{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004237495291008.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1371/journal.pone.0028413"}},{"identifier":{"@type":"URI","@value":"http://dx.plos.org/10.1371/journal.pone.0028413"}},{"identifier":{"@type":"PMID","@value":"22162769"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Nascentome Analysis Uncovers Futile Protein Synthesis in Escherichia coli"}],"description":[{"notation":[{"@value":"Although co-translational biological processes attract much attention, no general and easy method has been available to detect cellular nascent polypeptide chains, which we propose to call collectively a \"nascentome.\" We developed a method to selectively detect polypeptide portions of cellular polypeptidyl-tRNAs and used it to study the generality of the quality control reactions that rescue dead-end translation complexes. To detect nascent polypeptides, having their growing ends covalently attached to a tRNA, cellular extracts are separated by SDS-PAGE in two dimensions, first with the peptidyl-tRNA ester bonds preserved and subsequently after their in-gel cleavage. Pulse-labeled nascent polypeptides of Escherichia coli form a characteristic line below the main diagonal line, because each of them had contained a tRNA of nearly uniform size in the first-dimension electrophoresis but not in the second-dimension. The detection of nascent polypeptides, separately from any translation-completed polypeptides or degradation products thereof, allows us to follow their fates to gain deeper insights into protein biogenesis and quality control pathways. It was revealed that polypeptidyl-tRNAs were significantly stabilized in E. coli upon dysfunction of the tmRNA-ArfA ribosome-rescuing system, whose function had only been studied previously using model constructs. Our results suggest that E. coli cells are intrinsically producing aberrant translation products, which are normally eliminated by the ribosome-rescuing mechanisms."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658310074753","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90027334"},{"@type":"NRID","@value":"1000090027334"},{"@type":"NRID","@value":"9000399551640"},{"@type":"NRID","@value":"9000317166875"},{"@type":"NRID","@value":"9000382636915"},{"@type":"NRID","@value":"9000021756901"},{"@type":"NRID","@value":"9000313195017"},{"@type":"NRID","@value":"9000398031892"},{"@type":"NRID","@value":"9000253179801"},{"@type":"NRID","@value":"9000253470300"},{"@type":"NRID","@value":"9000273002568"},{"@type":"NRID","@value":"9000009938137"},{"@type":"NRID","@value":"9000002741001"},{"@type":"NRID","@value":"9000334425428"},{"@type":"NRID","@value":"9000020706725"},{"@type":"NRID","@value":"9000386450677"},{"@type":"NRID","@value":"9000002726103"},{"@type":"NRID","@value":"9000395374776"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0012386"}],"foaf:name":[{"@value":"Koreaki Ito"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237495291276","@type":"Researcher","foaf:name":[{"@value":"Yuhei Chadani"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237495291282","@type":"Researcher","foaf:name":[{"@value":"Kenta Nakamori"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801195187968","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20523517"},{"@type":"NRID","@value":"1000020523517"},{"@type":"NRID","@value":"9000399502579"},{"@type":"NRID","@value":"9000317166876"},{"@type":"NRID","@value":"9000397821407"},{"@type":"NRID","@value":"9000317166806"},{"@type":"NRID","@value":"9000001135203"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0193078"}],"foaf:name":[{"@value":"Shinobu Chiba"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276170242432","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10192460"},{"@type":"NRID","@value":"1000010192460"},{"@type":"ORCID","@value":"0000-0003-4483-5408"},{"@type":"CINII_AUTHOR_ID","@value":"DA16934705"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA16934705#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA16934705"},{"@type":"NRID","@value":"9000238282816"},{"@type":"NRID","@value":"9000002741863"},{"@type":"NRID","@value":"9000399502581"},{"@type":"NRID","@value":"9000239867923"},{"@type":"NRID","@value":"9000017331244"},{"@type":"NRID","@value":"9000316698027"},{"@type":"NRID","@value":"9000259306766"},{"@type":"NRID","@value":"9000411369797"},{"@type":"NRID","@value":"9000406216235"},{"@type":"NRID","@value":"9000384267633"},{"@type":"NRID","@value":"9000412228213"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000008535"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/yoshinoriakiyama"}],"foaf:name":[{"@value":"Yoshinori Akiyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237495291401","@type":"Researcher","foaf:name":[{"@value":"Tatsuhiko Abo"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1380004237495291274","@type":"Researcher","foaf:name":[{"@value":"Charalampos Babis Spilianakis"}],"role":"editor"}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"19326203"}],"prism:publicationName":[{"@value":"PLoS ONE"}],"dc:publisher":[{"@value":"Public Library of Science (PLoS)"}],"prism:publicationDate":"2011-12-05","prism:volume":"6","prism:number":"12","prism:startingPage":"e28413"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"http://dx.plos.org/10.1371/journal.pone.0028413"}],"createdAt":"2011-12-05","modifiedAt":"2021-12-18","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Proteomics","dc:title":"Proteomics"},{"@id":"https://cir.nii.ac.jp/all?q=Time%20Factors","dc:title":"Time Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Science","dc:title":"Science"},{"@id":"https://cir.nii.ac.jp/all?q=RNA,%20Transfer,%20Amino%20Acyl","dc:title":"RNA, Transfer, Amino Acyl"},{"@id":"https://cir.nii.ac.jp/all?q=Biochemistry","dc:title":"Biochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Models,%20Biological","dc:title":"Models, Biological"},{"@id":"https://cir.nii.ac.jp/all?q=RNA,%20Transfer","dc:title":"RNA, Transfer"},{"@id":"https://cir.nii.ac.jp/all?q=Escherichia%20coli","dc:title":"Escherichia