgenic mice: Induction of spontaneous and 12‐<i>O</i>‐tetradecanoylphorbol‐13‐acetate‐induced papillomas via a mechanism independent of Ha‐<i>ras</i> activation or overexpression"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846180433152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318838737792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo."}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320730471808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential Utilization and Localization of ErbB Receptor Tyrosine Kinases in Skin Compared to Normal and Malignant Keratinocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794611140864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions."}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268667009280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential ErbB1 Signaling in Squamous Cell versus Basal Cell Carcinoma of the Skin"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269782590592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Multiple mechanisms of Erbb2 action after ultraviolet irradiation of the skin"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270022717184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"EGFR Activation and Ultraviolet Light‐Induced Skin Carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1370861287966470400","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transgenic overexpression of transforming growth factor bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1371694371260459008","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of the epidermal growth factor receptor by skin tumor promoters and in skin tumors from SENCAR mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1371694371260459009","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Targeted overexpression of TGFα in the epidermis of transgenic mice elicits anomalous differentiation and spontaneous, self-regressing papillomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1371694371260459010","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The epidermal growth factor receptor is required to maintain the proliferative population in the basal compartment of epidermal tumors"}]},{"@id":"https://cir.nii.ac.jp/crid/1371694371260459012","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"High incidence of amplification of the epidermal growth factor receptor gene in human squamous carcinoma cell lines"}]},{"@id":"https://cir.nii.ac.jp/crid/1371694371260459013","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1371694371260459145","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transgenic mice provide genetic evidence that transforming growth factor a promotes skin tumorigenesis via H-Ras-dependent and H-Ras-independent pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1371694371260459264","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Targeted expression of activated erbB-2 to the epidermis of transgenic mice elicits striking developmental abnormalities in the epidermis and hair follicles"}]},{"@id":"https://cir.nii.ac.jp/crid/1371694371260459267","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Targeted disruption of the epidermal growth factor receptor impairs growth of squamous papillomas expressing the v-ras(Ha) oncogene but does not block in vitro keratinocyte responses to oncogenic ras"}]},{"@id":"https://cir.nii.ac.jp/crid/1371694371260459279","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A single physiologic dose of ultraviolet light exposure to human skin in vivo induces phosphorylation of epidermal growth factor receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1371694371260459396","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ultraviolet irradiation activates PI 3-kinase/AKT survival pathway via EGF receptors in human skin in vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1371694371260459399","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The expression of c-erbB-1 and c-erbB-2 oncogenes in basal cell carcinoma and squamous cell carcinoma of skin"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1158/1940-6207.capr-10-0010"},{"@type":"KAKEN","@value":"PRODUCT-13730705"},{"@type":"CROSSREF","@value":"10.1002/jhbp.67_references_DOI_9DLsbsclfy360gpNOfEOnZP8RgS"}]}