{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360004239505264640.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/mi5041188"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/2072-666X/5/4/1188/pdf"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"High Resolution Cell Positioning Based on a Flow Reduction Mechanism for Enhancing Deformability Mapping"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The dispersion of cell deformability mapping is affected not only by the resolution of the sensing system, but also by cell deformability itself. In order to extract the pure deformability characteristics of cells, it is necessary to improve the resolution of cell actuation in the sensing system, particularly in the case of active sensing, where an actuator is essential. This paper proposes a novel concept, a “flow reduction mechanism”, where a flow is generated by a macroactuator placed outside of a microfluidic chip. The flow can be drastically reduced at the cell manipulation point in a microchannel due to the elasticity embedded into the fluid circuit of the microfluidic system. The great advantage of this approach is that we can easily construct a high resolution cell manipulation system by combining a macro-scale actuator and a macro-scale position sensor, even though the resolution of the actuator is larger than the desired resolution for cell manipulation. Focusing on this characteristic, we successfully achieved the cell positioning based on a visual feedback control with a resolution of 240 nm, corresponding to one pixel of the vision system. We show that the utilization of this positioning system contributes to reducing the dispersion coming from the positioning resolution in the cell deformability mapping.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004239505264521","@type":"Researcher","foaf:name":[{"@value":"Shinya Sakuma"}],"jpcoar:affiliationName":[{"@value":"Department of Mechanical Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239505264514","@type":"Researcher","foaf:name":[{"@value":"Keisuke Kuroda"}],"jpcoar:affiliationName":[{"@value":"Department of Mechanical Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239505264644","@type":"Researcher","foaf:name":[{"@value":"Fumihito Arai"}],"jpcoar:affiliationName":[{"@value":"Department of Micro-Nano Systems Engineering, Nagoya University, Furo-Cho, Chikusa-Ku, Nagoya 464-8601, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001205269329921","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000297495412"},{"@type":"NRID","@value":"9000366511376"},{"@type":"NRID","@value":"9000316203533"},{"@type":"NRID","@value":"9000387482416"},{"@type":"NRID","@value":"9000375893220"},{"@type":"NRID","@value":"9000392518390"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/tatsunoritaniguchi"}],"foaf:name":[{"@value":"Tatsunori Taniguchi"}],"jpcoar:affiliationName":[{"@value":"Department of Cardiovascular Medicine, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239505264385","@type":"Researcher","foaf:name":[{"@value":"Tomohito Ohtani"}],"jpcoar:affiliationName":[{"@value":"Department of Cardiovascular Medicine, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239505264519","@type":"Researcher","foaf:name":[{"@value":"Yasushi Sakata"}],"jpcoar:affiliationName":[{"@value":"Department of Cardiovascular Medicine, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380004239505264515","@type":"Researcher","foaf:name":[{"@value":"Makoto Kaneko"}],"jpcoar:affiliationName":[{"@value":"Department of Mechanical Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"2072666X"}],"prism:publicationName":[{"@value":"Micromachines"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2014-11-18","prism:volume":"5","prism:number":"4","prism:startingPage":"1188","prism:endingPage":"1201"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.mdpi.com/2072-666X/5/4/1188/pdf"}],"createdAt":"2014-11-18","modifiedAt":"2025-10-11","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=high%20resolution","dc:title":"high resolution"},{"@id":"https://cir.nii.ac.jp/all?q=red%20blood%20cell","dc:title":"red blood cell"},{"@id":"https://cir.nii.ac.jp/all?q=flow%20reduction%20mechanism,%20cell%20positioning","dc:title":"flow reduction mechanism, cell positioning"},{"@id":"https://cir.nii.ac.jp/all?q=TJ1-1570","dc:title":"TJ1-1570"},{"@id":"https://cir.nii.ac.jp/all?q=deformability","dc:title":"deformability"},{"@id":"https://cir.nii.ac.jp/all?q=Mechanical%20engineering%20and%20machinery","dc:title":"Mechanical engineering and machinery"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782140461312","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23106003"},{"@type":"JGN","@value":"JP23106003"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-23106003/"}],"notation":[{"@language":"ja","@value":"超高速細胞システム特性計測"},{"@language":"en","@value":"Ultra-High Speed Measurement of Cell Properties"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782310733312","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26630098"},{"@type":"JGN","@value":"JP26630098"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26630098/"}],"notation":[{"@language":"ja","@value":"仮想減速器の着想と高分解能細胞位置決めへの挑戦"},{"@language":"en","@value":"New Concept of Virtual Reduction Mechanism and Apply for Cell Positioning with High Preciaison"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050019302705809024","@type":"Article","resourceType":"学術雑誌論文(journal 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