coli"},{"@id":"https://cir.nii.ac.jp/all?q=Electrophoresis,%20Gel,%20Two-Dimensional","dc:title":"Electrophoresis, Gel, Two-Dimensional"},{"@id":"https://cir.nii.ac.jp/all?q=Promoter%20Regions,%20Genetic","dc:title":"Promoter Regions, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Q","dc:title":"Q"},{"@id":"https://cir.nii.ac.jp/all?q=R","dc:title":"R"},{"@id":"https://cir.nii.ac.jp/all?q=Hydrogen-Ion%20Concentration","dc:title":"Hydrogen-Ion Concentration"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Biosynthesis","dc:title":"Protein Biosynthesis"},{"@id":"https://cir.nii.ac.jp/all?q=Mutation","dc:title":"Mutation"},{"@id":"https://cir.nii.ac.jp/all?q=Medicine","dc:title":"Medicine"},{"@id":"https://cir.nii.ac.jp/all?q=Electrophoresis,%20Polyacrylamide%20Gel","dc:title":"Electrophoresis, Polyacrylamide Gel"},{"@id":"https://cir.nii.ac.jp/all?q=Peptides","dc:title":"Peptides"},{"@id":"https://cir.nii.ac.jp/all?q=Ribosomes","dc:title":"Ribosomes"},{"@id":"https://cir.nii.ac.jp/all?q=Research%20Article","dc:title":"Research Article"},{"@id":"https://cir.nii.ac.jp/all?q=Bacterial%20Outer%20Membrane%20Proteins","dc:title":"Bacterial Outer Membrane Proteins"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782101198720","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22020035"},{"@type":"JGN","@value":"JP22020035"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22020035/"}],"notation":[{"@language":"ja","@value":"翻訳途上鎖のタンパク質社会における意義と役割"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782175593216","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23657128"},{"@type":"JGN","@value":"JP23657128"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23657128/"}],"notation":[{"@language":"ja","@value":"SRP経路を介した膜局在化による熱ショック転写因子シクマ32の分解機構"},{"@language":"en","@value":"Degradation mechanisms of sigma 32 by membrane targeting via SRP pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257007591040","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20247020"},{"@type":"JGN","@value":"JP20247020"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20247020/"}],"notation":[{"@language":"ja","@value":"Nascent Chain(合成途上鎖)の分子生物学"},{"@language":"en","@value":"Nascent chain biology"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257112131072","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22770125"},{"@type":"JGN","@value":"JP22770125"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22770125/"}],"notation":[{"@language":"ja","@value":"枯草菌蛋白質膜組込をモニターする翻訳途上鎖"},{"@language":"en","@value":"Nascent polypeptide chain that monitors membrane protein biogenesis in Bacullus subtilis."}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257436227328","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19058007"},{"@type":"JGN","@value":"JP19058007"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-19058007/"}],"notation":[{"@language":"ja","@value":"大腸菌膜タンパク質の機能発現と秩序維持機能"},{"@language":"en","@value":"Quality control of E. coli membrane proteins"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011145939846912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Codon usage determines translation rate in Escherichia coli"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283690830093568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Genome-wide Translation Profiling by Ribosome-Bound tRNA Capture"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692110595584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Integrated in vivo and in vitro nascent chain profiling reveals widespread translational pausing"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693613978496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Arrest Peptides: <i>Cis</i>-Acting Modulators of Translation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707124298240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Identification of a SecM segment required for export‐coupled release from elongation arrest"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285712542269952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nascent SecM Chain Outside the Ribosome Reinforces Translation Arrest"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292617911547648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619715532160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Relation between aminoacyl-tRNA stability and the fixed amino acid"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619931932032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Translation arrest of SecM is essential for the basal and regulated expression of SecA"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165775982592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Peptidyl-prolyl-tRNA at the ribosomal P-site reacts poorly with puromycin"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166742904064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A ribosome–nascent chain sensor of membrane protein biogenesis in Bacillus subtilis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168391631616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Translational Pausing Ensures Membrane Targeting and Cytoplasmic Splicing of\n                    <i>XBP1u</i>\n                    mRNA"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181953415808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Divergent stalling sequences sense and control cellular physiology"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181958513408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Ribosome rescue systems in bacteria"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183910584192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Recruitment of a species-specific translational arrest module to monitor different cellular processes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183915454464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nascent chain-monitored remodeling of the Sec machinery for salinity adaptation of marine bacteria"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185537121408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"ArfA recruits release factor 2 to rescue stalled ribosomes by peptidyl‐tRNA