{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004239488044800.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/ijerph10072813"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/1660-4601/10/7/2813/pdf"}},{"identifier":{"@type":"PMID","@value":"23880723"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Circulating Nitrite and Nitrate are Associated with Job-Related Fatigue in Women, but not in Men"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>A recent study indicated that serum nitrite and nitrate (NOx) is inversely associated with general fatigue. The purpose of this study was to confirm the negative association between nitric oxide (NO) and fatigue and to examine whether NO can prevent fatigue caused by job strain. The subjects, 570 workers (272 men and 298 women), answered self-administered questionnaires and underwent a medical examination. Job strain was measured using the Job Content Questionnaire. Fatigue was evaluated using the Profile of Mood States. Venous blood samples were collected after overnight fasting. Plasma NOx concentration was determined by the ozone-based chemiluminescence assay. Plasma NOx levels were significantly (p < 0.05) negatively associated with fatigue even after adjustment for job strain and potential confounders in women, but not in men. Significant (p < 0.05) interactions showed that, in women, as the level of the job strain worsened, fatigue was exacerbated, but the plasma NOx seemed to buffer the association, even after adjustment for potential confounders and the interaction between job strain and vegetable intake. In women, NO seemed to be inversely associated with fatigue and to buffer the association between job strain and fatigue, but not in men.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420282801187261824","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50384847"},{"@type":"NRID","@value":"1000050384847"},{"@type":"NRID","@value":"9000318135755"}],"foaf:name":[{"@value":"Jiro Takaki"}],"jpcoar:affiliationName":[{"@value":"Department of Public Health and Occupational Medicine, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"16604601"}],"prism:publicationName":[{"@value":"International Journal of Environmental Research and Public Health"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2013-07-05","prism:volume":"10","prism:number":"7","prism:startingPage":"2813","prism:endingPage":"2824"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/3.0/"],"url":[{"@id":"https://www.mdpi.com/1660-4601/10/7/2813/pdf"}],"createdAt":"2013-07-05","modifiedAt":"2025-10-11","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Work","dc:title":"Work"},{"@id":"https://cir.nii.ac.jp/all?q=Nitrates","dc:title":"Nitrates"},{"@id":"https://cir.nii.ac.jp/all?q=Adolescent","dc:title":"Adolescent"},{"@id":"https://cir.nii.ac.jp/all?q=interaction;%20demands-control%20model;%20fatigue;%20gender%20difference;%20job%20strain;%20nitric%20oxide","dc:title":"interaction; demands-control model; fatigue; gender difference; job strain; nitric oxide"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"},{"@id":"https://cir.nii.ac.jp/all?q=Young%20Adult","dc:title":"Young Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Japan","dc:title":"Japan"},{"@id":"https://cir.nii.ac.jp/all?q=Surveys%20and%20Questionnaires","dc:title":"Surveys and Questionnaires"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Fatigue","dc:title":"Fatigue"},{"@id":"https://cir.nii.ac.jp/all?q=Nitrites","dc:title":"Nitrites"},{"@id":"https://cir.nii.ac.jp/all?q=Stress,%20Psychological","dc:title":"Stress, Psychological"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257132396032","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23500802"},{"@type":"JGN","@value":"JP23500802"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500802/"}],"notation":[{"@language":"ja","@value":"職場におけるいじめ、ハラスメント、自殺の予防法の開発"},{"@language":"en","@value":"Development of prevention methods of bullying, harassment, and suicide in the workplace"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004231540476032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Modification Effects of Changes in Job Demands on Associations Between Changes in Testosterone Levels and Andropause Symptoms: 2-Year Follow-up Study in Male Middle-Aged Japanese Workers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144347363840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oxidative stress and redox signaling mechanisms of alcoholic liver disease: Updated experimental and clinical evidence"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144391970560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Serum nitric oxide metabolite levels in a general healthy population: Relation to sex and age"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708382278144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"C-reactive protein is associated with cigarette smoking-induced hyperfiltration and proteinuria in an apparently healthy population"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618727386752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gender Difference in Improvement of Endothelium-Dependent Vasodilation After Estrogen Supplementation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620912365952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Job Demands, Job Decision Latitude, and Mental Strain: Implications for Job Redesign"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621329408000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reversible Reduction in Plasma Concentration of Nitric Oxide Induced by Cigarette Smoking in Young Adults"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302865717603072","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hofstede’s Cultural Values and Birth Rate and Longevity: A National-Level Analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093525554560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569279950208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oxidative Stress in the Cardiorenal Metabolic Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043951203968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Smoking a Single Cigarette Rapidly Reduces Combined Concentrations of Nitrate and Nitrite and Concentrations of Antioxidants in Plasma"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519755621504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Acute and chronic effects of dinner with alcoholic beverages on nitric oxide metabolites in healthy men"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995320694144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exercise"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995594204288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469251961600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943338660224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Psychosocial work environment and medical symptoms among Swedish commercial airline cabin crew"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944863880576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Assessment of job stress dimensions based on the job demands-control model of employees of telecommunication and electric power companies in japan: reliability and validity of the japanese version of the job content questionnaire"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419178285056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419291670656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evidence for a Difference in Nitric Oxide Biosynthesis Between Healthy Women and Men"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894083552768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nitrite and nitrate determinations in plasma: a critical evaluation"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894284660608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Measurement of circulating nitrite and S-nitrosothiols by reductive chemiluminescence"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370851740160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association between ambulatory blood pressure and alternative formulations of job strain."}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843335411584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Psychosocial working conditions and exhaustion in a working population sample of Swedish middle-aged men and women"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844357470720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794493585536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dietary exposures to nitrate in the UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795775098112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A hard day’s night: a longitudinal study on the relationships among job demands and job control, sleep quality and fatigue"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795986182272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chronic Low-Grade Inflammation in Elderly Persons Is Associated with Altered Tryptophan and Tyrosine Metabolism: Role in Neuropsychiatric Symptoms"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271278883200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inorganic Nitrate Supplementation Lowers Blood Pressure in Humans"}]},{"@id":"https://cir.nii.ac.jp/crid/1370004239488044801","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Production of the Japanese edition of the Profile of Mood States (POMS): Assessment of reliability and validity"}]},{"@id":"https://cir.nii.ac.jp/crid/1370581936915041408","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cigarette smoke radicals and the role of free radicals in chemical carcinogenicity"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204239550976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A Practical Procedure for Achieving a Steady State of NOx Concentration in Plasma:  with Special Reference to the NOx Content of Japanese Daily Food"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206549014656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Validation of a Food Frequency Questionnaire Based on Food Groups for Estimating Individual Nutrient Intake."},{"@value":"栄養素および食品群別摂取量推定のための食品群をベースとした食物摂取頻度調査票の作成および妥当性"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679257459584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Moderating effects of salivary testosterone levels on associations between job demand and psychological stress response in Japanese medical workers"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.3390/ijerph10072813"},{"@type":"KAKEN","@value":"PRODUCT-13992553"},{"@type":"KAKEN","@value":"PRODUCT-13992536"},{"@type":"OPENAIRE","@value":"doi_dedup___::108334d4fd7178e79c2dc2827638a560"},{"@type":"CROSSREF","@value":"10.1007/s12529-015-9530-y_references_DOI_B4974XYxoakKBqmjzHShHwVxSxT"},{"@type":"CROSSREF","@value":"10.2486/indhealth.2015-0113_references_DOI_B4974XYxoakKBqmjzHShHwVxSxT"},{"@type":"CROSSREF","@value":"10.1007/s10804-023-09457-4_references_DOI_B4974XYxoakKBqmjzHShHwVxSxT"}]}