{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004237660926464.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1371/journal.ppat.1005048"}},{"identifier":{"@type":"URI","@value":"http://dx.plos.org/10.1371/journal.ppat.1005048"}},{"identifier":{"@type":"PMID","@value":"26172536"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"The Endosymbiotic Bacterium Wolbachia Selectively Kills Male Hosts by Targeting the Masculinizing Gene"}],"description":[{"notation":[{"@value":"Pathogens are known to manipulate the reproduction and development of their hosts for their own benefit. Wolbachia is an endosymbiotic bacterium that infects a wide range of insect species. Wolbachia is known as an example of a parasite that manipulates the sex of its host's progeny. Infection of Ostrinia moths by Wolbachia causes the production of all-female progeny, however, the mechanism of how Wolbachia accomplishes this male-specific killing is unknown. Here we show for the first time that Wolbachia targets the host masculinizing gene of Ostrinia to accomplish male-killing. We found that Wolbachia-infected O. furnacalis embryos do not express the male-specific splice variant of doublesex, a gene which acts at the downstream end of the sex differentiation cascade, throughout embryonic development. Transcriptome analysis revealed that Wolbachia infection markedly reduces the mRNA level of Masc, a gene that encodes a protein required for both masculinization and dosage compensation in the silkworm Bombyx mori. Detailed bioinformatic analysis also elucidated that dosage compensation of Z-linked genes fails in Wolbachia-infected O. furnacalis embryos, a phenomenon that is extremely similar to that observed in Masc mRNA-depleted male embryos of B. mori. Finally, injection of in vitro transcribed Masc cRNA into Wolbachia-infected embryos rescued male progeny. Our results show that Wolbachia-induced male-killing is caused by a failure of dosage compensation via repression of the host masculinizing gene. Our study also shows a novel strategy by which a pathogen hijacks the host sex determination cascade."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004237660926465","@type":"Researcher","foaf:name":[{"@value":"Takahiro Fukui"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237660926348","@type":"Researcher","foaf:name":[{"@value":"Munetaka Kawamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237660926347","@type":"Researcher","foaf:name":[{"@value":"Keisuke Shoji"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237660926469","@type":"Researcher","foaf:name":[{"@value":"Takashi Kiuchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237660926351","@type":"Researcher","foaf:name":[{"@value":"Sumio Sugano"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237660926343","@type":"Researcher","foaf:name":[{"@value":"Toru Shimada"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004237660926084","@type":"Researcher","foaf:name":[{"@value":"Yutaka Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326207222784","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20378863"},{"@type":"NRID","@value":"1000020378863"},{"@type":"NRID","@value":"9000413339117"},{"@type":"NRID","@value":"9000248225309"},{"@type":"NRID","@value":"9000006493839"},{"@type":"NRID","@value":"9000284270525"},{"@type":"NRID","@value":"9000398019986"},{"@type":"NRID","@value":"9000387900672"},{"@type":"NRID","@value":"9000014264062"},{"@type":"NRID","@value":"9000006811869"},{"@type":"NRID","@value":"9000406193247"},{"@type":"NRID","@value":"9000281375414"},{"@type":"NRID","@value":"9000388481471"},{"@type":"NRID","@value":"9000389943743"},{"@type":"NRID","@value":"9000375894027"},{"@type":"NRID","@value":"9000394460432"},{"@type":"NRID","@value":"9000412684641"},{"@type":"NRID","@value":"9000322105131"},{"@type":"NRID","@value":"9000253472072"},{"@type":"NRID","@value":"9000257895699"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/baculo"}],"foaf:name":[{"@value":"Susumu Katsuma"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1380004237660926345","@type":"Researcher","foaf:name":[{"@value":"Elizabeth Ann McGraw"}],"role":"editor"}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"15537374"}],"prism:publicationName":[{"@value":"PLOS Pathogens"}],"dc:publisher":[{"@value":"Public Library of Science (PLoS)"}],"prism:publicationDate":"2015-07-14","prism:volume":"11","prism:number":"7","prism:startingPage":"e1005048"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"http://dx.plos.org/10.1371/journal.ppat.1005048"}],"createdAt":"2015-07-14","modifiedAt":"2020-05-09","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=QH301-705.5","dc:title":"QH301-705.5"},{"@id":"https://cir.nii.ac.jp/all?q=Reverse%20Transcriptase%20Polymerase%20Chain%20Reaction","dc:title":"Reverse Transcriptase Polymerase Chain Reaction"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Sequence%20Data","dc:title":"Molecular Sequence Data"},{"@id":"https://cir.nii.ac.jp/all?q=Zinc%20Fingers","dc:title":"Zinc Fingers"},{"@id":"https://cir.nii.ac.jp/all?q=RC581-607","dc:title":"RC581-607"},{"@id":"https://cir.nii.ac.jp/all?q=Moths","dc:title":"Moths"},{"@id":"https://cir.nii.ac.jp/all?q=Transfection","dc:title":"Transfection"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Immunologic%20diseases.