hydrolysis in <i>Escherichia coli</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092651885568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Search for translation arrest peptides encoded upstream of genes for components of protein localization pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094510750592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"SecM facilitates translocase function of SecA by localizing its biosynthesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094517716480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Beyond ribosome rescue: tmRNA and co‐translational processes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094756795264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The ribosome as an entropy trap"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095524910080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transient ribosomal attenuation coordinates protein synthesis and co-translational folding"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232414912768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Proteomic analysis of nascent polypeptide chains that potentially induce translational pausing during elongation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360585256671354880","@type":"Article","resourceType":"preprint","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"ResQ, a release factor-dependent ribosome rescue factor in the Gram-positive bacterium\n                  <i>Bacillus subtilis</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855567871177216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568663256192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"On the chemical reactivity of aminoacyl-tRNA ester bond"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568705029248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"On the chemical reactivity of aminacyl-tRNA ester bond"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570004212864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>Escherichia coli</i> YaeJ protein mediates a novel ribosome‐rescue pathway distinct from SsrA‐ and ArfA‐mediated pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571093518336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Models of protein modification in Tris–glycine and neutral pH Bis–Tris gels during electrophoresis: Effect of gel pH"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707357802624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nascent peptide-induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707363134208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prophage excision switches the primary ribosome rescue pathway and rescue‐associated gene regulations in <i>Escherichia coli</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707376151040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A method to enrich polypeptidyl-tRNAs to capture snapshots of translation in the cell"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043420538112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Peptidyl transfer RNA dissociates during protein synthesis from ribosomes of Escherichia coli."}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044118395136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"On the chemical reactivity of aminoacyl-tRNA ester bond"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044753832832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of a Peptide Tagging System in Degradation of Proteins Synthesized from Damaged Messenger RNA"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045326982784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Secretion Monitor, SecM, Undergoes Self-Translation Arrest in the Cytosol"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045784572288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"tmRNA–SmpB: a journey to the centre of the bacterial ribosome"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518541843840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Visualizing the transfer-messenger RNA as the ribosome resumes translation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519550035968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Acrylamide in Polyacrylamide Gels Can Modify Proteins during Electrophoresis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520687651072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Instruction of Translating Ribosome by Nascent Peptide"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520848388096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Substrate Specificity of Ribosomal Peptidyl Transferase"}]},{"@id":"https://cir.nii.ac.jp/crid/1361694368391130880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nascent SecM chain interacts with outer ribosomal surface to stabilize translation arrest"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993479872640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prolyl cis-trans isomerization as a molecular timer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994320152704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Slow peptide bond formation by proline and other\n                    <i>N</i>\n                    -alkylamino acids in translation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995575939968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975843189149312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Release factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943373601152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The ribosomal tunnel as a functional environment for nascent polypeptide folding and translational stalling"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943891971200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Non‐stop mRNA decay initiates at the ribosome"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944848309760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetically Encoded but Nonpolypeptide Prolyl-tRNA Functions in the A Site for SecM-Mediated Ribosomal Stall"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419129184512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The accumulation as peptidyl-transfer RNA of isoaccepting transfer RNA families in Escherichia coli with temperature-sensitive peptidyl-transfer RNA hydrolase."