{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004239453796864.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3389/fnins.2018.00585"}},{"identifier":{"@type":"URI","@value":"https://www.frontiersin.org/article/10.3389/fnins.2018.00585/full"}},{"identifier":{"@type":"PMID","@value":"30344469"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Imaging Protein Misfolding in the Brain Using β-Sheet Ligands"}],"description":[{"notation":[{"@value":"Neurodegenerative diseases characterized by pathological protein accumulation in cells are termed \"proteinopathies.\" Although various protein aggregates share cross-β-sheet structures, actual conformations vary among each type of protein deposit. Recent progress in the development of radiotracers for positron emission tomography (PET) has enabled the visualization of protein aggregates in living brains. Amyloid PET tracers have been developed, and are widely used for the diagnosis of Alzheimer's disease and non-invasive assessment of amyloid burden in clinical trials of anti-dementia drugs. Furthermore, several tau PET tracers have been successfully developed and used in the clinical studies. However, recent studies have identified the presence of off-target binding of radiotracers in areas of tau deposition, suggesting that concomitant neuroinflammatory changes might affect tracer binding. In contrast to amyloid and tau PET, there are no established tracers for imaging Lewy bodies in the human brain. In this review, we describe lessons learned from the development of PET tracers and discuss the future direction of tracer development for protein misfolding diseases."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420564276176562048","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60735455"},{"@type":"NRID","@value":"1000060735455"},{"@type":"NRID","@value":"9000411833294"},{"@type":"NRID","@value":"9000411831636"},{"@type":"NRID","@value":"9000408481374"},{"@type":"NRID","@value":"9000018645182"},{"@type":"NRID","@value":"9000331090315"},{"@type":"NRID","@value":"9000408487938"},{"@type":"NRID","@value":"9000389553622"},{"@type":"NRID","@value":"9000304616056"},{"@type":"NRID","@value":"9000414748577"},{"@type":"NRID","@value":"9000408485862"},{"@type":"NRID","@value":"9000411833285"},{"@type":"NRID","@value":"9000408487723"},{"@type":"NRID","@value":"9000408916238"},{"@type":"NRID","@value":"9000403960554"},{"@type":"NRID","@value":"9000399336131"},{"@type":"NRID","@value":"9000411964609"},{"@type":"NRID","@value":"9000414748457"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000017810"}],"foaf:name":[{"@value":"Ryuichi 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Okamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239453797255","@type":"Researcher","foaf:name":[{"@value":"Shozo Furumoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801186934144","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50192787"},{"@type":"NRID","@value":"1000050192787"},{"@type":"CINII_AUTHOR_ID","@value":"DA13941839"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA13941839#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA13941839"},{"@type":"NRID","@value":"9000001055483"},{"@type":"NRID","@value":"9000411833293"},{"@type":"NRID","@value":"9000408480089"},{"@type":"NRID","@value":"9000021819077"},{"@type":"NRID","@value":"9000411831643"},{"@type":"NRID","@value":"9000408481373"},{"@type":"NRID","@value":"9000011266559"},{"@type":"NRID","@value":"9000253046054"},{"@type":"NRID","@value":"9000408480873"},{"@type":"NRID","@value":"9000018474351"},{"@type":"NRID","@value":"9000249260111"},{"@type":"NRID","@value":"9000408487942"},{"@type":"NRID","@value":"9000408480614"},{"@type":"NRID","@value":"9000399519944"},{"@type":"NRID","@value":"9000389553620"},{"@type":"NRID","@value":"9000001824525"},{"@type":"NRID","@value":"9000000613294"},{"@type":"NRID","@value":"9000255785435"},{"@type":"NRID","@value":"9000021325671"},{"@type":"NRID","@value":"9000249260119"},{"@type":"NRID","@value":"9000411830058"},{"@type":"NRID","@value":"9000415229327"},{"@type":"NRID","@value":"9000009591245"},{"@type":"NRID","@value":"9000018872516"},{"@type":"NRID","@value":"9000397656313"},{"@type":"NRID","@value":"9000414748570"},{"@type":"NRID","@value":"9000408768533"},{"@type":"NRID","@value":"9000