{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004239495711872.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/ijms20030649"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/1422-0067/20/3/649/pdf"}},{"identifier":{"@type":"DOI","@value":"10.5281/zenodo.13531169"}},{"identifier":{"@type":"DOI","@value":"10.5281/zenodo.13531168"}},{"identifier":{"@type":"PMID","@value":"30717382"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Interleukin-18 in Health and Disease"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation. Therefore, IL-12 is a commitment factor that induces the development of Th1 cells. In contrast, IL-18 is a proinflammatory cytokine that facilitates type 1 responses. However, IL-18 without IL-12 but with IL-2, stimulates NK cells, CD4+ NKT cells, and established Th1 cells, to produce IL-3, IL-9, and IL-13. Furthermore, together with IL-3, IL-18 stimulates mast cells and basophils to produce IL-4, IL-13, and chemical mediators such as histamine. Therefore, IL-18 is a cytokine that stimulates various cell types and has pleiotropic functions. IL-18 is a member of the IL-1 family of cytokines. IL-18 demonstrates a unique function by binding to a specific receptor expressed on various types of cells. In this review article, we will focus on the unique features of IL-18 in health and disease in experimental animals and humans.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326221490176","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50333539"},{"@type":"NRID","@value":"1000050333539"},{"@type":"NRID","@value":"9000406047168"},{"@type":"NRID","@value":"9000366497091"},{"@type":"NRID","@value":"9000001430626"},{"@type":"NRID","@value":"9000006604028"},{"@type":"NRID","@value":"9000001294136"},{"@type":"NRID","@value":"9000000376100"},{"@type":"NRID","@value":"9000391774458"},{"@type":"NRID","@value":"9000391777836"},{"@type":"NRID","@value":"9000318160006"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0100297"}],"foaf:name":[{"@value":"Koubun Yasuda"}],"jpcoar:affiliationName":[{"@value":"Department of Immunology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239495710208","@type":"Researcher","foaf:name":[{"@value":"Kenji Nakanishi"}],"jpcoar:affiliationName":[{"@value":"Department of Immunology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239495712384","@type":"Researcher","foaf:name":[{"@value":"Hiroko Tsutsui"}],"jpcoar:affiliationName":[{"@value":"Department of Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14220067"}],"prism:publicationName":[{"@value":"International Journal of Molecular Sciences"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2019-02-02","prism:volume":"20","prism:number":"3","prism:startingPage":"649"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.mdpi.com/1422-0067/20/3/649/pdf"}],"createdAt":"2019-02-05","modifiedAt":"2025-10-11","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=innate-type%20allergy","dc:title":"innate-type allergy"},{"@id":"https://cir.nii.ac.jp/all?q=bats","dc:title":"bats"},{"@id":"https://cir.nii.ac.jp/all?q=bat","dc:title":"bat"},{"@id":"https://cir.nii.ac.jp/all?q=Review","dc:title":"Review"},{"@id":"https://cir.nii.ac.jp/all?q=Chiroptera","dc:title":"Chiroptera"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Animalia","dc:title":"Animalia"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Targeted%20Therapy","dc:title":"Molecular Targeted Therapy"},{"@id":"https://cir.nii.ac.jp/all?q=Chordata","dc:title":"Chordata"},{"@id":"https://cir.nii.ac.jp/all?q=IFN-%CE%B3","dc:title":"IFN-γ"},{"@id":"https://cir.nii.ac.jp/all?q=Inflammation","dc:title":"Inflammation"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Interleukin-18","dc:title":"Receptors, Interleukin-18"},{"@id":"https://cir.nii.ac.jp/all?q=disease","dc:title":"disease"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-18","dc:title":"Interleukin-18"},{"@id":"https://cir.nii.ac.jp/all?q=therapeutic%20target","dc:title":"therapeutic target"},{"@id":"https://cir.nii.ac.jp/all?q=Biodiversity","dc:title":"Biodiversity"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-33","dc:title":"Interleukin-33"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation","dc:title":"Gene Expression Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=host%20defense","dc:title":"host defense"},{"@id":"https://cir.nii.ac.jp/all?q=Immune%20System","dc:title":"Immune System"},{"@id":"https://cir.nii.ac.jp/all?q=Mammalia","dc:title":"Mammalia"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Susceptibility","dc:title":"Disease Susceptibility"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Binding","dc:title":"Protein Binding"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781967923072","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17K08813"},{"@type":"JGN","@value":"JP17K08813"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K08813/"}],"notation":[{"@language":"ja","@value":"糞線虫感染排除後の肺に見られる高反応性ILC2に関する研究"},{"@language":"en","@value":"Highly reactive ILC2s in the lungs of Strongyloides venezuelensis infection-experienced mice"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001335805156480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The structural basis for receptor recognition of human interleukin-18."}]},{"@id":"https://cir.nii.ac.jp/crid/1050565162440399232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Innate immunity in diabetes and diabetic nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1050845760735242112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"TRAM Is Involved in IL-18 Signaling and Functions as a Sorting Adaptor for MyD88"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002215307430016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"CD8+ T cell granzyme B activates keratinocyte endogenous IL-18"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002216798951552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002218685032320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Augmentation of Immune Checkpoint Cancer Immunotherapy with IL18"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239438129408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulatory Mechanisms of IL-33-ST2-Mediated Allergic Inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143491481600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NALPs: a novel protein family involved in inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143713970560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical and Biological Effects of Recombinant Human Interleukin-18 Administered by Intravenous Infusion to Patients with Advanced Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143972814464","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144090664832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL‐18‐induced expression of high‐affinity IL‐2R on murine NK cells is essential for NK‐cell IFN‐γ production during murine <i>Plasmodium yoelii</i> infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144122990592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The tale of soluble receptors and binding proteins: From bench to bedside"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144480345856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin 18 Gene Promoter Polymorphisms and Susceptibility to Chronic Hepatitis B Infection: A Review Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144654582912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cloning of a new cytokine that induces IFN-γ production by T cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144803769088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Distant-Organ Changes after Acute Kidney Injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145017699968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145142966144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ethnicity-stratified analysis of the association between IL-18 polymorphisms and systemic lupus erythematosus in a European population: a meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145278840192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammasomes and Their Roles in Health and Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145463349760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A newly defined interleukin-1?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145594130432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Elevated Levels of Circulating Interleukin-18 in Human Immunodeficiency Virus-Infected Individuals: Role of Peripheral Blood Mononuclear Cells and Implications for AIDS Pathogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145599213824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A role for IL‐18 in protective immunity against <i>Mycobacterium tuberculosis</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145852083328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-18 (IL-18) Enhances Innate IL-12-Mediated Resistance to<i>Toxoplasma gondii</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145897269248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145952291712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"INTERLEUKIN-1F7B (IL-1H4/IL-1F7) IS PROCESSED BY CASPASE-1 AND MATURE IL-1F7B BINDS TO THE IL-18 RECEPTOR BUT DOES NOT INDUCE IFN-γ PRODUCTION"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145997499904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-12p40 and IL-18 Play Pivotal Roles in Orchestrating the Cell-Mediated Immune Response to a Poxvirus Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146057607168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regional specialization within the intestinal immune system"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146345654656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Caspase-1 Activation of IL-1β and IL-18 Are Essential for Shigella flexneri–Induced Inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146403265152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146407984896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016870028416128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of IL-18 (IFN-gamma-inducing factor) gene expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016870028506240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Influenza A Virus-Induced IFN-α/β and IL-18 Synergistically Enhance IFN-γ Gene Expression in Human T Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016870540308608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cloning of the cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016870540683136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Roles of IFN Consensus Sequence Binding Protein and PU.1 in Regulating IL-18 Gene Expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017279865043712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Loop Between NLRP3 Inflammasome and Reactive Oxygen Species"}]},{"@id":"https://cir.nii.ac.jp/crid/1360019299698960384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association of Interleukin-18 Gene Promoter −607 C>A and −137G>C Polymorphisms with Cancer Risk: A Meta-Analysis of 26 Studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283689513828864","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The adaptor ASC exacerbates lethal <i>Listeria monocytogenes</i> infection by mediating IL‐18 production in an inflammasome‐dependent and ‐independent manner"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283690957097088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Crucial role for autophagy in degranulation of mast cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691775605376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692108654464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Contribution of IL-33–activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692109369344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285714414886784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nematode-Infected Mice Acquire Resistance to Subsequent Infection With Unrelated Nematode by Inducing Highly Responsive Group 2 Innate Lymphoid Cells in the Lung"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618669432192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bruton’s Tyrosine Kinase Is Involved in miR-346-Related Regulation of IL-18 Release by Lipopolysaccharide-Activated Rheumatoid Fibroblast-Like Synoviocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618715647872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Metabolic Regulation of Adipose Tissue Macrophage Function in Obesity and Diabetes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618770790272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618907842176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association between interleukin-18 gene promoter (−607C/A and −137G/C) polymorphisms and chronic hepatitis C virus infections: A meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619157474944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The -137G>C polymorphism in interleukin-18 promoter region and cancer risk: evidence from a meta-analysis of 21 studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619259979264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619382212480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619412319104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619508573184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Alterations of a Zinc Finger-Encoding Gene,\n            <i>BCL-6</i>\n            , in Diffuse Large-Cell Lymphoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619964878592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Distant Effects of Experimental Renal Ischemia/Reperfusion Injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620133187584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620464792960","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620556984704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620621938304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620757951872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin‐18 gene polymorphisms and risk of recurrent pregnancy loss: A systematic review and meta‐analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620768301440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-18-Binding Protein Protects Against Lipopolysaccharide- Induced Lethality and Prevents the Development of Fas/Fas Ligand-Mediated Models of Liver Disease in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621039572864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"New mitochondrial DNA synthesis enables NLRP3 inflammasome activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621092302080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621158890496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-18 Regulates Intestinal Mastocytosis and Th2 Cytokine Production Independently of IFN-γ During <i>Trichinella spiralis</i> Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643800438656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cytokine profile in patients with chronic non-bacterial osteomyelitis, juvenile idiopathic arthritis, and insulin-dependent diabetes mellitus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294722494351744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-18, a Novel Immunoregulatory Cytokine, Is Up-Regulated in Crohn’s Disease: Expression and Localization in Intestinal Mucosal Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298343111899008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Eight novel susceptibility loci and putative causal variants in atopic dermatitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298345419651584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"High serum IL-6 level reflects susceptible status of the host to endotoxin and IL-1/tumor necrosis factor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298345517674240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-18 Up-Regulates Perforin-Mediated NK Activity Without Increasing Perforin Messenger RNA Expression by Binding to Constitutively Expressed IL-18 Receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298345517722368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cutting Edge: Generation of IL-18 Receptor-Deficient Mice: Evidence for IL-1 Receptor-Related Protein as an Essential IL-18 Binding Receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302865543241088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Monoclonal Antibodies Against Mature Interleukin-18 Ameliorate Colitis and Repair Goblet Cell Function"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302865545885440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"NLRP3 inflammasome-driven IL-1β and IL-18 contribute to lipopolysaccharide-induced septic cardiomyopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306906092326272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"IL-18 Blockage Reduces Neuroinflammation and Promotes Functional Recovery in a Mouse Model of Spinal Cord Injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165240756224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Zoledronic acid-induced expansion of γδ T cells from early-stage breast cancer patients: effect of IL-18 on helper NK cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565167524180224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Requirement of GATA-binding protein 3 for Il13 gene expression in IL-18-stimulated Th1 cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565169387980160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of Development of CD56brightCD11c+ NK-like Cells with Helper Function by IL-18"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565170630692096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Importance of Kupffer Cells in the Development of Acute Liver Injuries in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574092883365888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MicroRNAs: Target Recognition and Regulatory Functions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093497876480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094166075520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetic polymorphisms -137 (rs187238) and -607 (rs1946518) in the interleukin-18 promoter may not be associated with development of hepatocellular carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094296479744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-18 directly protects cortical neurons by activating PI3K/AKT/NF-κB/CREB pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094576676224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Incidence, risk factors, and outcomes of acute kidney injury after pediatric cardiac surgery: A prospective multicenter study*"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094991383296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Deregulated inflammasome signaling in disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095063434880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human ICE/CED-3 Protease Nomenclature"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095079030528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Contribution of TIR domain-containing adapter inducing IFN-β-mediated IL-18 release to LPS-induced liver injury in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095210781184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-15-Dependent NKp46+ Innate Lymphoid Cells Control Intestinal Inflammation by Recruiting Inflammatory Monocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095233682944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Potentiality of Interleukin-18 as a Useful Reagent for Treatment and Prevention of<i>Leishmania major</i>Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095390685184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association