{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004236679396864.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1177/0961203314536246"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/pdf/10.1177/0961203314536246"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/full-xml/10.1177/0961203314536246"}},{"identifier":{"@type":"PMID","@value":"24860121"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Long-term outcome in Japanese patients with lupus nephritis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p> The objective of this study was to clarify the long-term outcome in patients with lupus nephritis (LN) according to the International Society of Nephrology and Renal Pathology Society classification. This retrospective analysis comprised 186 Japanese patients given a diagnosis of LN by renal specimen with a mean observation period of 12 years. Primary end point was defined as death or end-stage renal disease, and standardized mortality ratios were calculated. Five patients presented with histopathological class I, 62 with II, 21 with III or III+V, 73 with IV or IV+V and 25 with V. Fourteen deaths occurred, corresponding to an overall standardized mortality ratio of 3.59 (95% confidence interval 2.02–5.81, p < 0.0001). Kaplan-Meier analysis revealed a 10-year overall survival of 95.7%. Nephrotic proteinuria (≥3.5 g/day) at baseline was identified as an independent poor prognostic factor for overall survival in Cox regression analysis. Kaplan-Meier analysis revealed a 10-year renal survival as 94.3%. Male gender and nephrotic proteinuria at baseline were identified as independent poor prognostic factors for renal survival in Cox regression analysis. In conclusion, LN was associated with a 3.59-fold increase in mortality compared with the general population. Male gender and nephrotic proteinuria were predictive for poor renal outcome. </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004231301038353","@type":"Researcher","foaf:name":[{"@value":"M Kono"}],"jpcoar:affiliationName":[{"@value":"Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236679396868","@type":"Researcher","foaf:name":[{"@value":"S Yasuda"}],"jpcoar:affiliationName":[{"@value":"Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236679396867","@type":"Researcher","foaf:name":[{"@value":"M Kato"}],"jpcoar:affiliationName":[{"@value":"Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236679396872","@type":"Researcher","foaf:name":[{"@value":"Y Kanetsuka"}],"jpcoar:affiliationName":[{"@value":"Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236679396871","@type":"Researcher","foaf:name":[{"@value":"T Kurita"}],"jpcoar:affiliationName":[{"@value":"Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236679396870","@type":"Researcher","foaf:name":[{"@value":"Y Fujieda"}],"jpcoar:affiliationName":[{"@value":"Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236679396993","@type":"Researcher","foaf:name":[{"@value":"K Otomo"}],"jpcoar:affiliationName":[{"@value":"Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236679396994","@type":"Researcher","foaf:name":[{"@value":"T Horita"}],"jpcoar:affiliationName":[{"@value":"Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236679396869","@type":"Researcher","foaf:name":[{"@value":"K Oba"}],"jpcoar:affiliationName":[{"@value":"Translational Research and Clinical Trial Center, Hokkaido University Hospital, Sapporo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236679396864","@type":"Researcher","foaf:name":[{"@value":"M Kondo"}],"jpcoar:affiliationName":[{"@value":"Department of Rheumatology, Sapporo City General Hospital, Sapporo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236679396995","@type":"Researcher","foaf:name":[{"@value":"M Mukai"}],"jpcoar:affiliationName":[{"@value":"Department of Rheumatology, Sapporo City General Hospital, Sapporo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236679396865","@type":"Researcher","foaf:name":[{"@value":"M Yanai"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology, Sapporo City General Hospital, Sapporo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236679396866","@type":"Researcher","foaf:name":[{"@value":"Y Fukasawa"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology, Sapporo City General Hospital, Sapporo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004236679396992","@type":"Researcher","foaf:name":[{"@value":"T Atsumi"}],"jpcoar:affiliationName":[{"@value":"Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09612033"},{"@type":"EISSN","@value":"14770962"}],"prism:publicationName":[{"@value":"Lupus"}],"dc:publisher":[{"@value":"SAGE Publications"}],"prism:publicationDate":"2014-05-23","prism:volume":"23","prism:number":"11","prism:startingPage":"1124","prism:endingPage":"1132"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://journals.sagepub.com/page/policies/text-and-data-mining-license"],"url":[{"@id":"https://journals.sagepub.com/doi/pdf/10.1177/0961203314536246"},{"@id":"https://journals.sagepub.com/doi/full-xml/10.1177/0961203314536246"}],"createdAt":"2014-05-24","modifiedAt":"2025-03-01","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Time%20Factors","dc:title":"Time 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