{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004236376805760.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1158/1940-6207.capr-13-0244"}},{"identifier":{"@type":"URI","@value":"https://aacrjournals.org/cancerpreventionresearch/article-pdf/6/11/1222/2252123/1222.pdf"}},{"identifier":{"@type":"PMID","@value":"24027214"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Deferasirox Induces Mesenchymal–Epithelial Transition in Crocidolite-Induced Mesothelial Carcinogenesis in Rats"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:p>Asbestos was used worldwide in huge quantities in the past century. However, because of the unexpected carcinogenicity to mesothelial cells with an extremely long incubation period, many countries face this long-lasting social problem. Mesothelioma is often diagnosed in an advanced stage, for which no effective therapeutic protocols are yet established. We previously reported on the basis of animal experiments that the major pathology in asbestos-induced mesothelial carcinogenesis is local iron overload. Here, we undertook to find an effective strategy to prevent, delay, or lower the malignant potential of mesothelioma during asbestos-induced carcinogenesis. We used intraperitoneal injections of crocidolite to rats. We carried out a 16-week study to seek the maximal-tolerated intervention for iron reduction via oral deferasirox administration or intensive phlebotomy. Splenic iron deposition was significantly decreased with either method, and we found that Perls' iron staining in spleen is a good indicator for iron reduction. We injected a total of 10 mg crocidolite at the age of six weeks, and the preventive measures were via repeated oral administration of 25 to 50 mg/kg/d deferasirox or weekly to bimonthly phlebotomy of 4 to 10 mL/kg/d. The animals were observed until 110 weeks. Deferasirox administration significantly increased the fraction of less malignant epithelioid subtype. Although we found a slightly prolonged survival in deferasirox-treated female rats, larger sample size and refinement of the current protocol are necessary to deduce the cancer-preventive effects of deferasirox. Still, our results suggest deferasirox serves as a potential preventive strategy in people already exposed to asbestos via iron reduction. Cancer Prev Res; 6(11); 1222–30. ©2013 AACR.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381412896283835264","@type":"Researcher","foaf:name":[{"@value":"Hirotaka Nagai"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya; and 2Division of Analytical and Physical Chemistry, Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751149598080","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30403489"},{"@type":"NRID","@value":"1000030403489"},{"@type":"NRID","@value":"9000283422851"},{"@type":"NRID","@value":"9000366128602"},{"@type":"NRID","@value":"9000398801595"},{"@type":"NRID","@value":"9000398801722"},{"@type":"NRID","@value":"9000378128259"},{"@type":"NRID","@value":"9000391552593"},{"@type":"NRID","@value":"9000009908699"},{"@type":"NRID","@value":"9000006780564"},{"@type":"NRID","@value":"9000261654699"},{"@type":"NRID","@value":"9000018762743"},{"@type":"NRID","@value":"9000019061581"},{"@type":"NRID","@value":"9000369748163"},{"@type":"NRID","@value":"9000366128597"},{"@type":"NRID","@value":"9000272994209"},{"@type":"NRID","@value":"9000242545028"},{"@type":"NRID","@value":"9000283422428"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0149073"}],"foaf:name":[{"@value":"Yasumasa Okazaki"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya; and 2Division of Analytical and Physical Chemistry, Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381412896283835266","@type":"Researcher","foaf:name":[{"@value":"Shan Hwu Chew"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya; and 2Division of Analytical and Physical Chemistry, Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381412896283835265","@type":"Researcher","foaf:name":[{"@value":"Nobuaki Misawa"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya; and 2Division of Analytical and Physical Chemistry, Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381412896283835397","@type":"Researcher","foaf:name":[{"@value":"Hiroyuki Yasui"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya; and 2Division of Analytical and Physical