of IL-18 promoter gene polymorphisms with rheumatoid arthritis: a meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095442638976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095473957376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095612047744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095647833856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cryopyrin activates the inflammasome in response to toxins and ATP"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095760529280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Inflammasomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096018874368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096035280128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-18 Contributes to Renal Damage after Ischemia-Reperfusion"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096150602496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A candidate gene for familial Mediterranean fever"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096311561984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096320372992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-18 and the Risk of Coronary Heart Disease in European Men"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096404833664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118738098432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Small Molecule Inhibitors Targeting Nuclear Factor κB Activation Markedly Reduce Expression of Interleukin-2, but Not Interferon-γ, Induced by Phorbol Esters and Calcium Ionophores"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576215909572864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-12 Up-Regulates IL-18 Receptor Expression on T Cells, Th1 Cells, and B Cells: Synergism with IL-18 for IFN-γ Production"}]},{"@id":"https://cir.nii.ac.jp/crid/1360579816409342336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential Capacities of CD4+, CD8+, and CD4−CD8− T Cell Subsets to Express IL-18 Receptor and Produce IFN-γ in Response to IL-18"}]},{"@id":"https://cir.nii.ac.jp/crid/1360579820397266432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-18 (IFN-γ-Inducing Factor) Regulates Early Cytokine Production in, and Promotes Resolution of, Bacterial Infection in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846639520362752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Frontline Science: IL-18 primes murine NK cells for proliferation by promoting protein synthesis, survival, and autophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643368360064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction of Colonic Regulatory T Cells by Indigenous\n                    <i>Clostridium</i>\n                    Species"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643389904512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Enhancement of Neutrophil Function by Interleukin-18 Therapy Protects Burn-Injured Mice from Methicillin-Resistant Staphylococcus aureus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643944354048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immunoenhancing therapy with interleukin-18 against bacterial infection in immunocompromised hosts after severe surgical stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656973758336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567550764288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Manipulation of epithelial integrity and mucosal immunity by host and microbiota‐derived metabolites"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567640235776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Lactococcus lactis subsp. Cremoris C60 restores T Cell Population in Small Intestinal Lamina Propria in Aged Interleukin-18 Deficient Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568464156288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-18 null mutation increases weight and food intake and reduces energy expenditure and lipid substrate utilization in high-fat diet fed mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568646907520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568665027712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Muscles, exercise and obesity: skeletal muscle as a secretory organ"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569046843648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-37 Confers Protection against Mycobacterial Infection Involving Suppressing Inflammation and Modulating T Cell Activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569085248256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569672271104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569701383808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570165677568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Increased Frequency of Mutations in the Gene Responsible for Familial Mediterranean Fever (MEFV) in a Cohort of Patients with Ulcerative Colitis: Evidence for a Potential Disease-Modifying Effect?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570285408768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The pathogenic basis of malaria"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570341409792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Caspases as the Key Effectors of Inflammatory Responses Against Bacterial Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570472667776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of interferon-γ production by IL-12 and IL-18"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570580542464","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The biology of DHX9 and its potential as a therapeutic target"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570677966720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Noncoding RNAs, cytokines, and inflammation-related diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570752924160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interferon-γ Mediates Gene Expression of IL-18 Binding Protein in Nonleukocytic Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570875825408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The TLR4/TRIF-Mediated Activation of NLRP3 Inflammasome Underlies Endotoxin-Induced Liver Injury in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570988711936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571135450368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin 18 and coronary heart disease: Prospective study and systematic review"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571248876800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cutting Edge: A Murine, IL-12-Independent Pathway of IFN-γ Induction by Gram-Negative Bacteria Based on STAT4 Activation by Type I IFN and IL-18 Signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571300925824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bacterial secretion systems and regulation of inflammasome activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857624283025280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Impaired Cytokine Signaling in Mice Lacking the IL-1 Receptor-Associated Kinase"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707134580096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Alveolar macrophages instruct CD8+ T cell expansion by antigen cross-presentation in lung"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707369862784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Generation of antagonistic monoclonal antibodies against the neoepitope of active mouse interleukin (IL)-18 cleaved by inflammatory caspases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043562486912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043785211648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Caspase 1-independent IL-1β release and inflammation induced by the apoptosis inducer Fas ligand"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044118844416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-18 Serum Level in Adult Onset Still’s Disease: A Marker of Disease Activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044695110656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of Interleukin-18 (IL-18) in Mycobacterial Infection in IL-18-Gene-Disrupted Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044746193664","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"NLRP3 inflammasome as a key driver of vascular disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044940095616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The widespread regulation of microRNA biogenesis, function and decay"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045062507648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045148788480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Natural killer cells and other innate lymphoid cells in cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045260787584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Long-term Risk of Mortality and Other Adverse Outcomes After Acute Kidney Injury: A Systematic Review and Meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045273509888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-18 Protects Mice against Acute Herpes Simplex Virus Type 1 Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045353073280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"RELMβ/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045608585088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Role of NLRP3 and IL-1β in the Pathogenesis of Inflammatory Bowel Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045654741248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045720593024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Intracellular production of interleukin-18 in human epithelial-like cell lines is enhanced by hyperosmotic stress in vitro"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045753192704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanism