{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004236401792000.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1159/000354151"}},{"identifier":{"@type":"URI","@value":"https://www.karger.com/Article/Pdf/354151"}},{"identifier":{"@type":"PMID","@value":"24008505"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Prompt Analgesic Effect of Antihistaminic Diphenhydramine Ointment on Bone-Joint-Muscle Pain as Assessed by Skin Impedance"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Pain is sensed, transmitted, and modified via a variety of mediators and their receptors. Histamine is a well-known mediator of pain. In addition to their antagonistic effects against histamine, classical antihistaminics possess, to various degrees, antimuscarinergic, antiserotonergic, antiadrenergic, local anesthetic, membrane-stabilizing and other pharmacologic actions. Although there have been many attempts to use classical antihistaminics as analgesics and/or analgesic adjuvants, the appearance of non-steroidal anti-inflammatory drugs discouraged such efforts.<b> </b>Here, we compared the analgesic effect of an ointment containing 1% diphenhydramine (a typical first-generation antihistaminic drug) with that of indomethacin (a typical non-steroidal anti-inflammatory drug) in elderly patients with osteoarthritis and/or osteoporosis who complained of bone-joint-muscle pain.<b> </b>Analgesic effects were evaluated by measuring skin impedance and by subjective pain assessments (using a visual recording system) before and after ointment application.<b> </b>Diphenhydramine ointment exerted a prompt and marked analgesic effect that lasted for several hours, as assessed by either skin impedance or subjective pain evaluation. In contrast, the analgesic effect of indomethacin ointment was marginal, and significant only an hour or more later than that of diphenhydramine.<b> </b>These results suggest that diphenhydramine ointment may be useful for the relief of the bone-joint-muscle pains that are common in elderly subjects.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004236401792004","@type":"Researcher","foaf:name":[{"@value":"Takuo Fujita"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236401792003","@type":"Researcher","foaf:name":[{"@value":"Yoshio Fujii"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236401792006","@type":"Researcher","foaf:name":[{"@value":"Mutsumi Ohue"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236401792000","@type":"Researcher","foaf:name":[{"@value":"Tsuyoshi Jotoku"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236401792001","@type":"Researcher","foaf:name":[{"@value":"Akimitsu Miyauchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236401792005","@type":"Researcher","foaf:name":[{"@value":"Yasuyuki Takagi"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276165022464","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60372322"},{"@type":"NRID","@value":"1000060372322"},{"@type":"CINII_AUTHOR_ID","@value":"DA19374527"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA19374527#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA19374527"},{"@type":"NRID","@value":"9000004275387"},{"@type":"NRID","@value":"9000004728118"},{"@type":"NRID","@value":"9000409021041"},{"@type":"NRID","@value":"9000023740731"},{"@type":"NRID","@value":"9000021819068"},{"@type":"NRID","@value":"9000362198419"},{"@type":"NRID","@value":"9000345272244"},{"@type":"NRID","@value":"9000375858327"},{"@type":"NRID","@value":"9000318583752"},{"@type":"NRID","@value":"9000405688388"},{"@type":"NRID","@value":"9000257873115"},{"@type":"NRID","@value":"9000360565060"},{"@type":"NRID","@value":"9000257874732"},{"@type":"NRID","@value":"9000379606246"},{"@type":"NRID","@value":"9000322102718"},{"@type":"NRID","@value":"9000305637307"},{"@type":"NRID","@value":"9000402946481"},{"@type":"NRID","@value":"9000409809678"},{"@type":"NRID","@value":"9000257888789"},{"@type":"NRID","@value":"9000004386010"},{"@type":"NRID","@value":"9000411964053"},{"@type":"NRID","@value":"9000387897927"},{"@type":"NRID","@value":"9000345218622"},{"@type":"NRID","@value":"9000024064197"},{"@type":"NRID","@value":"9000345352718"},{"@type":"NRID","@value":"9000409789559"},{"@type":"NRID","@value":"9000411632225"},{"@type":"NRID","@value":"9000378115565"},{"@type":"NRID","@value":"9000322102696"},{"@type":"NRID","@value":"9000286624955"},{"@type":"NRID","@value":"9000398138101"},{"@type":"NRID","@value":"9000406308975"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0055346"}],"foaf:name":[{"@value":"Masahiro Tsuchiya"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236401791872","@type":"Researcher","foaf:name":[{"@value":"Yasuo Endo"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00317012"},{"@type":"EISSN","@value":"14230313"}],"prism:publicationName":[{"@value":"Pharmacology"}],"dc:publisher":[{"@value":"S. Karger