{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004239205124992.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3109/07420528.2014.931413"}},{"identifier":{"@type":"URI","@value":"http://www.tandfonline.com/doi/pdf/10.3109/07420528.2014.931413"}},{"identifier":{"@type":"PMID","@value":"24984029"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Controlling access time to a high-fat diet during the inactive period protects against obesity in mice"}],"description":[{"notation":[{"@value":"Free feeding (FF) with a high fat diet (HFD) causes excessive body weight gain, whereas restricted feeding (RF) with a HFD attenuates body weight gain. The effects of timing of feeding with a HFD (day vs. night) and feeding duration on energy homeostasis have not yet been investigated. In this study, we fed mice a HFD or a normal diet (ND) twice a day, during their active and inactive periods, on a schedule. The amount of food was regulated by feeding duration (2, 4 or 8 h). First, we investigated the effects of 4-h RF during active-inactive periods (ND-ND, HFD-HFD, ND-HFD or HFD-ND). Among all the 4-h RF groups, mice consumed almost the same amount of calories as those in the FF[ND] group, even those fed a HFD. Body weight and visceral fat in these three groups were lower than that in the FF[HFD] group. Second, we investigated the effects of RF duration. Body weight and visceral fat were higher in the 8-h groups than in the 4-h groups. Body weight and visceral fat were higher in the 2-h groups than in the 4-h groups even though the 2-h groups had less food. Third, we investigated the effects of eating a HFD during the inactive period, when RF duration was extended (2, 6 or 12 h). Mice were fed with a HFD during the inactive period for 2 h and fed with a ND during the active period for 2, 6 or 12 h. Body weight and visceral fat in these mice were comparable to those in the FF[ND] mice. The results of our first set of experiments suggest that 4-h RF was an adequate feeding duration to control the effect of a HFD on obesity. The results of our second set of experiments suggest 2-h RF (such as speed-eating) and 8-h RF, representative of eating disorders, are unhealthy feeding patterns related to obesity. The results of our third set of experiments suggest that eating a HFD for a short period during the night does not affect body weight and visceral fat. Taken together, these results indicate that consideration to feeding with a HFD during the inactive period and restricting eating habits relieve the risks of body weight gain and visceral fat accumulation."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004239205124864","@type":"Researcher","foaf:name":[{"@value":"Atsushi Haraguchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239205124999","@type":"Researcher","foaf:name":[{"@value":"Natsumi Aoki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239205124994","@type":"Researcher","foaf:name":[{"@value":"Teiji Ohtsu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239205124995","@type":"Researcher","foaf:name":[{"@value":"Yuko Ikeda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239205124998","@type":"Researcher","foaf:name":[{"@value":"Yu 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