and Regulation of NLRP3 Inflammasome Activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045758649728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammasomes in the Pathophysiology of Kidney Diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045911106176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Old, new and emerging functions of caspases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046070339456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The NLRP3 inflammasome in kidney disease and autoimmunity"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046163254016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Natural history and risk factors for immunoglobulin a nephropathy in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046231084160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"C-Type Lectin Receptors Dectin-3 and Dectin-2 Form a Heterodimeric Pattern-Recognition Receptor for Host Defense against Fungal Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518403425792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518538541056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interferon-γ: the Major Mediator of Resistance Against\n            <i>Toxoplasma gondii</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518605826944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NLRP3 inflammasome: Its regulation and involvement in atherosclerosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518835117440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Engineering Approaches in Human Gamma Delta T Cells for Cancer Immunotherapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518991838976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-γ and IL-13 production"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518995068288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519191458560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammasomes and Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519210239360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Acute Trypanosoma cruzi infection: IL-12, IL-18, TNF, sTNFR and NO in T. rangeli-vaccinated mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519308477184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pathophysiological roles of interleukin-18 in inflammatory liver diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519371562880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519457334144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-18 Is a Strong Predictor of Cardiovascular Death in Stable and Unstable Angina"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519473219840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Functional IL18 polymorphism and susceptibility to Chronic Chagas Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519572949376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519836420608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-18 Activates STAT3 in the Natural Killer Cell Line 92, Augments Cytotoxic Activity, and Mediates IFN-γ Production by the Stress Kinase p38 and by the Extracellular Regulated Kinases p44\n                    <i>erk-1</i>\n                    and p42\n                    <i>erk-2</i>\n                    1"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519980655744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-18 genetic polymorphisms contribute differentially to the susceptibility to Crohn’s disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519996109696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520041365504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immunity to uropathogens: the emerging roles of inflammasomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520045601664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"At the Bedside: Innate immunity as an immunotherapy tool for hematological malignancies"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520170029696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The role of sex hormones in the development of Th2 immunity in a gender‐biased model of <i>Trichuris muris</i> infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520254092416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The promoter of IL-18 binding protein: Activation by an IFN-γ-induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein β"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520361596288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520571358208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520941898752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Caspase-1–deficient mice are protected against cisplatin-induced apoptosis and acute tubular necrosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521075873280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521123718784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Myocardial Gene Expression of<i>T-bet</i>,<i>GATA-3</i>,<i>Ror-</i><mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" id=\"M1\"><mml:mrow><mml:mi mathvariant=\"italic\">γ</mml:mi></mml:mrow></mml:math>t,<i>FoxP3</i>, and Hallmark Cytokines in Chronic Chagas Disease Cardiomyopathy: An Essentially Unopposed T<sub>H</sub>1-Type Response"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521129985664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Plasma Levels of Interleukin-18 and Interleukin-18 Binding Protein Are Elevated in Patients with Chronic Liver Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521204010368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-12 but not interleukin-18 is required for immunity to Trypanosoma cruzi in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521221449216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Control of brown and beige fat development"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521510237056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of the Nlrp3 inflammasome by mitochondrial reactive oxygen species: A novel mechanism of albumin-induced tubulointerstitial inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993427080576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993906798080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency Genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994113290112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association of Single Nucleotide Polymorphisms in the IL‐18 Gene with Production of IL‐18 Protein by Mononuclear Cells from Healthy Donors"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994128454656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Orchestration of NLRP3 Inflammasome Activation by Ion Fluxes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994210461440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammatory Caspases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994322223104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Batf3/Nlrp3/IL-18 Axis Promotes Natural Killer Cell IL-10 Production during Listeria monocytogenes Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994379694336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The <scp>AIM</scp>2 inflammasome: Sensor of pathogens and cellular perturbations"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994494436352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994546780288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-18 gene promoter 607A polymorphism, but not 137C polymorphism, is a protective factor for ischemic stroke in the Chinese population: A meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994566695680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994721230720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pharmacokinetics of IL-18 binding protein in healthy volunteers and subjects with rheumatoid arthritis or plaque psoriasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994796059520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulatory effects of IL-18 on cytokine profiles and development of myocarditis during Trypanosoma cruzi infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994799718912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin 37 expression protects mice from colitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994890071424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994903110656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prevention and cure of rotavirus infection via TLR5/NLRC4–mediated production of IL-22 and IL-18"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995059630080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-18 Binding Protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995321923200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Inflammasomes: Guardians of the Body"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995341391232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Interleukin-18 Promoter -607C>A Polymorphism Contributes to Nasopharyngeal Carcinoma Risk: Evidence from a Meta-analysis Including 1,886 Subjects"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995455667968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immunohistochemical and immuno-electron-microscopic detection of interferon-γ-inducing factor (”interleukin-18\") in mouse intestinal epithelial cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995494206848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin‐18 prevents apoptosis via PI3K/Akt pathway in normal human keratinocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995547345408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ancient Missense Mutations in a New Member of the RoRet Gene Family Are Likely to Cause Familial Mediterranean Fever"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995581318016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Polymorphisms in the Interleukin 18 Receptor 1 Gene and Tuberculosis Susceptibility among