AG"}],"prism:publicationDate":"2013","prism:volume":"92","prism:number":"3-4","prism:startingPage":"158","prism:endingPage":"166"},"reviewed":"false","dc:rights":["https://www.karger.com/Services/SiteLicenses","https://www.karger.com/Services/SiteLicenses"],"url":[{"@id":"https://www.karger.com/Article/Pdf/354151"}],"createdAt":"2013-09-05","modifiedAt":"2025-04-23","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Aged,%2080%20and%20over","dc:title":"Aged, 80 and over"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Analgesics","dc:title":"Analgesics"},{"@id":"https://cir.nii.ac.jp/all?q=Anti-Inflammatory%20Agents,%20Non-Steroidal","dc:title":"Anti-Inflammatory Agents, Non-Steroidal"},{"@id":"https://cir.nii.ac.jp/all?q=Indomethacin","dc:title":"Indomethacin"},{"@id":"https://cir.nii.ac.jp/all?q=Histamine%20Antagonists","dc:title":"Histamine Antagonists"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Ointments","dc:title":"Ointments"},{"@id":"https://cir.nii.ac.jp/all?q=Diphenhydramine","dc:title":"Diphenhydramine"},{"@id":"https://cir.nii.ac.jp/all?q=Musculoskeletal%20Pain","dc:title":"Musculoskeletal Pain"},{"@id":"https://cir.nii.ac.jp/all?q=Osteoarthritis","dc:title":"Osteoarthritis"},{"@id":"https://cir.nii.ac.jp/all?q=Electric%20Impedance","dc:title":"Electric Impedance"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Osteoporosis","dc:title":"Osteoporosis"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Pain%20Measurement","dc:title":"Pain Measurement"},{"@id":"https://cir.nii.ac.jp/all?q=Skin","dc:title":"Skin"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257177586944","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24390429"},{"@type":"JGN","@value":"JP24390429"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24390429/"}],"notation":[{"@language":"ja","@value":"マクロファージ賦活化による慢性筋痛新規治療法の開発"},{"@language":"en","@value":"Development of a novel method using macrophage-activated for therapy against chronic muscle pain"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011145155002880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Possible Involvement of Histamine in Muscular Fatigue in Temporomandibular Disorders: Animal and Human Studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145678323328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"There is more than one interleukin 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rat"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298344582101632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Double-blinded comparison of diphenhydramine versus lidocaine as a local anesthetic"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165857036416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Analgesic effects of the non-nitrogen-containing bisphosphonates etidronate and clodronate, independent of anti-resorptive effects on bone"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182172739968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prime role of bone IL-1 in mice may lie in emergency Ca2+-supply to soft tissues, not in bone-remodeling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093740416256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Parathyroid hormone induces a rapid increase in the number of active osteoclasts by releasing histamine from mast cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095811039744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical efficacy of antihistaminics as analgesics"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846645842305280","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Enhanced Nerve–Mast Cell Interaction by a Neuronal Short Isoform of Cell Adhesion Molecule-1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569825684992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Determination of histamine and polyamines in calcified tissues of mice: Contribution of mast cells and histidine decarboxylase to the amount of histamine in the 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the fall of skin impedance"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894518955392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Histamine participates in the early phase of trabecular bone loss in ovariectomized rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369674519552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The effect of lipopolysaccharide, interleukin‐1 and tumour necrosis factor on the hepatic accumulation of 5‐hydroxytryptamine and platelets in the mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370717033088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Calcium paradox disease: Calcium deficiency prompting secondary hyperparathyroidism and cellular calcium overload"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204631773952","@type":"Article","resourceType":"学術雑誌論文(journal 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