Modeling the functions of condensin in chromosome shaping and segregation
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- Alexandre V. Morozov
- editor
書誌事項
- 公開日
- 2018-06-18
- 資源種別
- journal article
- 権利情報
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- http://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.1371/journal.pcbi.1006152
- 公開者
- Public Library of Science (PLoS)
説明
The mechanistic details underlying the assembly of rod-shaped chromosomes during mitosis and how they segregate from each other to act as individually mobile units remain largely unknown. Here, we construct a coarse-grained physical model of chromosomal DNA and condensins, a class of large protein complexes that plays key roles in these processes. We assume that condensins have two molecular activities: consecutive loop formation in DNA and inter-condensin attractions. Our simulation demonstrates that both of these activities and their balancing acts are essential for the efficient shaping and segregation of mitotic chromosomes. Our results also demonstrate that the shaping and segregation processes are strongly correlated, implying their mechanistic coupling during mitotic chromosome assembly. Our results highlight the functional importance of inter-condensin attractions in chromosome shaping and segregation.
収録刊行物
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- PLOS Computational Biology
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PLOS Computational Biology 14 (6), e1006152-, 2018-06-18
Public Library of Science (PLoS)
