{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004236436204416.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1161/hypertensionaha.113.02426"}},{"identifier":{"@type":"URI","@value":"https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.113.02426"}},{"identifier":{"@type":"PMID","@value":"24379178"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Possible Role of Angiotensin-Converting Enzyme 2 and Activation of Angiotensin II Type 2 Receptor by Angiotensin-(1–7) in Improvement of Vascular Remodeling by Angiotensin II Type 1 Receptor Blockade"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n            Cross talk between the angiotensin-converting enzyme (ACE)/angiotensin II (Ang II)/Ang II type 1 (AT\n            <jats:sub>1</jats:sub>\n            ) receptor axis and the ACE2/Ang-(1–7)/Mas axis plays a role in the pathogenesis of cardiovascular remodeling. Furthermore, possible stimulation of the Ang II type 2 (AT\n            <jats:sub>2</jats:sub>\n            ) receptor by Ang-(1–7) has been highlighted as a new pathway. Therefore, we examined the possibility of whether the ACE2/Ang-(1–7)/Mas axis and Ang-(1–7)/AT\n            <jats:sub>2</jats:sub>\n            receptor axis are involved in the inhibitory effects of AT\n            <jats:sub>1</jats:sub>\n            receptor blockers on vascular remodeling. Wild-type, Mas-knockout, and AT\n            <jats:sub>2</jats:sub>\n            receptor knockout mice were used in this study. Vascular injury was induced by polyethylene-cuff placement around the mouse femoral artery. Some mice were treated with azilsartan, an AT\n            <jats:sub>1</jats:sub>\n            receptor blocker, or Ang-(1–7). Neointimal formation 2 weeks after cuff placement was more marked in Mas-knockout mice compared with wild-type mice. Treatment with azilsartan or Ang-(1–7) attenuated neointimal area, vascular smooth muscle cell proliferation, increases in the mRNA levels of monocyte chemoattractant protein-1, tumor necrosis factor-α, and interleukin-1β, and superoxide anion production in the injured artery; however, these inhibitory effects of azilsartan and Ang-(1–7) were less marked in Mas-knockout mice. Administration of azilsartan or Ang-(1–7) attenuated the decrease in ACE2 mRNA and increased AT\n            <jats:sub>2</jats:sub>\n            receptor mRNA but did not affect AT\n            <jats:sub>1</jats:sub>\n            receptor mRNA or the decrease in Mas mRNA. The inhibitory effect of Ang-(1–7) on neointimal formation was less marked in AT\n            <jats:sub>2</jats:sub>\n            receptor knockout mice compared with wild-type mice. These results suggest that blockade of the AT\n            <jats:sub>1</jats:sub>\n            receptor by azilsartan could enhance the activities of the ACE2/Ang-(1–7)/Mas axis and ACE2/Ang-(1–7)/AT\n            <jats:sub>2</jats:sub>\n            receptor axis, thereby inhibiting neointimal formation.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004236436204290","@type":"Researcher","foaf:name":[{"@value":"Kousei Ohshima"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Molecular Cardiovascular Biology and Pharmacology (K.O., M.M., H.N., J.I., L.-J.M., H.K., K.T., H.-Y.B., X.-L.W., M.H.), Cardiology, Pulmonology, Hypertension and Nephrology (K.O., A.O., J.H.), and Pediatrics (T.C.), Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326229400576","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20363236"},{"@type":"NRID","@value":"1000020363236"},{"@type":"NRID","@value":"9000001828541"},{"@type":"NRID","@value":"9000408485404"},{"@type":"NRID","@value":"9000001680389"},{"@type":"NRID","@value":"9000257801468"},{"@type":"NRID","@value":"9000335555166"},{"@type":"NRID","@value":"9000014270231"},{"@type":"NRID","@value":"9000017178608"},{"@type":"NRID","@value":"9000001449153"},{"@type":"NRID","@value":"9000018648754"},{"@type":"NRID","@value":"9000017394887"},{"@type":"NRID","@value":"9000414517829"},{"@type":"NRID","@value":"9000403421526"},{"@type":"NRID","@value":"9000397959596"},{"@type":"NRID","@value":"9000414220257"},{"@type":"NRID","@value":"9000017179112"},{"@type":"NRID","@value":"9000258726429"},{"@type":"NRID","@value":"9000019064434"},{"@type":"NRID","@value":"9000017178828"},{"@type":"NRID","@value":"9000345433024"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0125349"}],"foaf:name":[{"@value":"Masaki Mogi"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Molecular Cardiovascular Biology and Pharmacology (K.O., M.M., H.N., J.I., L.