{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004237552748032.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1371/journal.pone.0104925"}},{"identifier":{"@type":"URI","@value":"http://dx.plos.org/10.1371/journal.pone.0104925"}},{"identifier":{"@type":"PMID","@value":"25141153"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Sox17 Regulates Liver Lipid Metabolism and Adaptation to Fasting"}],"description":[{"notation":[{"@value":"Liver is a major regulator of lipid metabolism and adaptation to fasting, a process involving PPARalpha activation. We recently showed that the Vnn1 gene is a PPARalpha target gene in liver and that release of the Vanin-1 pantetheinase in serum is a biomarker of PPARalpha activation. Here we set up a screen to identify new regulators of adaptation to fasting using the serum Vanin-1 as a marker of PPARalpha activation. Mutagenized mice were screened for low serum Vanin-1 expression. Functional interactions with PPARalpha were investigated by combining transcriptomic, biochemical and metabolic approaches. We characterized a new mutant mouse in which hepatic and serum expression of Vanin-1 is depressed. This mouse carries a mutation in the HMG domain of the Sox17 transcription factor. Mutant mice display a metabolic phenotype featuring lipid abnormalities and inefficient adaptation to fasting. Upon fasting, a fraction of the PPARα-driven transcriptional program is no longer induced and associated with impaired fatty acid oxidation. The transcriptional phenotype is partially observed in heterozygous Sox17+/- mice. In mutant mice, the fasting phenotype but not all transcriptomic signature is rescued by the administration of the PPARalpha agonist fenofibrate. These results identify a novel role for Sox17 in adult liver as a modulator of the metabolic adaptation to fasting."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004237552747915","@type":"Researcher","foaf:name":[{"@value":"Samuel Rommelaere"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237552748038","@type":"Researcher","foaf:name":[{"@value":"Virginie Millet"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237552747908","@type":"Researcher","foaf:name":[{"@value":"Thien-Phong Vu Manh"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237552748160","@type":"Researcher","foaf:name":[{"@value":"Thomas Gensollen"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237552748175","@type":"Researcher","foaf:name":[{"@value":"Pierre Andreoletti"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237552748161","@type":"Researcher","foaf:name":[{"@value":"Mustapha Cherkaoui-Malki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237552748032","@type":"Researcher","foaf:name":[{"@value":"Christophe Bourges"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237552747788","@type":"Researcher","foaf:name":[{"@value":"Bertrand Escalière"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237552747780","@type":"Researcher","foaf:name":[{"@value":"Xin Du"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237552747781","@type":"Researcher","foaf:name":[{"@value":"Jean Imbert"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237552747782","@type":"Researcher","foaf:name":[{"@value":"Yu Xia"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237552747787","@type":"Researcher","foaf:name":[{"@value":"Bruce Beutler"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751138209792","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30260326"},{"@type":"NRID","@value":"1000030260326"},{"@type":"NRID","@value":"9000000810924"},{"@type":"NRID","@value":"9000253282317"},{"@type":"NRID","@value":"9000009971527"},{"@type":"NRID","@value":"9000415337645"},{"@type":"NRID","@value":"9000415338236"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0123258"}],"foaf:name":[{"@value":"Yoshiakira Kanai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237552747912","@type":"Researcher","foaf:name":[{"@value":"Bernard Malissen"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237552748162","@type":"Researcher","foaf:name":[{"@value":"Marie Malissen"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237552748176","@type":"Researcher","foaf:name":[{"@value":"Anne Tailleux"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237552747789","@type":"Researcher","foaf:name":[{"@value":"Bart Staels"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237552747910","@type":"Researcher","foaf:name":[{"@value":"Franck Galland"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237552748173","@type":"Researcher","foaf:name":[{"@value":"Philippe Naquet"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1380004237552748033","@type":"Researcher","foaf:name":[{"@value":"Hervé Guillou"}],"role":"editor"}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"19326203"}],"prism:publicationName":[{"@value":"PLoS ONE"}],"dc:publisher":[{"@value":"Public Library of Science (PLoS)"}],"prism:publicationDate":"2014-08-20","prism:volume":"9","prism:number":"8","prism:startingPage":"e104925"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"http://dx.plos.org/10.1371/journal.pone.0104925"}],"createdAt":"2014-08-20","modifiedAt":"2022-04-15","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Science","dc:title":"Science"},{"@id":"https://cir.nii.ac.jp/all?q=Q","dc:title":"Q"},{"@id":"https://cir.nii.ac.jp/all?q=R","dc:title":"R"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Transgenic","dc:title":"Mice, Transgenic"},{"@id":"https://cir.nii.ac.jp/all?q=SOX9%20Transcription%20Factor","dc:title":"SOX9 Transcription Factor"},{"@id":"https://cir.nii.ac.jp/all?q=Fasting","dc:title":"Fasting"},{"@id":"https://cir.nii.ac.jp/all?q=GPI-Linked%20Proteins","dc:title":"GPI-Linked Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Lipid%20Metabolism","dc:title":"Lipid Metabolism"},{"@id":"https://cir.nii.ac.jp/all?q=Adaptation,%20Physiological","dc:title":"Adaptation, Physiological"},{"@id":"https://cir.nii.ac.jp/all?q=Amidohydrolases","dc:title":"Amidohydrolases"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Liver","dc:title":"Liver"},{"@id":"https://cir.nii.ac.jp/all?q=HMGB%20Proteins","dc:title":"HMGB Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=SOXF%20Transcription%20Factors","dc:title":"SOXF Transcription Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Medicine","dc:title":"Medicine"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=PPAR%20alpha","dc:title":"PPAR alpha"},{"@id":"https://cir.nii.ac.jp/all?q=Transcriptome","dc:title":"Transcriptome"},{"@id":"https://cir.nii.ac.jp/all?q=Research%20Article","dc:title":"Research 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