{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004239458475520.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3389/fphar.2019.00208"}},{"identifier":{"@type":"URI","@value":"https://www.frontiersin.org/article/10.3389/fphar.2019.00208/full"}},{"identifier":{"@type":"PMID","@value":"30890942"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Inhibitors of Human ABCG2: From Technical Background to Recent Updates With Clinical Implications"}],"description":[{"notation":[{"@value":"The ATP-binding cassette transporter G2 (ABCG2; also known as breast cancer resistance protein, BCRP) has been suggested to be involved in clinical multidrug resistance (MDR) in cancer like other ABC transporters such as ABCB1 ("}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420564276178752768","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80650340"},{"@type":"NRID","@value":"1000080650340"},{"@type":"NRID","@value":"9000019138055"},{"@type":"NRID","@value":"9000397801201"},{"@type":"NRID","@value":"9000411803086"},{"@type":"NRID","@value":"9000403275817"},{"@type":"NRID","@value":"9000412321883"},{"@type":"NRID","@value":"9000386307689"},{"@type":"NRID","@value":"9000415229538"},{"@type":"NRID","@value":"9000397687726"},{"@type":"NRID","@value":"9000404484378"},{"@type":"NRID","@value":"9000412339927"},{"@type":"NRID","@value":"9000329014773"},{"@type":"NRID","@value":"9000335564209"},{"@type":"NRID","@value":"9000345267870"},{"@type":"NRID","@value":"9000360584388"},{"@type":"NRID","@value":"9000321414824"},{"@type":"NRID","@value":"9000241480960"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read_toyoda"}],"foaf:name":[{"@value":"Yu Toyoda"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276179504512","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90376468"},{"@type":"NRID","@value":"1000090376468"},{"@type":"NRID","@value":"9000018284292"},{"@type":"NRID","@value":"9000020152964"},{"@type":"NRID","@value":"9000257892590"},{"@type":"NRID","@value":"9000409990060"},{"@type":"NRID","@value":"9000378128590"},{"@type":"NRID","@value":"9000006821788"},{"@type":"NRID","@value":"9000415229539"},{"@type":"NRID","@value":"9000399379996"},{"@type":"NRID","@value":"9000257892847"},{"@type":"NRID","@value":"9000412339929"},{"@type":"NRID","@value":"9000415234662"},{"@type":"NRID","@value":"9000404650725"},{"@type":"NRID","@value":"9000016401552"},{"@type":"NRID","@value":"9000347318485"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/TappeiTakada"}],"foaf:name":[{"@value":"Tappei Takada"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239458475652","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Suzuki"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"16639812"}],"prism:publicationName":[{"@value":"Frontiers in Pharmacology"}],"dc:publisher":[{"@value":"Frontiers Media SA"}],"prism:publicationDate":"2019-03-05","prism:volume":"10","prism:startingPage":"208"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.frontiersin.org/article/10.3389/fphar.2019.00208/full"}],"createdAt":"2019-03-05","modifiedAt":"2022-09-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Pharmacology","dc:title":"Pharmacology"},{"@id":"https://cir.nii.ac.jp/all?q=Ko143","dc:title":"Ko143"},{"@id":"https://cir.nii.ac.jp/all?q=drug%20repurposing","dc:title":"drug repurposing"},{"@id":"https://cir.nii.ac.jp/all?q=febuxostat","dc:title":"febuxostat"},{"@id":"https://cir.nii.ac.jp/all?q=RM1-950","dc:title":"RM1-950"},{"@id":"https://cir.nii.ac.jp/all?q=cancer%20chemotherapy","dc:title":"cancer chemotherapy"},{"@id":"https://cir.nii.ac.jp/all?q=multidrug%20resistance","dc:title":"multidrug resistance"},{"@id":"https://cir.nii.ac.jp/all?q=BCRP","dc:title":"BCRP"},{"@id":"https://cir.nii.ac.jp/all?q=Therapeutics.%20Pharmacology","dc:title":"Therapeutics. Pharmacology"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782006593152","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18KK0247"},{"@type":"JGN","@value":"JP18KK0247"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18KK0247/"}],"notation":[{"@language":"ja","@value":"遺伝的背景の違いを利用した新規尿酸輸送体の探索：チェコ共和国との国際共同研究"},{"@language":"en","@value":"International collaboration on the research of novel urate transporters by leveraging genetic differences between the Japanese and the Czech"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256810331264","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15H05610"},{"@type":"JGN","@value":"JP15H05610"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H05610/"}],"notation":[{"@language":"ja","@value":"ヒト体臭発生機序の分子生理基盤：体質や健康状態のにおい診断実現を目指した基礎研究"},{"@language":"en","@value":"Research for molecular bases relating to the development of body odor from armpits"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256871938816","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16H01808"},{"@type":"JGN","@value":"JP16H01808"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H01808/"}],"notation":[{"@language":"ja","@value":"新規血清尿酸値制御因子を標的とした機能性食品成分の探索"},{"@language":"en","@value":"Studies searching for functional food components to control novel SUA regulators"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002216803203328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Decreased extra-renal urate excretion is a common cause of hyperuricemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232002061952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Characterization of human ATP-binding cassette protein subfamily D reconstituted into proteoliposomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233534270592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004234756306688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Novel dysfunctional variant in<i>ABCG2</i>as a cause of severe tophaceous gout: biochemical, molecular genetics and functional analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239457803008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of Febuxostat as a New Strong ABCG2 Inhibitor: Potential Applications and Risks in Clinical Situations"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143923135616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Revisiting the role of ABC transporters in multidrug-resistant cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144774075648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145117207040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146030714112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bafetinib (INNO-406) reverses multidrug resistance by inhibiting the efflux function of ABCB1 and ABCG2 transporters"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146074441216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ABCG2: structure, function and role in drug response"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146519993472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular Pharmacology of ABCG2 and Its Role in Chemoresistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016870538742272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021389799567360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"SVCT2/SLC23A2 is a sodium-dependent urate transporter: functional properties and practical application"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706395623424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prediction of Drug Transfer into Milk Considering Breast Cancer Resistance Protein (BCRP)-Mediated Transport"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285714455958016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Functional Characterization of Clinically-Relevant Rare Variants in ABCG2 Identified in a Gout and Hyperuricemia Cohort"}]},{"@id":"https://cir.nii.ac.jp/crid/1360286995769809920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Regulation of breast cancer resistance protein and P-glycoprotein by ezrin, radixin and moesin in lung, intestinal and renal cancer cell lines"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617812004352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Identification of Two Dysfunctional Variants in the ABCG2 Urate Transporter Associated with Pediatric-Onset of Familial Hyperuricemia and Early-Onset Gout"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619532922624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ABCG2 Polymorphism Markedly Affects the Pharmacokinetics of Atorvastatin and Rosuvastatin"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619788954112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cobicistat: A New Boost for the Treatment of Human Immunodeficiency Virus Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619956429952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A multidrug resistance transporter from human MCF-7 breast cancer cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168497116160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Multiple common and rare variants of <i>ABCG2</i> cause gout"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185887437056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthetic Analogs of Curcumin Modulate the Function of Multidrug Resistance–Linked ATP-Binding Cassette Transporter ABCG2"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092648833920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Physiological Roles of ERM Proteins and Transcriptional Regulators in Supporting Membrane Expression of Efflux Transporters as Factors of Drug Resistance in Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574092887218560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Membrane transporters in drug development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093512653312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Involvement of Breast Cancer Resistance Protein (ABCG2) in the Biliary Excretion Mechanism of Fluoroquinolones"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094593582976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094963455744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pheophorbide a Is a Specific Probe for ABCG2 Function and Inhibition"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095124897792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"FLORENCE: a randomized, double-blind, phase III pivotal study of febuxostat versus allopurinol for the prevention of tumor lysis syndrome (TLS) in patients with hematologic malignancies at intermediate to high TLS risk"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096287232640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthesis and Quantitative Structure–Activity Relationships of Selective BCRP Inhibitors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118780613632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Porphyrin accumulation in humans with common dysfunctional variants of ABCG2, a porphyrin transporter: potential association with acquired photosensitivity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576123079550208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Soy Isoflavone Genistein Inhibits an Axillary Osmidrosis Risk Factor ABCC11: In Vitro Screening and Fractional Approach for ABCC11-Inhibitory Activities in Plant Extracts and Dietary Flavonoids"}]},{"@id":"https://cir.nii.ac.jp/crid/1360845539073898240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport—an Update"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656933685248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"BCRP/ABCG2 and high-alert medications: Biochemical, pharmacokinetic, pharmacogenetic, and clinical implications"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658417628800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660598920832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an<i>in vivo</i>inhibitor of BCRP"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570809610624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pharmacophore Modeling of Nilotinib as an Inhibitor of ATP-Binding Cassette Drug Transporters and BCR-ABL Kinase Using a Three-Dimensional Quantitative Structure–Activity Relationship Approach"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570917650560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epidermal growth factor receptor (EGFR) inhibitor PD153035 reverses ABCG2-mediated multidrug resistance in non-small cell lung cancer: In vitro and in vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570925090176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structure