-J.M., H.K., K.T., H.-Y.B., X.-L.W., M.H.), Cardiology, Pulmonology, Hypertension and Nephrology (K.O., A.O., J.H.), and Pediatrics (T.C.), Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236436204417","@type":"Researcher","foaf:name":[{"@value":"Hirotomo Nakaoka"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Molecular Cardiovascular Biology and Pharmacology (K.O., M.M., H.N., J.I., L.-J.M., H.K., K.T., H.-Y.B., X.-L.W., M.H.), Cardiology, Pulmonology, Hypertension and Nephrology (K.O., A.O., J.H.), and Pediatrics (T.C.), Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801214159488","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90624792"},{"@type":"NRID","@value":"1000090624792"},{"@type":"NRID","@value":"9000408485399"},{"@type":"NRID","@value":"9000017430455"},{"@type":"NRID","@value":"9000408487208"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000014892"}],"foaf:name":[{"@value":"Jun Iwanami"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Molecular Cardiovascular Biology and Pharmacology (K.O., M.M., H.N., J.I., L.-J.M., H.K., K.T., H.-Y.B., X.-L.W., M.H.), Cardiology, Pulmonology, Hypertension and Nephrology (K.O., A.O., J.H.), and Pediatrics (T.C.), Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236436204293","@type":"Researcher","foaf:name":[{"@value":"Li-Juan Min"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Molecular Cardiovascular Biology and Pharmacology (K.O., M.M., H.N., J.I., L.-J.M., H.K., K.T., H.-Y.B., X.-L.W., M.H.), Cardiology, Pulmonology, Hypertension and Nephrology (K.O., A.O., J.H.), and Pediatrics (T.C.), Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236436204419","@type":"Researcher","foaf:name":[{"@value":"Harumi Kanno"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Molecular Cardiovascular Biology and Pharmacology (K.O., M.M., H.N., J.I., L.-J.M., H.K., K.T., H.-Y.B., X.-L.W., M.H.), Cardiology, Pulmonology, Hypertension and Nephrology (K.O., A.O., J.H.), and Pediatrics (T.C.), Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236436204422","@type":"Researcher","foaf:name":[{"@value":"Kana Tsukuda"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Molecular Cardiovascular Biology and Pharmacology (K.O., M.M., H.N., J.I., L.-J.M., H.K., K.T., H.-Y.B., X.-L.W., M.H.), Cardiology, Pulmonology, Hypertension and Nephrology (K.O., A.O., J.H.), and Pediatrics (T.C.), Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236436204421","@type":"Researcher","foaf:name":[{"@value":"Toshiyuki Chisaka"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Molecular Cardiovascular Biology and Pharmacology (K.O., M.M., H.N., J.I., L.-J.M., H.K., K.T., H.-Y.B., X.-L.W., M.H.), Cardiology, Pulmonology, Hypertension and Nephrology (K.O., A.O., J.H.), and Pediatrics (T.C.), Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236436204416","@type":"Researcher","foaf:name":[{"@value":"Hui-Yu Bai"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Molecular Cardiovascular Biology and Pharmacology (K.O., M.M., H.N., J.I., L.-J.M., H.K., K.T., H.-Y.B., X.-L.W., M.H.), Cardiology, Pulmonology, Hypertension and Nephrology (K.O., A.O., J.H.), and Pediatrics (T.C.), Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236436204292","@type":"Researcher","foaf:name":[{"@value":"Xiao-Li Wang"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Molecular Cardiovascular Biology and Pharmacology (K.O., M.M., H.N., J.I., L.-J.M., H.K., K.T., H.-Y.B., X.-L.W., M.H.), Cardiology, Pulmonology, Hypertension and Nephrology (K.O., A.O., J.H.), and Pediatrics (T.C.), Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658799995776","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00403832"},{"@type":"NRID","@value":"1000000403832"},{"@type":"NRID","@value":"9000263044968"}],"foaf:name":[{"@value":"Akiyoshi Ogimoto"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Molecular Cardiovascular Biology and Pharmacology (K.O., M.M., H.N., J.I., L.