{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004239446388736.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3389/fnagi.2014.00230"}},{"identifier":{"@type":"PMID","@value":"25221510"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"The Intriguing Regulators of Muscle Mass in Sarcopenia and Muscular Dystrophy"}],"description":[{"notation":[{"@value":"Recent advances in our understanding of the biology of muscle have led to new interest in the pharmacological treatment of muscle wasting. Loss of muscle mass and increased intramuscular fibrosis occur in both sarcopenia and muscular dystrophy. Several regulators (mammalian target of rapamycin, serum response factor, atrogin-1, myostatin, etc.) seem to modulate protein synthesis and degradation or transcription of muscle-specific genes during both sarcopenia and muscular dystrophy. This review provides an overview of the adaptive changes in several regulators of muscle mass in both sarcopenia and muscular dystrophy."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751163782784","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60291176"},{"@type":"NRID","@value":"1000060291176"},{"@type":"CINII_AUTHOR_ID","@value":"DA18805747"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA18805747#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA18805747"},{"@type":"NRID","@value":"9000003202979"},{"@type":"NRID","@value":"9000006254871"},{"@type":"NRID","@value":"9000018321076"},{"@type":"NRID","@value":"9000003208723"},{"@type":"NRID","@value":"9000001696556"},{"@type":"NRID","@value":"9000002873662"},{"@type":"NRID","@value":"9000363374405"},{"@type":"NRID","@value":"9000363377907"},{"@type":"NRID","@value":"9000363373780"},{"@type":"NRID","@value":"9000283506608"},{"@type":"NRID","@value":"9000409888874"},{"@type":"NRID","@value":"9000363372214"},{"@type":"NRID","@value":"9000321623544"},{"@type":"NRID","@value":"9000363381438"},{"@type":"NRID","@value":"9000321623929"},{"@type":"NRID","@value":"9000283506563"},{"@type":"NRID","@value":"9000243891065"},{"@type":"NRID","@value":"9000380133423"},{"@type":"NRID","@value":"9000363379486"},{"@type":"NRID","@value":"9000021282730"},{"@type":"NRID","@value":"9000321623335"},{"@type":"NRID","@value":"9000402907331"},{"@type":"NRID","@value":"9000340440762"},{"@type":"NRID","@value":"9000020727508"},{"@type":"NRID","@value":"9000276435452"},{"@type":"NRID","@value":"9000259327400"},{"@type":"NRID","@value":"9000363376977"},{"@type":"NRID","@value":"9000363379494"},{"@type":"NRID","@value":"9000363381902"},{"@type":"NRID","@value":"9000321623414"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0209358"}],"foaf:name":[{"@value":"Kunihiro Sakuma"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239446390280","@type":"Researcher","foaf:name":[{"@value":"Wataru Aoi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239446389120","@type":"Researcher","foaf:name":[{"@value":"Akihiko Yamaguchi"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"16634365"}],"prism:publicationName":[{"@value":"Frontiers in Aging Neuroscience"}],"dc:publisher":[{"@value":"Frontiers Media SA"}],"prism:publicationDate":"2014-08-29","prism:volume":"6","prism:startingPage":"230"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","createdAt":"2014-08-29","modifiedAt":"2022-04-15","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=autophagy","dc:title":"autophagy"},{"@id":"https://cir.nii.ac.jp/all?q=Sarcopenia","dc:title":"Sarcopenia"},{"@id":"https://cir.nii.ac.jp/all?q=serum%20rsponse%20factor","dc:title":"serum rsponse factor"},{"@id":"https://cir.nii.ac.jp/all?q=Neurosciences.%20Biological%20psychiatry.%20Neuropsychiatry","dc:title":"Neurosciences. 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Neuropsychiatry"},{"@id":"https://cir.nii.ac.jp/all?q=Myostatin","dc:title":"Myostatin"},{"@id":"https://cir.nii.ac.jp/all?q=Muscular%20Dystrophies","dc:title":"Muscular Dystrophies"},{"@id":"https://cir.nii.ac.jp/all?q=sarcopenia","dc:title":"sarcopenia"},{"@id":"https://cir.nii.ac.jp/all?q=myostatin","dc:title":"myostatin"},{"@id":"https://cir.nii.ac.jp/all?q=Autophagy","dc:title":"Autophagy"},{"@id":"https://cir.nii.ac.jp/all?q=mTOR","dc:title":"mTOR"},{"@id":"https://cir.nii.ac.jp/all?q=muscular%20dystrophies","dc:title":"muscular dystrophies"},{"@id":"https://cir.nii.ac.jp/all?q=serum%20response%20factor","dc:title":"serum response factor"},{"@id":"https://cir.nii.ac.jp/all?q=RC321-571","dc:title":"RC321-571"},{"@id":"https://cir.nii.ac.jp/all?q=Neuroscience","dc:title":"Neuroscience"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782293004160","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26350815"},{"@type":"JGN","@value":"JP26350815"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26350815/"}],"notation":[{"@language":"ja","@value":"加齢性筋減弱症における小胞体ストレスとオートファジーの役割の解明"},{"@language":"en","@value":"Elucidation of the functional role of endoplasmic reticulum stress and autophagy for sarcopenia"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001202554046976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Transmitochondrial mito-miceΔ and mtDNA mutator mice but not aged mice share the same spectrum of musculoskeletal 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