{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004239086785408.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2533/chimia.2018.848"}},{"identifier":{"@type":"URI","@value":"https://www.chimia.ch/chimia/article/download/2018_848/853"}},{"identifier":{"@type":"PMID","@value":"30648949"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Helical Structures of Cyclopentene-based α,α-Disubstituted α-Amino Acid Homopeptides"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The cyclopentene-based α,α-disubstituted α-amino acid Ac5c= and its homopeptides, up to nonapeptides, were synthesized. The side-chain cyclopentene was expected to become symmetric, the Cα-carbon to be puckered, and other Cβ, Cβ', Cγ, Cγ'-carbons to be coplanar. As expected, side-chain cyclopentene conformations became symmetric and Cα-carbons were puckered. Conformational studies using FT-IR absorption, 1H NMR spectra, and X-ray crystallographic analyses revealed that Ac5c= homopeptides did not form a planar conformation, but assumed a 310-helical structure, similar to cyclopentane-based α,α-disubstituted α-amino acid homopeptides.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420564276169173632","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00227175"},{"@type":"NRID","@value":"1000000227175"},{"@type":"NRID","@value":"9000411814056"},{"@type":"NRID","@value":"9000391964300"},{"@type":"NRID","@value":"9000391961400"},{"@type":"NRID","@value":"9000411815921"},{"@type":"NRID","@value":"9000411812694"},{"@type":"NRID","@value":"9000005291398"},{"@type":"NRID","@value":"9000391970576"},{"@type":"NRID","@value":"9000254713545"},{"@type":"NRID","@value":"9000408665228"},{"@type":"NRID","@value":"9000005182194"},{"@type":"NRID","@value":"9000411818656"},{"@type":"NRID","@value":"9000254714485"},{"@type":"NRID","@value":"9000283259765"},{"@type":"NRID","@value":"9000411821948"},{"@type":"NRID","@value":"9000411803110"},{"@type":"NRID","@value":"9000391968355"},{"@type":"NRID","@value":"9000391959675"},{"@type":"NRID","@value":"9000391960517"},{"@type":"NRID","@value":"9000018566987"},{"@type":"NRID","@value":"9000389547137"},{"@type":"NRID","@value":"9000411811115"},{"@type":"NRID","@value":"9000411816844"},{"@type":"NRID","@value":"9000411818284"},{"@type":"NRID","@value":"9000254242932"},{"@type":"NRID","@value":"9000411821732"},{"@type":"NRID","@value":"9000414244569"},{"@type":"NRID","@value":"9000254242745"},{"@type":"NRID","@value":"9000254697757"},{"@type":"NRID","@value":"9000408634278"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0172370"}],"foaf:name":[{"@value":"Masakazu Tanaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239086785408","@type":"Researcher","foaf:name":[{"@value":"Haruka Yakabi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239086785412","@type":"Researcher","foaf:name":[{"@value":"Haruki Nakatani"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801205469184","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10732315"},{"@type":"NRID","@value":"1000010732315"},{"@type":"NRID","@value":"9000411815918"},{"@type":"NRID","@value":"9000016772288"},{"@type":"NRID","@value":"9000411811672"},{"@type":"NRID","@value":"9000411818651"},{"@type":"NRID","@value":"9000405895501"},{"@type":"NRID","@value":"9000409508460"},{"@type":"NRID","@value":"9000411821942"},{"@type":"NRID","@value":"9000411815982"},{"@type":"NRID","@value":"9000411815913"},{"@type":"NRID","@value":"9000411815831"},{"@type":"NRID","@value":"9000010672053"},{"@type":"NRID","@value":"9000411820079"},{"@type":"NRID","@value":"9000411821728"},{"@type":"NRID","@value":"9000414244564"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/aueda"}],"foaf:name":[{"@value":"Atsushi Ueda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239086785413","@type":"Researcher","foaf:name":[{"@value":"Mitsunobu Doi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239086785411","@type":"Researcher","foaf:name":[{"@value":"Makoto Oba"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"26732424"},{"@type":"PISSN","@value":"00094293"}],"prism:publicationName":[{"@value":"CHIMIA"}],"dc:publisher":[{"@value":"Swiss Chemical Society"}],"prism:publicationDate":"2018-12-19","prism:volume":"72","prism:number":"12","prism:startingPage":"848"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by-nc/4.0/"],"url":[{"@id":"https://www.chimia.ch/chimia/article/download/2018_848/853"}],"createdAt":"2019-01-16","modifiedAt":"2024-11-11","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Models,%20Molecular","dc:title":"Models, Molecular"},{"@id":"https://cir.nii.ac.jp/all?q=Helix","dc:title":"Helix"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Conformation","dc:title":"Protein Conformation"},{"@id":"https://cir.nii.ac.jp/all?q=Cyclopentanes","dc:title":"Cyclopentanes"},{"@id":"https://cir.nii.ac.jp/all?q=Chemistry","dc:title":"Chemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Cyclopentene","dc:title":"Cyclopentene"},{"@id":"https://cir.nii.ac.jp/all?q=Peptide","dc:title":"Peptide"},{"@id":"https://cir.nii.ac.jp/all?q=%CE%B1,%CE%B1-disubstituted%20%CE%B1-amino%20acid","dc:title":"α,α-disubstituted α-amino acid"},{"@id":"https://cir.nii.ac.jp/all?q=Conformation","dc:title":"Conformation"},{"@id":"https://cir.nii.ac.jp/all?q=Amino%20Acids","dc:title":"Amino Acids"},{"@id":"https://cir.nii.ac.jp/all?q=Peptides","dc:title":"Peptides"},{"@id":"https://cir.nii.ac.jp/all?q=QD1-999","dc:title":"QD1-999"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781925308928","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16K18847"},{"@type":"JGN","@value":"JP16K18847"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K18847/"}],"notation":[{"@language":"ja","@value":"コンフォメーション制御と分子認識を基盤とした架橋ペプチド触媒の創製"},{"@language":"en","@value":"Development of stapled peptide catalysts based on restriction of conformational freedom and molecular recognition"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256934051712","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17H03998"},{"@type":"JGN","@value":"JP17H03998"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H03998/"}],"notation":[{"@language":"ja","@value":"配座制限環状アミノ酸のデノボ設計と創薬化学への応用"},{"@language":"en","@value":"De novo design of conformational-freedom restricted cyclic amino acids and their application to medicinal chemistry"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256980779008","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K14870"},{"@type":"JGN","@value":"JP18K14870"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K14870/"}],"notation":[{"@language":"ja","@value":"ジ置換アミノ酸を利用した新規ペプチドフォールドマーの設計と合成"},{"@language":"en","@value":"Design and synthesis of peptide foldamer using alpha,alpha-disubstituted alpha-amino acids"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1880302167576705664","@type":"Dataset","relationType":["isSupplementedBy"],"jpcoar:relatedTitle":[{"@value":"CCDC 1855421: Experimental Crystal Structure Determination"}]},{"@id":"https://cir.nii.ac.jp/crid/1883961342977703168","@type":"Dataset","relationType":["isSupplementedBy"],"jpcoar:relatedTitle":[{"@value":"CCDC 1855422: Experimental Crystal Structure 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