{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004239205113984.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3109/07420528.2014.1003350"}},{"identifier":{"@type":"URI","@value":"http://www.tandfonline.com/doi/pdf/10.3109/07420528.2014.1003350"}},{"identifier":{"@type":"PMID","@value":"25798696"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Atypical expression of circadian clock genes in denervated mouse skeletal muscle"}],"description":[{"notation":[{"@value":"The central circadian clock in the suprachiasmatic nucleus of the hypothalamus synchronizes peripheral clocks through neural and humoral signals in most mammalian tissues. Here, we analyzed the effects of unilateral sciatic denervation on the expression of circadian clock- and clock-controlled genes in the gastrocnemius muscles of mice twice per day on days 0, 3, 7, 9, 11 and 14 after denervation and six times on each of days 7 and 28 after denervation to assess the regulation mechanism of the circadian clock in skeletal muscle. Sciatic denervation did not affect systemic circadian rhythms since core body temperature (Day 7), corticosterone secretion (Days 7 and 28), and hepatic clock gene expression remained intact (Days 7 and 28). Expression levels of most circadian clock-related genes such as Arntl, Per1, Rora, Nr1d1 and Dbp were reduced in accordance with the extent of muscle atrophy, although circadian Per2 expression was significantly augmented (Day 28). Cosinor analysis revealed that the circadian expression of Arntl (Days 7 and 28) and Dbp (Day 28) was phase advanced in denervated muscle. The mRNA expression of Clock was significantly increased in denervated muscle on Day 3 when the severe atrophy was absent, and it was not affected by atrophic progression for 28 days. Sciatic denervation did not affect the expression of these genes in the contralateral muscle (Days 7 and 28), suggesting that humoral changes were not involved in denervation-induced muscle clock disruption. We then analyzed genome-wide gene expression using microarrays to determine the effects of disrupting the molecular clock in muscle on circadian rhythms at Day 7. Among 478 circadian genes, 313 lost rhythmicity in the denervated muscles. These denervation-sensitive genes included the lipid metabolism-related genes, Nrip1, Bbs1, Ptgis, Acot1, Scd2, Hpgd, Insig1, Dhcr24, Ldlr and Mboat1. Our findings revealed that sciatic denervation disrupts the circadian expression of clock and clock-controlled genes either directly or indirectly via muscle atrophy in the gastrocnemius muscles of mice in a gene-specific manner."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420282801184201088","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20582696"},{"@type":"NRID","@value":"1000020582696"},{"@type":"ORCID","@value":"0000-0002-1119-4598"},{"@type":"NRID","@value":"9000398801898"},{"@type":"NRID","@value":"9000411518395"},{"@type":"NRID","@value":"9000257900078"},{"@type":"NRID","@value":"9000006358318"},{"@type":"NRID","@value":"9000283280824"},{"@type":"NRID","@value":"9000257900399"},{"@type":"NRID","@value":"9000283280827"},{"@type":"NRID","@value":"9000390883108"},{"@type":"NRID","@value":"9000375857167"},{"@type":"NRID","@value":"9000006629993"}],"foaf:name":[{"@value":"Reiko Nakao"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239205114112","@type":"Researcher","foaf:name":[{"@value":"Saori Yamamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239205114114","@type":"Researcher","foaf:name":[{"@value":"Kazumasa Horikawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239205114240","@type":"Researcher","foaf:name":[{"@value":"Yuki Yasumoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276182602368","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20263824"},{"@type":"NRID","@value":"1000020263824"},{"@type":"ORCID","@value":"0000-0002-3691-2250"},{"@type":"NRID","@value":"9000408835684"},{"@type":"NRID","@value":"9000408835669"},{"@type":"NRID","@value":"9000410014679"},{"@type":"NRID","@value":"9000414343726"},{"@type":"NRID","@value":"9000257756723"},{"@type":"NRID","@value":"9000362188402"},{"@type":"NRID","@value":"9000257900020"},{"@type":"NRID","@value":"9000408834257"},{"@type":"NRID","@value":"9000408834242"},{"@type":"NRID","@value":"9000345336920"},{"@type":"NRID","@value":"9000414833874"},{"@type":"NRID","@value":"9000257999095"},{"@type":"NRID","@value":"9000404469654"},{"@type":"NRID","@value":"9000414728195"},{"@type":"NRID","@value":"9000414552358"},{"@type":"NRID","@value":"9000367421674"},{"@type":"NRID","@value":"9000283208564"},{"@type":"NRID","@value":"9000404129027"},{"@type":"NRID","@value":"9000375857193"},{"@type":"NRID","@value":"9000410622566"},{"@type":"NRID","@value":"9000292880133"},{"@type":"NRID","@value":"9000345352566"},{"@type":"NRID","@value":"9000316690232"},{"@type":"NRID","@value":"9000241808