{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004239472509696.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/antib4040409"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/2073-4468/4/4/409/pdf"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Regenerating Gene Protein as a Novel Autoantigen in the Pathogenesis of Sjögren’s Syndrome"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Sjögren’s syndrome, an autoimmune disease characterized by exocrine gland dysfunction leading to dry mouth and dry eye diseases, is typified by lymphoplasmacytic infiltrations and a progressive destruction of the salivary and lacrimal glands. Despite an ever-increasing focus on identifying the underlying etiology of Sjögren’s syndrome, the factors that initiate this autoimmune disease and the mechanisms that cause the subsequent exocrine gland dysfunction remain a mystery. The original explanatory concept for the pathogenesis of Sjögren’s syndrome proposed a specific, self-perpetuating, immune-mediated loss of acinar and ductal cells as the principal cause of salivary gland dysfunction. We highlight the possible involvement of regenerating gene (Reg) in the regeneration and destruction of salivary gland acinar and ductal cells in Sjögren’s syndrome. The Reg gene was originally isolated as a gene specifically overexpressed in regenerating pancreatic islets and constitutes a growth factor family (Reg family). We describe how salivary gland dysfunction is initiated and maintained and how it can be regenerated or progressed, mediated by the Reg gene, Reg protein, and anti-REG autoantibodies in Sjögren’s syndrome.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004239472509826","@type":"Researcher","foaf:name":[{"@value":"Takashi Fujimoto"}],"jpcoar:affiliationName":[{"@value":"The Center for Rheumatic Diseases, Nara Medical University Hospital, 840 Shijo-cho, Kashihara 634-8522, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239472509825","@type":"Researcher","foaf:name":[{"@value":"Kiyomi Yoshimoto"}],"jpcoar:affiliationName":[{"@value":"Department of General Medicine, Nara Medical University, 840 Shijo-cho, Kashihara 634-8522, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239472509568","@type":"Researcher","foaf:name":[{"@value":"Takanori Fujimura"}],"jpcoar:affiliationName":[{"@value":"The Center for Rheumatic Diseases, Nara Medical University Hospital, 840 Shijo-cho, Kashihara 634-8522, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239472509443","@type":"Researcher","foaf:name":[{"@value":"Maiko Takeda"}],"jpcoar:affiliationName":[{"@value":"Department of Diagnostic Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8522, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326234867968","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70361110"},{"@type":"NRID","@value":"1000070361110"},{"@type":"NRID","@value":"9000257793273"},{"@type":"NRID","@value":"9000257793437"},{"@type":"NRID","@value":"9000017313982"},{"@type":"NRID","@value":"9000001471509"},{"@type":"NRID","@value":"9000410264702"},{"@type":"NRID","@value":"9000258419462"},{"@type":"NRID","@value":"9000257792893"},{"@type":"NRID","@value":"9000257794190"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0211907"}],"foaf:name":[{"@value":"Akiyo Yamauchi"}],"jpcoar:affiliationName":[{"@value":"Department of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239472509696","@type":"Researcher","foaf:name":[{"@value":"Asako Itaya-Hironaka"}],"jpcoar:affiliationName":[{"@value":"Department of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239472509312","@type":"Researcher","foaf:name":[{"@value":"Shin Takasawa"}],"jpcoar:affiliationName":[{"@value":"Department of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20734468"}],"prism:publicationName":[{"@value":"Antibodies"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2015-12-07","prism:volume":"4","prism:number":"4","prism:startingPage":"409","prism:endingPage":"425"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.mdpi.com/2073-4468/4/4/409/pdf"}],"createdAt":"2015-12-09","modifiedAt":"2025-10-11","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=interleukin-6","dc:title":"interleukin-6"},{"@id":"https://cir.nii.ac.jp/all?q=RC581-607","dc:title":"RC581-607"},{"@id":"https://cir.nii.ac.jp/all?q=ductal%20epithelial%20cells","dc:title":"ductal epithelial cells"},{"@id":"https://cir.nii.ac.jp/all?q=Sj%C3%B6gren%E2%80%99s%20syndrome","dc:title":"Sjögren’s syndrome"},{"@id":"https://cir.nii.ac.jp/all?q=anti-REG%20autoantibody","dc:title":"anti-REG autoantibody"},{"@id":"https://cir.nii.ac.jp/all?q=Immunologic%20diseases.%20Allergy","dc:title":"Immunologic diseases. Allergy"},{"@id":"https://cir.nii.ac.jp/all?q=regenerating%20gene","dc:title":"regenerating gene"},{"@id":"https://cir.nii.ac.jp/all?q=Janus%20kinase","dc:title":"Janus kinase"},{"@id":"https://cir.nii.ac.jp/all?q=signal%20transducer%20and%20activator%20of%20transcription","dc:title":"signal transducer and activator of transcription"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782273427584","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25860220"},{"@type":"JGN","@value":"JP25860220"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860220/"}],"notation":[{"@language":"ja","@value":"膵β細胞の再生増殖におけるヒトREGファミリー遺伝子の役割の解明"},{"@language":"en","@value":"Roles of human REG family genes in pancreatic beta cell regeneration"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144481623680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"REG I  protein mediates an anti-apoptotic effect of STAT3 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Self-Duplication"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420412830720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epidemiology of primary Sjögren's syndrome in north-west Greece, 1982–2003"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893529519232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"New Concepts in the Pathogenesis of Sjögren's Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893874032256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of IL-18 and Th17 Cells in Salivary Glands of Patients with Sjögren’s Syndrome, and Amplification of IL-17-Mediated Secretion of Inflammatory Cytokines from Salivary Gland Cells by IL-18"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895034334080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-8 Regulates Expression of Reg Protein in Helicobacter pylori-Infected 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protein."}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369427068928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Elevated interleukin-6 plasma levels are regulated by the promoter region polymorphism of the IL6 gene in primary Sjogren's syndrome and correlate with the clinical manifestations of the disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369740828928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tofacitinib or Adalimumab versus Placebo in Rheumatoid Arthritis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371031839872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pancreatic reg Gene Expression Is Inhibited During Cellular Differentiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845561518720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gene expression profiles of cardiomyocytes in rat autoimmune myocarditis by DNA 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