Chinese"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995784293120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995941041664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association between Genetic Polymorphisms in Interleukin Genes and Recurrent Pregnancy Loss – A Systematic Review and Meta-Analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996047194496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Aldosterone-induced cardiomyocyte growth, and fibroblast migration and proliferation are mediated by TRAF3IP2"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996301863680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"γδ T cell effector functions: a blend of innate programming and acquired plasticity"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996483169024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Functional Reconstitution and Regulation of IL-18 Activity by the IL-18Rβ Chain"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468848648064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1β and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468868985728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Frontline: Interferon regulatory factor‐1 as a protective gene in intestinal inflammation: role of TCR γ δ T cells and interleukin‐18‐binding protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468878809600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-37 is a fundamental inhibitor of innate immunity"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468937390720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammatory Monocytes Activate Memory CD8+ T and Innate NK Lymphocytes Independent of Cognate Antigen during Microbial Pathogen Invasion"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469001457792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"miR-197 Expression in Peripheral Blood Mononuclear Cells from Hepatitis B Virus-Infected Patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469040231296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469114111744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469603445120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Critical Roles of Myeloid Differentiation Factor 88-Dependent Proinflammatory Cytokine Release in Early Phase Clearance of\n                    <i>Listeria monocytogenes</i>\n                    in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470022670848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470049023872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammasome, Inflammation, and Tissue Homeostasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470268743936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470520799360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Decreased Susceptibility of Mice to Infection with<i>Listeria monocytogenes</i>in the Absence of Interleukin-18"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470591143424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Associations between TNF-α and interleukin gene polymorphisms with polycystic ovary syndrome risk: a systematic review and meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470828711936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Contribution of IL-18-induced innate T cell activation to airway inflammation with mucus hypersecretion and airway hyperresponsiveness"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470914888704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471033480704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The <scp>NLRC</scp>4 Inflammasome"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471098461568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Unique Action of Interleukin-18 on T Cells and Other Immune Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471188904704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association of Definition of Acute Kidney Injury by Cystatin C Rise With Biomarkers and Clinical Outcomes in Children Undergoing Cardiac Surgery"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471314748928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Intra-tumoral production of IL18, but not IL12, by TCR-engineered T cells is non-toxic and counteracts immune evasion of solid tumors"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471412909440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Defective Interleukin (IL)-18–mediated Natural Killer and T Helper Cell Type 1 Responses in IL-1 Receptor–associated Kinase (IRAK)-deficient Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471479807488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin 33 as a Mechanically Responsive Cytokine Secreted by Living Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943519426304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Serum IL-18 Is Closely Associated with Renal Tubulointerstitial Injury and Predicts Renal Prognosis in IgA Nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943602937088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943747421952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A role for mitochondria in NLRP3 inflammasome activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943961729920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Metabolic regulation of <scp>NLRP</scp>3"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944012704384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IFN-γ Plays a Unique Role in Protection against Low Virulent Trypanosoma cruzi Strain"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944267580928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Plasma interleukin (IL)-18 concentrations is elevated in patients with previous myocardial infarction and related to severity of coronary atherosclerosis independently of C-reactive protein and IL-6"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944558183808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neuro-Immune Interactions at Barrier Surfaces"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944749168512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inducible Foxp3\n                    <sup>+</sup>\n                    regulatory T-cell development by a commensal bacterium of the intestinal microbiota"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944779427328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TLR4 links innate immunity and fatty acid–induced insulin resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944879917312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-18 promoter polymorphisms and plasma levels are associated with increased risk of periodontitis: a meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944949051392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-1 Receptor-Associated Kinase 4 Is Essential for IL-18-Mediated NK and Th1 Cell Responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945144699648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Caspases: pharmacological manipulation of cell death"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945325562240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<scp>IL</scp>‐37 Expression is Upregulated in Patients with Tuberculosis and Induces Macrophages Towards an M2‐like Phenotype"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945389033216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-18 promoter -607 C/A and -137 G/C polymorphisms and susceptibility to type 1 diabetes: A meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945484784000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945713068800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin 18 Acts on Memory T Helper Cells Type 1 to Induce Airway Inflammation and Hyperresponsiveness in a Naive Host Mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945873466368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ASC is essential for LPS‐induced activation of procaspase‐1 independently of TLR‐associated signal adaptor molecules"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946164370688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammasome and Fas-Mediated IL-1β Contributes to Th17/Th1 Cell Induction in Pathogenic Bacterial Infection In Vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946374329216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418563507840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"AMPK in skeletal muscle function and metabolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418770466176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418813826176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin 18 stimulates HIV type 1 in monocytic cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419079078016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419283330304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Perforin and the granule exocytosis cytotoxicity pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419295752704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanisms of Inhibition of Collagen-Induced Arthritis by Murine IL-18 Binding Protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419380467968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tissue signals imprint ILC2 identity with anticipatory function"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419473286656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin (Il)-18 Promotes the Development of Chronic Gastrointestinal Helminth Infection by Downregulating IL-13"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419494646656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The -137G/C single nucleotide polymorphism in IL-18 gene promoter contributes to tuberculosis susceptibility in Chinese Han population"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419685276672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419812423936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"BCAP links IL-1R to the PI3K–mTOR pathway and