-J.M., H.K., K.T., H.-Y.B., X.-L.W., M.H.), Cardiology, Pulmonology, Hypertension and Nephrology (K.O., A.O., J.H.), and Pediatrics (T.C.), Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236436204288","@type":"Researcher","foaf:name":[{"@value":"Jitsuo Higaki"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Molecular Cardiovascular Biology and Pharmacology (K.O., M.M., H.N., J.I., L.-J.M., H.K., K.T., H.-Y.B., X.-L.W., M.H.), Cardiology, Pulmonology, Hypertension and Nephrology (K.O., A.O., J.H.), and Pediatrics (T.C.), Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236436204418","@type":"Researcher","foaf:name":[{"@value":"Masatsugu Horiuchi"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Molecular Cardiovascular Biology and Pharmacology (K.O., M.M., H.N., J.I., L.-J.M., H.K., K.T., H.-Y.B., X.-L.W., M.H.), Cardiology, Pulmonology, Hypertension and Nephrology (K.O., A.O., J.H.), and Pediatrics (T.C.), Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0194911X"},{"@type":"EISSN","@value":"15244563"}],"prism:publicationName":[{"@value":"Hypertension"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2014-03","prism:volume":"63","prism:number":"3","prism:startingPage":"e53"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.113.02426"}],"createdAt":"2013-12-31","modifiedAt":"2024-05-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Vasodilator%20Agents","dc:title":"Vasodilator Agents"},{"@id":"https://cir.nii.ac.jp/all?q=Peptidyl-Dipeptidase%20A","dc:title":"Peptidyl-Dipeptidase A"},{"@id":"https://cir.nii.ac.jp/all?q=Real-Time%20Polymerase%20Chain%20Reaction","dc:title":"Real-Time Polymerase Chain Reaction"},{"@id":"https://cir.nii.ac.jp/all?q=Immunohistochemistry","dc:title":"Immunohistochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Receptor,%20Angiotensin,%20Type%202","dc:title":"Receptor, Angiotensin, Type 2"},{"@id":"https://cir.nii.ac.jp/all?q=Peptide%20Fragments","dc:title":"Peptide Fragments"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Oxidative%20Stress","dc:title":"Oxidative Stress"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation","dc:title":"Gene Expression Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=RNA","dc:title":"RNA"},{"@id":"https://cir.nii.ac.jp/all?q=Vascular%20Resistance","dc:title":"Vascular Resistance"},{"@id":"https://cir.nii.ac.jp/all?q=Angiotensin-Converting%20Enzyme%202","dc:title":"Angiotensin-Converting Enzyme 2"},{"@id":"https://cir.nii.ac.jp/all?q=Angiotensin%20I","dc:title":"Angiotensin I"},{"@id":"https://cir.nii.ac.jp/all?q=Angiotensin%20II%20Type%201%20Receptor%20Blockers","dc:title":"Angiotensin II Type 1 Receptor Blockers"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782152548608","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23390188"},{"@type":"JGN","@value":"JP23390188"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390188/"}],"notation":[{"@language":"ja","@value":"サルコペニック肥満の病態解明に関する研究"},{"@language":"en","@value":"Pathophysiological mechanisms in sarcopenic obesity"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782246182528","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25293310"},{"@type":"JGN","@value":"JP25293310"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25293310/"}],"notation":[{"@language":"ja","@value":"アンジオテンシンIIタイプ２受容体機能調節物質を軸とした体系的認知機能増加制御"},{"@language":"en","@value":"Systematic Approach for the Enhancement of Cognitive Function by the Activation of Angiotensin Type 2 receptor Associated Protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257143495936","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23591048"},{"@type":"JGN","@value":"JP23591048"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591048/"}],"notation":[{"@language":"ja","@value":"特発性心筋症における網羅的遺伝子解析による心血管事故リスク層別化の検討"},{"@language":"en","@value":"Risk Assessment of Cardiovascular Events by Meta-Analysis of Genome-Wide Association Studies for Atrial Fibrillation in Patients 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