{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004239442615808.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3389/fmicb.2017.00410"}},{"identifier":{"@type":"URI","@value":"http://journal.frontiersin.org/article/10.3389/fmicb.2017.00410/full"}},{"identifier":{"@type":"PMID","@value":"28348551"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Evolutionary Constraints on the Norovirus Pandemic Variant GII.4_2006b over the Five-Year Persistence in Japan"}],"description":[{"notation":[{"@value":"Norovirus GII.4 is a major cause of global outbreaks of viral gastroenteritis in humans, and has evolved by antigenic changes under the constantly changing human herd immunity. Major shift in the pandemic GII.4 strain periodically occurs concomitant with changes in the antigenic capsid protein VP1. However, how the newly emerged strain evolves after the onset of pandemic remains unclear. To address this issue, we examined molecular evolution of a pandemic lineage, termed the GII.4_2006b, by using the full-length viral genome and VP1 sequences ("}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004239442616069","@type":"Researcher","foaf:name":[{"@value":"Hironori 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