regulates pathogenic Th17 cell differentiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420189139584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Context-dependent role of IL-18 in cancer biology and counter-regulation by IL-18BP"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420537506048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The role of hybrid ubiquitin chains in the MyD88 and other innate immune signalling pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420603268096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lipopolysaccharide-Induced IL-18 Secretion from Murine Kupffer Cells Independently of Myeloid Differentiation Factor 88 That Is Critically Involved in Induction of Production of IL-12 and IL-1β"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420624554624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Review and pooled analysis of studies on -607(C/A) and -137(G/C) polymorphisms in IL-18 and cancer risk"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420644820224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The NLRP3 inflammasome: Role in metabolic disorders and regulation by metabolic pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420962396672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420984084224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Peripheral blood monocytes are responsible for γδ T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421073200640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of the Pyrin Inflammasome by Intracellular <i>Burkholderia cenocepacia</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421209002112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Relationship of Kidney Injury Biomarkers with Long-Term Cardiovascular Outcomes after Cardiac Surgery"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421232429440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-27 Regulates IL-18 Binding Protein in Skin Resident Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421345236608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system"}]},{"@id":"https://cir.nii.ac.jp/crid/1362820494018396800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Interleukin-1/-33 Signaling Pathways as Therapeutic Targets for Endometriosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893376780416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Atherosclerosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893801323264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893813204224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Inflammasome"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893961098112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MyD88/IL-18-dependent pathways rather than TLRs control early parasitaemia in non-lethal Plasmodium yoelii infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893985096832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evidence of foam cell and cholesterol crystal formation in macrophages incubated with oxidized LDL by fluorescence and electron microscopy."}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894178596608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction of allergic inflammation by interleukin‐18 in experimental animal models"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894458247680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association of cytokine gene polymorphisms (IL‑6, IL‑12B, IL‑18) with Behcet’s disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894578716032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894981352192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neutrophil-independent mechanisms of caspase-1– and IL-18–mediated ischemic acute tubular necrosis in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895015195392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-18 Regulates Both Th1 and Th2 Responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895139806976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epithelial Cell Inflammasomes in Intestinal Immunity and Inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895422429952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hyperglycemia Activates Caspase-1 and TXNIP-Mediated IL-1β Transcription in Human Adipose Tissue"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895675823232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Development and maintenance of intestinal regulatory T cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895685758848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IFN-  is a master regulator of endotoxin shock syndrome in mice primed with heat-killed Propionibacterium acnes"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895725262976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL18 Gene Variants Influence the Susceptibility to Chagas Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895728144000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Failure of Interferon γ to Induce the Anti-Inflammatory Interleukin 18 Binding Protein in Familial Hemophagocytosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895756507520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Impaired IL-18 processing protects caspase-1–deficient mice from ischemic acute renal failure"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895790074496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Detection of MCT and MCTC types of human mast cells by immunohistochemistry using new monoclonal anti-tryptase and anti-chymase antibodies."}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895941428224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896011536640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Contribution of IL-18 to Th1 Response and Host Defense Against Infection by\n                    <i>Mycobacterium tuberculosis</i>\n                    : A Comparative Study with IL-12p40"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896013996928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neutrophil Proteinase 3-Mediated Induction of Bioactive IL-18 Secretion by Human Oral Epithelial Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896136032640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896213645696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biomarkers in acute kidney injury – pathophysiological basis and clinical performance"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368378420864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammasome is a central player in the induction of obesity and insulin resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368514658816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interferon-<b>α</b>induces interleukin-18 binding protein in chronic hepatitis C patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368561208320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Role of IL-18 in Blood-Stage Immunity Against Murine Malaria\n                    <i>Plasmodium yoelii</i>\n                     \n                    <i>265</i>\n                    and\n                    <i>Plasmodium berghei</i>\n                     \n                    <i>ANKA</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369063816832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Caspase-1-Independent, Fas/Fas Ligand–Mediated IL-18 Secretion from Macrophages Causes Acute Liver Injury in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369302147712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The role of IL-13 in helminth-induced inflammation and protective immunity against nematode infections"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369685735040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of Inflammasomes in Intestinal Inflammation and Crohnʼs Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370048831872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters."}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370078761728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The IL-18 Antagonist IL-18–Binding Protein Is Produced in the Human Ovarian Cancer Microenvironment"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370093862656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The enigmatic processing and secretion of interleukin-33"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370248946176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370279268352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Both IL‐12 and IL‐18 contribute to small intestinal Th1‐type immunopathology following oral infection with <i>Toxoplasma gondii</i>, but IL‐12 is dominant over IL‐18 in parasite control"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370406891904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human Mast Cell Chymase Cleaves Pro-IL-18 and Generates a Novel and Biologically Active IL-18 Fragment"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370419600384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TLR4 enhances TGF-β signaling and hepatic fibrosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370675448576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"PI3K-mediated negative feedback regulation of IL-12 production in DCs"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370691183744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IFN-α and IL-18 synergistically enhance IFN-γ production in human NK cells: differential regulation of Stat4 activation and IFN-γ gene expression by IFN-α and IL-12"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370964680448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fas-Mediated Inflammatory Response in <i>Listeria monocytogenes</i> Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371144239872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-18 neutralization ameliorates obstruction-induced epithelial–mesenchymal transition and renal fibrosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371237480320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843620015488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844037304064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844042605184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-18 with IL-2 protects against\n                    <i>Strongyloides venezuelensis</i>\n                    infection by activating mucosal mast cell–dependent type 2 innate immunity"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844092115072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of a new putative functional IL18 gene variant through an association study in systemic lupus erythematosus"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844201146112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844305455104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-12 (IL-12) and IL-18 Are Important in Innate Defense against Genital Herpes Simplex Virus Type 2 Infection in Mice but Are Not Required for the Development of Acquired Gamma Interferon-Mediated Protective Immunity"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844325378816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844480133760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-12 and interleukin-18 are indispensable for protective immunity against enteropathogenicYersinia"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844505888640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844519241472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844624995328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844672903808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844739280640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844751242112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Decreased Expression of Cytokines That Induce Type 1 Helper T Cell/Interferon-γ Responses in Genetically Susceptible Mice Infected withMycobacterium avium"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844806030976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Involvement of CD56brightCD11c+ Cells in IL-18–Mediated Expansion of Human γδ T Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844836271104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Dose-Escalation Study of Recombinant Human Interleukin-18 Using Two Different Schedules of Administration in Patients with Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844871389056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An Absolute Requirement for STAT4 and a Role for IFN-γ as an Amplifying Factor in IL-12 Induction of the Functional IL-18 Receptor Complex"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844970053888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845012510976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An NLRP3 inflammasome–triggered Th2-biased adaptive immune response promotes leishmaniasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845020448768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Effect of Cytokines and Pharmacologic Agents on Chronic HIV Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845491431168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-18 binding protein fusion construct delays the development of diabetes in adoptive transfer and cyclophosphamide-induced diabetes in NOD mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845654771328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prevalence of Inflammatory Bowel Disease Among Adults Aged ≥18 Years — United States, 2015"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846140475392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cloning and expression of interleukin‐18 binding protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846334395904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Involvement of interleukin-18 in severe Plasmodium falciparum malaria"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318227077248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lack of association of interleukin-18 gene promoter −607 A/C polymorphism with susceptibility to autoimmune diseases: a meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318239669248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318264484480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of mRNA Translation and Stability by microRNAs"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318348089600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318397933568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318700476032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Granzyme B is a novel interleukin-18 converting enzyme"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318748992896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetically Resistant Mice Lacking IL-18 Gene Develop Th1 Response and Control Cutaneous\n                    <i>Leishmania major</i>\n                    Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318770508672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii."}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319477693312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TAK1 is a ubiquitin-dependent kinase of MKK and IKK"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319505093632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of IL-18 on Expansion of γδ T Cells Stimulated by Zoledronate and IL-2"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319715375232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Urinary Biomarkers of AKI and Mortality 3 Years after Cardiac Surgery"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320434073344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320468552704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Urinary interleukin-18 is a marker of human acute tubular necrosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320523386496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Restoration of Natural IgM Production from Liver B Cells by Exogenous IL-18 Improves the Survival of Burn-Injured Mice Infected with\n                    <i>Pseudomonas aeruginosa</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320532266752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biologic basis for interleukin-1 in disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320602840832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"High Glucose Induces Toll-Like Receptor Expression in Human Monocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320656076416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammasomes in the urinary tract: a disease-based review"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320685251712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-18 Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320985607680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321097003008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Follicular Helper CD4 T Cells (T<sub>FH</sub>)"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321143795968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression of Interleukin-18 in Human Atherosclerotic Plaques and Relation to Plaque Instability"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321165752704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Paradoxical Effect of IL-18 Therapy on the Severe and Mild Escherichia coli Infections in Burn-Injured Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321206744576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gout-associated uric acid crystals activate the NALP3 inflammasome"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321255271680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human CARD9: A Critical Molecule of Fungal Immune Surveillance"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321285131008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Dose-Escalation Study of Recombinant Human Interleukin-18 in Combination With Rituximab in Patients With Non-Hodgkin Lymphoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793237373824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Critical Role for Interleukin 18 in Primary and Memory Effector Responses to <i>Listeria monocytogenes</i> That Extends Beyond Its Effects on Interferon γ Production"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793767697280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association of IL-18 polymorphisms with rheumatoid arthritis and systemic lupus erythematosus in Asian populations: a meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793889322496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association between interleukin-18 polymorphisms and systemic lupus erythematosus: a meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793929771520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NLRP3 inflammasomes link inflammation and metabolic disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794304972928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The -607C/A Polymorphisms in Interleukin-18 Gene Promoter Contributes to Cancer Risk: Evidence from A Meta-Analysis of 22 Case-Control Studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794352656256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Th2–mediated host protective immunity to intestinal nematode infections"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794751917312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"High circulating levels of free interleukin-18 in patients with active SLE in the presence of elevated levels of interleukin-18 binding protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794934248192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bcl6 Is a Transcriptional Repressor for the\n                    <i>IL-18</i>\n                    Gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795173096704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-22 Induces Interleukin-18 Expression from Epithelial Cells during