336"},{"@type":"NRID","@value":"9000014175681"},{"@type":"NRID","@value":"9000022199437"},{"@type":"NRID","@value":"9000370764932"},{"@type":"NRID","@value":"9000257900081"},{"@type":"NRID","@value":"9000257834807"},{"@type":"NRID","@value":"9000408840600"},{"@type":"NRID","@value":"9000408840610"},{"@type":"NRID","@value":"9000305637523"},{"@type":"NRID","@value":"9000283280826"},{"@type":"NRID","@value":"9000022200629"},{"@type":"NRID","@value":"9000350641826"},{"@type":"NRID","@value":"9000381062973"},{"@type":"NRID","@value":"9000366126139"},{"@type":"NRID","@value":"9000248218517"},{"@type":"NRID","@value":"9000020309282"},{"@type":"NRID","@value":"9000305637481"},{"@type":"NRID","@value":"9000257900397"},{"@type":"NRID","@value":"9000406212254"},{"@type":"NRID","@value":"9000313189424"},{"@type":"NRID","@value":"9000399157891"},{"@type":"NRID","@value":"9000415040800"},{"@type":"NRID","@value":"9000370765052"},{"@type":"NRID","@value":"9000345257519"},{"@type":"NRID","@value":"9000283280833"},{"@type":"NRID","@value":"9000363175614"},{"@type":"NRID","@value":"9000411588528"},{"@type":"NRID","@value":"9000409467433"},{"@type":"NRID","@value":"9000398802279"},{"@type":"NRID","@value":"9000322100394"},{"@type":"NRID","@value":"9000362187765"},{"@type":"NRID","@value":"9000408831939"},{"@type":"NRID","@value":"9000408831930"},{"@type":"NRID","@value":"9000408835755"},{"@type":"NRID","@value":"9000408835767"},{"@type":"NRID","@value":"9000414221613"},{"@type":"NRID","@value":"9000392763397"},{"@type":"NRID","@value":"9000018211488"},{"@type":"NRID","@value":"9000397934248"},{"@type":"NRID","@value":"9000411000816"},{"@type":"NRID","@value":"9000397694673"},{"@type":"NRID","@value":"9000006345524"},{"@type":"NRID","@value":"9000390883111"},{"@type":"NRID","@value":"9000356488986"},{"@type":"NRID","@value":"9000375857175"},{"@type":"NRID","@value":"9000411817745"},{"@type":"NRID","@value":"9000408832786"},{"@type":"NRID","@value":"9000408832801"},{"@type":"NRID","@value":"9000360557487"},{"@type":"NRID","@value":"9000390878094"},{"@type":"NRID","@value":"9000412006330"},{"@type":"NRID","@value":"9000408841658"},{"@type":"NRID","@value":"9000408841650"},{"@type":"NRID","@value":"9000360557549"},{"@type":"NRID","@value":"9000367421702"},{"@type":"NRID","@value":"9000409858968"},{"@type":"NRID","@value":"9000257900379"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0184061"}],"foaf:name":[{"@value":"Takeshi Nikawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239205113984","@type":"Researcher","foaf:name":[{"@value":"Chiaki Mukai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239205114113","@type":"Researcher","foaf:name":[{"@value":"Katsutaka Oishi"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"07420528"},{"@type":"EISSN","@value":"15256073"}],"prism:publicationName":[{"@value":"Chronobiology International"}],"dc:publisher":[{"@value":"Informa UK Limited"}],"prism:publicationDate":"2015-03-23","prism:volume":"32","prism:number":"4","prism:startingPage":"486","prism:endingPage":"496"},"reviewed":"false","url":[{"@id":"http://www.tandfonline.com/doi/pdf/10.3109/07420528.2014.1003350"}],"createdAt":"2015-03-23","modifiedAt":"2016-12-12","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=CLOCK%20Proteins","dc:title":"CLOCK Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression","dc:title":"Gene Expression"},{"@id":"https://cir.nii.ac.jp/all?q=Period%20Circadian%20Proteins","dc:title":"Period Circadian Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Circadian%20Rhythm","dc:title":"Circadian Rhythm"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Circadian%20Clocks","dc:title":"Circadian Clocks"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Suprachiasmatic%20Nucleus","dc:title":"Suprachiasmatic Nucleus"},{"@id":"https://cir.nii.ac.jp/all?q=Muscle,%20Skeletal","dc:title":"Muscle, Skeletal"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781832247808","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15H04960"},{"@type":"JGN","@value":"JP15H04960"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04960/"}],"notation":[{"@language":"ja","@value":"筋収縮機能を回復するミトコンドリア・リハビリテーション学"},{"@language":"en","@value":"Molecular rehabilitation of mitochondrial function towards preventing muscle atrophy"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782218224256","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24620015"},{"@type":"JGN","@value":"JP24620015"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24620015/"}],"notation":[{"@language":"ja","@value":"廃用性筋萎縮の新たなメカニズムの解明：体内時計の乱れは筋肉をも壊してしまうのか？"},{"@language":"en","@value":"Investigating potential relationship between circadian clodk and skeletal muscle atrophy."