%20Allergy","dc:title":"Immunologic diseases. Allergy"},{"@id":"https://cir.nii.ac.jp/all?q=Biology%20(General)","dc:title":"Biology (General)"},{"@id":"https://cir.nii.ac.jp/all?q=Phylogeny","dc:title":"Phylogeny"},{"@id":"https://cir.nii.ac.jp/all?q=Wolbachia","dc:title":"Wolbachia"},{"@id":"https://cir.nii.ac.jp/all?q=Research%20Article","dc:title":"Research Article"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781859104896","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K14893"},{"@type":"JGN","@value":"JP15K14893"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K14893/"}],"notation":[{"@language":"ja","@value":"ボルバキアによる雄殺しの分子機構の解明"},{"@language":"en","@value":"Elucidation of the machanism of how Wolbachia accomplishes the male-specific killing"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050304183894718976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A Wolbachia factor for male killing in lepidopteran insects"}]},{"@id":"https://cir.nii.ac.jp/crid/1050586963913297152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Male-killing virus in a noctuid moth Spodoptera litura"},{"@value":"Male-killing virus in a noctuid moth<i>Spodoptera litura</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360001114139266560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"FISH identification of Helicoverpa armigera and Mamestra brassicae chromosomes by BAC and fosmid probes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002214546897792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Feminizing\n                    <i>Wolbachia</i>\n                    endosymbiont disrupts maternal sex chromosome inheritance in a butterfly species"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002216806368256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Integrated molecular analysis of clear-cell renal cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004229799587200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Identification of a bipartite nuclear localization signal in the silkworm Masc protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233982408320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Two Conserved Cysteine Residues Are Required for the Masculinizing Activity of the Silkworm Masc Protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005516671320192","@type":"Article","resourceType":"学術雑誌論文(journal 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Hosts"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017280670035584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Diverse Molecular Mechanisms Underlying Microbe-Inducing Male Killing in the Moth Homona magnanima"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017282220544256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Masculinizer is not post-transcriptionally regulated by female-specific piRNAs during sex determination in the Asian corn borer, Ostrinia furnacalis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017282429732608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cell-based analysis reveals that sex-determining gene signals in <i>Ostrinia</i> are pivotally changed by male-killing <i>Wolbachia</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021389825675648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cell-based assays and comparative genomics revealed the conserved and hidden effects of\n                  <i>Wolbachia</i>\n                  on insect sex determination"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025429446004992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prophage-encoded Hm-oscar gene recapitulates Wolbachia-induced male-killing in the tea tortrix moth Homona magnanima"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692748698624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Double trouble: combined action of meiotic drive and\n            <i>Wolbachia</i>\n            feminization in\n            <i>Eurema</i>\n            butterflies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707159547776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Misdirection of dosage compensation underlies bidirectional sex-specific death in Wolbachia-infected Ostrinia scapulalis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618836880384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Opposite sex–specific effects of<i>Wolbachia</i>and interference with the sex determination of its host<i>Ostrinia scapulalis</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618957503104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Functional Dosage Compensation Complex Required for Male Killing in\n                    <i>Drosophila</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620801657856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sex determination in the silkworm, Bombyx mori: A female determinant on the W chromosome and the sex-determining gene cascade"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621450423424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sexually biased transcripts at early embryonic stages of the silkworm depend on the sex chromosome constitution"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643700316800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Characterization of nuclear localization signal in <i>Ostrinia furnacalis</i> Masculinizer protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643701187456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"RNase κ promotes robust piRNA production by generating 2′,3′-cyclic phosphate-containing