{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004237583666176.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1371/journal.pone.0145630"}},{"identifier":{"@type":"URI","@value":"http://dx.plos.org/10.1371/journal.pone.0145630"}},{"identifier":{"@type":"PMID","@value":"26695186"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"DNA Methylation in the Exon 1 Region and Complex Regulation of Twist1 Expression in Gastric Cancer Cells"}],"description":[{"notation":[{"@value":"Twist1 overexpression is frequently observed in various cancers including gastric cancer (GC). Although DNA methylation of the Twist1 gene has been reported in cancer cells, the mechanisms underlying transcriptional activation remain uncertain. In this study, we first examined epigenetic alterations of the Twist1 using Twist1 transcription-positive and -negative cell lines that are derived from our established diffuse-type GC mouse model. Treatment with a DNA demethylation agent 5-aza-dC re-activated Twist1 expression in Twist1 expression-negative GC cells. According to methylation-specific PCR and bisulfite sequencing analysis, methylation at the CpG-rich region within Twist1 coding exon 1, rather than its promoter region, was tightly linked to transcriptional silencing of the Twist1 expression in mouse GC cells. Chromatin immunoprecipitation assays revealed that active histone mark H3K4me3 was enriched in Twist1 expression-positive cells, and inactive histone mark H3K9me3 was enriched in Twist1 expression-negative cells. The expression levels of Suv39h1 and Suv39h2, histone methyltransferases for H3K9me3, were inversely correlated with Twist1 expression, and knockdown of Suv39h1 or Suv39h2 induced Twist1 expression. Moreover, Sp1 transcription factor bound to the exon 1 CpG-rich region in Twist1 expression-positive cell lines, and Twist1 expression was diminished by mithramycin, which that interferes with Sp1 binding to CpG-rich regulatory sequences. Our studies suggested that the Twist1 transcription in GC cells might be regulated through potential cooperation of DNA methylation, histone modification in complex with Sp1 binding to CpG-rich regions within the exon 1 region."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004237583666443","@type":"Researcher","foaf:name":[{"@value":"Ayuna Sakamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237583666315","@type":"Researcher","foaf:name":[{"@value":"Yoshimitsu Akiyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801206461952","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20609705"},{"@type":"NRID","@value":"1000020609705"},{"@type":"NRID","@value":"9000006483631"},{"@type":"NRID","@value":"9000401720119"},{"@type":"NRID","@value":"9000403262342"},{"@type":"NRID","@value":"9000107391715"},{"@type":"NRID","@value":"9000391863337"},{"@type":"NRID","@value":"9000019112200"},{"@type":"NRID","@value":"9000317147330"},{"@type":"NRID","@value":"9000401712691"}],"foaf:name":[{"@value":"Shu Shimada"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237583666438","@type":"Researcher","foaf:name":[{"@value":"Wei-Guo Zhu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237583666436","@type":"Researcher","foaf:name":[{"@value":"Yasuhito Yuasa"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276172589824","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30253420"},{"@type":"NRID","@value":"1000030253420"},{"@type":"NRID","@value":"9000391695918"},{"@type":"NRID","@value":"9000000949422"},{"@type":"NRID","@value":"9000256630078"},{"@type":"NRID","@value":"9000018700611"},{"@type":"NRID","@value":"9000413480593"},{"@type":"NRID","@value":"9000283225799"},{"@type":"NRID","@value":"9000107386339"},{"@type":"NRID","@value":"9000242077223"},{"@type":"NRID","@value":"9000256359665"},{"@type":"NRID","@value":"9000391589007"},{"@type":"NRID","@value":"9000258113389"},{"@type":"NRID","@value":"9000016392239"},{"@type":"NRID","@value":"9000405918392"},{"@type":"NRID","@value":"9000259333745"},{"@type":"NRID","@value":"9000258279939"},{"@type":"NRID","@value":"9000016391496"},{"@type":"NRID","@value":"9000323295115"},{"@type":"NRID","@value":"9000415072193"},{"@type":"NRID","@value":"9000006776218"},{"@type":"NRID","@value":"9000248228227"},{"@type":"NRID","@value":"9000018461751"},{"@type":"NRID","@value":"9000002202956"},{"@type":"NRID","@value":"9000255891786"},{"@type":"ORCID","@value":"0000-0002-7718-3453"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/shinjitanaka"}],"foaf:name":[{"@value":"Shinji Tanaka"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1380004237583666441","@type":"Researcher","foaf:name":[{"@value":"Tae-Young Roh"}],"role":"editor"}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"19326203"}],"prism:publicationName":[{"@value":"PLOS ONE"}],"dc:publisher":[{"@value":"Public Library of Science (PLoS)"}],"prism:publicationDate":"2015-12-22","prism:volume":"10","prism:number":"12","prism:startingPage":"e0145630"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"http://dx.plos.org/10.1371/journal.pone.0145630"}],"createdAt":"2015-12-22","modifiedAt":"2024-06-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Knockout","dc:title":"Mice, Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=Transcription,%20Genetic","dc:title":"Transcription, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Science","dc:title":"Science"},{"@id":"https://cir.nii.ac.jp/all?q=Q","dc:title":"Q"},{"@id":"https://cir.nii.ac.jp/all?q=Twist-Related%20Protein%201","dc:title":"Twist-Related Protein 1"},{"@id":"https://cir.nii.ac.jp/all?q=R","dc:title":"R"},{"@id":"https://cir.nii.ac.jp/all?q=Nuclear%20Proteins","dc:title":"Nuclear Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=DNA,%20Neoplasm","dc:title":"DNA, Neoplasm"},{"@id":"https://cir.nii.ac.jp/all?q=Exons","dc:title":"Exons"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasms,%20Experimental","dc:title":"Neoplasms, Experimental"},{"@id":"https://cir.nii.ac.jp/all?q=Plicamycin","dc:title":"Plicamycin"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20Methylation","dc:title":"DNA Methylation"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasm%20Proteins","dc:title":"Neoplasm Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation,%20Neoplastic","dc:title":"Gene Expression