{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004237563476992.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1371/journal.pone.0119347"}},{"identifier":{"@type":"URI","@value":"http://dx.plos.org/10.1371/journal.pone.0119347"}},{"identifier":{"@type":"PMID","@value":"25764183"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Condensin HEAT Subunits Required for DNA Repair, Kinetochore/Centromere Function and Ploidy Maintenance in Fission Yeast"}],"description":[{"notation":[{"@value":"Condensin, a central player in eukaryotic chromosomal dynamics, contains five evolutionarily-conserved subunits. Two SMC (structural maintenance of chromosomes) subunits contain ATPase, hinge, and coiled-coil domains. One non-SMC subunit is similar to bacterial kleisin, and two other non-SMC subunits contain HEAT (similar to armadillo) repeats. Here we report isolation and characterization of 21 fission yeast (Schizosaccharomyces pombe) mutants for three non-SMC subunits, created using error-prone mutagenesis that resulted in single-amino acid substitutions. Beside condensation, segregation, and DNA repair defects, similar to those observed in previously isolated SMC and cnd2 mutants, novel phenotypes were observed for mutants of HEAT-repeats containing Cnd1 and Cnd3 subunits. cnd3-L269P is hypersensitive to the microtubule poison, thiabendazole, revealing defects in kinetochore/centromere and spindle assembly checkpoints. Three cnd1 and three cnd3 mutants increased cell size and doubled DNA content, thereby eliminating the haploid state. Five of these mutations reside in helix B of HEAT repeats. Two non-SMC condensin subunits, Cnd1 and Cnd3, are thus implicated in ploidy maintenance."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004237563477256","@type":"Researcher","foaf:name":[{"@value":"Xingya Xu"}]},{"@id":"https://cir.nii.ac.jp/crid/1030285133775610240","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70514751"},{"@type":"NRID","@value":"1000070514751"},{"@type":"NRID","@value":"9000267801459"},{"@type":"NRID","@value":"9000409185251"},{"@type":"NRID","@value":"9000391931122"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/nnakazawa"}],"foaf:name":[{"@value":"Norihiko Nakazawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237563476867","@type":"Researcher","foaf:name":[{"@value":"Mitsuhiro Yanagida"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1380004237563477265","@type":"Researcher","foaf:name":[{"@value":"Valentin V Rybenkov"}],"role":"editor"}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"19326203"}],"prism:publicationName":[{"@value":"PLOS ONE"}],"dc:publisher":[{"@value":"Public Library of Science (PLoS)"}],"prism:publicationDate":"2015-03-12","prism:volume":"10","prism:number":"3","prism:startingPage":"e0119347"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"http://dx.plos.org/10.1371/journal.pone.0119347"}],"createdAt":"2015-03-12","modifiedAt":"2022-05-02","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adenosine%20Triphosphatases","dc:title":"Adenosine Triphosphatases"},{"@id":"https://cir.nii.ac.jp/all?q=Ploidies","dc:title":"Ploidies"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20Repair","dc:title":"DNA Repair"},{"@id":"https://cir.nii.ac.jp/all?q=Science","dc:title":"Science"},{"@id":"https://cir.nii.ac.jp/all?q=Q","dc:title":"Q"},{"@id":"https://cir.nii.ac.jp/all?q=Centromere","dc:title":"Centromere"},{"@id":"https://cir.nii.ac.jp/all?q=R","dc:title":"R"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Cycle%20Proteins","dc:title":"Cell Cycle Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Structure,%20Tertiary","dc:title":"Protein Structure, Tertiary"},{"@id":"https://cir.nii.ac.jp/all?q=DNA-Binding%20Proteins","dc:title":"DNA-Binding Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Multiprotein%20Complexes","dc:title":"Multiprotein Complexes"},{"@id":"https://cir.nii.ac.jp/all?q=Thiabendazole","dc:title":"Thiabendazole"},{"@id":"https://cir.nii.ac.jp/all?q=Mutation","dc:title":"Mutation"},{"@id":"https://cir.nii.ac.jp/all?q=Schizosaccharomyces","dc:title":"Schizosaccharomyces"},{"@id":"https://cir.nii.ac.jp/all?q=Medicine","dc:title":"Medicine"},{"@id":"https://cir.nii.ac.jp/all?q=M%20Phase%20Cell%20Cycle%20Checkpoints","dc:title":"M Phase Cell Cycle Checkpoints"},{"@id":"https://cir.nii.ac.jp/all?q=Schizosaccharomyces%20pombe%20Proteins","dc:title":"Schizosaccharomyces pombe Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Chromosomes,%20Fungal","dc:title":"Chromosomes, Fungal"},{"@id":"https://cir.nii.ac.jp/all?q=DNA,%20Fungal","dc:title":"DNA, Fungal"},{"@id":"https://cir.nii.ac.jp/all?q=Research%20Article","dc:title":"Research Article"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782272800640","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25840013"},{"@type":"JGN","@value":"JP25840013"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25840013/"}],"notation":[{"@language":"ja","@value":"分裂期の遺伝子発現制御と染色体分配におけるコンデンシンの役割"},{"@language":"en","@value":"Role of condensin on mitotic gene expression and chromosome segregation"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782425078784","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"12J01979"},{"@type":"JGN","@value":"JP12J01979"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12J01979/"}],"notation":[{"@language":"ja","@value":"Ｂｉａｌｌｅｌｉｃ　ｍｕｔａｇｅｎｅｓｉｓ　ｉｎ　ｈｕｍａｎ　ｉＰＳ　ｃｅｌｌｓ"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001202471528576","@type":"Article","resourceType":"学術雑誌論文(journal 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<scp>M</scp>is19 links <scp>M</scp>is16 and <scp>M</scp>is18 to recruit <scp>CENP</scp>‐A through interacting with <scp>NMD</scp> factors and the <scp>SWI</scp>/<scp>SNF</scp> complex"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619095113472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MITOTIC CHROMOSOME CONDENSATION"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620490973696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Universal and essential role of MPFcdc2+"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166769148800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The maintenance of chromosome structure: positioning and functioning of SMC complexes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094302659840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ATM Activation and Its Recruitment to Damaged 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vitro"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570771936640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Genetic Screen for Functional Partners of Condensin in Fission Yeast"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044321827456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"HEAT repeats in the Huntington's disease protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044424774912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Crystal Structure of a TOG Domain: Conserved Features of XMAP215/Dis1-Family TOG Domains and Implications for Tubulin Binding"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045372661504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dissection of the essential steps for condensin accumulation at kinetochores and rDNAs during fission yeast mitosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045617774592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"M phase–specific kinetochore proteins in fission yeast"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045878320384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The spindle-assembly checkpoint in space and time"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046506003456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cnd2 has dual roles in mitotic condensation and interphase"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519446451840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Type II Myosin Heavy Chain Encoded by the <i>myo2</i> Gene Composes the Contractile Ring during Cytokinesis in <i>Schizosaccharomyces pombe</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519512659712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A role for Drosophila SMC4 in the resolution of sister chromatids in mitosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995609164032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fission yeast condensin complex: essential roles of non-SMC subunits for condensation and Cdc2 phosphorylation of Cut3/SMC4"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996391577856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Condensins are Required for Maintenance of  Nuclear Architecture"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468411411712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation, defines a subgroup within the SMC family."