018373668"},{"@type":"NRID","@value":"9000001824506"},{"@type":"NRID","@value":"9000022288502"},{"@type":"NRID","@value":"9000411830198"},{"@type":"NRID","@value":"9000410510946"},{"@type":"NRID","@value":"9000408485867"},{"@type":"NRID","@value":"9000006939135"},{"@type":"NRID","@value":"9000411833290"},{"@type":"NRID","@value":"9000408487724"},{"@type":"NRID","@value":"9000408916229"},{"@type":"NRID","@value":"9000257869332"},{"@type":"NRID","@value":"9000257923860"},{"@type":"NRID","@value":"9000016330063"},{"@type":"NRID","@value":"9000015268205"},{"@type":"NRID","@value":"9000408916240"},{"@type":"NRID","@value":"9000256759250"},{"@type":"NRID","@value":"9000257867975"},{"@type":"NRID","@value":"9000265249354"},{"@type":"NRID","@value":"9000390925438"},{"@type":"NRID","@value":"9000365026879"},{"@type":"NRID","@value":"9000403960569"},{"@type":"NRID","@value":"9000414220254"},{"@type":"NRID","@value":"9000392082604"},{"@type":"NRID","@value":"9000408485055"},{"@type":"NRID","@value":"9000020501582"},{"@type":"NRID","@value":"9000414748463"},{"@type":"NRID","@value":"9000414748031"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0191452"}],"foaf:name":[{"@value":"Kazuhiko Yanai"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"1662453X"}],"prism:publicationName":[{"@value":"Frontiers in Neuroscience"}],"dc:publisher":[{"@value":"Frontiers Media SA"}],"prism:publicationDate":"2018-08-21","prism:volume":"12","prism:startingPage":"585"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.frontiersin.org/article/10.3389/fnins.2018.00585/full"}],"createdAt":"2018-08-21","modifiedAt":"2018-09-25","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=PET","dc:title":"PET"},{"@id":"https://cir.nii.ac.jp/all?q=%CE%B2-sheet%20ligands","dc:title":"β-sheet ligands"},{"@id":"https://cir.nii.ac.jp/all?q=proteinopathies","dc:title":"proteinopathies"},{"@id":"https://cir.nii.ac.jp/all?q=Neurosciences.%20Biological%20psychiatry.%20Neuropsychiatry","dc:title":"Neurosciences. Biological psychiatry. Neuropsychiatry"},{"@id":"https://cir.nii.ac.jp/all?q=tau","dc:title":"tau"},{"@id":"https://cir.nii.ac.jp/all?q=protein%20aggregates","dc:title":"protein aggregates"},{"@id":"https://cir.nii.ac.jp/all?q=RC321-571","dc:title":"RC321-571"},{"@id":"https://cir.nii.ac.jp/all?q=Neuroscience","dc:title":"Neuroscience"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781922114304","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16K15570"},{"@type":"JGN","@value":"JP16K15570"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15570/"}],"notation":[{"@language":"ja","@value":"コンフォメーション特異的PETプローブの探索"},{"@language":"en","@value":"Search of conformation-specific PET probe"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782004367360","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K15538"},{"@type":"JGN","@value":"JP18K15538"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K15538/"}],"notation":[{"@language":"ja","@value":"神経変性プロセス可視化のためのPETプローブの開発"},{"@language":"en","@value":"Development of PET probes for visualization of neurodegenerative process"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256970118016","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18H02771"},{"@type":"JGN","@value":"JP18H02771"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02771/"}],"notation":[{"@language":"ja","@value":"神経原線維変化とアストログリオーシスの選択的描出によるアルツハイマー病の病態解明"},{"@language":"en","@value":"Imaging neurofibrillary tangles and astrogliosis for the clarification of the pathogenesis of Alzheimer's disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257256582528","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26117003"},{"@type":"JGN","@value":"JP26117003"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-26117003/"}],"notation":[{"@language":"ja","@value":"蛋白特異的PETイメージングによる神経回路破綻機序の解明"},{"@language":"en","@value":"Elucidation of neural network disruption mechanisms by protein specific PET imaging"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001202549787904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Biochemical classification of tauopathies by immunoblot protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002214590836736","@type":"Article","resourceType":"学術雑誌論文(journal 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