{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004239478435584.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/cancers9090111"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/2072-6694/9/9/111/pdf"}},{"identifier":{"@type":"PMID","@value":"28850056"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Microphthalmia-associated transcription (MiT) family translocation renal cell carcinoma (tRCC) comprises Xp11 tRCC and t(6;11) RCC. Due to the presence of fusion genes, Xp11 tRCC and t(6;11) RCC are also known as TFE3- and TFEB-rearranged RCC, respectively. TFE3 and TFEB belong to the MiT family, which regulates melanocyte and osteoclast differentiation, and TFE3- and TFEB-rearranged RCC show characteristic clinicopathological and immunohistochemical features. Recent studies identified the fusion partner-dependent clinicopathological and immunohistochemical features in TFE3-rearranged RCC. Furthermore, RCC with chromosome 6p amplification, including TFEB, was identified as a unique subtype of RCC, along with ALK-rearranged RCC. This review summarizes these recent advancements in our tRCC-related knowledge.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004239478435712","@type":"Researcher","foaf:name":[{"@value":"Kentaro Inamura"}],"jpcoar:affiliationName":[{"@value":"Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20726694"}],"prism:publicationName":[{"@value":"Cancers"}],"dc:publisher":[{"@value":"MDPI 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