Regulation, Neoplastic"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Stomach%20Neoplasms","dc:title":"Stomach Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Medicine","dc:title":"Medicine"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=CpG%20Islands","dc:title":"CpG Islands"},{"@id":"https://cir.nii.ac.jp/all?q=Research%20Article","dc:title":"Research Article"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781823992576","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15H01484"},{"@type":"JGN","@value":"JP15H01484"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-15H01484/"}],"notation":[{"@language":"ja","@value":"可視化がん幹細胞による細胞競合の解析と根治的癌治療開発"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257188960256","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24590444"},{"@type":"JGN","@value":"JP24590444"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24590444/"}],"notation":[{"@language":"ja","@value":"胃がんの組織内多様性と遺伝子のエピジェネティックな変化の関連性"},{"@language":"en","@value":"Epigenetic alterations and tumor heterogeneity in gastric cancers"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257216388992","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25253081"},{"@type":"JGN","@value":"JP25253081"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25253081/"}],"notation":[{"@language":"ja","@value":"幹細胞可視化システムに基づいた難治性消化器癌の先端的治療開発"},{"@language":"en","@value":"Innovative treatment of refractory digestive cancers based on the stemness visualization system"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257249417984","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25830074"},{"@type":"JGN","@value":"JP25830074"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25830074/"}],"notation":[{"@language":"ja","@value":"胃がんマウスモデルを利用した未分化型胃がんの新規エピジェネティクス治療薬の開発"},{"@language":"en","@value":"Targeting epigenetic alterations in a mouse model of E-cadherin/p53-deficient diffuse-type gastric cancer"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002219914386944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Oncogenic roles of the SETDB2 histone methyltransferase in gastric cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233431168384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011142940566016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Methylation of Adjacent CpG Sites Affects Sp1/Sp3 Binding and Activity in the <i>p21<sup>Cip1</sup></i> Promoter"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145226115968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620225039104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Unique CCT repeats mediate transcription of the TWIST1 gene in mesenchymal cell lines"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620720956032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>TWIST1</i> hypermethylation is observed frequently in colorectal tumors and its overexpression is associated with unfavorable outcomes in patients with colorectal cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621337584896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Sp-family of transcription factors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168486132224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093461106304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TWIST1 promoter methylation is associated with prognosis in tonsillar squamous cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094105019264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Aberrant histone methylation and the effect of Suv39H1 siRNA on gastric carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641751632640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568825229824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TWIST1 Promoter Methylation in Primary Colorectal Carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570300656128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DNA methylation profiles of gastric carcinoma characterized by quantitative DNA methylation analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518536950400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"CpG island shore methylation regulates caveolin-1 expression in breast cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518643053056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gastric Adenocarcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521423898752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Twist Function Is Required for the Morphogenesis of the Cephalic Neural Tube and the Differentiation of the Cranial Neural Crest Cells in the Mouse Embryo"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993425666816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A twist of insight - the role of Twist-family bHLH factors in development"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993762587520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Japanese classification of gastric carcinoma: 3rd English edition"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995085662336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995091559936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995293727232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The dioxin receptor is silenced by promoter hypermethylation in human acute lymphoblastic leukemia through inhibition of Sp1 binding"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996357385344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epigenetic gene silencing in cancer: the DNA hypermethylome"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470047091968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gastric Cancer: Current Status of Diagnosis and Treatment"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470772900736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470987933312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epigenetic modifications and human disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471130230400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypermethylation of a Small CpGuanine-Rich Region Correlates with Loss of Activator Protein-2α Expression during Progression of Breast Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471416087424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Control of gut differentiation and