}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468711004800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Subpathways of nucleotide excision repair and their regulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469158326400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of two new genes,mukE andmukF, involved in chromosome partitioning inEscherichia coli"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469214148992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dynamic molecular linkers of the genome: the first decade of SMC proteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469512109696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Quantitative Analysis of Chromosome Condensation in Fission 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I and II in Mitotic Chromosome Assembly in Human Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945475976192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fission yeast minichromosome loss mutants mis cause lethal aneuploidy and replication abnormality."}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945938101120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structural View of the Ran–Importin β Interaction at 2.3 Å Resolution"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418583396608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family."}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418785814784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The ATRs, ATMs, and TORs Are Giant HEAT Repeat Proteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418842785664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structure of importin-β bound to the IBB domain of importin-α"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419221706240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"HEAT Repeats Associated with Condensins, Cohesins, and Other Complexes Involved in Chromosome-Related Functions"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419617371520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mis6, a Fission Yeast Inner Centromere Protein, Acts during G1/S and Forms Specialized Chromatin Required for Equal Segregation"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420071225984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fission yeast cut3 and cut14, members of a ubiquitous protein family, are required for chromosome condensation and segregation in mitosis."}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420197894272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A meiotic mutant of the fission yeast Schizosaccharomyces pombe that produces mature asci containing two diploid spores"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420843341184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Condensins, Chromosome Condensation Protein Complexes Containing XCAP-C, XCAP-E and a Xenopus Homolog of the Drosophila Barren Protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420891886720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Spindle Checkpoint Signaling Requires the Mis6 Kinetochore Subcomplex, Which Interacts with Mad2 and Mitotic Spindles"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421076630144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interdependency of Fission Yeast Alp14/TOG and Coiled Coil Protein Alp7 in Microtubule Localization and Bipolar Spindle Formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893337787008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Condensin phosphorylated by the Aurora-B-like kinase Ark1 is continuously required until telophase in a mode distinct from Top2"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893436379776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DPY-27: A chromosome condensation protein homolog that regulates C. elegans dosage compensation through association with the X chromosome"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894067473152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The SNP c.1326T>G in the non-SMC condensin I complex, subunit G (NCAPG) gene encoding a p.Ile442Met variant is associated with an increase in body frame size at puberty in cattle"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894438323200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fission Yeast Slp1: An Effector of the Mad2-Dependent Spindle Checkpoint"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895408849152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cold-sensitive and caffeine-supersensitive mutants of the Schizosaccharomyces pombe dis genes implicated in sister chromatid separation during mitosis."}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895904211584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The\n            <i>Schizosaccharomyces pombe</i>\n            spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368285047936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The new gene mukB codes for a 177 kd protein with coiled-coil domains involved in chromosome partitioning of E. coli."}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368306377984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fission yeast enters the stationary phase G0 state from either mitotic G1 or G2"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368986776064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"p93dis1, which is required for sister chromatid separation, is a novel microtubule and spindle pole body-associating protein phosphorylated at the Cdc2 target sites."}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369093731712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Symmetrical Structure of Structural Maintenance of Chromosomes (SMC) and MukB Proteins: Long, Antiparallel Coiled Coils, Folded at a Flexible Hinge"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369989804800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cross-breed comparisons identified a critical 591-kb region for bovine carcass weight QTL (CW-2) on chromosome 6 and the Ile-442-Met substitution in NCAPG as a positional candidate"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370988088320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of Nuclear Proteasome by Rhp6/Ubc2 through Ubiquitination and Destruction of the Sensor and Anchor Cut8"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843716915840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Preferential, cooperative binding of DNA topoisomerase II to scaffold-associated regions."}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843916648832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Structure of the Protein Phosphatase 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