Intestinal Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795361452800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin 18 Contributes to Host Resistance and Gamma Interferon Production in Mice Infected with Virulent<i>Salmonella typhimurium</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795610703488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin (IL)-18 Binding Protein Deficiency Disrupts Natural Killer Cell Maturation and Diminishes Circulating IL-18"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795788869504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immunology of<i>Toxoplasma gondii</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795914068352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human T Cell Receptor γδ Cells Recognize Endogenous Mevalonate Metabolites in Tumor Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796063761664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796250308096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-18 Production Downstream of the Nlrp3 Inflammasome Confers Protection against Colorectal Tumor Formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268510377856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268869949696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-18 Binding Protein in the Sera of Patients with Wegener’s Granulomatosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269012533504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269056938240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Shaping of Natural Killer Cell Antitumor Activity by Ex Vivo Cultivation"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269116336256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-18 Receptor β-Induced Changes in the Presentation of IL-18 Binding Sites Affect Ligand Binding and Signal Transduction"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269135467776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TAB2 and TAB3 Activate the NF-κB Pathway through Binding to Polyubiquitin Chains"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269343441536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Blockade of IL-18 Receptor Signaling Delays the Onset of Autoimmune Disease in MRL-\n                    <i>Fas</i>\n                    <i>lpr</i>\n                    Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269416404992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Redefining interferon-producing killer dendritic cells as a novel intermediate in NK-cell differentiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269583755904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular mechanisms of inflammasome signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269668350208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Upregulation of circulating microRNA-134 in adult-onset Still’s disease and its use as potential biomarker"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269709324800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270105297024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The NALP3 inflammasome is involved in the innate immune response to amyloid-β"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270150436096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Recent advances in inflammasome biology"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270167790720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270236659840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association of IL-8 gene promoter -251 A/T and IL-18 gene promoter -137 G/C polymorphisms with head and neck cancer risk: a comprehensive meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270369867904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Natural history of idiopathic IgA nephropathy: Role of clinical and histological prognostic factors"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270394935424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The NLRP1-IL18 Connection: A Stab in the Back of Obesity-Induced Inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270431866880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human Intelectin Is a Novel Soluble Lectin That Recognizes Galactofuranose in Carbohydrate Chains of Bacterial Cell Wall"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270514684928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270589845888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NLRP6: A Multifaceted Innate Immune Sensor"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270803712128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammatory bowel disease in non-Ashkenazi Jews with familial Mediterranean fever"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271123037696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bacterial Manipulation of NK Cell Regulatory Activity Increases Susceptibility to Listeria monocytogenes Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271213477376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Type 1 Interferon (IFNα/β) and Type 2 Nitric Oxide Synthase Regulate the Innate Immune Response to a Protozoan Parasite"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271213875328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Multiple interleukin-18 injections promote both mouse Th1 and Th2 responses after sublethal<i>Escherichia coli</i>infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271282755072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Caspase-1-Mediated Activation of Interleukin-1β (IL-1β) and IL-18 Contributes to Innate Immune Defenses against<i>Salmonella enterica</i>Serovar Typhimurium Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1370004239495710601","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Assessmentofbrownadiposetissuefunction"}]},{"@id":"https://cir.nii.ac.jp/crid/1370004239495710994","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Serum levels of interleukin-18 in patients with uncomplicated Plasmodium falciparum malaria"}]},{"@id":"https://cir.nii.ac.jp/crid/1370004239495711878","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Dual Effects of Interleukin-18 in Tumor Progression"}]},{"@id":"https://cir.nii.ac.jp/crid/1370004239495712020","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Macrophage Switch in Obesity Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1370582246937174913","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1370582246937175040","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1370582246937175168","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Revisiting the prominent anti-tumoral potential of pre-mNK cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1370582246937175808","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants"}]},{"@id":"https://cir.nii.ac.jp/crid/1370582246937175936","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Open-label, multicentre, dose-escalating phase II clinical trial on the safety and efficacy of tadekinig alfa (IL-18BP) in adult-onset Still’s disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1390853122769790976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"NLRP3 Inflammasome as a Common Denominator of Atherosclerosis and Abdominal Aortic Aneurysm"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854176491096192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans"},{"@value":"Dectin-1 is required for host defense against <italic>Pneumocystis carinii</italic> but not against <italic>Candida albicans</italic>"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698601324117376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia"},{"@value":"C-type lectin Mincle is an activating receptor for pathogenic fungus, <italic>Malassezia</italic>"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950401123852416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans"},{"@value":"Dectin-2 Recognition of a-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans"},{"@value":"Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans"},{"@value":"Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against <italic>Candida albicans.</italic>"}]},{"@id":"https://cir.nii.ac.jp/crid/1880583642673645952","@type":"Dataset","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Faculty Opinions recommendation of A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production."}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.3390/ijms20030649"},{"@type":"KAKEN","@value":"PRODUCT-22063191"},{"@type":"OPENAIRE","@value":"doi_dedup___::c328777493df0b44bc4cb9b53c0e54d3"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-21-0258_references_DOI_AhTNBoBpx8xeSQaSpM2VbwyUxLI"},{"@type":"CROSSREF","@value":"10.1089/ars.2020.8257_references_DOI_AhTNBoBpx8xeSQaSpM2VbwyUxLI"},{"@type":"CROSSREF","@value":"10.1093/cvr/cvab010_references_DOI_AhTNBoBpx8xeSQaSpM2VbwyUxLI"},{"@type":"CROSSREF","@value":"10.1016/j.cyto.2021.155521_references_DOI_AhTNBoBpx8xeSQaSpM2VbwyUxLI"},{"@type":"CROSSREF","@value":"10.1016/j.jaci.2021.04.019_references_DOI_AhTNBoBpx8xeSQaSpM2VbwyUxLI"},{"@type":"CROSSREF","@value":"10.1007/s10620-024-08453-2_references_DOI_AhTNBoBpx8xeSQaSpM2VbwyUxLI"},{"@type":"CROSSREF","@value":"10.1016/j.yjmcc.2023.05.003_references_DOI_AhTNBoBpx8xeSQaSpM2VbwyUxLI"},{"@type":"CROSSREF","@value":"10.3390/biom15010016_references_DOI_AhTNBoBpx8xeSQaSpM2VbwyUxLI"},{"@type":"CROSSREF","@value":"10.3390/ijms222313098_references_DOI_AhTNBoBpx8xeSQaSpM2VbwyUxLI"},{"@type":"CROSSREF","@value":"10.1002/eji.201948478_references_DOI_AhTNBoBpx8xeSQaSpM2VbwyUxLI"},{"@type":"CROSSREF","@value":"10.3390/nu12113287_references_DOI_AhTNBoBpx8xeSQaSpM2VbwyUxLI"},{"@type":"CROSSREF","@value":"10.1016/j.celrep.2022.111828_references_DOI_AhTNBoBpx8xeSQaSpM2VbwyUxLI"},{"@type":"CROSSREF","@value":"10.1016/j.abb.2022.109322_references_DOI_AhTNBoBpx8xeSQaSpM2VbwyUxLI"},{"@type":"CROSSREF","@value":"10.3389/fimmu.2019.02021_references_DOI_AhTNBoBpx8xeSQaSpM2VbwyUxLI"}]}