precursors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302865728512128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Expression of the\n                    <i>Wolbachia</i>\n                    male‐killing factor Oscar impairs dosage compensation in lepidopteran embryos"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166755926272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Male-killing symbiont damages host’s dosage-compensated sex chromosome to induce embryonic apoptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565167084077952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Extensive synteny conservation of holocentric chromosomes in Lepidoptera despite high rates of local genome rearrangements"}]},{"@id":"https://cir.nii.ac.jp/crid/1360568465756916352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Closely Related Male-Killing and Nonmale-Killing Wolbachia Strains in the Oriental Tea Tortrix Homona magnanima"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576284037174144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Sex determination systems as the interface between male-killing bacteria and their hosts"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232429949056","@type":"Article","resourceType":"preprint","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Distinct Effects of the Male-Killing Bacteria\n                  <i>Wolbachia</i>\n                  and\n                  <i>Spiroplasma</i>\n                  and a Partiti-Like Virus in the Tea Pest Moth,\n                  <i>Homona magnanima</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232429968896","@type":"Article","resourceType":"preprint","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Male-killing-associated bacteriophage WO identified from comparisons of\n                  <i>Wolbachia</i>\n                  endosymbionts of\n                  <i>Homona magnanima</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588380594165248","@type":"Article","resourceType":"preprint","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prophage-encoded Hm-oscar gene recapitulates Wolbachia-induced male killing in the tea tortrix moth Homona magnanima"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588380609778816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Identification and functional analysis of sex-determining genes in the spongy moth, Lymantria dispar (lepidoptera: Erebidae)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588381083134592","@type":"Article","resourceType":"preprint","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prophage-encoded Hm-oscar gene recapitulates Wolbachia-induced male killing in the tea tortrix moth Homona magnanima"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641729156992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A single female-specific piRNA is the primary determiner of sex in the silkworm"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846642702063488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A male-killing\n                    <i>Wolbachia</i>\n                    carries a feminizing factor and is associated with degradation of the sex-determining system of its host"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657020730368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Wolbachia Protein TomO Targets nanos mRNA and Restores Germ Stem Cells in Drosophila Sex-lethal Mutants"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571043634176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sex Chromosomes and Sex Determination in Lepidoptera"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865815496445824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Combined actions of bacteriophage-encoded genes in Wolbachia-induced male lethality"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865815697444608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Genomic insights into <i>Spiroplasma</i> endosymbionts that induce male-killing and protective phenotypes in the pea aphid"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869855106240512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Evolution of Wolbachia male-killing mechanism within a host species"}]},{"@id":"https://cir.nii.ac.jp/crid/1361131416805910272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Two CCCH-type zinc finger domains in the Masc protein are dispensable for masculinization and dosage compensation in Bombyx mori"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045519454720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A rearrangement of the Z chromosome topology influences the sex-linked gene display in the European corn borer, Ostrinia nubilalis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994292669440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of a Male-Specific RNA Binding Protein That Regulates Sex-Specific Splicing of <i>Bmdsx</i> by Increasing RNA Binding Activity of BmPSI"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994801140480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of the male BmDSX protein in the sexual differentiation of <i>Bombyx mori</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468591120128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evolutionarily Stable Infection by a Male-Killing Endosymbiont in Drosophila innubilaSequence data from this article have been deposited with the EMBL/GenBank Data Libraries under accession nos. 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