intestinal-type gastric carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945379904000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DNA Methylation Affects the SP1-regulated Transcription of FOXF2 in Breast Cancer Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945522076160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"KLF6/Sp1 initiates transcription of the <i>tmsg</i>‐1 gene in human prostate carcinoma cells: An exon involved mechanism"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946373656064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial–mesenchymal transition and invasive properties of prostate cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418464244224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sp1 expression regulates lung tumor progression"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418485190144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of the human PAX6 gene through the exon 1 enhancer by transcription factors SEF and Sp1"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419834516608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420586866944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression and significance of TWIST basic helix-loop-helix protein over-expression in gastric cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893985373568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Spl elements protect a CpG island from de novo methylation"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894812042496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Critical Role of Histone Methylation in Tumor Suppressor Gene Silencing in Colorectal Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894972309120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Carcinogen exposure differentially modulates RAR-  promoter hypermethylation, an early and frequent event in mouse lung carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894993493376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sequence of the twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryos."}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895783291392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Modulation of specificity protein 1 by mithramycin A as a novel therapeutic strategy for cervical cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368908654080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mithramycin Is a Gene-Selective Sp1 Inhibitor That Identifies a Biological Intersection between Cancer and Neurodegeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370998144384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Methylation of the TWIST1 Promoter, TWIST1 mRNA Levels, and Immunohistochemical Expression of TWIST1 in Breast Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843432613504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epigenetic Regulation of Surfactant Protein A Gene (<i>SP-A</i>) Expression in Fetal Lung Reveals a Critical Role for Suv39h Methyltransferases during Development and Hypoxia"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843498763392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Analysis of SEMA3B methylation and expression patterns in gastric cancer tissue and cell lines"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844207520640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845999649536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cancer epigenetics reaches mainstream oncology"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318609421568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A decade of exploring the cancer epigenome — biological and translational implications"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319099240192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Isolation and Characterization of <i>Suv39h2</i>, a Second Histone H3 Methyltransferase Gene That Displays Testis-Specific Expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793776457088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential Expression of the Epithelial-Mesenchymal Transition Regulators Snail, SIP1, and Twist in Gastric Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793882623488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MLL protects CpG clusters from methylation within the\n            <i>Hoxa9</i>\n            gene, maintaining transcript expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270814502144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Establishment of two cell lines from human gastric scirrhous carcinoma that possess the potential to metastasize spontaneously in nude mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1370004237583666189","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Histone lysine methylation and demethylation pathways in cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1370004237583666306","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"p53 gene mutations and protein nuclear accumulation are early events in intestinal type gastric cancer but late events in diffuse type"}]},{"@id":"https://cir.nii.ac.jp/crid/1370004237583666309","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of Dietary Folate and Alcohol Intake on Promoter Methylation in Sporadic Colorectal Cancer: The Netherlands Cohort Study on Diet and Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1370004237583666310","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"E-cadherin gene mutations provide clues to diffuse type gastric carcinomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1370004237583666440","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcription factor Sp1 expression is a significant predictor of survival in human gastric cancer"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1371/journal.pone.0145630"},{"@type":"KAKEN","@value":"PRODUCT-20351581"},{"@type":"KAKEN","@value":"PRODUCT-20505203"},{"@type":"KAKEN","@value":"PRODUCT-20424669"},{"@type":"KAKEN","@value":"PRODUCT-20581099"},{"@type":"OPENAIRE","@value":"doi_dedup___::278d81fa7993bcb92f49cab0d8601f7c"},{"@type":"CROSSREF","@value":"10.18632/oncotarget.11625_references_DOI_3QelMCNzBlaJjpbDvFMyrxN0T62"},{"@type":"CROSSREF","@value":"10.1038/s41416-018-0008-y_references_DOI_3QelMCNzBlaJjpbDvFMyrxN0T62"}]}