of the human multidrug transporter ABCG2"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869454285447552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Regulation of Urate Homeostasis by Membrane Transporters"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869854338202880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Asciminib, a novel allosteric inhibitor of <scp>BCR‐ABL1</scp>, shows synergistic effects when used in combination with imatinib with or without drug resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044071903232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ins and outs of the ABCG2 multidrug transporter: An update on in vitro functional assays"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044094018176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ulixertinib (BVD-523) antagonizes ABCB1- and ABCG2-mediated chemotherapeutic drug resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044232475392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structural basis of small-molecule inhibition of human multidrug transporter ABCG2"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044398672640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"QSAR analysis and molecular modeling of ABCG2-specific inhibitors"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518503855744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Physiological and pharmacological roles of ABCG2 (BCRP): Recent findings in Abcg2 knockout mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518581010048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of the Hepatic Efflux Transporters of Organic Anions Using Double-Transfected Madin-Darby Canine Kidney II Cells Expressing Human Organic Anion-Transporting Polypeptide 1B1 (OATP1B1)/Multidrug Resistance-Associated Protein 2, OATP1B1/Multidrug Resistance 1, and OATP1B1/Breast Cancer Resistance Protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518697283840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Drug Transporters and Imatinib Treatment: Implications for Clinical Practice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519369466240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Membrane reconstitution of ABC transporters and assays of translocator function"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520060322304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Critical Role of ABCG2 in ALA-Photodynamic Diagnosis and Therapy of Human Brain Tumor"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995462781952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995731949696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Assessment of ABCG2-mediated transport of xenobiotics across the blood–milk barrier of dairy animals using a new MDCKII in vitro model"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468605769728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ABCG2/BCRP Expression Modulates\n                    <scp>d</scp>\n                    -Luciferin–Based Bioluminescence Imaging"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469762901120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ABCG2/BCRP: Specific and Nonspecific Modulators"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469820967040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Calcium Channel Blockers, 1,4-Dihydropyridines, Are Substrates of the Multidrug Resistance-Linked ABC Drug Transporter, ABCG2"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943374854144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of Breast Cancer Resistance Protein (Bcrp1/Abcg2) in the Extrusion of Glucuronide and Sulfate Conjugates from Enterocytes to Intestinal Lumen"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943997067904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ABCG2 Transports Sulfated Conjugates of Steroids and Xenobiotics"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944343174784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prevention and treatment of tumor lysis syndrome, and the efficacy and role of rasburicase"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944961081344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ABCG2 functions as a general phytoestrogen sulfate transporter\n                    <i>in vivo</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946342805760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Novel chalcone and flavone derivatives as selective and dual inhibitors of the transport proteins ABCB1 and ABCG2"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419290480256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"In Vivo Bioluminescent Imaging of ATP-Binding Cassette Transporter-Mediated Efflux at the Blood–Brain Barrier"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419975312896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human ABC Transporter ABCG2 in Cancer Chemotherapy: Drug Molecular Design to Circumvent Multidrug Resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420837688320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Efficacy and safety of febuxostat for prevention of tumor lysis syndrome in patients with malignant tumors receiving chemotherapy: a phase III, randomized, multi-center trial comparing febuxostat and allopurinol"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895032225920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Functional Validation of the Genetic Polymorphisms of Human ATP-Binding Cassette (ABC) Transporter ABCG2: Identification of Alleles That Are Defective in Porphyrin Transport"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895283954304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evaluation of the Role of Breast Cancer Resistance Protein (BCRP/ABCG2) and Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) in The Urinary Excretion of Sulfate and Glucuronide Metabolites of Edaravone (MCI-186; 3-Methyl-1-phenyl-2-pyrazolin-5-one)"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895313584512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896192805120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Polymorphisms