{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004239477359488.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/cancers10090338"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/2072-6694/10/9/338/pdf"}},{"identifier":{"@type":"PMID","@value":"30231543"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Phase I Study of Carbon Ion Radiotherapy and Image-Guided Brachytherapy for Locally Advanced Cervical Cancer"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>A phase I study was performed to determine the recommended dose of carbon ion radiotherapy and 3D image-guided brachytherapy for histologically confirmed stage II (≥4 cm), III, or IVA cervical cancer. Dose-limiting toxicities (treatment-related toxicities occurring within three months from the start of carbon ion radiotherapy) included Grade 3 non-hematological toxicity, Grade 4 hematological toxicity, or interruption of treatment for more than two weeks due to treatment-related toxicities. Carbon ion radiotherapy consisted of whole-pelvic irradiation with 36.0 Gy (relative biological effectiveness) in 12 fractions and local boost with 19.2 Gy in four fractions for the primary site, and for positive lymph nodes. Three sessions of three-dimensional (3D) image-guided brachytherapy were administered after completion of carbon ion radiotherapy. Weekly cisplatin at a dose of 40 mg/m2 was given concurrently. At a dose level of one, a total rectosigmoid D2cc dose between 67.2 Gy and 71.3 Gy at a biological equivalent dose of 2 Gy per fraction from carbon ion radiotherapy and 3D image-guided brachytherapy was prescribed. Six patients were enrolled into this dose level. No patients developed the pre-defined dose-limiting toxicities. For late toxicities, however, one patient developed Grade 3 rectal hemorrhage requiring transfusion at 10 months after treatment. The median survival time was 50.0 months for the five surviving patients. No further dose escalation was performed, and we determined the dose of level one as the recommended rectosigmoid dose. Although our results are preliminary, the study regimen encourages further investigation (registration: UMIN000013340).</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004239477359496","@type":"Researcher","foaf:name":[{"@value":"Yuya Yoshimoto"}],"jpcoar:affiliationName":[{"@value":"Gunma University Heavy Ion Medical Center, Gunma University, 3-39-22 Showa, Maebashi, Gunma 371-8511, 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radiotherapy"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781851972736","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K09989"},{"@type":"JGN","@value":"JP15K09989"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09989/"}],"notation":[{"@language":"ja","@value":"子宮頸癌に対するマルチモダリティ画像誘導小線源治療の確立"},{"@language":"en","@value":"Establishment of multi-modality image-guided brachytherapy for cervical cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000781917080832","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16K11130"},{"@type":"JGN","@value":"JP16K11130"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K11130/"}],"notation":[{"@language":"ja","@value":"卵巣癌におけるレチノイン酸シグナル伝達の機能解析"},{"@language":"en","@value":"Functional analysis of retinoic acid signaling in ovarian 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