{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004237487763584.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1371/journal.pone.0018410"}},{"identifier":{"@type":"URI","@value":"http://dx.plos.org/10.1371/journal.pone.0018410"}},{"identifier":{"@type":"PMID","@value":"21490918"}},{"identifier":{"@type":"NAID","@value":"10030957626"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Delayed Re-Epithelialization in Periostin-Deficient Mice during Cutaneous Wound Healing"}],"description":[{"notation":[{"@value":"Matricellular proteins, including periostin, are important for tissue regeneration.Presently we investigated the function of periostin in cutaneous wound healing by using periostin-deficient ⁻/⁻ mice. Periostin mRNA was expressed in both the epidermis and hair follicles, and periostin protein was located at the basement membrane in the hair follicles together with fibronectin and laminin γ2. Periostin was associated with laminin γ2, and this association enhanced the proteolytic cleavage of the laminin γ2 long form to produce its short form. To address the role of periostin in wound healing, we employed a wound healing model using WT and periostin⁻/⁻ mice and the scratch wound assay in vitro. We found that the wound closure was delayed in the periostin⁻/⁻ mice coupled with a delay in re-epithelialization and with reduced proliferation of keratinocytes. Furthermore, keratinocyte proliferation was enhanced in periostin-overexpressing HaCaT cells along with up-regulation of phosphorylated NF-κB.These results indicate that periostin was essential for keratinocyte proliferation for re-epithelialization during cutaneous wound healing."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751161042560","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30647011"},{"@type":"NRID","@value":"1000030647011"},{"@type":"NRID","@value":"9000018883252"},{"@type":"NRID","@value":"9000303164794"},{"@type":"NRID","@value":"9000403895116"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/tnishiyama"}],"foaf:name":[{"@value":"Takashi Nishiyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801212772096","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80401561"},{"@type":"NRID","@value":"1000080401561"},{"@type":"NRID","@value":"9000017331346"},{"@type":"NRID","@value":"9000326666103"},{"@type":"NRID","@value":"9000400187733"},{"@type":"NRID","@value":"9000326648739"},{"@type":"NRID","@value":"9000001711681"},{"@type":"NRID","@value":"9000410155246"},{"@type":"NRID","@value":"9000303164793"},{"@type":"NRID","@value":"9000409509201"},{"@type":"NRID","@value":"9000329440263"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0102185"}],"foaf:name":[{"@value":"Isao Kii"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237487763459","@type":"Researcher","foaf:name":[{"@value":"Takeshi G. Kashima"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751156430976","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90512260"},{"@type":"NRID","@value":"1000090512260"},{"@type":"NRID","@value":"9000017696256"},{"@type":"NRID","@value":"9000001200372"},{"@type":"NRID","@value":"9000398132767"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/Yoshinao_Kikuchi"}],"foaf:name":[{"@value":"Yoshinao Kikuchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326220233472","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40266169"},{"@type":"NRID","@value":"1000040266169"},{"@type":"NRID","@value":"9000018193961"},{"@type":"NRID","@value":"9000005787727"},{"@type":"NRID","@value":"9000020098578"},{"@type":"NRID","@value":"9000399218992"},{"@type":"NRID","@value":"9000258389064"},{"@type":"NRID","@value":"9000415214684"},{"@type":"NRID","@value":"9000257942712"},{"@type":"NRID","@value":"9000001749230"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/dtcpdw-62q"}],"foaf:name":[{"@value":"Atsushi Ohazama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237487763331","@type":"Researcher","foaf:name":[{"@value":"Masashi Shimazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237487763335","@type":"Researcher","foaf:name":[{"@value":"Masashi Fukayama"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658372775809","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70178002"},{"@type":"NRID","@value":"1000070178002"}],"foaf:name":[{"@value":"Akira Kudo"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1380004237487763588","@type":"Researcher","foaf:name":[{"@value":"Sudha Agarwal"}],"role":"editor"}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"19326203"}],"prism:publicationName":[{"@value":"PLoS ONE"}],"dc:publisher":[{"@value":"Public Library of Science (PLoS)"}],"prism:publicationDate":"2011-04-07","prism:volume":"6","prism:number":"4","prism:startingPage":"e18410"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"http://dx.plos.org/10.1371/journal.pone.0018410"}],"createdAt":"2011-04-07","modifiedAt":"2021-11-21","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=570","dc:title":"570"},{"@id":"https://cir.nii.ac.jp/all?q=Science","dc:title":"Science"},{"@id":"https://cir.nii.ac.jp/all?q=Blotting,%20Western","dc:title":"Blotting, Western"},{"@id":"https://cir.nii.ac.jp/all?q=Basement%20Membrane","dc:title":"Basement Membrane"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line","dc:title":"Cell