of the Multidrug Pump ABCG2: A Systematic Review of Their Effect on Protein Expression, Function, and Drug Pharmacokinetics"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896235257728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368537883264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Alpha-Mangostin Reverses Multidrug Resistance by Attenuating the Function of the Multidrug Resistance-Linked ABCG2 Transporter"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369090852992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Increased Oral Bioavailability of Topotecan in Combination With the Breast Cancer Resistance Protein and P-Glycoprotein Inhibitor GF120918"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370642216064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Functional ABCG2 is overexpressed on primary CML CD34+ cells and is inhibited by imatinib mesylate"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370847120768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370872747648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A malachite green procedure for orthophosphate determination and its use in alkaline phosphatase-based enzyme immunoassay"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845199257856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318288100352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A New Strategy of High-Speed Screening and Quantitative Structure-Activity Relationship Analysis to Evaluate Human ATP-Binding Cassette Transporter ABCG2-Drug Interactions"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318321052672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Involvement of BCRP (ABCG2) in the Biliary Excretion of Pitavastatin"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318336483584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Virtual Screening of DrugBank Reveals Two Drugs as New BCRP Inhibitors"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318932762880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Functional Characterization of Human Breast Cancer Resistance Protein (BCRP, ABCG2) Expressed in the Oocytes of Xenopus laevis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319195289984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320137760512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268779772928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ABCG2: A perspective"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268887888512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"[36] Purification and reconstitution of human P-glycoprotein"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269108478720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ATP/Mg2+-dependent Cardiac Transport System for Glutathione S-Conjugates"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269539846016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ABCG2-overexpressing H460/MX20 cell xenografts in athymic nude mice maintained original biochemical and cytological characteristics"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270526349056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Novel Synthetic Dihydroindeno[1,2-b] Indole Derivative (LS-2-3j) Reverses ABCB1- and ABCG2-Mediated Multidrug Resistance in Cancer Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270642438656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors"}]},{"@id":"https://cir.nii.ac.jp/crid/1370004239458475138","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein."}]},{"@id":"https://cir.nii.ac.jp/crid/1370004239458475140","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"BCRP/ABCG2 inhibitors: a patent review (2009-present)."}]},{"@id":"https://cir.nii.ac.jp/crid/1370004239458475141","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C."}]},{"@id":"https://cir.nii.ac.jp/crid/1370004239458475264","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance."}]},{"@id":"https://cir.nii.ac.jp/crid/1370004239458475653","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Impaired renal excretion of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) sulfate in breast cancer resistance protein (BCRP1/ABCG2) knockout mice."}]},{"@id":"https://cir.nii.ac.jp/crid/1370004239458475656","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C."}]},{"@id":"https://cir.nii.ac.jp/crid/1370004239458475780","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin."}]},{"@id":"https://cir.nii.ac.jp/crid/1370004239458475790","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes."}]},{"@id":"https://cir.nii.ac.jp/crid/1390006773236163840","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pathophysiological impact of dysfunctional common and rare variants of urate transporter ABCG2 on urate-related diseases"},{"@language":"ja","@value":"痛風病因としての尿酸トランスポーターABCG2の病態生理学的重要性とレアバリアント解析"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.3389/fphar.2019.00208"},{"@type":"KAKEN","@value":"PRODUCT-22369206"},{"@type":"KAKEN","@value":"PRODUCT-22182840"},{"@type":"KAKEN","@value":"PRODUCT-22245623"},{"@type":"OPENAIRE","@value":"doi_dedup___::544e4dc62aaf5ad21c25e0e5cb4962a1"},{"@type":"CROSSREF","@value":"10.2198/electroph.65.1_references_DOI_582Fx24LkqvXFouDeyP2UEVXHu9"},{"@type":"CROSSREF","@value":"10.1007/s00424-023-02792-1_references_DOI_582Fx24LkqvXFouDeyP2UEVXHu9"},{"@type":"CROSSREF","@value":"10.1016/j.jbc.2023.104976_references_DOI_582Fx24LkqvXFouDeyP2UEVXHu9"},{"@type":"CROSSREF","@value":"10.3390/cells8040363_references_DOI_582Fx24LkqvXFouDeyP2UEVXHu9"},{"@type":"CROSSREF","@value":"10.1111/jphp.13225_references_DOI_582Fx24LkqvXFouDeyP2UEVXHu9"},{"@type":"CROSSREF","@value":"10.3390/ijms22041935_references_DOI_582Fx24LkqvXFouDeyP2UEVXHu9"},{"@type":"CROSSREF","@value":"10.3390/nu12082452_references_DOI_582Fx24LkqvXFouDeyP2UEVXHu9"},{"@type":"CROSSREF","@value":"10.3390/gucdd2020016_references_DOI_582Fx24LkqvXFouDeyP2UEVXHu9"},{"@type":"CROSSREF","@value":"10.3390/cancers12113352_references_DOI_582Fx24LkqvXFouDeyP2UEVXHu9"},{"@type":"CROSSREF","@value":"10.1007/s13577-021-00534-y_references_DOI_582Fx24LkqvXFouDeyP2UEVXHu9"},{"@type":"CROSSREF","@value":"10.1002/prp2.1214_references_DOI_582Fx24LkqvXFouDeyP2UEVXHu9"}]}