Chemistry, Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801202513920","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90252460"},{"@type":"NRID","@value":"1000090252460"},{"@type":"ORCID","@value":"0000-0002-5757-1109"},{"@type":"NDL_AUTHOR_ID","@value":"01147585"},{"@type":"CINII_AUTHOR_ID","@value":"DA13635173"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA13635173#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA13635173"},{"@type":"NRID","@value":"9000002126939"},{"@type":"NRID","@value":"9000004687137"},{"@type":"NRID","@value":"9000398406103"},{"@type":"NRID","@value":"9000255942150"},{"@type":"NRID","@value":"9000283422858"},{"@type":"NRID","@value":"9000283422387"},{"@type":"NRID","@value":"9000004298953"},{"@type":"NRID","@value":"9000004108491"},{"@type":"NRID","@value":"9000257906835"},{"@type":"NRID","@value":"9000257907120"},{"@type":"NRID","@value":"9000002833927"},{"@type":"NRID","@value":"9000018565772"},{"@type":"NRID","@value":"9000254646097"},{"@type":"NRID","@value":"9000254192352"},{"@type":"NRID","@value":"9000002126228"},{"@type":"NRID","@value":"9000004039140"},{"@type":"NRID","@value":"9000415038892"},{"@type":"NRID","@value":"9000366128609"},{"@type":"NRID","@value":"9000411077102"},{"@type":"NRID","@value":"9000398801596"},{"@type":"NRID","@value":"9000391999155"},{"@type":"NRID","@value":"9000257906611"},{"@type":"NRID","@value":"9000024285860"},{"@type":"NRID","@value":"9000398406117"},{"@type":"NRID","@value":"9000398801723"},{"@type":"NRID","@value":"9000283422480"},{"@type":"NRID","@value":"9000415313975"},{"@type":"NRID","@value":"9000023018218"},{"@type":"NRID","@value":"9000021744566"},{"@type":"NRID","@value":"9000022199580"},{"@type":"NRID","@value":"9000391552595"},{"@type":"NRID","@value":"9000317154718"},{"@type":"NRID","@value":"9000006602503"},{"@type":"NRID","@value":"9000000697155"},{"@type":"NRID","@value":"9000399532254"},{"@type":"NRID","@value":"9000380962511"},{"@type":"NRID","@value":"9000391595628"},{"@type":"NRID","@value":"9000254641681"},{"@type":"NRID","@value":"9000272994174"},{"@type":"NRID","@value":"9000257742946"},{"@type":"NRID","@value":"9000001949391"},{"@type":"NRID","@value":"9000318134252"},{"@type":"NRID","@value":"9000237784908"},{"@type":"NRID","@value":"9000410510166"},{"@type":"NRID","@value":"9000283423115"},{"@type":"NRID","@value":"9000283421656"},{"@type":"NRID","@value":"9000261654701"},{"@type":"NRID","@value":"9000003102038"},{"@type":"NRID","@value":"9000369748160"},{"@type":"NRID","@value":"9000345218942"},{"@type":"NRID","@value":"9000312723941"},{"@type":"NRID","@value":"9000347192907"},{"@type":"NRID","@value":"9000290132498"},{"@type":"NRID","@value":"9000413359377"},{"@type":"NRID","@value":"9000283421647"},{"@type":"NRID","@value":"9000000989319"},{"@type":"NRID","@value":"9000344126877"},{"@type":"NRID","@value":"9000400189181"},{"@type":"NRID","@value":"9000238862178"},{"@type":"NRID","@value":"9000366128594"},{"@type":"NRID","@value":"9000255679582"},{"@type":"NRID","@value":"9000016391498"},{"@type":"NRID","@value":"9000018473091"},{"@type":"NRID","@value":"9000280547061"},{"@type":"NRID","@value":"9000000731938"},{"@type":"NRID","@value":"9000005729220"},{"@type":"NRID","@value":"9000310741633"},{"@type":"NRID","@value":"9000309574144"},{"@type":"NRID","@value":"9000257907463"},{"@type":"NRID","@value":"9000272994214"},{"@type":"NRID","@value":"9000254645003"},{"@type":"NRID","@value":"9000403159597"},{"@type":"NRID","@value":"9000283423146"},{"@type":"NRID","@value":"9000283421586"},{"@type":"NRID","@value":"9000242545035"},{"@type":"NRID","@value":"9000399480826"},{"@type":"NRID","@value":"9000283422432"},{"@type":"NRID","@value":"9000010696473"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0046817"}],"foaf:name":[{"@value":"Shinya Toyokuni"}],"jpcoar:affiliationName":[{"@value":"Authors' Affiliations: 1Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya; and 2Division of Analytical and Physical Chemistry, Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"19406207"},{"@type":"EISSN","@value":"19406215"}],"prism:publicationName":[{"@value":"Cancer Prevention Research"}],"dc:publisher":[{"@value":"American Association for Cancer Research (AACR)"}],"prism:publicationDate":"2013-11-01","prism:volume":"6","prism:number":"11","prism:startingPage":"1222","prism:endingPage":"1230"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://aacrjournals.org/cancerpreventionresearch/article-pdf/6/11/1222/2252123/1222.pdf"}],"createdAt":"2013-09-12","modifiedAt":"2022-06-08","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Mesothelioma","dc:title":"Mesothelioma"},{"@id":"https://cir.nii.ac.jp/all?q=Epithelial-Mesenchymal%20Transition","dc:title":"Epithelial-Mesenchymal Transition"},{"@id":"https://cir.nii.ac.jp/all?q=Iron","dc:title":"Iron"},{"@id":"https://cir.nii.ac.jp/all?q=Asbestos,%20Crocidolite","dc:title":"Asbestos, Crocidolite"},{"@id":"https://cir.nii.ac.jp/all?q=Triazoles","dc:title":"Triazoles"},{"@id":"https://cir.nii.ac.jp/all?q=Iron%20Chelating%20Agents","dc:title":"Iron