Line"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Immunoprecipitation","dc:title":"Immunoprecipitation"},{"@id":"https://cir.nii.ac.jp/all?q=Phosphorylation","dc:title":"Phosphorylation"},{"@id":"https://cir.nii.ac.jp/all?q=In%20Situ%20Hybridization","dc:title":"In Situ Hybridization"},{"@id":"https://cir.nii.ac.jp/all?q=Skin","dc:title":"Skin"},{"@id":"https://cir.nii.ac.jp/all?q=Wound%20Healing","dc:title":"Wound Healing"},{"@id":"https://cir.nii.ac.jp/all?q=Reverse%20Transcriptase%20Polymerase%20Chain%20Reaction","dc:title":"Reverse Transcriptase Polymerase Chain Reaction"},{"@id":"https://cir.nii.ac.jp/all?q=Q","dc:title":"Q"},{"@id":"https://cir.nii.ac.jp/all?q=R","dc:title":"R"},{"@id":"https://cir.nii.ac.jp/all?q=NF-kappa%20B","dc:title":"NF-kappa B"},{"@id":"https://cir.nii.ac.jp/all?q=Immunohistochemistry","dc:title":"Immunohistochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Fibronectins","dc:title":"Fibronectins"},{"@id":"https://cir.nii.ac.jp/all?q=Epidermal%20Cells","dc:title":"Epidermal Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Medicine","dc:title":"Medicine"},{"@id":"https://cir.nii.ac.jp/all?q=Laminin","dc:title":"Laminin"},{"@id":"https://cir.nii.ac.jp/all?q=Epidermis","dc:title":"Epidermis"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Adhesion%20Molecules","dc:title":"Cell Adhesion Molecules"},{"@id":"https://cir.nii.ac.jp/all?q=Hair%20Follicle","dc:title":"Hair Follicle"},{"@id":"https://cir.nii.ac.jp/all?q=Research%20Article","dc:title":"Research Article"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Binding","dc:title":"Protein 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promotes chronic allergic inflammation in response to Th2 cytokines"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657159077632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The usefulness of measuring tear periostin for the diagnosis and management of ocular allergic diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658342039808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Periostin Controls Keratinocyte Proliferation and Differentiation by Interacting with the Paracrine IL-1α/IL-6 Loop"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660761287168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Constitutive overexpression of periostin delays wound healing in mouse 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pancreas"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519092967168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Periostin is essential for cardiac healingafter acute myocardial infarction"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519609275136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mammalian Tolloid Metalloproteinase, and Not Matrix Metalloprotease 2 or Membrane Type 1 Metalloprotease, Processes Laminin-5 in Keratinocytes and Skin"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520620499200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Targeted Deletion of the Integrin β4 Signaling Domain Suppresses Laminin-5-Dependent Nuclear Entry of Mitogen-Activated Protein Kinases and NF-κB, Causing Defects in Epidermal Growth and Migration"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995982994688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Keratinocyte migration requires α2β1 integrin-mediated interaction with the laminin 5 γ2 chain"}]},{"@id":"https://cir.nii.ac.jp/crid/1361978698491418752","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@value":"Periostin in dental science"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469688886144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Keratinocyte Stem Cells: a Commentary1"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469805894400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Keratinocyte Hypermotility/Growth-Arrest Response Involving Laminin 5 and p16INK4A Activated in Wound Healing and Senescence"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470232787840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mesenchymal stem cell-conditioned medium accelerates skin wound healing: An in vitro study of fibroblast and keratinocyte scratch assays"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471300422144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinicopathologic significance of laminin-5 ?2 chain expression in squamous cell carcinoma of the tongue"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945441569536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine."}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945635836288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An Extended Epidermal Response Heals Cutaneous Wounds in the Absence 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Healing"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368775629824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fibronectin at a glance"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368910826112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetic Manipulation of Periostin Expression Reveals a Role in Cardiac Hypertrophy and Ventricular Remodeling"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843355853440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318295115264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Form and function: The laminin family of 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