}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257177395968","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24390355"},{"@type":"JGN","@value":"JP24390355"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24390355/"}],"notation":[{"@language":"ja","@value":"廃用性筋萎縮の鍵を握るミトコンドリア生物学"},{"@language":"en","@value":"Mitochondria is a key signal inducer for unloading stress toward muscle atrophy"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257225206784","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25350179"},{"@type":"JGN","@value":"JP25350179"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25350179/"}],"notation":[{"@language":"ja","@value":"睡眠障害性代謝異常のメカニズムの解明とその時間栄養学的改善方法の開発"},{"@language":"en","@value":"Chrono-nutrition research to improve the circadian disruption-related metabolic disorders"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050022708920105856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Ketogenic diet induces skeletal muscle atrophy via reducing muscle protein synthesis and possibly activating proteolysis in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360001113994275712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Resetting of Circadian Time in Peripheral Tissues by Glucocorticoid Signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360001114040526080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360001114040561664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Humoral signals mediate the circadian expression of rat period homologue (rPer2) mRNA in peripheral tissues"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232103231360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Day-Night Oscillation of Atrogin1 and Timing-Dependent Preventive Effect of Weight-Bearing on Muscle Atrophy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232370092416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Short-term feeding at the wrong time is sufficient to desynchronize peripheral clocks and induce obesity with hyperphagia, physical inactivity and metabolic disorders in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146079314816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential Control of Bmal1 Circadian Transcription by REV-ERB and ROR Nuclear 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Differences between endogenous and exogenous insulin effects"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567189406718720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Role of Circadian Rhythms in Muscular and Osseous Physiology and Their Regulation by Nutrition and Exercise"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095694101376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Circadian Oscillations of Protein-Coding and Regulatory RNAs in a Highly Dynamic Mammalian Liver Epigenome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641132457088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Determination of reference genes that are independent of feeding rhythms for circadian studies of mouse metabolic 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Ligases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044083477504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanisms regulating skeletal muscle growth and atrophy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518829284864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"CLOCK and BMAL1 regulate\n            <i>MyoD</i>\n            and are necessary for maintenance of skeletal muscle phenotype and function"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469348995456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470757811200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Adrenergic regulation of clock gene expression in mouse 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Clock"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895216500480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Proteasome-dependent Activation of Mammalian Target of Rapamycin Complex 1 (mTORC1) Is Essential for Autophagy Suppression and Muscle Remodeling Following Denervation"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895855324928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368626227712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of the circadian transcriptome in adult mouse skeletal muscle"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368857907584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369655263616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Persistence of myosin heavy chain-based fiber types in innervated but silenced rat fast muscle"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845341258496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845568331136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319196314624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Circadian Rhythms, Skeletal Muscle Molecular Clocks, and 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