Chelating Agents"},{"@id":"https://cir.nii.ac.jp/all?q=Benzoates","dc:title":"Benzoates"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Deferasirox","dc:title":"Deferasirox"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Transformation,%20Neoplastic","dc:title":"Cell Transformation, Neoplastic"},{"@id":"https://cir.nii.ac.jp/all?q=Phlebotomy","dc:title":"Phlebotomy"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Spleen","dc:title":"Spleen"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782103318016","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"221S0001"},{"@type":"JGN","@value":"JP221S0001"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-221S0001/"}],"notation":[{"@language":"ja","@value":"がん研究分野の特性等を踏まえた支援活動"},{"@language":"en","@value":"Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782189874816","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24108008"},{"@type":"JGN","@value":"JP24108008"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-24108008/"}],"notation":[{"@language":"ja","@value":"プラズマ医療科学の臨床応用論的学術基盤の構築と体系化"},{"@language":"en","@value":"Systematization and development of clinical applications for plasma medicine based on scientific infrastructure"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782199943936","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24390094"},{"@type":"JGN","@value":"JP24390094"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24390094/"}],"notation":[{"@language":"ja","@value":"中皮細胞の発がん機構解析による予防基盤の形成"},{"@language":"en","@value":"Establishing preventive strategy for mesothelioma by elucidating its carcinogenic mechanism"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782273489280","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25860292"},{"@type":"JGN","@value":"JP25860292"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860292/"}],"notation":[{"@language":"ja","@value":"発がん動物モデルを用いた悪性中皮腫におけるTwist-1の機能解析"},{"@language":"en","@value":"Functional analyses of Twist-1 in malignant mesothelioma using animal carcinogensis model."}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050845763736000896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Non-thermal plasma induces a stress response in mesothelioma cells resulting in increased endocytosis, lysosome biogenesis and autophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002215778026368","@type":"Article","resourceType":"学術雑誌論文(journal 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hypoxia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005520491040512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Frequent homozygous deletion of <i>Cdkn2a/2b</i> in tremolite‐induced malignant mesothelioma in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142886257792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142906713984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate 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update"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693331688064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis‐resistance to non‐thermal plasma therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707137087616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Iron addiction with ferroptosis-resistance in asbestos-induced mesothelial carcinogenesis: Toward the era of mesothelioma prevention"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710464132224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"CD146 and insulin‐like growth factor 2 <scp>mRNA</scp>‐binding protein 3 predict prognosis of asbestos‐induced rat mesothelioma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617624176128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Overexpression of miR‐199/214 is a distinctive feature of iron‐induced and asbestos‐induced sarcomatoid mesothelioma in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618788292480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Deferasirox: uncertain future following renal failure fatalities, agranulocytosis and other toxicities"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618852129664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Deferasirox-induced renal impairment in children: an increasing concern for pediatricians"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619737021824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammation and EMT: an alliance towards organ fibrosis 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