}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420023458816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Translational Coupling Controls Expression and Function of the DrrAB Drug Efflux Pump"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421345828352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stability of peptidyl-tRNA — The intermediate of protein synthesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895004140544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prolyl-tRNAPro in the A-site of SecM-arrested Ribosomes Inhibits the Recruitment of Transfer-messenger RNA"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895159405568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulatory Nascent Peptides in the Ribosomal Tunnel"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896031661184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"tmRNA regulates synthesis of the ArfA ribosome rescue factor"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368696465024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dom34:Hbs1 Promotes Subunit Dissociation and Peptidyl-tRNA Drop-Off to Initiate No-Go Decay"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368734732928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structural Insight into Nascent Polypeptide Chain–Mediated Translational Stalling"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369936811264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"No mercy for messages that mess with the ribosome"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843921984000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cell-free translation reconstituted with purified components"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320339830784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biology of <i>trans</i>-Translation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793354346368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Ribosomal Exit Tunnel Functions as a Discriminating Gate"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793892268928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ribosome rescue by Escherichia coli ArfA (YhdL) in the absence of trans-translation system"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794102144128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ribosome rescue: tmRNA tagging activity and capacity in <i>Escherichia coli</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796045752192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A tRNA-like structure is present in 10Sa RNA, a small stable RNA from Escherichia coli."}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268289800832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular Mechanism of Drug-Dependent Ribosome Stalling"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268442980608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The tmRNA System for Translational Surveillance and Ribosome Rescue"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268839272448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fidelity at the Molecular Level: Lessons from Protein Synthesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270874723072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nascent peptide-mediated translation elongation arrest coupled with mRNA degradation in the\n                    <i>CGS1</i>\n                    gene of\n                    <i>Arabidopsis</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1370004237495291392","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Experiments in Molecular Genetics."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205472579072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"trans-translation-mediated tight regulation of the expression of the alternative ribosome-rescue factor ArfA in Escherichia coli"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1371/journal.pone.0028413"},{"@type":"KAKEN","@value":"PRODUCT-13153294"},{"@type":"KAKEN","@value":"PRODUCT-14265574"},{"@type":"KAKEN","@value":"PRODUCT-11979189"},{"@type":"KAKEN","@value":"PRODUCT-11979137"},{"@type":"KAKEN","@value":"PRODUCT-13702609"},{"@type":"KAKEN","@value":"PRODUCT-11353597"},{"@type":"KAKEN","@value":"PRODUCT-11353645"},{"@type":"OPENAIRE","@value":"doi_dedup___::b65f0fa00002008641dfd54d760c4274"},{"@type":"CROSSREF","@value":"10.1016/j.celrep.2018.03.035_references_DOI_BarHbou8mgIPLOZWPc4SpT4SxjQ"},{"@type":"CROSSREF","@value":"10.1073/pnas.1520560113_references_DOI_BarHbou8mgIPLOZWPc4SpT4SxjQ"},{"@type":"CROSSREF","@value":"10.1016/j.febslet.2014.06.038_references_DOI_BarHbou8mgIPLOZWPc4SpT4SxjQ"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0122017_references_DOI_BarHbou8mgIPLOZWPc4SpT4SxjQ"},{"@type":"CROSSREF","@value":"10.1073/pnas.1513001112_references_DOI_BarHbou8mgIPLOZWPc4SpT4SxjQ"},{"@type":"CROSSREF","@value":"10.1111/j.1365-2958.2012.08190.x_references_DOI_BarHbou8mgIPLOZWPc4SpT4SxjQ"},{"@type":"CROSSREF","@value":"10.1146/annurev-biochem-080211-105026_references_DOI_BarHbou8mgIPLOZWPc4SpT4SxjQ"},{"@type":"CROSSREF","@value":"10.1093/nar/gkab024_references_DOI_BarHbou8mgIPLOZWPc4SpT4SxjQ"},{"@type":"CROSSREF","@value":"10.1093/bbb/zbac097_references_DOI_BarHbou8mgIPLOZWPc4SpT4SxjQ"},{"@type":"CROSSREF","@value":"10.1101/732420_references_DOI_BarHbou8mgIPLOZWPc4SpT4SxjQ"},{"@type":"CROSSREF","@value":"10.1038/s41467-022-35156-x_references_DOI_BarHbou8mgIPLOZWPc4SpT4SxjQ"},{"@type":"CROSSREF","@value":"10.1111/mmi.15003_references_DOI_BarHbou8mgIPLOZWPc4SpT4SxjQ"},{"@type":"CROSSREF","@value":"10.1093/nar/gkac1276_references_DOI_BarHbou8mgIPLOZWPc4SpT4SxjQ"},{"@type":"CROSSREF","@value":"10.1042/bcj20190723_references_DOI_BarHbou8mgIPLOZWPc4SpT4SxjQ"},{"@type":"CROSSREF","@value":"10.1038/s41467-019-13408-7_references_DOI_BarHbou8mgIPLOZWPc4SpT4SxjQ"},{"@type":"CROSSREF","@value":"10.1016/j.biochi.2014.11.014_references_DOI_BarHbou8mgIPLOZWPc4SpT4SxjQ"}]}